Comparison of background EEG activity of different groups of patients with idiopathic epilepsy using Shannon spectral entropy and cluster-based permutation statistical testing

Idiopathic epilepsy is characterized by generalized seizures with no apparent cause. One of its main problems is the lack of biomarkers to monitor the evolution of patients. The only tools they can use are limited to inspecting the amount of seizures during previous periods of time and assessing the...

Full description

Saved in:

Bibliographic Details
Published in:	PloS one Vol. 12; no. 9; p. e0184044
Main Authors:	Urigüen, Jose Antonio, García-Zapirain, Begoña, Artieda, Julio, Iriarte, Jorge, Valencia, Miguel
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 18.09.2017 Public Library of Science (PLoS)
Subjects:	Adolescent Adult Aged Automatic Data Processing - methods Biology and Life Sciences Biomarkers Biomedical engineering Care and treatment Child Comparative analysis Diagnosis EEG Electroencephalography Electroencephalography - methods Engineering Engineering and Technology Entropy Entropy (Information theory) Epilepsy Epilepsy - physiopathology Evolution Female Humans International conferences Male Medicine and Health Sciences Methods Middle Aged Patients Physical Sciences Physiology Research and Analysis Methods Seizing Seizures Seizures (Medicine) Signal processing Spectra Statistical analysis Statistical tests Studies Spain
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	Idiopathic epilepsy is characterized by generalized seizures with no apparent cause. One of its main problems is the lack of biomarkers to monitor the evolution of patients. The only tools they can use are limited to inspecting the amount of seizures during previous periods of time and assessing the existence of interictal discharges. As a result, there is a need for improving the tools to assist the diagnosis and follow up of these patients. The goal of the present study is to compare and find a way to differentiate between two groups of patients suffering from idiopathic epilepsy, one group that could be followed-up by means of specific electroencephalographic (EEG) signatures (intercritical activity present), and another one that could not due to the absence of these markers. To do that, we analyzed the background EEG activity of each in the absence of seizures and epileptic intercritical activity. We used the Shannon spectral entropy (SSE) as a metric to discriminate between the two groups and performed permutation-based statistical tests to detect the set of frequencies that show significant differences. By constraining the spectral entropy estimation to the [6.25-12.89) Hz range, we detect statistical differences (at below 0.05 alpha-level) between both types of epileptic patients at all available recording channels. Interestingly, entropy values follow a trend that is inversely related to the elapsed time from the last seizure. Indeed, this trend shows asymptotical convergence to the SSE values measured in a group of healthy subjects, which present SSE values lower than any of the two groups of patients. All these results suggest that the SSE, measured in a specific range of frequencies, could serve to follow up the evolution of patients suffering from idiopathic epilepsy. Future studies remain to be conducted in order to assess the predictive value of this approach for the anticipation of seizures.
AbstractList	Idiopathic epilepsy is characterized by generalized seizures with no apparent cause. One of its main problems is the lack of biomarkers to monitor the evolution of patients. The only tools they can use are limited to inspecting the amount of seizures during previous periods of time and assessing the existence of interictal discharges. As a result, there is a need for improving the tools to assist the diagnosis and follow up of these patients. The goal of the present study is to compare and find a way to differentiate between two groups of patients suffering from idiopathic epilepsy, one group that could be followed-up by means of specific electroencephalographic (EEG) signatures (intercritical activity present), and another one that could not due to the absence of these markers. To do that, we analyzed the background EEG activity of each in the absence of seizures and epileptic intercritical activity. We used the Shannon spectral entropy (SSE) as a metric to discriminate between the two groups and performed permutation-based statistical tests to detect the set of frequencies that show significant differences. By constraining the spectral entropy estimation to the [6.25-12.89) Hz range, we detect statistical differences (at below 0.05 alpha-level) between both types of epileptic patients at all available recording channels. Interestingly, entropy values follow a trend that is inversely related to the elapsed time from the last seizure. Indeed, this trend shows asymptotical convergence to the SSE values measured in a group of healthy subjects, which present SSE values lower than any of the two groups of patients. All these results suggest that the SSE, measured in a specific range of frequencies, could serve to follow up the evolution of patients suffering from idiopathic epilepsy. Future studies remain to be conducted in order to assess the predictive value of this approach for the anticipation of seizures. Idiopathic epilepsy is characterized by generalized seizures with no apparent cause. One of its main problems is the lack of biomarkers to monitor the evolution of patients. The only tools they can use are limited to inspecting the amount of seizures during previous periods of time and assessing the existence of interictal discharges. As a result, there is a need for improving the tools to assist the diagnosis and follow up of these patients. The goal of the present study is to compare and find a way to differentiate between two groups of patients suffering from idiopathic epilepsy, one group that could be followed-up by means of specific electroencephalographic (EEG) signatures (intercritical activity present), and another one that could not due to the absence of these markers. To do that, we analyzed the background EEG activity of each in the absence of seizures and epileptic intercritical activity. We used the Shannon spectral entropy (SSE) as a metric to discriminate between the two groups and performed permutation-based statistical tests to detect the set of frequencies that show significant differences. By constraining the spectral entropy estimation to the [6.25-12.89) Hz range, we detect statistical differences (at below 0.05 alpha-level) between both types of epileptic patients at all available recording channels. Interestingly, entropy values follow a trend that is inversely related to the elapsed time from the last seizure. Indeed, this trend shows asymptotical convergence to the SSE values measured in a group of healthy subjects, which present SSE values lower than any of the two groups of patients. All these results suggest that the SSE, measured in a specific range of frequencies, could serve to follow up the evolution of patients suffering from idiopathic epilepsy. Future studies remain to be conducted in order to assess the predictive value of this approach for the anticipation of seizures.Idiopathic epilepsy is characterized by generalized seizures with no apparent cause. One of its main problems is the lack of biomarkers to monitor the evolution of patients. The only tools they can use are limited to inspecting the amount of seizures during previous periods of time and assessing the existence of interictal discharges. As a result, there is a need for improving the tools to assist the diagnosis and follow up of these patients. The goal of the present study is to compare and find a way to differentiate between two groups of patients suffering from idiopathic epilepsy, one group that could be followed-up by means of specific electroencephalographic (EEG) signatures (intercritical activity present), and another one that could not due to the absence of these markers. To do that, we analyzed the background EEG activity of each in the absence of seizures and epileptic intercritical activity. We used the Shannon spectral entropy (SSE) as a metric to discriminate between the two groups and performed permutation-based statistical tests to detect the set of frequencies that show significant differences. By constraining the spectral entropy estimation to the [6.25-12.89) Hz range, we detect statistical differences (at below 0.05 alpha-level) between both types of epileptic patients at all available recording channels. Interestingly, entropy values follow a trend that is inversely related to the elapsed time from the last seizure. Indeed, this trend shows asymptotical convergence to the SSE values measured in a group of healthy subjects, which present SSE values lower than any of the two groups of patients. All these results suggest that the SSE, measured in a specific range of frequencies, could serve to follow up the evolution of patients suffering from idiopathic epilepsy. Future studies remain to be conducted in order to assess the predictive value of this approach for the anticipation of seizures.
Audience	Academic
Author	Iriarte, Jorge Urigüen, Jose Antonio Artieda, Julio Valencia, Miguel García-Zapirain, Begoña
AuthorAffiliation	1 Deustotech-Life (eVida), Universidad de Deusto, Bilbao, Spain 4 Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain 3 Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain 2 Clínica Universidad de Navarra (CUN), Universidad de Navarra, Pamplona, Spain Radboud Universiteit, NETHERLANDS
AuthorAffiliation_xml	– name: 4 Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain – name: 3 Centro de Investigación Médica Aplicada (CIMA), Universidad de Navarra, Pamplona, Spain – name: 1 Deustotech-Life (eVida), Universidad de Deusto, Bilbao, Spain – name: Radboud Universiteit, NETHERLANDS – name: 2 Clínica Universidad de Navarra (CUN), Universidad de Navarra, Pamplona, Spain
Author_xml	– sequence: 1 givenname: Jose Antonio orcidid: 0000-0003-0172-4281 surname: Urigüen fullname: Urigüen, Jose Antonio – sequence: 2 givenname: Begoña surname: García-Zapirain fullname: García-Zapirain, Begoña – sequence: 3 givenname: Julio surname: Artieda fullname: Artieda, Julio – sequence: 4 givenname: Jorge surname: Iriarte fullname: Iriarte, Jorge – sequence: 5 givenname: Miguel surname: Valencia fullname: Valencia, Miguel
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28922360$$D View this record in MEDLINE/PubMed
BookMark	eNqNk99qFDEUxgep2D_6BqIBQfRi1ySTZDJeCKWstVAoWPU2ZDLJbGp2Mk0y1X0qX9GMu5VuKSJzkXDy-76cnDnnsNjrfa-L4jmCc1RW6N2VH0Mv3XzI4TlEnEBCHhUHqC7xjGFY7t3Z7xeHMV5BSEvO2JNiH_Ma45LBg-LXiV8NMtjoe-ANaKT63gU_9i1YLE6BVMne2LSejlprjA66T2AChjjFBplsjkTww6YlsK31ObK0CujBOj3ENRij7TtwuZR9Th_EQasUpANZFPywBjJfpNwYkw6zRkbdgkGH1Ziy74RPa0xWZUXSedN3T4vHRrqon23Xo-Lrx8WXk0-z84vTs5Pj85liNU4zSRTVipQlbQxnUkFkDFe1QQrCuqFVaTDHmPJKsrLlpTYVxYgaSBplSIVleVS83PgOzkexrXUUqCYQMc4Qz8TZhmi9vBJDsCsZ1sJLK_4EfOiEDDl3pwVE0uicCmlJQ0jVcIg1rxmHZVVrRNrs9WF729isdKum8ki3Y7p70tul6PyNoAximn_wUfFmaxD89ZhLJVY2Ku2c7LUfN3nTmtBqyvvVPfTh122pTuYH2N74fK-aTMUxhRRjAhnL1PwBKn-tXlmVG9PkNtgVvN0RZCbpn6mTY4zi7PLz_7MX33bZ13fYpZYuLaN349RGcRd8cbfSf0t8OxEZeL8BVPAxBm2Espt2zE-zTiAopvG7LZqYxk9sxy-LyT3xrf8_Zb8BX7w3sw
CitedBy_id	crossref_primary_10_1038_s41598_023_39799_8 crossref_primary_10_1016_j_yebeh_2021_108047 crossref_primary_10_1140_epjs_s11734_025_01587_y crossref_primary_10_1016_j_brainres_2022_148131 crossref_primary_10_1088_1741_2552_ac7b4b crossref_primary_10_3390_s23136001 crossref_primary_10_3390_ijms24010047 crossref_primary_10_3390_biology12070967 crossref_primary_10_1016_j_yebeh_2020_107427 crossref_primary_10_1093_braincomms_fcaf319 crossref_primary_10_1002_hfm_70010 crossref_primary_10_1007_s11055_021_01070_w crossref_primary_10_1371_journal_pone_0208517 crossref_primary_10_1109_TBCAS_2024_3456825 crossref_primary_10_1186_s40708_022_00159_3 crossref_primary_10_1016_j_csbj_2023_12_006 crossref_primary_10_3390_signals1010003 crossref_primary_10_1038_s42003_025_08090_z crossref_primary_10_3389_fnins_2023_1275184 crossref_primary_10_3390_brainsci10060352 crossref_primary_10_1109_JBHI_2023_3238421 crossref_primary_10_1145_3351259 crossref_primary_10_1016_j_bspc_2022_103743 crossref_primary_10_1016_j_cmpb_2018_06_011 crossref_primary_10_3758_s13428_023_02335_7 crossref_primary_10_1016_j_clinph_2020_04_174
Cites_doi	10.1109/TBME.2008.919872 10.1007/s10916-008-9231-z 10.1007/s11517-010-0590-5 10.1088/0305-4470/12/11/017 10.1109/IEMBS.2007.4352700 10.1016/j.jneumeth.2007.03.024 10.1002/hbm.1058 10.1109/BMEI.2010.5639894 10.1016/j.cmpb.2005.06.012 10.1109/EMBC.2013.6609524 10.1088/0967-3334/27/3/003 10.1088/1741-2560/12/3/031001 10.1103/PhysRevE.62.8380 10.1088/0967-3334/27/11/004 10.2174/1874120701004010223 10.1016/0013-4694(91)90138-T 10.1111/j.1469-8986.2011.01273.x 10.1088/1741-2560/11/2/026010 10.1016/j.cmpb.2005.04.006 10.1016/j.jneumeth.2003.10.009 10.1109/ICASSP.1999.758408 10.1109/51.805149 10.1111/j.1469-8986.2011.01272.x 10.1109/ISSPA.2003.1224801 10.1007/s11517-008-0392-1 10.1016/j.neuroimage.2006.11.004
ContentType	Journal Article
Copyright	COPYRIGHT 2017 Public Library of Science 2017 Urigüen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2017 Urigüen et al 2017 Urigüen et al
Copyright_xml	– notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Urigüen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2017 Urigüen et al 2017 Urigüen et al
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0184044
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Opposing Viewpoints (Gale In Context) Gale in Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic Agricultural Science Database MEDLINE
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Engineering
DocumentTitleAlternate	SSE and permutation statistical testing to differentiate patients suffering from idiopathic epilepsy
EISSN	1932-6203
ExternalDocumentID	1940168618 oai_doaj_org_article_01afe35b4d4b447b802e89680379e14d PMC5602520 A505224066 28922360 10_1371_journal_pone_0184044
Genre	Clinical Trial Journal Article
GeographicLocations	Spain
GeographicLocations_xml	– name: Spain
GrantInformation_xml	– fundername: ; grantid: 267230 – fundername: ; grantid: 114/2014
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 5PM AAPBV ABPTK
ID	FETCH-LOGICAL-c692t-a4c5ec4335bf86ac01ff8c9f1c009b573f2822587a63d83ef75215f04bcf472a3
IEDL.DBID	FPL
ISICitedReferencesCount	26
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000411059300010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Sun Nov 05 00:20:58 EDT 2023 Mon Nov 10 04:35:11 EST 2025 Tue Nov 04 02:06:01 EST 2025 Sun Nov 09 09:37:19 EST 2025 Tue Oct 07 07:41:08 EDT 2025 Sat Nov 29 13:00:42 EST 2025 Sat Nov 29 09:57:39 EST 2025 Wed Nov 26 09:52:24 EST 2025 Wed Nov 26 10:14:56 EST 2025 Thu May 22 21:21:46 EDT 2025 Wed Feb 19 02:00:50 EST 2025 Sat Nov 29 05:35:27 EST 2025 Tue Nov 18 21:29:44 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	9
Language	English
License	This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c692t-a4c5ec4335bf86ac01ff8c9f1c009b573f2822587a63d83ef75215f04bcf472a3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ORCID	0000-0003-0172-4281
OpenAccessLink	http://dx.doi.org/10.1371/journal.pone.0184044
PMID	28922360
PQID	1940168618
PQPubID	1436336
PageCount	e0184044
ParticipantIDs	plos_journals_1940168618 doaj_primary_oai_doaj_org_article_01afe35b4d4b447b802e89680379e14d pubmedcentral_primary_oai_pubmedcentral_nih_gov_5602520 proquest_miscellaneous_1940594578 proquest_journals_1940168618 gale_infotracmisc_A505224066 gale_infotracacademiconefile_A505224066 gale_incontextgauss_ISR_A505224066 gale_incontextgauss_IOV_A505224066 gale_healthsolutions_A505224066 pubmed_primary_28922360 crossref_citationtrail_10_1371_journal_pone_0184044 crossref_primary_10_1371_journal_pone_0184044
PublicationCentury	2000
PublicationDate	2017-09-18
PublicationDateYYYYMMDD	2017-09-18
PublicationDate_xml	– month: 09 year: 2017 text: 2017-09-18 day: 18
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, CA USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2017
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	JA Urigüen (ref2) 2014; 12 TE Nichols (ref12) 2001; 15 GE Powell (ref26) 1979; 12 C Gómez (ref27) 2010; 2010 A Delorme (ref9) 2004; 134 ref16 C Guerrero-Mosquera (ref3) 2010; 48 ref19 DE Abásolo (ref25) 2008; 46 DM Groppe (ref14) 2011; 48 R Hornero (ref17) 1999; 18 N Kannathal (ref28) 2005; 80 DP Subha (ref29) 2010; 34 E Maris (ref13) 2007; 164 R Hornero (ref24) 2008; 55 J Escudero (ref23) 2006; 27 ref20 A Delorme (ref10) 2006; 34 ref21 Z Liang (ref8) 2015; 9 N Päivinen (ref4) 2005; 79 J Poza (ref30) 2014; 11 TN Alotaiby (ref7) 2014; 2014 J Engel (ref1) 2007 RQ Quiroga (ref18) 2000; 62 G Giannakakis (ref6) 2015 DM Groppe (ref15) 2011; 48 ref5 D Abásolo (ref22) 2006; 27 T Inouye (ref11) 1991; 79 11138137 - Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Dec;62(6 Pt B):8380-6 21895683 - Psychophysiology. 2011 Dec;48(12):1711-25 18784948 - Med Biol Eng Comput. 2008 Oct;46(10):1019-28 20217264 - Med Biol Eng Comput. 2010 Apr;48(4):321-30 11747097 - Hum Brain Mapp. 2002 Jan;15(1):1-25 24608272 - J Neural Eng. 2014 Apr;11(2):026010 16219385 - Comput Methods Programs Biomed. 2005 Dec;80(3):187-94 20433058 - J Med Syst. 2010 Apr;34(2):195-212 15102499 - J Neurosci Methods. 2004 Mar 15;134(1):9-21 17517438 - J Neurosci Methods. 2007 Aug 15;164(1):177-90 21895684 - Psychophysiology. 2011 Dec;48(12):1726-37 1714811 - Electroencephalogr Clin Neurophysiol. 1991 Sep;79(3):204-10 18714829 - IEEE Trans Biomed Eng. 2008 Jun;55(6):1658-65 24109711 - Conf Proc IEEE Eng Med Biol Soc. 2013;2013:413-6 18002366 - Conf Proc IEEE Eng Med Biol Soc. 2007;2007:1953-6 10576077 - IEEE Eng Med Biol Mag. 1999 Nov-Dec;18(6):73-9 17028404 - Physiol Meas. 2006 Nov;27(11):1091-106 21625647 - Open Biomed Eng J. 2010;4:223-35 17188898 - Neuroimage. 2007 Feb 15;34(4):1443-9 16462011 - Physiol Meas. 2006 Mar;27(3):241-53 25834104 - J Neural Eng. 2015 Jun;12(3):031001 25741277 - Front Comput Neurosci. 2015 Feb 18;9:16 16005102 - Comput Methods Programs Biomed. 2005 Aug;79(2):151-9
References_xml	– volume: 55 start-page: 1658 issue: 6 year: 2008 ident: ref24 article-title: Spectral and nonlinear analyses of MEG background activity in patients with Alzheimer’s disease publication-title: IEEE Transactions on Biomedical Engineering doi: 10.1109/TBME.2008.919872 – volume: 34 start-page: 195 issue: 2 year: 2010 ident: ref29 article-title: EEG Signal Analysis: A Survey publication-title: Journal of Medical Systems doi: 10.1007/s10916-008-9231-z – year: 2007 ident: ref1 article-title: Epilepsy: A Comprehensive Textbook – volume: 48 start-page: 321 issue: 4 year: 2010 ident: ref3 article-title: New feature extraction approach for epileptic EEG signal detection using time-frequency distributions publication-title: Medical & Biological Engineering doi: 10.1007/s11517-010-0590-5 – volume: 12 start-page: 2053 issue: 11 year: 1979 ident: ref26 article-title: A spectral entropy method for distinguishing regular and irregular motion of Hamiltonian systems publication-title: Journal of Physics A: Mathematical and General doi: 10.1088/0305-4470/12/11/017 – ident: ref5 doi: 10.1109/IEMBS.2007.4352700 – volume: 2014 issue: 183 year: 2014 ident: ref7 article-title: EEG seizure detection and prediction algorithms: a survey publication-title: EURASIP Journal on Advances in Signal Processing – volume: 164 start-page: 177 year: 2007 ident: ref13 article-title: Nonparametric statistical testing of EEG- and MEG-data publication-title: Journal of Neuroscience Methods doi: 10.1016/j.jneumeth.2007.03.024 – volume: 15 start-page: 1 year: 2001 ident: ref12 article-title: Nonparametric Permutation Tests For Functional Neuroimaging: A Primer with Examples publication-title: Human Brain Mapping doi: 10.1002/hbm.1058 – ident: ref19 doi: 10.1109/BMEI.2010.5639894 – volume: 80 start-page: 187 issue: 3 year: 2005 ident: ref28 article-title: Entropies for detection of epilepsy in EEG publication-title: Computer Methods and Programs in Biomedicine doi: 10.1016/j.cmpb.2005.06.012 – ident: ref20 doi: 10.1109/EMBC.2013.6609524 – volume: 27 start-page: 241 issue: 3 year: 2006 ident: ref22 article-title: Entropy analysis of the EEG background activity in Alzheimer’s disease patients publication-title: Physiological Measurement doi: 10.1088/0967-3334/27/3/003 – volume: 12 start-page: 031001 issue: 3 year: 2014 ident: ref2 article-title: EEG artifact removal—State-of-the-art and guidelines publication-title: Journal of Neural Engineering doi: 10.1088/1741-2560/12/3/031001 – volume: 62 start-page: 8380 issue: 6 Pt B year: 2000 ident: ref18 article-title: Kulback-Leibler and renormalized entropies: applications to electroencephalograms of epilepsy patients publication-title: Physical review E, Statistical physics, plasmas, fluids, and related interdisciplinary topics doi: 10.1103/PhysRevE.62.8380 – volume: 27 start-page: 1091 issue: 11 year: 2006 ident: ref23 article-title: Analysis of electroencephalograms in Alzheimer’s disease patients with multiscale entropy publication-title: Physiological Measurement doi: 10.1088/0967-3334/27/11/004 – volume: 2010 start-page: 223 issue: 4 year: 2010 ident: ref27 article-title: Entropy and Complexity Analyses in Alzheimer’s Disease: An MEG Study publication-title: The Open Biomedical Engineering Journal doi: 10.2174/1874120701004010223 – volume: 79 start-page: 204 issue: 3 year: 1991 ident: ref11 article-title: Quantification of EEG irregularity by use of the entropy of the power spectrum publication-title: Electroencephalography and Clinical Neurophysiology doi: 10.1016/0013-4694(91)90138-T – volume: 48 start-page: 1711 issue: 12 year: 2011 ident: ref14 article-title: Mass univariate analysis of event—related brain potentialsfields I: A critical tutorial review publication-title: Psychophysiology doi: 10.1111/j.1469-8986.2011.01273.x – volume: 11 start-page: 026010 issue: 3 year: 2014 ident: ref30 article-title: Analysis of neural dynamics in mild cognitive impairment and Alzheimer’s disease using wavelet turbulence publication-title: Journal of Neural Engineering doi: 10.1088/1741-2560/11/2/026010 – volume: 79 start-page: 151 year: 2005 ident: ref4 article-title: Epileptic seizure detection: a nonlinear viewpoint publication-title: Computer Methods and Programs in Biomedicine doi: 10.1016/j.cmpb.2005.04.006 – volume: 134 start-page: 9 year: 2004 ident: ref9 article-title: EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics publication-title: Journal of Neuroscience Methods doi: 10.1016/j.jneumeth.2003.10.009 – ident: ref21 doi: 10.1109/ICASSP.1999.758408 – volume: 18 start-page: 73 year: 1999 ident: ref17 article-title: Estimating complexity from EEG background activity of epileptic patients publication-title: Engineering in Medicine and Biology Magazine, IEEE doi: 10.1109/51.805149 – start-page: 131 year: 2015 ident: ref6 article-title: Modern Electroencephalographic Assessment Techniques. vol. 91 of Neuromethods – volume: 48 start-page: 1726 issue: 12 year: 2011 ident: ref15 article-title: Mass univariate analysis of event—related brain potentialsfields II: Simulation studies publication-title: Psychophysiology doi: 10.1111/j.1469-8986.2011.01272.x – ident: ref16 doi: 10.1109/ISSPA.2003.1224801 – volume: 46 start-page: 1019 issue: 10 year: 2008 ident: ref25 article-title: Approximate entropy and auto mutual information analysis of the electroencephalogram in Alzheimer’s disease patients publication-title: Medical & Biological Engineering & Computing doi: 10.1007/s11517-008-0392-1 – volume: 9 issue: 16 year: 2015 ident: ref8 article-title: EEG entropy measures in anesthesia publication-title: Frontiers in Computational Neuroscience – volume: 34 start-page: 1443 year: 2006 ident: ref10 article-title: Enhanced detection of artifacts in EEG data using higher-order statistics and independent component analysis publication-title: NeuroImage doi: 10.1016/j.neuroimage.2006.11.004 – reference: 21625647 - Open Biomed Eng J. 2010;4:223-35 – reference: 21895683 - Psychophysiology. 2011 Dec;48(12):1711-25 – reference: 17517438 - J Neurosci Methods. 2007 Aug 15;164(1):177-90 – reference: 17028404 - Physiol Meas. 2006 Nov;27(11):1091-106 – reference: 11747097 - Hum Brain Mapp. 2002 Jan;15(1):1-25 – reference: 20433058 - J Med Syst. 2010 Apr;34(2):195-212 – reference: 24608272 - J Neural Eng. 2014 Apr;11(2):026010 – reference: 16462011 - Physiol Meas. 2006 Mar;27(3):241-53 – reference: 24109711 - Conf Proc IEEE Eng Med Biol Soc. 2013;2013:413-6 – reference: 18714829 - IEEE Trans Biomed Eng. 2008 Jun;55(6):1658-65 – reference: 10576077 - IEEE Eng Med Biol Mag. 1999 Nov-Dec;18(6):73-9 – reference: 20217264 - Med Biol Eng Comput. 2010 Apr;48(4):321-30 – reference: 18784948 - Med Biol Eng Comput. 2008 Oct;46(10):1019-28 – reference: 16219385 - Comput Methods Programs Biomed. 2005 Dec;80(3):187-94 – reference: 15102499 - J Neurosci Methods. 2004 Mar 15;134(1):9-21 – reference: 1714811 - Electroencephalogr Clin Neurophysiol. 1991 Sep;79(3):204-10 – reference: 17188898 - Neuroimage. 2007 Feb 15;34(4):1443-9 – reference: 25741277 - Front Comput Neurosci. 2015 Feb 18;9:16 – reference: 21895684 - Psychophysiology. 2011 Dec;48(12):1726-37 – reference: 16005102 - Comput Methods Programs Biomed. 2005 Aug;79(2):151-9 – reference: 25834104 - J Neural Eng. 2015 Jun;12(3):031001 – reference: 18002366 - Conf Proc IEEE Eng Med Biol Soc. 2007;2007:1953-6 – reference: 11138137 - Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Dec;62(6 Pt B):8380-6
SSID	ssj0053866
Score	2.376443
Snippet	Idiopathic epilepsy is characterized by generalized seizures with no apparent cause. One of its main problems is the lack of biomarkers to monitor the...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e0184044
SubjectTerms	Adolescent Adult Aged Automatic Data Processing - methods Biology and Life Sciences Biomarkers Biomedical engineering Care and treatment Child Comparative analysis Diagnosis EEG Electroencephalography Electroencephalography - methods Engineering Engineering and Technology Entropy Entropy (Information theory) Epilepsy Epilepsy - physiopathology Evolution Female Humans International conferences Male Medicine and Health Sciences Methods Middle Aged Patients Physical Sciences Physiology Research and Analysis Methods Seizing Seizures Seizures (Medicine) Signal processing Spectra Statistical analysis Statistical tests Studies
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQxYELoryaUsAgJOCQNg8nto-l2gISKogC6i1y_NiuWCVRs4vUX8VfZCb2Rg2qVA6cVorHG2denkk83xDySlpjmS5MnPKkxrdVOq6F5TGzmeEO9nTlu5Z84icn4uxMfrnS6gvPhHl4YM-4gyRVzuZFzQyrGeO1SDIrZCmSnEubMoPeN-Fyk0x5HwxWXJahUC7n6UGQy37XNnY_waSGsclGNOD1j155q1u2_XUh598nJ69sRcf3yN0QQ9JDv_Ztcss298l2sNKevglQ0m8fkN9HY5tB2jpaK_0TyzgaQ2ez9xRrGrB1BA5tGqWs6FDn0eO1gLnaU3xZSxdm0Q79izW1HfiSrr-keGp-Tk_PVdPAHYaqTbgxxWW33SVVcCO9XCMWQ4zbpaEdbARr__WfYi3TABMNM1YI9tHMH5Lvx7NvRx_i0KIh1qXMVrECOVvNchCQE6XSSeqc0NKlGmK3uuC5w2OqheCqzI3IreMQLhQuYbV2jGcqf0S2YIF2h9CcKcsM5KMGUhz4laaQri6ZzKVwmakjkm_kVemAX45tNJbV8FGOQx7j2V-hlKsg5YjE46zO43fcQP8OVWGkRfTt4QLoZBV0srpJJyPyHBWp8qWsow-pDrFrIIZQZUReDhSIwNHgEZ-5Wvd99fHzj38gOv06IXodiFwL7NAqlFXAMyGy14Ryb0IJfkRPhndQ7Tdc6atUQu5dijIVMHNjCtcPvxiH8U_x2F5j27WnKSSDXSEij73ljJyFTB9C0zKJCJ_Y1IT105FmcT4AoEOUnhVZsvs_ZPWE3MkwUsOuIGKPbK0u1vYpua1_gQVcPBu8yh-PrIEc priority: 102 providerName: Directory of Open Access Journals – databaseName: Nursing & Allied Health Database dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZg4QAHoOXRQAGDkKCHtHk4sXNCpWoBCRXUQtVb5PixXbFKwmYXqb-Kv8hM4oQGVYDEaaV4vI7tedmZ-YaQF5nRhqlE-yEPCrytUn4hDPeZiTS3YNNlV7XkAz88FKen2Sd34da4sMpeJ7aKWlcK78h34LAN3olIQ_G6_uZj1Sj8uupKaFwl10L0jYGf-dFJr4lBltPUpcvFPNxxu7NdV6XZDvBow9jIHLWo_YNuntTzqrnM8fw9fvKCQTq4_b9TuUNuOVeU7na8s0aumHKd3LwAULhO1pzoN_SVw6feukt-7A21C2llaSHVV8wNKTXd339LMVEC61FgU199ZUnb5JEGnzkg14biDTCd6VnVFkVW1NSgoOrmnGIo_pQen8myhBHaVFAYmOIqVPU5lTCQmq8Q4MFHG6xpDdZl1YUUUEyQarGnoccSEUTK6T3y5WD_894739V98FWaRUtfAvMYxeI4KaxIpQpCa4XKbKjAISwSHluMfU0El2msRWwsBx8ksQErlGU8kvF9MoEXNBuExkwapuGQq-HcBL-ZTjJbpCyLM2EjXXgk7rc_Vw4UHWtzzPP2Sx-Hw1G3GTkyTe6YxiP-0KvuQEH-Qv8GOWugRUjv9kG1mOZOQwCttAamzDQrGOOFCCIjslQEMc9MyLRHniJf5l1-7KCY8l0sRYh-WeqR5y0FwnqUGDc0laumyd9_PPkHouOjEdFLR2QrWA4lXa4GzAnhwkaUmyNKUE5q1LyBUtSvSpP_4n3o2UvH5c3Phmb8U4wFLE216miSjIGp8ciDThCHlY1EBv5uGniEj0R0tPTjlnJ21qKqg-sfJVHw8M-v9YjciNCxwyIiYpNMlouVeUyuq-_A24snrfr5CTQ0lH4 priority: 102 providerName: ProQuest
Title	Comparison of background EEG activity of different groups of patients with idiopathic epilepsy using Shannon spectral entropy and cluster-based permutation statistical testing
URI	https://www.ncbi.nlm.nih.gov/pubmed/28922360 https://www.proquest.com/docview/1940168618 https://www.proquest.com/docview/1940594578 https://pubmed.ncbi.nlm.nih.gov/PMC5602520 https://doaj.org/article/01afe35b4d4b447b802e89680379e14d http://dx.doi.org/10.1371/journal.pone.0184044
Volume	12
WOSCitedRecordID	wos000411059300010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & allied health premium. customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELbolgMcgJZHF8piEBL0kJKHYzvHttpC1QdRC1XhEiWO3VaskqjZReqv4i8y42RDU7UCLrNSPF47fszD8XxDyNtI55qpMHc84WZ4WqWcTGrhMO3nwoBOT5usJXvi4ECenETxH0fx2hf8QHgf2jFdr8pCr7vokDC2QBb9gHN0trbjvbnkhb3LeRsed1vNnvqxKP2dLB5Uk7K-ydC8fl_yigLafvi_XX9EHrSmJt1o1sYSuaOLZXL_CgDhMllqt3ZN37f402uPya-tLjchLQ3NUvUDYz-KnI7HHykGQmC-CSyaZ1eZUhscUuOzFqi1pnjCS8_z89ImPVZUVyCAqvqS4lX7U3p0lhYFtGBDPaFhim9dVpc0hYbUZIYADg7q2JxWoD1mzZUBigFQFlsaakwRIaQ4fUK-bo-_bH1y2rwOjuKRP3VSWBxasSAIMyN5qlzPGKki4ykw-LJQBAbvtoZSpDzIZaCNABsjNC7LlGHCT4OnZAAd1CuEBizVLAcnNge_CH6jPIxMxlkURNL4eTYkwXy6E9WCnmPujUliv-QJcH6ayUhwjpJ2jobE6WpVDejHX_g3cSV1vAjZbR_AYkhaCQC8qdHwyixnGWMik66vZcSlG4hIeywfkle4DpMm_rUTPMkGphpEu4sPyRvLgbAdBd4LOk1ndZ3sfD7-B6ajwx7Tu5bJlDAcKm1jMeCdEA6sx7na4wTho3rFK7hr5qNSJ14EDjuX3JNQc76Tbi5-3RXjn-Jdv0KXs4YnjBiokiF51my8bmR9GYE9y90hEb0t2Rv6fklxfmZR08G090PffX57j1-Qez4abZggRK6SwfRipl-Su-onrOuLEVkQh8dIT4SlEqjc8kZkcXN8EB-O7GnOyAokoLub60D33V2kIrb0CGgcfoca8c5-_O03SwSPMg
linkProvider	Public Library of Science
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3bTtRAdIKrifqggheqKKPRqA-FbjvtTB-MQVxkw7oSQEN8qe1cFiJpK93V8FP6i57Tm9QQ9YUHn5p0znSmp-c6PRdCHodaaSZ9Zfe5k-BplbQTobnNtKu4AZ0eV11LRnw8Fvv74fYc-d7kwmBYZSMTS0GtMoln5KvgbIN1IoK-eJl_sbFrFP5dbVpoVGSxpU--gctWvBi-hu_7xHU3Bnvrm3bdVcCWQehO7Ri2piXzPD8xIoil0zdGyND0JZgbic89g5GVvuBx4CnhacNBw_nGYYk0jLuxB8-9QC4y5jrIRdv-x0byg-wIgjo9z-P91ZoaVvIs1SsOulKMddRf2SWg1QW9_CgrzjJ0f4_XPKUAN67_b6i7Qa7VpjZdq3hjnszpdIFcPVWAcYHM16KtoM_q-tvPb5If621vRpoZmsTyM-a-pIoOBm8oJoJgvw0carrLTGmZHFPgvbpQbUHxhJseqsOsbPosqc5BAOfFCcVUgwndPYjTFFYoU11hYYpYz_ITGsNC8miGBSxstDEUzUF7zqqQCYoJYGVtbZgxxQop6eQWeX8uaLxNerBBvUiox2LNFDjxCvxCuIbKD00SsNALhXFVYhGvIbdI1kXfsffIUVT-yeTg_FUfI0IijWoitYjdzsqroid_gX-FlNzCYsny8kZ2PIlqCQiwsdHwykyxhDGeCMfVIgyE4_FQ95myyDLyQVTl_7aCN1rDVotodwYWeVRCYNmSFOOiJvGsKKLhuw__ALS70wF6WgOZDNAh4zoXBd4Jy6F1IJc6kCB8ZWd4Ebm2wUoR_eI1mNlw49nDD9thfCjGOqY6m1UwfshAlVrkTsX4LWZdEYI9HzgW4R2R0EF9dyQ9PCirxoNr4_quc_fP21omlzf33o6i0XC8dY9ccdGIxYYpYon0psczfZ9ckl-Bzo8flKKPkk_nLTB-Aua78SY
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKQQgOQMujC4UaBAIOabOJEzsHhEofsGq1VC2giktI_NhWVEnY7IL2V3Hn1zGTOKFBFXDpgVOkeJw49vibGWcehDyOtNJMBsrpczfF0yrppEJzh2lPcQMyPamrluzy4VAcHkZ7c-RHEwuDbpUNJlZArXKJZ-RrYGyDdiLCvlgz1i1ib3P7ZfHFwQpS-Ke1KadRs8iOnn0D8618MdiEtX7iedtb7zbeOLbCgCPDyJs4CQxTS-b7QWpEmEi3b4yQkelLUD3SgPsGvSwDwZPQV8LXhoO0C4zLUmkY9xIfnnuBXORgY6I74V7wsZECgCNhaEP1fN5fs5yxWuSZXnXRrGKsIwqrigGtXJgvTvLyLKX3d9_NU8Jw-_r_PI03yDWrgtP1es8skDmdLZKrpxIzLpIFC3klfWbzcj-_Sb5vtDUbaW5omsjPGBOTKbq19ZpigAjW4cCmpurMhFZBMyXeswlsS4on3_RYHedVMWhJdQHAXJQziiEII3pwlGQZvKEKgYUXU1yBvJjRBF4kT6aY2MJB3UPRAqTqtHaloBgYVuXchh4TzJySjW6R9-cyjbfJPAxQLxHqs0QzBca9AnsRrpEKIpOGLPIjYTyV9ojfsF4sbTJ4rElyEld_ODkYhfVixMiwsWXYHnHaXkWdDOUv9K-Qq1taTGVe3cjHo9giI9AmRsMnM8VSxngqXE-LKBSuzyPdZ6pHVnBPxHVccAvI8TqWYER9NOyRRxUFpjPJkKNHybQs48HbD_9AdLDfIXpqiUwO0yETG6MC34Rp0jqUyx1KAGXZaV7CHdzMShn_2nfQs9mZZzc_bJvxoegDmel8WtMEEQMR2yN3ahBoZ9YTEej5odsjvAMPnanvtmTHR1U2eTB5vMBz7_55WCvkMuBEvDsY7twjVzzUbbGOilgm85PxVN8nl-RXYPPxgwoFKfl03njxE8j0-fA
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Comparison+of+background+EEG+activity+of+different+groups+of+patients+with+idiopathic+epilepsy+using+Shannon+spectral+entropy+and+cluster-based+permutation+statistical+testing&rft.jtitle=PloS+one&rft.au=Urig%C3%BCen%2C+Jose+Antonio&rft.au=Garc%C3%ADa-Zapirain%2C+Bego%C3%B1a&rft.au=Artieda%2C+Julio&rft.au=Iriarte%2C+Jorge&rft.date=2017-09-18&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=12&rft.issue=9&rft.spage=e0184044&rft_id=info:doi/10.1371%2Fjournal.pone.0184044&rft.externalDocID=A505224066
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon