Endobiont Viruses Sensed by the Human Host – Beyond Conventional Antiparasitic Therapy

Wide-spread protozoan parasites carry endosymbiotic dsRNA viruses with uncharted implications to the human host. Among them, Trichomonas vaginalis, a parasite adapted to the human genitourinary tract, infects globally ∼250 million each year rendering them more susceptible to devastating pregnancy co...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 11; p. e48418
Main Authors:	Fichorova, Raina N., Lee, Yujin, Yamamoto, Hidemi S., Takagi, Yuko, Hayes, Gary R., Goodman, Russell P., Chepa-Lotrea, Xenia, Buck, Olivia R., Murray, Ryan, Kula, Tomasz, Beach, David H., Singh, Bibhuti N., Nibert, Max L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 07.11.2012 Public Library of Science (PLoS)
Subjects:	Animals Anti-Bacterial Agents - pharmacology Antibiotics Antiparasitic Agents - pharmacology Antiprotozoan agents Biochemistry Biological response modifiers Biology Birth Cancer Cascades Chemokines Clinical isolates Complications Double-stranded RNA Epithelial cells Female Genitourinary tract Gynecology Health aspects HIV HIV infections Hospitals Host-Pathogen Interactions - drug effects Host-Pathogen Interactions - immunology Human immunodeficiency virus Humans Immunity, Innate - drug effects Immunology Infection Infections Inflammation Inflammation - pathology Interferon Interferon Regulatory Factor-3 - metabolism Laboratories Leishmania Medical schools Medicine Metronidazole Metronidazole - pharmacology Models, Biological Molecular biology Obstetrics Papillomavirus infections Parasites Parasites - drug effects Parasites - virology Parasitic diseases Pregnancy Pregnancy complications Premature birth Premature infants Protozoa Ribonuclease III - metabolism Risk factors RNA, Double-Stranded - metabolism Sexually transmitted diseases Signal Transduction - drug effects Signal Transduction - immunology STD Symbiosis - drug effects TLR3 protein Toll-Like Receptor 3 - metabolism Toll-like receptors Totiviridae - drug effects Trichomonas vaginalis Trichomonas vaginalis - drug effects Trichomonas vaginalis - isolation & purification Trichomonas vaginalis - pathogenicity Trichomonas vaginalis - virology Trichomoniasis Vagina - immunology Vagina - parasitology Vagina - pathology Vagina - virology Viral infections Virion - drug effects Virus Diseases - immunology Virus Diseases - pathology Viruses Womens health New York United States > US Massachusetts
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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