A Conserved BDNF, Glutamate- and GABA-Enriched Gene Module Related to Human Depression Identified by Coexpression Meta-Analysis and DNA Variant Genome-Wide Association Studies

Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related information, but heterogeneity and various sources of noise have limited the discovery of disease mech...

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Veröffentlicht in:	PloS one Jg. 9; H. 3; S. e90980
Hauptverfasser:	Chang, Lun-Ching, Jamain, Stephane, Lin, Chien-Wei, Rujescu, Dan, Tseng, George C., Sibille, Etienne
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 07.03.2014 Public Library of Science (PLoS)
Schlagworte:	Aged Analysis Anopheles Bioinformatics Biology Bipolar disorder Brain Brain - metabolism Brain - physiopathology Brain research Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Case-Control Studies Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Deoxyribonucleic acid Depression (Mood disorder) Depressive Disorder, Major - genetics Depressive Disorder, Major - metabolism Depressive Disorder, Major - physiopathology Disease DNA Epidemiology Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Female GABA Gene expression Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks Genes Genetic aspects Genetic Predisposition to Disease Genetics Genome, Human Genome-wide association studies Genome-Wide Association Study Genomes Genomics Glutamate Heterogeneity Humans Hypotheses Male Medical research Medicine Mental depression Meta-analysis Metabolic Networks and Pathways - genetics Middle Aged Multigene Family Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system diseases Neurosciences Noise control Psychiatry Receptors, Eph Family - genetics Receptors, Eph Family - metabolism Receptors, GABA - genetics Receptors, GABA - metabolism Receptors, Metabotropic Glutamate - genetics Receptors, Metabotropic Glutamate - metabolism Reelin Protein Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Single nucleotide polymorphisms Studies Transcriptome
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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