Angiography with optical coherence tomography as a biomarker in multiple sclerosis

To investigate superficial retinal microvascular plexuses detected by optical coherence tomography angiography (OCT-A) in multiple sclerosis (MS) subjects and compare them with healthy controls. A total of 92 eyes from 92 patients with relapsing-remitting MS and 149 control eyes were included in thi...

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Bibliographic Details
Published in:PloS one Vol. 15; no. 12; p. e0243236
Main Authors: Cordon, Beatriz, Vilades, Elisa, Orduna, Elvira, Satue, María, Perez-Velilla, Javier, Sebastian, Berta, Polo, Vicente, Larrosa, Jose Manuel, Pablo, Luis Emilio, Garcia-Martin, Elena
Format: Journal Article
Language:English
Published: United States Public Library of Science 08.12.2020
Public Library of Science (PLoS)
Subjects:
Adult
Angiography
Autoimmune diseases
Biology and Life Sciences
Biomarkers
Blood vessels
Density
Diagnosis
Disease
Epidemics
Eye (anatomy)
Female
Genotype & phenotype
Glaucoma
Hospitals
Humans
Male
Medical examination
Medical imaging
Medical research
Medicine and Health Sciences
Methods
Microvasculature
Middle Aged
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - diagnostic imaging
Nervous system
Neuritis
Neurodegeneration
Neurology
Observational studies
Ophthalmology
Optic Disk - blood supply
Optic Disk - diagnostic imaging
Optic nerve
Optic neuritis
Optical Coherence Tomography
Optical tomography
Research and Analysis Methods
Retina
Retinal Vessels - diagnostic imaging
Sexually transmitted diseases
Social Sciences
STD
Tomography
Tomography, Optical Coherence
Vascularization
Spain
ISSN:1932-6203, 1932-6203
Online Access:Get full text
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Description
Summary:To investigate superficial retinal microvascular plexuses detected by optical coherence tomography angiography (OCT-A) in multiple sclerosis (MS) subjects and compare them with healthy controls. A total of 92 eyes from 92 patients with relapsing-remitting MS and 149 control eyes were included in this prospective observational study. OCT-A imaging was performed using Triton Swept-Source OCT (Topcon Corporation, Japan). The vessel density (VD) percentage in the superficial retinal plexus and optic disc area (6 x 6 mm grid) was measured and compared between groups. MS patients showed a significant decrease VD in the superior (p = 0.005), nasal (p = 0.029) and inferior (p = 0.040) parafoveal retina compared with healthy subjects. Patients with disease durations of more than 5 years presented lower VD in the superior (p = 0.002), nasal (p = 0.017) and inferior (p = 0.022) parafoveal areas compared with healthy subjects. Patients with past optic neuritis episodes did not show retinal microvasculature alterations, but patients with an EDSS score of less than 3 showed a significant decrease in nasal (p = 0.024) and superior (p = 0.006) perifoveal VD when compared with healthy subjects. MS produces a decrease in retinal vascularization density in the superficial plexus of the parafoveal retina. Alterations in retinal vascularization observed in MS patients are independent of the presence of optic nerve inflammation. OCT-A has the ability to detect subclinical vascular changes and is a potential biomarker for diagnosing the presence and progression of MS.
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Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0243236