Effects of Oral Lycopene Supplementation on Vascular Function in Patients with Cardiovascular Disease and Healthy Volunteers: A Randomised Controlled Trial

The mechanisms by which a 'Mediterranean diet' reduces cardiovascular disease (CVD) burden remain poorly understood. Lycopene is a potent antioxidant found in such diets with evidence suggesting beneficial effects. We wished to investigate the effects of lycopene on the vasculature in CVD...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 6; p. e99070
Main Authors:	Gajendragadkar, Parag R., Hubsch, Annette, Mäki-Petäjä, Kaisa M., Serg, Martin, Wilkinson, Ian B., Cheriyan, Joseph
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 09.06.2014 Public Library of Science (PLoS)
Subjects:	Acetylcholine Administration, Oral Adult Aged Aged, 80 and over Antioxidants Antioxidants (Nutrients) Antioxidants - administration & dosage Antioxidants - therapeutic use Arginine Atherosclerosis Bioavailability Biology and Life Sciences Blood pressure Blood Pressure - drug effects Cardiac patients Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - drug therapy Cardiovascular Diseases - physiopathology Care and treatment Carotenoids - administration & dosage Carotenoids - therapeutic use Cholesterol Clinical trials Diabetes Diet Dietary supplements Dietary Supplements - analysis Disease control Disease prevention Double-Blind Method Endothelium Exercise Female Forearm Health services Hospitals Humans Hypertension Lipids Lipoproteins (low density) Low density lipoprotein Low density lipoproteins Lycopene Male Medicine and Health Sciences Mediterranean diet Middle Aged Monomethyl-L-arginine Nitric oxide Nitroprusside Oxidative stress Patients Pharmacology Physiology Plethysmography Randomization Regional Blood Flow - drug effects Signal transduction Sodium Sodium nitroprusside Statins Stiffness Studies Supplementation Vascular Stiffness - drug effects Vasodilation
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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