The Association of Depression and Anxiety with Pain: A Study from NESDA

Chronic pain is commonly co-morbid with a depressive or anxiety disorder. Objective of this study is to examine the influence of depression, along with anxiety, on pain-related disability, pain intensity, and pain location in a large sample of adults with and without a depressive and/or anxiety diso...

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Veröffentlicht in:PloS one Jg. 9; H. 10; S. e106907
Hauptverfasser: de Heer, Eric W., Gerrits, Marloes M. J. G., Beekman, Aartjan T. F., Dekker, Jack, van Marwijk, Harm W. J., de Waal, Margot W. M., Spinhoven, Philip, Penninx, Brenda W. J. H., van der Feltz-Cornelis, Christina M.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 15.10.2014
Public Library of Science (PLoS)
Schlagworte:
Adult
Adults
Analysis
Anxiety
Anxiety Disorders - epidemiology
Anxiety Disorders - etiology
Back pain
Biology and Life Sciences
Cardiovascular disease
Chronic illnesses
Chronic pain
Chronic Pain - complications
Chronic Pain - epidemiology
Comorbidity
Constraining
Cytokines
Depressive Disorder - epidemiology
Depressive Disorder - etiology
Female
Humans
Intestine
Male
Medical diagnosis
Medicine and Health Sciences
Mental depression
Mental disorders
Mental health care
Middle Aged
Pain
Pain Measurement
Population studies
Primary care
Psychiatry
Psychopathology
Regression analysis
Research and Analysis Methods
Respiratory diseases
Severity of Illness Index
Social Sciences
Studies
Surveys and Questionnaires
Netherlands
ISSN:1932-6203, 1932-6203
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:Chronic pain is commonly co-morbid with a depressive or anxiety disorder. Objective of this study is to examine the influence of depression, along with anxiety, on pain-related disability, pain intensity, and pain location in a large sample of adults with and without a depressive and/or anxiety disorder. The study population consisted of 2981 participants with a depressive, anxiety, co-morbid depressive and anxiety disorder, remitted disorder or no current disorder (controls). Severity of depressive and anxiety symptoms was also assessed. In separate multinomial regression analyses, the association of presence of depressive or anxiety disorders and symptom severity with the Chronic Pain Grade and location of pain was explored. Presence of a depressive (OR = 6.67; P<.001), anxiety (OR = 4.84; P<.001), or co-morbid depressive and anxiety disorder (OR = 30.26; P<.001) was associated with the Chronic Pain Grade. Moreover, symptom severity was associated with more disabling and severely limiting pain. Also, a remitted depressive or anxiety disorder showed more disabling and severely limiting pain (OR = 3.53; P<.001) as compared to controls. A current anxiety disorder (OR = 2.96; p<.001) and a co-morbid depressive and anxiety disorder (OR = 5.15; P<.001) were more strongly associated with cardio-respiratory pain, than gastro-intestinal or musculoskeletal pain. These findings remain after adjustment for chronic cardio respiratory illness. Patients with a current and remitted depressive and/or anxiety disorder and those with more severe symptoms have more disabling pain and pain of cardio-respiratory nature, than persons without a depressive or anxiety disorder. This warrants further research.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors of this manuscript have read the journal's policy and have the following competing interests: ATFB reports grants from Eli Lilly, grants from Astra Zeneca, grants from Jansen, grants from Shire, personal fees (as a speaker) from Eli Lilly, and personal fees (as a speaker) from Lundbeck, outside the submitted work. JD and CMFC report grants from Eli Lilly, outside the submitted work. BWJHP reports grants from Dutch government, ministry of Health (ZonMw), during the conduct of the study. This does not alter their adherence to PLOS ONE policies on sharing data and materials, except those mentioned in the data availability statement.
Conceived and designed the experiments: BWJHP ATFB PS HWJM. Performed the experiments: BWJHP ATFB PS HWJM. Analyzed the data: EH MMJGG BWJHP HWJM MWMW PS. Contributed reagents/materials/analysis tools: BWJHP ATFB PS HWJM. Contributed to the writing of the manuscript: EH MMJGG ATFB JD BWJHP HWJM MWMW PS CMFC.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0106907