Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012

Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV...

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Veröffentlicht in:	PloS one Jg. 10; H. 10; S. e0140765
Hauptverfasser:	Looker, Katharine J., Magaret, Amalia S., May, Margaret T., Turner, Katherine M. E., Vickerman, Peter, Gottlieb, Sami L., Newman, Lori M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 28.10.2015 Public Library of Science (PLoS)
Schlagworte:	Adolescent Adult Child Child, Preschool Distribution Encephalitis Epidemiology Estimates Female Genetic aspects Herpes simplex Herpes Simplex - epidemiology Herpes Simplex - prevention & control Herpes Simplex - virology Herpes simplex encephalitis Herpes viruses Herpesvirus 1, Human - immunology Herpesvirus 1, Human - pathogenicity Herpesvirus 2, Human - immunology Herpesvirus 2, Human - pathogenicity Humans Immunoglobulins Incidence Infant Infant, Newborn Infections Literature reviews Male Medicine Middle Aged Prevalence Reproductive health Risk factors Studies Ulcers Vaccines Viruses Young Adult Africa United Kingdom > UK United States > US Switzerland Tanzania
ISSN:	1932-6203, 1932-6203
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Abstract	Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated. We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital. We estimated that 3709 million people (range: 3440-3878 million) aged 0-49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific. The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection.
AbstractList	Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated. We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital. We estimated that 3709 million people (range: 3440-3878 million) aged 0-49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific. The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection. Background Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated. Methods We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital. Findings We estimated that 3709 million people (range: 3440-3878 million) aged 0-49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific. Conclusions The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection. Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated. We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital. We estimated that 3709 million people (range: 3440-3878 million) aged 0-49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific. The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection. Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated.BACKGROUNDHerpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated.We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital.METHODSWe fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital.We estimated that 3709 million people (range: 3440-3878 million) aged 0-49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific.FINDINGSWe estimated that 3709 million people (range: 3440-3878 million) aged 0-49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific.The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection.CONCLUSIONSThe global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection. Background Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated. Methods We fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital. Findings We estimated that 3709 million people (range: 3440–3878 million) aged 0–49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67–212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific. Conclusions The global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection. BackgroundHerpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of genital infection. Previously, the World Health Organization estimated the global burden of HSV-2 for 2003 and for 2012. The global burden of HSV-1 has not been estimated.MethodsWe fitted a constant-incidence model to pooled HSV-1 prevalence data from literature searches for 6 World Health Organization regions and used 2012 population data to derive global numbers of 0-49-year-olds with prevalent and incident HSV-1 infection. To estimate genital HSV-1, we applied values for the proportion of incident infections that are genital.FindingsWe estimated that 3709 million people (range: 3440-3878 million) aged 0-49 years had prevalent HSV-1 infection in 2012 (67%), with highest prevalence in Africa, South-East Asia and Western Pacific. Assuming 50% of incident infections among 15-49-year-olds are genital, an estimated 140 million (range: 67-212 million) people had prevalent genital HSV-1 infection, most of which occurred in the Americas, Europe and Western Pacific.ConclusionsThe global burden of HSV-1 infection is huge. Genital HSV-1 burden can be substantial but varies widely by region. Future control efforts, including development of HSV vaccines, should consider the epidemiology of HSV-1 in addition to HSV-2, and especially the relative contribution of HSV-1 to genital infection.
Audience	Academic
Author	May, Margaret T. Gottlieb, Sami L. Newman, Lori M. Looker, Katharine J. Vickerman, Peter Magaret, Amalia S. Turner, Katherine M. E.
AuthorAffiliation	University of Pittsburgh School of Medicine, UNITED STATES 2 Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America 1 School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom 3 Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
AuthorAffiliation_xml	– name: University of Pittsburgh School of Medicine, UNITED STATES – name: 2 Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America – name: 1 School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom – name: 3 Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
Author_xml	– sequence: 1 givenname: Katharine J. surname: Looker fullname: Looker, Katharine J. – sequence: 2 givenname: Amalia S. surname: Magaret fullname: Magaret, Amalia S. – sequence: 3 givenname: Margaret T. surname: May fullname: May, Margaret T. – sequence: 4 givenname: Katherine M. E. surname: Turner fullname: Turner, Katherine M. E. – sequence: 5 givenname: Peter surname: Vickerman fullname: Vickerman, Peter – sequence: 6 givenname: Sami L. surname: Gottlieb fullname: Gottlieb, Sami L. – sequence: 7 givenname: Lori M. surname: Newman fullname: Newman, Lori M.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/26510007$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1093/infdis/jit458 10.1053/j.spid.2004.09.007 10.1086/510537 10.1371/journal.pone.0059037 10.1016/j.vaccine.2013.08.066 10.7326/0003-4819-121-11-199412010-00004 10.1136/sti.2004.012039 10.1097/00007435-200302000-00015 10.1128/JCM.40.3.1071-1072.2002 10.1001/jama.296.8.964 10.1001/jama.289.2.203 10.1542/peds.2005-1778 10.1056/NEJM198706043162304 10.1016/S0140-6736(00)04331-2 10.1128/JCM.01336-09 10.1056/NEJM199708213370801 10.1136/sti.2008.034751 10.1136/sextrans-2013-051453 10.1136/sti.2008.033902 10.1111/j.1600-0714.1997.tb00012.x 10.1056/NEJM199007263230406 10.1093/cid/cis891 10.1056/NEJMoa1103151 10.1056/NEJMra0807633 10.1056/NEJM199911043411904 10.1016/S0140-6736(07)61908-4 10.1371/journal.pone.0114989 10.1016/S0140-6736(09)62038-9 10.2471/BLT.07.046128 10.1097/QAD.0b013e3282004929 10.1097/01.aids.0000198081.09337.a7 10.1016/S0140-6736(13)62035-8 10.1086/368357 10.1128/JCM.36.3.845-847.1998 10.1086/343739 10.1086/342104 10.1097/01.OLQ.0000092387.58746.C7
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: KJL LMN. Performed the experiments: KJL. Analyzed the data: KJL ASM MTM KMET PV SLG LMN. Contributed reagents/materials/analysis tools: KJL ASM MTM KMET PV. Wrote the paper: KJL ASM MTM KMET PV SLG LMN. Contributed to the ongoing progress and direction of the research: KJL ASM MTM KMET PV SLG LMN. Provided technical expertise and input: KJL ASM MTM KMET PV SLG LMN.
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References	KC Pena (ref8) 2010; 48 R Gupta (ref1) 2007; 370 AG Langenberg (ref36) 1999; 341 SJ Reynolds (ref25) 2003; 187 C Johnston (ref42) 2014; 32 A Wald (ref29) 2002; 35 KJ Looker (ref16) 2008; 86 J Benedetti (ref18) 1994; 121 AS Magaret (ref30) 2009; 85 KJ Looker (ref17) 2015; 1 KK Tassiopoulos (ref39) 2007; 195 KJ Looker (ref2) 2005; 81 ZA Brown (ref21) 2003; 289 R Engelberg (ref19) 2003; 30 (ref38) 2010; 59 E Gray (ref11) 2008; 121 H Muench (ref34) 1959 ZA Brown (ref37) 1997; 337 RB Belshe (ref41) 2012; 366 H Tuokko (ref10) 2014; 90 DI Bernstein (ref13) 2013; 56 JL Kelsey (ref31) 1986 RJ Whitley (ref7) 2005; 16 RH Gray (ref27) 2001; 357 JA Ribes (ref33) 2002; 40 RY Kropp (ref22) 2006; 117 J Groen (ref32) 1998; 36 (ref35) 2013 H Bradley (ref40) 2014; 209 DA Scott (ref4) 1997; 26 F Xu (ref14) 2006; 296 JM Brown (ref24) 2007; 21 J Todd (ref26) 2013; 8 WE Lafferty (ref5) 1987; 16 JR Lingappa (ref28) 2010; 375 RJ Whitley (ref6) 1990; 323 JS Smith (ref3) 2002; 186 CH Mercer (ref15) 2013; 382 N Ryder (ref12) 2009; 85 L Corey (ref20) 2009; 361 CM Roberts (ref9) 2003; 30 EE Freeman (ref23) 2006; 20
References_xml	– volume: 209 start-page: 325 year: 2014 ident: ref40 article-title: Seroprevalence of herpes simplex virus types 1 and 2—United States, 1999–2010 publication-title: J Infect Dis doi: 10.1093/infdis/jit458 – volume: 16 start-page: 17 year: 2005 ident: ref7 article-title: Herpes simplex encephalitis: children and adolescents publication-title: Semin Pediatr Infect Dis doi: 10.1053/j.spid.2004.09.007 – volume: 195 start-page: 493 year: 2007 ident: ref39 article-title: Predictors of herpes simplex virus type 2 prevalence and incidence among bar and hotel workers in Moshi, Tanzania publication-title: J Infect Dis doi: 10.1086/510537 – volume: 8 start-page: e59037 year: 2013 ident: ref26 article-title: Effect of genital herpes on cervicovaginal HIV shedding in women co-infected with HIV AND HSV-2 in Tanzania publication-title: PLoS One doi: 10.1371/journal.pone.0059037 – volume: 32 start-page: 1553 year: 2014 ident: ref42 article-title: Current status and prospects for development of an HSV vaccine publication-title: Vaccine doi: 10.1016/j.vaccine.2013.08.066 – volume: 121 start-page: 847 year: 1994 ident: ref18 article-title: Recurrence rates in genital herpes after symptomatic first-episode infection publication-title: Ann Intern Med doi: 10.7326/0003-4819-121-11-199412010-00004 – year: 1959 ident: ref34 – volume: 81 start-page: 103 year: 2005 ident: ref2 article-title: A systematic review of the epidemiology and interaction of herpes simplex virus types 1 and 2 publication-title: Sex Transm Infect doi: 10.1136/sti.2004.012039 – volume: 121 start-page: 43 year: 2008 ident: ref11 article-title: Herpes simplex type 1 versus Herpes simplex type 2 in anogenital herpes; a 10 year study from the Waikato region of New Zealand publication-title: N Z Med J – volume: 30 start-page: 174 year: 2003 ident: ref19 article-title: Natural history of genital herpes simplex virus type 1 infection publication-title: Sex Transm Dis doi: 10.1097/00007435-200302000-00015 – volume: 40 start-page: 1071 year: 2002 ident: ref33 article-title: Comparative performance of herpes simplex virus type 1-specific serologic assays from MRL and Meridian Diagnostics publication-title: J Clin Microbiol doi: 10.1128/JCM.40.3.1071-1072.2002 – volume: 296 start-page: 964 year: 2006 ident: ref14 article-title: Trends in herpes simplex virus type 1 and type 2 seroprevalence in the United States publication-title: JAMA doi: 10.1001/jama.296.8.964 – volume: 289 start-page: 203 year: 2003 ident: ref21 article-title: Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant publication-title: JAMA doi: 10.1001/jama.289.2.203 – year: 2013 ident: ref35 article-title: World Population Prospects: The 2012 Revision – volume: 117 start-page: 1955 year: 2006 ident: ref22 article-title: Neonatal herpes simplex virus infections in Canada: results of a 3-year national prospective study publication-title: Pediatrics doi: 10.1542/peds.2005-1778 – volume: 16 start-page: 1444 year: 1987 ident: ref5 article-title: Recurrences after oral and genital herpes simplex virus infection. Influence of site of infection and viral type publication-title: N Engl J Med doi: 10.1056/NEJM198706043162304 – volume: 357 start-page: 1149 year: 2001 ident: ref27 article-title: Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda publication-title: Lancet doi: 10.1016/S0140-6736(00)04331-2 – volume: 48 start-page: 150 year: 2010 ident: ref8 article-title: Genital herpes simplex virus type 1 in women: detection in cervicovaginal specimens from gynecological practices in the United States publication-title: J Clin Microbiol doi: 10.1128/JCM.01336-09 – volume: 337 start-page: 509 year: 1997 ident: ref37 article-title: The acquisition of herpes simplex virus during pregnancy publication-title: N Engl J Med doi: 10.1056/NEJM199708213370801 – volume: 85 start-page: 270 year: 2009 ident: ref30 article-title: Use of the designation "shedder" in mucosal detection of herpes simplex virus DNA involving repeated sampling publication-title: Sex Transm Infect doi: 10.1136/sti.2008.034751 – volume: 59 start-page: 456 year: 2010 ident: ref38 article-title: Seroprevalence of herpes simplex virus type 2 among persons aged 14–49 years—United States, 2005–2008 publication-title: MMWR Morb Mortal Wkly Rep – volume: 90 start-page: 160 year: 2014 ident: ref10 article-title: Herpes simplex virus type 1 genital herpes in young women: current trend in Northern Finland publication-title: Sex Transm Infect doi: 10.1136/sextrans-2013-051453 – volume: 85 start-page: 416 year: 2009 ident: ref12 article-title: Increasing role of herpes simplex virus type 1 in first-episode anogenital herpes in heterosexual women and younger men who have sex with men, 1992–2006 publication-title: Sex Transm Infect doi: 10.1136/sti.2008.033902 – volume: 26 start-page: 441 year: 1997 ident: ref4 article-title: Oral shedding of herpes simplex virus type 1: a review publication-title: J Oral Pathol Med doi: 10.1111/j.1600-0714.1997.tb00012.x – volume: 323 start-page: 242 year: 1990 ident: ref6 article-title: Viral encephalitis publication-title: N Engl J Med doi: 10.1056/NEJM199007263230406 – volume: 56 start-page: 344 year: 2013 ident: ref13 article-title: Epidemiology, clinical presentation, and antibody response to primary infection with herpes simplex virus type 1 and type 2 in young women publication-title: Clin Infect Dis doi: 10.1093/cid/cis891 – volume: 366 start-page: 34 year: 2012 ident: ref41 article-title: Efficacy results of a trial of a herpes simplex vaccine publication-title: N Engl J Med doi: 10.1056/NEJMoa1103151 – volume: 361 start-page: 1376 year: 2009 ident: ref20 article-title: Maternal and neonatal herpes simplex virus infections publication-title: N Engl J Med doi: 10.1056/NEJMra0807633 – year: 1986 ident: ref31 article-title: Methods in Observational Epidemiology (Monographs in Epidemiology & Biostatistics) – volume: 341 start-page: 1432 year: 1999 ident: ref36 article-title: A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group publication-title: N Engl J Med doi: 10.1056/NEJM199911043411904 – volume: 370 start-page: 2127 year: 2007 ident: ref1 article-title: Genital herpes publication-title: Lancet doi: 10.1016/S0140-6736(07)61908-4 – volume: 1 start-page: e114989 year: 2015 ident: ref17 article-title: Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012 publication-title: PLoS One doi: 10.1371/journal.pone.0114989 – volume: 375 start-page: 824 year: 2010 ident: ref28 article-title: Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(09)62038-9 – volume: 86 start-page: 805 year: 2008 ident: ref16 article-title: An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection publication-title: Bull World Health Organ doi: 10.2471/BLT.07.046128 – volume: 21 start-page: 1515 year: 2007 ident: ref24 article-title: Incident and prevalent herpes simplex virus type 2 infection increases risk of HIV acquisition among women in Uganda and Zimbabwe publication-title: AIDS doi: 10.1097/QAD.0b013e3282004929 – volume: 20 start-page: 73 year: 2006 ident: ref23 article-title: Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies publication-title: AIDS doi: 10.1097/01.aids.0000198081.09337.a7 – volume: 382 start-page: 1781 year: 2013 ident: ref15 article-title: Changes in sexual attitudes and lifestyles in Britain through the life course and over time: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal) publication-title: Lancet doi: 10.1016/S0140-6736(13)62035-8 – volume: 187 start-page: 1513 year: 2003 ident: ref25 article-title: Recent herpes simplex virus type 2 infection and the risk of human immunodeficiency virus type 1 acquisition in India publication-title: J Infect Dis doi: 10.1086/368357 – volume: 36 start-page: 845 year: 1998 ident: ref32 article-title: Comparison of two enzyme-linked immunosorbent assays and one rapid immunoblot assay for detection of herpes simplex virus type 2-specific antibodies in serum publication-title: J Clin Microbiol doi: 10.1128/JCM.36.3.845-847.1998 – volume: 186 start-page: S3 issue: Suppl 1 year: 2002 ident: ref3 article-title: Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review publication-title: J Infect Dis doi: 10.1086/343739 – volume: 35 start-page: S173 year: 2002 ident: ref29 article-title: Serological testing for herpes simplex virus (HSV)-1 and HSV-2 infection publication-title: Clin Infect Dis doi: 10.1086/342104 – volume: 30 start-page: 797 year: 2003 ident: ref9 article-title: Increasing proportion of herpes simplex virus type 1 as a cause of genital herpes infection in college students publication-title: Sex Transm Dis doi: 10.1097/01.OLQ.0000092387.58746.C7
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Snippet	Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing cause of... Background Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing... BackgroundHerpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing... Background Herpes simplex virus type 1 (HSV-1) commonly causes orolabial ulcers, while HSV-2 commonly causes genital ulcers. However, HSV-1 is an increasing...
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SubjectTerms	Adolescent Adult Child Child, Preschool Distribution Encephalitis Epidemiology Estimates Female Genetic aspects Herpes simplex Herpes Simplex - epidemiology Herpes Simplex - prevention & control Herpes Simplex - virology Herpes simplex encephalitis Herpes viruses Herpesvirus 1, Human - immunology Herpesvirus 1, Human - pathogenicity Herpesvirus 2, Human - immunology Herpesvirus 2, Human - pathogenicity Humans Immunoglobulins Incidence Infant Infant, Newborn Infections Literature reviews Male Medicine Middle Aged Prevalence Reproductive health Risk factors Studies Ulcers Vaccines Viruses Young Adult
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Title	Global and Regional Estimates of Prevalent and Incident Herpes Simplex Virus Type 1 Infections in 2012
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