Proton NMR-Based Metabolite Analyses of Archived Serial Paired Serum and Urine Samples from Myeloma Patients at Different Stages of Disease Activity Identifies Acetylcarnitine as a Novel Marker of Active Disease
Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers indicative of phenotype that can be used to characterize transitions between health and disease, disease progression and therapeutic responses. The...
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| Published in: | PloS one Vol. 8; no. 2; p. e56422 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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19.02.2013
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers indicative of phenotype that can be used to characterize transitions between health and disease, disease progression and therapeutic responses. The desire to reproducibly detect ever greater numbers of metabolites at ever diminishing levels has naturally nurtured advances in best practice for sample procurement, storage and analysis. Reciprocally, since many of the available extensive clinical archives were established prior to the metabolomics era and were not processed in such an 'ideal' fashion, considerable scepticism has arisen as to their value for metabolomic analysis. Here we have challenged that paradigm.
We performed proton nuclear magnetic resonance spectroscopy-based metabolomics on blood serum and urine samples from 32 patients representative of a total cohort of 1970 multiple myeloma patients entered into the United Kingdom Medical Research Council Myeloma IX trial.
Using serial paired blood and urine samples we detected metabolite profiles that associated with diagnosis, post-treatment remission and disease progression. These studies identified carnitine and acetylcarnitine as novel potential biomarkers of active disease both at diagnosis and relapse and as a mediator of disease associated pathologies.
These findings show that samples conventionally processed and archived can provide useful metabolomic information that has important implications for understanding the biology of myeloma, discovering new therapies and identifying biomarkers potentially useful in deciding the choice and application of therapy. |
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| AbstractList | Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers indicative of phenotype that can be used to characterize transitions between health and disease, disease progression and therapeutic responses. The desire to reproducibly detect ever greater numbers of metabolites at ever diminishing levels has naturally nurtured advances in best practice for sample procurement, storage and analysis. Reciprocally, since many of the available extensive clinical archives were established prior to the metabolomics era and were not processed in such an 'ideal' fashion, considerable scepticism has arisen as to their value for metabolomic analysis. Here we have challenged that paradigm. We performed proton nuclear magnetic resonance spectroscopy-based metabolomics on blood serum and urine samples from 32 patients representative of a total cohort of 1970 multiple myeloma patients entered into the United Kingdom Medical Research Council Myeloma IX trial. Using serial paired blood and urine samples we detected metabolite profiles that associated with diagnosis, post-treatment remission and disease progression. These studies identified carnitine and acetylcarnitine as novel potential biomarkers of active disease both at diagnosis and relapse and as a mediator of disease associated pathologies. These findings show that samples conventionally processed and archived can provide useful metabolomic information that has important implications for understanding the biology of myeloma, discovering new therapies and identifying biomarkers potentially useful in deciding the choice and application of therapy. Background Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers indicative of phenotype that can be used to characterize transitions between health and disease, disease progression and therapeutic responses. The desire to reproducibly detect ever greater numbers of metabolites at ever diminishing levels has naturally nurtured advances in best practice for sample procurement, storage and analysis. Reciprocally, since many of the available extensive clinical archives were established prior to the metabolomics era and were not processed in such an ‘ideal’ fashion, considerable scepticism has arisen as to their value for metabolomic analysis. Here we have challenged that paradigm. Methods We performed proton nuclear magnetic resonance spectroscopy-based metabolomics on blood serum and urine samples from 32 patients representative of a total cohort of 1970 multiple myeloma patients entered into the United Kingdom Medical Research Council Myeloma IX trial. Findings Using serial paired blood and urine samples we detected metabolite profiles that associated with diagnosis, post-treatment remission and disease progression. These studies identified carnitine and acetylcarnitine as novel potential biomarkers of active disease both at diagnosis and relapse and as a mediator of disease associated pathologies. Conclusions These findings show that samples conventionally processed and archived can provide useful metabolomic information that has important implications for understanding the biology of myeloma, discovering new therapies and identifying biomarkers potentially useful in deciding the choice and application of therapy. BACKGROUND: Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers indicative of phenotype that can be used to characterize transitions between health and disease, disease progression and therapeutic responses. The desire to reproducibly detect ever greater numbers of metabolites at ever diminishing levels has naturally nurtured advances in best practice for sample procurement, storage and analysis. Reciprocally, since many of the available extensive clinical archives were established prior to the metabolomics era and were not processed in such an 'ideal' fashion, considerable scepticism has arisen as to their value for metabolomic analysis. Here we have challenged that paradigm. METHODS: We performed proton nuclear magnetic resonance spectroscopy-based metabolomics on blood serum and urine samples from 32 patients representative of a total cohort of 1970 multiple myeloma patients entered into the United Kingdom Medical Research Council Myeloma IX trial. FINDINGS: Using serial paired blood and urine samples we detected metabolite profiles that associated with diagnosis, post-treatment remission and disease progression. These studies identified carnitine and acetylcarnitine as novel potential biomarkers of active disease both at diagnosis and relapse and as a mediator of disease associated pathologies. CONCLUSIONS: These findings show that samples conventionally processed and archived can provide useful metabolomic information that has important implications for understanding the biology of myeloma, discovering new therapies and identifying biomarkers potentially useful in deciding the choice and application of therapy. Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers indicative of phenotype that can be used to characterize transitions between health and disease, disease progression and therapeutic responses. The desire to reproducibly detect ever greater numbers of metabolites at ever diminishing levels has naturally nurtured advances in best practice for sample procurement, storage and analysis. Reciprocally, since many of the available extensive clinical archives were established prior to the metabolomics era and were not processed in such an 'ideal' fashion, considerable scepticism has arisen as to their value for metabolomic analysis. Here we have challenged that paradigm.BACKGROUNDBiomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers indicative of phenotype that can be used to characterize transitions between health and disease, disease progression and therapeutic responses. The desire to reproducibly detect ever greater numbers of metabolites at ever diminishing levels has naturally nurtured advances in best practice for sample procurement, storage and analysis. Reciprocally, since many of the available extensive clinical archives were established prior to the metabolomics era and were not processed in such an 'ideal' fashion, considerable scepticism has arisen as to their value for metabolomic analysis. Here we have challenged that paradigm.We performed proton nuclear magnetic resonance spectroscopy-based metabolomics on blood serum and urine samples from 32 patients representative of a total cohort of 1970 multiple myeloma patients entered into the United Kingdom Medical Research Council Myeloma IX trial.METHODSWe performed proton nuclear magnetic resonance spectroscopy-based metabolomics on blood serum and urine samples from 32 patients representative of a total cohort of 1970 multiple myeloma patients entered into the United Kingdom Medical Research Council Myeloma IX trial.Using serial paired blood and urine samples we detected metabolite profiles that associated with diagnosis, post-treatment remission and disease progression. These studies identified carnitine and acetylcarnitine as novel potential biomarkers of active disease both at diagnosis and relapse and as a mediator of disease associated pathologies.FINDINGSUsing serial paired blood and urine samples we detected metabolite profiles that associated with diagnosis, post-treatment remission and disease progression. These studies identified carnitine and acetylcarnitine as novel potential biomarkers of active disease both at diagnosis and relapse and as a mediator of disease associated pathologies.These findings show that samples conventionally processed and archived can provide useful metabolomic information that has important implications for understanding the biology of myeloma, discovering new therapies and identifying biomarkers potentially useful in deciding the choice and application of therapy.CONCLUSIONSThese findings show that samples conventionally processed and archived can provide useful metabolomic information that has important implications for understanding the biology of myeloma, discovering new therapies and identifying biomarkers potentially useful in deciding the choice and application of therapy. Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers indicative of phenotype that can be used to characterize transitions between health and disease, disease progression and therapeutic responses. The desire to reproducibly detect ever greater numbers of metabolites at ever diminishing levels has naturally nurtured advances in best practice for sample procurement, storage and analysis. Reciprocally, since many of the available extensive clinical archives were established prior to the metabolomics era and were not processed in such an 'ideal' fashion, considerable scepticism has arisen as to their value for metabolomic analysis. Here we have challenged that paradigm. We performed proton nuclear magnetic resonance spectroscopy-based metabolomics on blood serum and urine samples from 32 patients representative of a total cohort of 1970 multiple myeloma patients entered into the United Kingdom Medical Research Council Myeloma IX trial. Using serial paired blood and urine samples we detected metabolite profiles that associated with diagnosis, post-treatment remission and disease progression. These studies identified carnitine and acetylcarnitine as novel potential biomarkers of active disease both at diagnosis and relapse and as a mediator of disease associated pathologies. These findings show that samples conventionally processed and archived can provide useful metabolomic information that has important implications for understanding the biology of myeloma, discovering new therapies and identifying biomarkers potentially useful in deciding the choice and application of therapy. |
| Audience | Academic |
| Author | Morgan, Gareth J. Lodi, Alessia Günther, Ulrich L. Viant, Mark R. Bunce, Christopher M. Tiziani, Stefano Khanim, Farhat L. Drayson, Mark T. |
| AuthorAffiliation | 3 Dell Pediatric Research Institute, The University of Texas at Austin, Austin, Texas, United States of America 1 School of Cancer Sciences, The University of Birmingham, Birmingham, United Kingdom George Washington University, United States of America 4 School of Biosciences, The University of Birmingham, Birmingham, United Kingdom 5 Institute of Cancer Research, Royal Marsden NHS Foundation Trust, London, United Kingdom 2 Department of Nutritional Sciences, The University of Texas at Austin, Austin, Texas, United States of America 6 School of Immunity and Infection, The University of Birmingham, Birmingham, United Kingdom |
| AuthorAffiliation_xml | – name: 2 Department of Nutritional Sciences, The University of Texas at Austin, Austin, Texas, United States of America – name: 1 School of Cancer Sciences, The University of Birmingham, Birmingham, United Kingdom – name: 5 Institute of Cancer Research, Royal Marsden NHS Foundation Trust, London, United Kingdom – name: 6 School of Immunity and Infection, The University of Birmingham, Birmingham, United Kingdom – name: 4 School of Biosciences, The University of Birmingham, Birmingham, United Kingdom – name: George Washington University, United States of America – name: 3 Dell Pediatric Research Institute, The University of Texas at Austin, Austin, Texas, United States of America |
| Author_xml | – sequence: 1 givenname: Alessia surname: Lodi fullname: Lodi, Alessia – sequence: 2 givenname: Stefano surname: Tiziani fullname: Tiziani, Stefano – sequence: 3 givenname: Farhat L. surname: Khanim fullname: Khanim, Farhat L. – sequence: 4 givenname: Ulrich L. surname: Günther fullname: Günther, Ulrich L. – sequence: 5 givenname: Mark R. surname: Viant fullname: Viant, Mark R. – sequence: 6 givenname: Gareth J. surname: Morgan fullname: Morgan, Gareth J. – sequence: 7 givenname: Christopher M. surname: Bunce fullname: Bunce, Christopher M. – sequence: 8 givenname: Mark T. surname: Drayson fullname: Drayson, Mark T. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23431376$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3324/haematol.13369 10.1007/s11899-010-0047-9 10.1002/ijc.20651 10.1016/S1567-5769(01)00105-9 10.1038/nrclinonc.2011.63 10.1006/jmra.1995.1047 10.1039/b209155k 10.1042/bj20021878 10.1007/s00223-004-0147-4 10.1182/blood-2011-06-357038 10.1038/leu.2010.60 10.1056/NEJMra1011442 10.1021/ac051632c 10.1016/S0272-6386(03)00112-4 10.1038/leu.2008.336 10.1182/blood-2011-02-338665 10.1038/nprot.2007.376 10.1002/cem.1006 10.1146/annurev.nu.06.070186.003023 10.1016/S0167-4838(01)00147-9 10.1186/1471-2105-8-234 10.1158/1078-0432.CCR-09-0251 10.1038/leu.2009.295 10.1016/j.ymben.2009.02.001 10.1097/MPH.0b013e3181d419d6 10.1200/JCO.2010.34.0760 10.1007/s11306-007-0099-6 10.1038/nrc2222 10.1016/B978-0-12-386469-7.00002-5 10.1152/ajprenal.2000.278.4.F667 10.1016/j.aca.2008.11.058 10.1158/0008-5472.CAN-05-3197 10.1021/ac062305n 10.1053/j.seminhematol.2010.11.001 10.1002/mrc.2519 10.1016/j.ctrv.2010.08.008 10.1016/j.aca.2008.06.051 10.1016/j.ab.2008.01.037 10.1016/j.pnmrs.2005.09.001 10.1002/nbm.1940080308 10.1007/s10495-006-0191-9 10.1182/blood-2006-03-008953 10.1093/ije/dym284 10.1016/j.cell.2008.08.026 10.1371/journal.pone.0010883 10.1038/nature09837 10.1593/neo.81396 10.1200/JCO.2010.30.8791 10.1200/JCO.2007.14.7827 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2013 Public Library of Science 2013 Lodi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Lodi et al 2013 Lodi et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Clinical lead on Myeloma IX: GJM. Clinical investigator on Myeloma IX: MTD. Conceived and designed the experiments: AL ST FLK ULG MRV GJM CMB MTD. Performed the experiments: AL ST. Analyzed the data: AL ST FLK ULG MRV GJM CMB MTD. Contributed reagents/materials/analysis tools: ULG MRV GJM CMB MTD. Wrote the paper: AL ST FLK ULG MRV GJM CMB MTD. |
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| References | N Siliprandi (ref42) 1989; 183 UL Günther (ref31) 2000; 145 M Bylesjo (ref32) 2006; 20 AH Bryce (ref3) 2009; 94 GJ Morgan (ref27) 2011; 118 MA Chapman (ref14) 2011; 471 A Palumbo (ref2) 2011; 364 TL Hwang (ref29) 1995; 112 RH Barton (ref22) 2008; 37 E Holmes (ref34) 2007; 79 MA Dimopoulos (ref4) 2010; 28 E Holmes (ref23) 2008; 134 HM Parsons (ref28) 2007; 8 F Dieterle (ref30) 2006; 78 JA Westerhuis (ref33) 2008; 4 RA Kyle (ref12) 2010; 24 J Wang (ref48) 2006; 11 SHG Khoo (ref40) 2009; 11 TL Whitehead (ref20) 2005; 47 X Li (ref37) 2009; 633 SV Rajkumar (ref9) 2011; 8 RA Kyle (ref13) 2010; 5 ref36 HM Lazarus (ref8) 2008; 26 ref38 EA Hamed (ref51) 2010; 32 S Bandyopadhyay (ref47) 2006; 66 H Xie (ref52) 2008; 35 GJ Morgan (ref26) 2012; 119 C Ludwig (ref19) 2009; 47 M Drayson (ref7) 2006; 108 NW van de Donk (ref11) 2011; 37 AR Minter (ref5) 2011; 48 S Tiziani (ref24) 2008; 377 NS Radin (ref44) 2003; 371 I Athanassakis (ref39) 2001; 1 M Lemaire (ref1) 2011; 110 DA MacIntyre (ref15) 2010; 24 S Tiziani (ref17) 2009; 11 JA Menendez (ref49) 2007; 7 CS Mitsiades (ref10) 2011; 29 P Hersey (ref46) 2009; 15 HC Gao (ref21) 2008; 624 C Hoppel (ref41) 2003; 41 RR Ramsay (ref43) 2001; 1546 M Kuliszkiewiczjanus (ref35) 1995; 8 GD Roodman (ref6) 2009; 23 S Colucci (ref50) 2005; 76 K Odunsi (ref16) 2005; 113 JT Brindle (ref18) 2003; 128 D Portilla (ref45) 2000; 278 O Beckonert (ref25) 2007; 2 |
| References_xml | – volume: 94 start-page: 380 year: 2009 ident: ref3 article-title: Translocation t(11;14) and survival of patients with light chain (AL) amyloidosis publication-title: Haematologica doi: 10.3324/haematol.13369 – volume: 5 start-page: 62 year: 2010 ident: ref13 article-title: Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma publication-title: Curr Hematol Malig Rep doi: 10.1007/s11899-010-0047-9 – volume: 113 start-page: 782 year: 2005 ident: ref16 article-title: Detection of epithelial ovarian cancer using H-1-NMR-based metabonomics publication-title: Int J Cancer doi: 10.1002/ijc.20651 – volume: 1 start-page: 1813 year: 2001 ident: ref39 article-title: L-carnitine modifies the humoral immune response in mice after in vitro or in vivo treatment publication-title: Int Immunopharmacol doi: 10.1016/S1567-5769(01)00105-9 – volume: 35 start-page: 419 year: 2008 ident: ref52 article-title: L-Carnitine protects against apoptosis of murine MC3T3-E1 osteoblastic cells. Amino Acids – volume: 8 start-page: 479 year: 2011 ident: ref9 article-title: Treatment of multiple myeloma publication-title: Nat Rev Clin Oncol doi: 10.1038/nrclinonc.2011.63 – volume: 112 start-page: 275 year: 1995 ident: ref29 article-title: Water suppression that works - Excitation sculpting using arbitrary wave-forms and pulsed-field gradients publication-title: J Magn Reson Ser A doi: 10.1006/jmra.1995.1047 – volume: 128 start-page: 32 year: 2003 ident: ref18 article-title: Application of chemometrics to H-1 NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension publication-title: Analyst doi: 10.1039/b209155k – volume: 371 start-page: 243 year: 2003 ident: ref44 article-title: Killing tumours by ceramide-induced apoptosis: a critique of available drugs publication-title: Biochem J doi: 10.1042/bj20021878 – volume: 76 start-page: 458 year: 2005 ident: ref50 article-title: L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitro publication-title: Calcified Tissue Int doi: 10.1007/s00223-004-0147-4 – volume: 119 start-page: 7 year: 2012 ident: ref26 article-title: The role of maintenance thalidomide therapy in multiple myeloma: MRC Myeloma IX results and meta-analysis publication-title: Blood doi: 10.1182/blood-2011-06-357038 – volume: 183 start-page: 3 year: 1989 ident: ref42 article-title: Carnitine: Metabolism and clinical chemistry Clin Chim Acta – volume: 24 start-page: 1121 year: 2010 ident: ref12 article-title: Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management publication-title: Leukemia doi: 10.1038/leu.2010.60 – volume: 364 start-page: 1046 year: 2011 ident: ref2 article-title: Multiple myeloma publication-title: N Engl J Med doi: 10.1056/NEJMra1011442 – volume: 78 start-page: 4281 year: 2006 ident: ref30 article-title: Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in H-1 NMR metabonomics publication-title: Anal Chem doi: 10.1021/ac051632c – volume: 41 start-page: S4 year: 2003 ident: ref41 article-title: The role of carnitine in normal and altered fatty acid metabolism publication-title: Am J Kidney Dis doi: 10.1016/S0272-6386(03)00112-4 – volume: 23 start-page: 435 year: 2009 ident: ref6 article-title: Pathogenesis of myeloma bone disease publication-title: Leukemia doi: 10.1038/leu.2008.336 – volume: 145 start-page: 201 year: 2000 ident: ref31 article-title: NMRLAB - Advanced NMR data processing in MATLAB J Magn Reson – volume: 118 start-page: 1231 year: 2011 ident: ref27 article-title: Cyclophosphamide, thalidomide, and dexamethasone (CTD) as initial therapy for patients with multiple myeloma unsuitable for autologous transplantation publication-title: Blood doi: 10.1182/blood-2011-02-338665 – volume: 2 start-page: 2692 year: 2007 ident: ref25 article-title: Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts publication-title: Nat Protoc doi: 10.1038/nprot.2007.376 – volume: 20 start-page: 341 year: 2006 ident: ref32 article-title: OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification publication-title: J Chemometr doi: 10.1002/cem.1006 – ident: ref36 doi: 10.1146/annurev.nu.06.070186.003023 – volume: 1546 start-page: 21 year: 2001 ident: ref43 article-title: Molecular enzymology of carnitine transfer and transport publication-title: Biochim Biophys Acta-Protein Struct Molec Enzym doi: 10.1016/S0167-4838(01)00147-9 – volume: 8 start-page: 234 year: 2007 ident: ref28 article-title: Improved classification accuracy in 1-and 2-dimensional NMR metabolomics data using the variance stabilising generalised logarithm transformation publication-title: BMC Bioinformatics doi: 10.1186/1471-2105-8-234 – volume: 15 start-page: 6490 year: 2009 ident: ref46 article-title: Metabolic Approaches to Treatment of Melanoma publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-09-0251 – volume: 24 start-page: 788 year: 2010 ident: ref15 article-title: Serum metabolome analysis by H-1-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups publication-title: Leukemia doi: 10.1038/leu.2009.295 – volume: 11 start-page: 199 year: 2009 ident: ref40 article-title: Metabolic characterization of a hyper-productive state in an antibody producing NS0 myeloma cell line publication-title: Metab Eng doi: 10.1016/j.ymben.2009.02.001 – volume: 32 start-page: 267 year: 2010 ident: ref51 article-title: Iron Chelation Therapy in Upper Egyptian Transfusion-dependent Pediatric Homozygous beta-Thalassemia Major Impact on Serum L-Carnitine/Free Fatty Acids, Osteoprotegerin/The Soluble Receptor Activator of Nuclear Factor-kappa beta Ligand Systems, and Bone Mineral Density publication-title: J Pediatr Hematol Oncol doi: 10.1097/MPH.0b013e3181d419d6 – volume: 29 start-page: 1916 year: 2011 ident: ref10 article-title: Future directions of next-generation novel therapies, combination approaches, and the development of personalized medicine in myeloma publication-title: J Clin Oncol doi: 10.1200/JCO.2010.34.0760 – volume: 4 start-page: 81 year: 2008 ident: ref33 article-title: Assessment of PLSDA cross validation publication-title: Metabolomics doi: 10.1007/s11306-007-0099-6 – volume: 7 start-page: 763 year: 2007 ident: ref49 article-title: Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis publication-title: Nat Rev Cancer doi: 10.1038/nrc2222 – volume: 110 start-page: 19 year: 2011 ident: ref1 article-title: The microenvironment and molecular biology of the multiple myeloma tumor publication-title: Adv Cancer Res doi: 10.1016/B978-0-12-386469-7.00002-5 – volume: 278 start-page: F667 year: 2000 ident: ref45 article-title: Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure publication-title: Am J Phisiol-Renal doi: 10.1152/ajprenal.2000.278.4.F667 – volume: 633 start-page: 257 year: 2009 ident: ref37 article-title: Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry for metabonomics: Biomarker discovery for diabetes mellitus publication-title: Anal Chim Acta doi: 10.1016/j.aca.2008.11.058 – volume: 66 start-page: 5934 year: 2006 ident: ref47 article-title: Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-3197 – volume: 79 start-page: 2629 year: 2007 ident: ref34 article-title: Detection of urinary drug metabolite (Xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy publication-title: Anal Chem doi: 10.1021/ac062305n – volume: 48 start-page: 55 year: 2011 ident: ref5 article-title: Bone disease from monoclonal gammopathy of undetermined significance to multiple myeloma: pathogenesis, interventions, and future opportunities publication-title: Semin Hematol doi: 10.1053/j.seminhematol.2010.11.001 – volume: 47 start-page: S68 year: 2009 ident: ref19 article-title: Fast targeted multidimensional NMR metabolomics of colorectal cancer publication-title: Magn Reson Chem doi: 10.1002/mrc.2519 – volume: 37 start-page: 266 year: 2011 ident: ref11 article-title: Treatment of relapsed and refractory multiple myeloma in the era of novel agents publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2010.08.008 – volume: 624 start-page: 269 year: 2008 ident: ref21 article-title: Metabonomic profiling of renal cell carcinoma: High-resolution proton nuclear magnetic resonance spectroscopy of human serum with multivariate data analysis publication-title: Anal Chim Acta doi: 10.1016/j.aca.2008.06.051 – volume: 377 start-page: 16 year: 2008 ident: ref24 article-title: Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy publication-title: Anal Biochem doi: 10.1016/j.ab.2008.01.037 – volume: 47 start-page: 165 year: 2005 ident: ref20 article-title: Applying in vitro NMR spectroscopy and H-1 NMR metabonomics to breast cancer characterization and detection publication-title: Prog Nucl Magn Reson Spectrosc doi: 10.1016/j.pnmrs.2005.09.001 – volume: 8 start-page: 127 year: 1995 ident: ref35 article-title: Chemotherapy-associated chnages in P-31 MRS spectra of sera from patients with multiple-myeloma publication-title: NMR Biomed doi: 10.1002/nbm.1940080308 – volume: 11 start-page: 2043 year: 2006 ident: ref48 article-title: Ceramide induces apoptosis via a peroxisome proliferator-activated receptor gamma-dependent pathway publication-title: Apoptosis doi: 10.1007/s10495-006-0191-9 – volume: 108 start-page: 2013 year: 2006 ident: ref7 article-title: Effects of paraprotein heavy and light chain types and free light chain load on survival in myeloma: an analysis of patients receiving conventional-dose chemotherapy in Medical Research Council UK multiple myeloma trials publication-title: Blood doi: 10.1182/blood-2006-03-008953 – volume: 37 start-page: 31 year: 2008 ident: ref22 article-title: High-throughput H-1 NMR-based metabolic analysis of human serum and urine for large-scale epidemiological studies: validation study publication-title: Int J Epidemiol doi: 10.1093/ije/dym284 – volume: 134 start-page: 714 year: 2008 ident: ref23 article-title: Metabolic phenotyping in health and disease publication-title: Cell doi: 10.1016/j.cell.2008.08.026 – ident: ref38 doi: 10.1371/journal.pone.0010883 – volume: 471 start-page: 467 year: 2011 ident: ref14 article-title: Initial genome sequencing and analysis of multiple myeloma publication-title: Nature doi: 10.1038/nature09837 – volume: 11 start-page: 269 year: 2009 ident: ref17 article-title: Early Stage Diagnosis of Oral Cancer Using H-1 NMR-Based Metabolomics publication-title: Neoplasia doi: 10.1593/neo.81396 – volume: 28 start-page: 4976 year: 2010 ident: ref4 article-title: Renal impairment in patients with multiple myeloma: a consensus statement on behalf of the International Myeloma Working Group publication-title: J Clin Oncol doi: 10.1200/JCO.2010.30.8791 – volume: 26 start-page: 2240 year: 2008 ident: ref8 article-title: High-dose melphalan and the development of hematopoietic stem-cell transplantation: 25 years later publication-title: J Clin Oncol doi: 10.1200/JCO.2007.14.7827 |
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| Snippet | Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields biomarkers... Background Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields... BACKGROUND: Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields... Background Biomarker identification is becoming increasingly important for the development of personalized or stratified therapies. Metabolomics yields... |
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| SubjectTerms | Acetylcarnitine - blood Acetylcarnitine - urine Aged Aged, 80 and over Apoptosis Archives Archives & records B cells Best practice Biological products Biology Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - urine Blood Cancer therapies Carnitine Carnitine - blood Carnitine - urine Chemistry Chemotherapy Clinical Trials, Phase III as Topic Development and progression Diagnosis Diagnostic imaging Drug dosages Fatty acids Female Health aspects Humans Magnetic resonance Magnetic Resonance Spectroscopy Male Medical prognosis Medical research Medical treatment Medicine Metabolism Metabolites Metabolome Metabolomics Middle Aged Multicenter Studies as Topic Multiple myeloma Multiple Myeloma - blood Multiple Myeloma - pathology Multiple Myeloma - therapy Multiple Myeloma - urine Multivariate Analysis Neoplasm Staging NMR Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Patients Pediatrics Procurement Remission Remission Induction Spectroscopy Treatment Outcome Urine |
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| Title | Proton NMR-Based Metabolite Analyses of Archived Serial Paired Serum and Urine Samples from Myeloma Patients at Different Stages of Disease Activity Identifies Acetylcarnitine as a Novel Marker of Active Disease |
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