Origin of HAV strains responsible for 2016–2017 outbreak among MSM: Viral phylodynamics in Lazio region

In Europe HAV infection occurs mainly among specific risk groups, such as consumers of specific food. Sexual transmission of HAV has been demonstrated, particularly among Men-Who-Have-Sex-With-Men (MSM), causing MSM-specific outbreaksin Europe. Here we report a molecular epidemiologic and phylodynam...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:PloS one Ročník 15; číslo 5; s. e0234010
Hlavní autoři: Minosse, Claudia, Messina, Francesco, Garbuglia, Anna Rosa, Meschi, Silvia, Scognamiglio, Paola, Capobianchi, Maria Rosaria, Ippolito, Giuseppe, Lanini, Simone
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 29.05.2020
Public Library of Science (PLoS)
Témata:
Analysis
Automation
Biology and Life Sciences
Computer and Information Sciences
Demographic aspects
Disease transmission
Earth Sciences
Ecology and Environmental Sciences
Enzymes
Epidemics
Epidemiology
Europe
Genetic diversity
Genotype & phenotype
Health aspects
Health surveillance
Hepatitis
Hepatitis A
Hepatovirus
Infections
Infectious diseases
Laboratories
Medicine and health sciences
MSM (Men who have sex with men)
Outbreaks
Pathogens
People and Places
Phylogenetics
Phylogeny
Research and Analysis Methods
Risk groups
Statistics
Thermal cycling
Europe
United States > US
Italy
Germany
ISSN:1932-6203, 1932-6203
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:In Europe HAV infection occurs mainly among specific risk groups, such as consumers of specific food. Sexual transmission of HAV has been demonstrated, particularly among Men-Who-Have-Sex-With-Men (MSM), causing MSM-specific outbreaksin Europe. Here we report a molecular epidemiologic and phylodynamic analysis on HAV sequences in Lazio (central Italy)to identify genetic background and the phylogenetic relations, and test the HAV infection dynamics during a large outbreak through phylodynamic model.Among all HAV sequences found during 2013-2018 in Lazio, low genetic diversity was observed in HAV population in 2016 and 2017, along with high frequenciesVRD_521_2016and RIVM-HAV16-090, suggesting a large expansion event of viral population. The initial expansion of both VRD_521_2016 and RIVM-HAV16-090 clusters dated back to 2012 (95% HPD:2006-2015). During the2016-2017outbreak in Lazio region, the Re peaked around mid-2016, with a value of 1.73 (95% HPD: 1.03-2.37), consistent with incidence trend of AHA cases in Lazio between 2016 and mid-2017. This study showed the magnitude of HAV outbreak in Lazio during 2016-2017, demonstrating the epidemic continuity to MSM-specific outbreak in Europe. The HAV dataset is available on interactive phylodynamic platform https://nextstrain.org to real-time update of future outbreaks.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0234010