Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus (PPN) Influences Visual Contrast Sensitivity in Human Observers
The parapontine nucleus of the thalamus (PPN) is a neuromodulatory midbrain structure with widespread connectivity to cortical and subcortical motor structures, as well as the spinal cord. The PPN also projects to the thalamus, including visual relay nuclei like the LGN and the pulvinar. Moreover, t...
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| Published in: | PloS one Vol. 11; no. 5; p. e0155206 |
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | The parapontine nucleus of the thalamus (PPN) is a neuromodulatory midbrain structure with widespread connectivity to cortical and subcortical motor structures, as well as the spinal cord. The PPN also projects to the thalamus, including visual relay nuclei like the LGN and the pulvinar. Moreover, there is intense connectivity with sensory structures of the tegmentum in particular with the superior colliculus (SC). Given the existence and abundance of projections to visual sensory structures, it is likely that activity in the PPN has some modulatory influence on visual sensory selection. Here we address this possibility by measuring the visual discrimination performance (luminance contrast thresholds) in a group of patients with Parkinson's Disease (PD) treated with deep-brain stimulation (DBS) of the PPN to control gait and postural motor deficits. In each patient we measured the luminance-contrast threshold of being able to discriminate an orientation-target (Gabor-grating) as a function of stimulation frequency (high 60Hz, low 8/10, no stimulation). Thresholds were determined using a standard staircase-protocol that is based on parameter estimation by sequential testing (PEST). We observed that under low frequency stimulation thresholds increased relative to no and high frequency stimulation in five out of six patients, suggesting that DBS of the PPN has a frequency-dependent impact on visual selection processes at a rather elementary perceptual level. |
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| AbstractList | The parapontine nucleus of the thalamus (PPN) is a neuromodulatory midbrain structure with widespread connectivity to cortical and subcortical motor structures, as well as the spinal cord. The PPN also projects to the thalamus, including visual relay nuclei like the LGN and the pulvinar. Moreover, there is intense connectivity with sensory structures of the tegmentum in particular with the superior colliculus (SC). Given the existence and abundance of projections to visual sensory structures, it is likely that activity in the PPN has some modulatory influence on visual sensory selection. Here we address this possibility by measuring the visual discrimination performance (luminance contrast thresholds) in a group of patients with Parkinson's Disease (PD) treated with deep-brain stimulation (DBS) of the PPN to control gait and postural motor deficits. In each patient we measured the luminance-contrast threshold of being able to discriminate an orientation-target (Gabor-grating) as a function of stimulation frequency (high 60Hz, low 8/10, no stimulation). Thresholds were determined using a standard staircase-protocol that is based on parameter estimation by sequential testing (PEST). We observed that under low frequency stimulation thresholds increased relative to no and high frequency stimulation in five out of six patients, suggesting that DBS of the PPN has a frequency-dependent impact on visual selection processes at a rather elementary perceptual level. |
| Audience | Academic |
| Author | Kaufmann, Joern Schoenfeld, Mircea Ariel Panther, Patricia Hopf, Jens-Max Noesselt, Toemme Voges, Jürgen Heinze, Hans-Jochen Strumpf, Hendrik |
| AuthorAffiliation | 3 Clinic for Neurology, Otto-von-Guericke University, Magdeburg, Germany 2 Institute for Biological Psychology, Otto-von-Guericke University, Magdeburg, Germany 1 Leibniz Institute for Neurobiology, Magdeburg, Germany 4 Clinic for Stereotactic Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany 5 Kliniken Schmieder, Allensbach, Germany University of Bologna, ITALY |
| AuthorAffiliation_xml | – name: University of Bologna, ITALY – name: 2 Institute for Biological Psychology, Otto-von-Guericke University, Magdeburg, Germany – name: 3 Clinic for Neurology, Otto-von-Guericke University, Magdeburg, Germany – name: 1 Leibniz Institute for Neurobiology, Magdeburg, Germany – name: 5 Kliniken Schmieder, Allensbach, Germany – name: 4 Clinic for Stereotactic Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany |
| Author_xml | – sequence: 1 givenname: Hendrik surname: Strumpf fullname: Strumpf, Hendrik – sequence: 2 givenname: Toemme surname: Noesselt fullname: Noesselt, Toemme – sequence: 3 givenname: Mircea Ariel surname: Schoenfeld fullname: Schoenfeld, Mircea Ariel – sequence: 4 givenname: Jürgen surname: Voges fullname: Voges, Jürgen – sequence: 5 givenname: Patricia surname: Panther fullname: Panther, Patricia – sequence: 6 givenname: Joern surname: Kaufmann fullname: Kaufmann, Joern – sequence: 7 givenname: Hans-Jochen surname: Heinze fullname: Heinze, Hans-Jochen – sequence: 8 givenname: Jens-Max surname: Hopf fullname: Hopf, Jens-Max |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27167979$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s00330_017_5299_5 crossref_primary_10_3389_fnins_2020_00367 crossref_primary_10_1016_j_neuroimage_2020_117627 crossref_primary_10_1093_brain_awaa374 |
| Cites_doi | 10.1002/cne.902620109 10.1002/cne.903440205 10.1002/cne.902530409 10.1016/0306-4522(95)00265-K 10.1016/S0166-4328(01)00181-4 10.1016/0165-0173(94)90016-7 10.1016/S0896-6273(03)00716-5 10.1152/jn.2002.88.2.715 10.3389/fneur.2013.00068 10.1162/jocn.2009.21225 10.1016/j.concog.2015.05.007 10.5665/sleep.2234 10.1523/JNEUROSCI.5602-05.2006 10.1097/00001756-200412030-00012 10.1097/01.wnr.0000187637.20771.a0 10.1111/j.1460-9568.2012.08002.x 10.1093/brain/awp229 10.1038/nrn2196 10.1038/nn1169 10.1016/S0304-3940(97)00254-1 10.3171/jns.2002.96.2.0269 10.1016/j.tins.2004.07.009 10.1016/0301-0082(95)00023-O 10.1016/0006-8993(87)91455-7 10.1002/cne.903440204 10.1093/brain/awq322 10.1136/jnnp.2009.189324 10.1038/nature01341 10.1093/brain/123.9.1767 10.1093/brain/awn075 10.1093/brain/awp261 10.1172/JCI42642 10.1054/jocn.2001.0943 10.1073/pnas.81.14.4586 10.1038/nature07382 10.1016/S0361-9230(98)00136-1 10.1146/annurev-neuro-062012-170249 10.1016/0301-0082(91)90016-T 10.1016/j.neuroimage.2007.05.050 10.1002/ana.410260106 10.1152/jn.1995.74.2.713 10.1002/cne.22065 10.3171/JNS-07/10/0814 10.1037/0735-7044.114.2.285 10.1152/jn.1999.82.3.1642 10.1121/1.1910407 10.1073/pnas.0408311101 10.1038/nature09995 10.1016/S0165-0173(03)00143-7 10.1002/mds.21481 10.1097/01.wnr.0000187629.38010.12 |
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| Copyright | COPYRIGHT 2016 Public Library of Science 2016 Strumpf et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 Strumpf et al 2016 Strumpf et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: HS TN MAS H-JH J-MH. Performed the experiments: HS JV. Analyzed the data: HS TN PP J-MH JK. Contributed reagents/materials/analysis tools: JV PP H-JH JK. Wrote the paper: MAS TN J-MH. |
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| References | JR Muller (ref38) 2005; 102 M Tamietto (ref39) 2010; 22 A Peppe (ref21) 2012; 35 K McAlonan (ref32) 2006; 26 F Crick (ref31) 1984; 81 WL Inglis (ref29) 2000; 114 CW Berridge (ref57) 2003; 42 B Noudoost (ref43) 2011; 474 T Moore (ref42) 2003; 40 BR Aravamuthan (ref7) 2007; 37 M Beninato (ref9) 1987; 412 PA Pahapill (ref15) 2000; 123 WL Inglis (ref27) 2001; 123 J Voges (ref45) 2002; 96 J Kojima (ref14) 1997; 226 RM Zweig (ref16) 1989; 26 D Nandi (ref10) 2002; 9 A Celeghin (ref40) 2015; 36 J Voges (ref44) 2007; 22 B Lavoie (ref6) 1994; 344 ML Kringelbach (ref17) 2007; 8 E Moro (ref50) 2010; 133 P Winn (ref53) 1998; 47 E Garcia-Rill (ref3) 2014 A Ignashchenkova (ref35) 2004; 7 MU Ferraye (ref22) 2010; 133 RJ Krauzlis (ref37) 2013; 36 M Matsumura (ref13) 2005; 252 K McAlonan (ref33) 2008; 456 GM Krauthamer (ref34) 1995; 69 E Garcia-Rill (ref1) 1991; 36 T Moore (ref41) 2003; 421 L Zrinzo (ref47) 2008; 131 N Jenkinson (ref12) 2004; 15 H Aizawa (ref24) 1999; 82 NB Reese (ref28) 1995; 47 E Garcia-Rill (ref11) 2004; 143 DL Robinson (ref36) 1995; 74 KA Muthusamy (ref8) 2007; 107 C Karachi (ref18) 2010; 120 J Mena-Segovia (ref2) 2004; 27 P Mazzone (ref20) 2005; 16 B Lavoie (ref5) 1994; 344 MM Taylor (ref48) 1967; 41 JA Obeso (ref52) 2008; 64 P Plaha (ref19) 2005; 16 A Stefani (ref51) 2013; 4 M Beninato (ref25) 1986; 253 T Steckler (ref4) 1994; 19 G Schaltenbrand (ref46) 1977 TL Tattersall (ref23) 2014 C Martinez-Gonzalez (ref55) 2012; 35 AE Hallanger (ref30) 1987; 262 Y Kobayashi (ref26) 2002; 88 J Mena-Segovia (ref54) 2009; 515 M Alam (ref56) 2011; 134 W Thevathasan (ref49) 2010; 81 15570164 - Neuroreport. 2004 Dec 3;15(17):2621-4 16222438 - J Neurol. 2005 Oct;252 Suppl 4:IV5-IV12 18849967 - Nature. 2008 Nov 20;456(7220):391-4 6589612 - Proc Natl Acad Sci U S A. 1984 Jul;81(14):4586-90 7820134 - Brain Res Brain Res Rev. 1994 Aug;19(3):298-318 14653172 - Prog Brain Res. 2004;143:283-90 10960043 - Brain. 2000 Sep;123 ( Pt 9):1767-83 2549845 - Ann Neurol. 1989 Jul;26(1):41-6 1887068 - Prog Neurobiol. 1991;36(5):363-89 10832790 - Behav Neurosci. 2000 Apr;114(2):285-94 7472376 - J Neurophysiol. 1995 Aug;74(2):713-21 23761781 - Front Neurol. 2013 Jun 05;4:68 10482780 - J Neurophysiol. 1999 Sep;82(3):1642-6 15601760 - Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):524-9 16624964 - J Neurosci. 2006 Apr 19;26(16):4444-50 17937229 - J Neurosurg. 2007 Oct;107(4):814-20 20628197 - J Clin Invest. 2010 Aug;120(8):2745-54 8552245 - Neuroscience. 1995 Nov;69(2):507-17 23204606 - Sleep. 2012 Dec;35(12):1637-42 14699418 - Nat Neurosci. 2004 Jan;7(1):56-64 21572439 - Nature. 2011 Jun 16;474(7351):372-5 19773356 - Brain. 2010 Jan;133(Pt 1):205-14 17644361 - Neuroimage. 2007 Sep 1;37(3):694-705 20562469 - J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1099-104 8711130 - Prog Neurobiol. 1995 Oct;47(2):105-33 19320547 - J Cogn Neurosci. 2010 May;22(5):888-902 22356461 - Eur J Neurosci. 2012 Mar;35(5):723-34 24880787 - J Neural Transm (Vienna). 2015 Feb;122(2):225-35 17516483 - Mov Disord. 2007 Jul 30;22(10):1486-9 7915727 - J Comp Neurol. 1994 Jun 8;344(2):232-41 18467343 - Brain. 2008 Jun;131(Pt 6):1588-98 24487235 - Nat Neurosci. 2014 Mar;17(3):449-54 23682659 - Annu Rev Neurosci. 2013 Jul 8;36:165-82 16272872 - Neuroreport. 2005 Nov 28;16(17):1883-7 2442206 - J Comp Neurol. 1987 Aug 1;262(1):105-24 19459217 - J Comp Neurol. 2009 Aug 1;515(4):397-408 16272871 - Neuroreport. 2005 Nov 28;16(17):1877-81 15374668 - Trends Neurosci. 2004 Oct;27(10):585-8 3540040 - J Comp Neurol. 1986 Nov 22;253(4):525-38 11838801 - J Neurosurg. 2002 Feb;96(2):269-79 12540901 - Nature. 2003 Jan 23;421(6921):370-3 10078613 - Brain Res Bull. 1998 Dec;47(6):551-63 19846583 - Brain. 2010 Jan;133(Pt 1):215-24 21147837 - Brain. 2011 Jan;134(Pt 1):11-23 3038263 - Brain Res. 1987 May 26;412(1):169-74 19127584 - Ann Neurol. 2008 Dec;64 Suppl 2:S30-46 11922707 - J Clin Neurosci. 2002 Mar;9(2):170-4 12668290 - Brain Res Brain Res Rev. 2003 Apr;42(1):33-84 9159502 - Neurosci Lett. 1997 Apr 25;226(2):111-4 8077458 - J Comp Neurol. 1994 Jun 8;344(2):210-31 11399325 - Behav Brain Res. 2001 Sep 14;123(2):117-31 26058355 - Conscious Cogn. 2015 Nov;36:414-25 14622573 - Neuron. 2003 Nov 13;40(4):671-83 12163524 - J Neurophysiol. 2002 Aug;88(2):715-31 17637800 - Nat Rev Neurosci. 2007 Aug;8(8):623-35 |
| References_xml | – year: 2014 ident: ref3 article-title: The physiology of the pedunculopontine nucleus: implications for deep brain stimulation publication-title: J Neural Transm – volume: 252 start-page: IV5 issue: Suppl 4 year: 2005 ident: ref13 article-title: The pedunculopontine tegmental nucleus and experimental parkinsonism. A review publication-title: Journal of neurology – volume: 262 start-page: 105 issue: 1 year: 1987 ident: ref30 article-title: The origins of cholinergic and other subcortical afferents to the thalamus in the rat publication-title: J Comp Neurol doi: 10.1002/cne.902620109 – volume: 344 start-page: 232 issue: 2 year: 1994 ident: ref6 article-title: Pedunculopontine nucleus in the squirrel monkey: cholinergic and glutamatergic projections to the substantia nigra publication-title: J Comp Neurol doi: 10.1002/cne.903440205 – volume: 253 start-page: 525 issue: 4 year: 1986 ident: ref25 article-title: A cholinergic projection to the rat superior colliculus demonstrated by retrograde transport of horseradish peroxidase and choline acetyltransferase immunohistochemistry publication-title: J Comp Neurol doi: 10.1002/cne.902530409 – volume: 69 start-page: 507 issue: 2 year: 1995 ident: ref34 article-title: Putative cholinergic neurons of the pedunculopontine tegmental nucleus projecting to the superior colliculus consist of sensory responsive and unresponsive populations which are functionally distinct from other mesopontine neurons publication-title: Neuroscience doi: 10.1016/0306-4522(95)00265-K – volume: 123 start-page: 117 issue: 2 year: 2001 ident: ref27 article-title: Selective deficits in attentional performance on the 5-choice serial reaction time task following pedunculopontine tegmental nucleus lesions publication-title: Behav Brain Res doi: 10.1016/S0166-4328(01)00181-4 – volume: 19 start-page: 298 issue: 3 year: 1994 ident: ref4 article-title: The pedunculopontine tegmental nucleus: a role in cognitive processes? publication-title: Brain Res Brain Res Rev doi: 10.1016/0165-0173(94)90016-7 – volume: 40 start-page: 671 issue: 4 year: 2003 ident: ref42 article-title: Visuomotor origins of covert spatial attention publication-title: Neuron doi: 10.1016/S0896-6273(03)00716-5 – volume: 88 start-page: 715 issue: 2 year: 2002 ident: ref26 article-title: Contribution of pedunculopontine tegmental nucleus neurons to performance of visually guided saccade tasks in monkeys publication-title: J Neurophysiol doi: 10.1152/jn.2002.88.2.715 – volume: 4 start-page: 68 year: 2013 ident: ref51 article-title: The serendipity case of the pedunculopontine nucleus low-frequency brain stimulation: chasing a gait response, finding sleep, and cognition improvement publication-title: Frontiers in neurology doi: 10.3389/fneur.2013.00068 – volume: 22 start-page: 888 issue: 5 year: 2010 ident: ref39 article-title: Collicular vision guides nonconscious behavior publication-title: J Cogn Neurosci doi: 10.1162/jocn.2009.21225 – volume: 143 start-page: 283 year: 2004 ident: ref11 article-title: Arousal mechanisms related to posture and locomotion: 1. Descending modulation publication-title: Prog Brain Res – volume: 36 start-page: 414 year: 2015 ident: ref40 article-title: From affective blindsight to emotional consciousness publication-title: Conscious Cogn doi: 10.1016/j.concog.2015.05.007 – volume: 35 start-page: 1637 issue: 12 year: 2012 ident: ref21 article-title: Deep brain stimulation of pedunculopontine tegmental nucleus: role in sleep modulation in advanced Parkinson disease patients: one-year follow-up publication-title: Sleep doi: 10.5665/sleep.2234 – year: 2014 ident: ref23 article-title: Imagined gait modulates neuronal network dynamics in the human pedunculopontine nucleus publication-title: Nat Neurosci – volume: 26 start-page: 4444 issue: 16 year: 2006 ident: ref32 article-title: Attentional modulation of thalamic reticular neurons publication-title: J Neurosci doi: 10.1523/JNEUROSCI.5602-05.2006 – volume: 15 start-page: 2621 issue: 17 year: 2004 ident: ref12 article-title: Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey publication-title: Neuroreport doi: 10.1097/00001756-200412030-00012 – volume: 16 start-page: 1883 issue: 17 year: 2005 ident: ref19 article-title: Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson's disease publication-title: Neuroreport doi: 10.1097/01.wnr.0000187637.20771.a0 – volume: 35 start-page: 723 issue: 5 year: 2012 ident: ref55 article-title: Subpopulations of cholinergic, GABAergic and glutamatergic neurons in the pedunculopontine nucleus contain calcium-binding proteins and are heterogeneously distributed publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.2012.08002.x – volume: 64 start-page: S30 issue: Suppl 2 year: 2008 ident: ref52 article-title: The basal ganglia in Parkinson's disease: current concepts and unexplained observations publication-title: Ann Neurol – volume: 133 start-page: 205 issue: Pt 1 year: 2010 ident: ref22 article-title: Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease publication-title: Brain doi: 10.1093/brain/awp229 – volume: 8 start-page: 623 issue: 8 year: 2007 ident: ref17 article-title: Translational principles of deep brain stimulation publication-title: Nat Rev Neurosci doi: 10.1038/nrn2196 – volume: 7 start-page: 56 issue: 1 year: 2004 ident: ref35 article-title: Neuron-specific contribution of the superior colliculus to overt and covert shifts of attention publication-title: Nat Neurosci doi: 10.1038/nn1169 – volume: 226 start-page: 111 issue: 2 year: 1997 ident: ref14 article-title: Excitotoxic lesions of the pedunculopontine tegmental nucleus produce contralateral hemiparkinsonism in the monkey publication-title: Neurosci Lett doi: 10.1016/S0304-3940(97)00254-1 – volume: 96 start-page: 269 issue: 2 year: 2002 ident: ref45 article-title: Bilateral high-frequency stimulation in the subthalamic nucleus for the treatment of Parkinson disease: correlation of therapeutic effect with anatomical electrode position publication-title: Journal of neurosurgery doi: 10.3171/jns.2002.96.2.0269 – volume: 27 start-page: 585 issue: 10 year: 2004 ident: ref2 article-title: Pedunculopontine nucleus and basal ganglia: distant relatives or part of the same family? publication-title: Trends Neurosci doi: 10.1016/j.tins.2004.07.009 – volume: 47 start-page: 105 issue: 2 year: 1995 ident: ref28 article-title: The pedunculopontine nucleus—auditory input, arousal and pathophysiology publication-title: Prog Neurobiol doi: 10.1016/0301-0082(95)00023-O – volume: 412 start-page: 169 issue: 1 year: 1987 ident: ref9 article-title: A cholinergic projection to the rat substantia nigra from the pedunculopontine tegmental nucleus publication-title: Brain Res doi: 10.1016/0006-8993(87)91455-7 – volume: 344 start-page: 210 issue: 2 year: 1994 ident: ref5 article-title: Pedunculopontine nucleus in the squirrel monkey: projections to the basal ganglia as revealed by anterograde tract-tracing methods publication-title: J Comp Neurol doi: 10.1002/cne.903440204 – volume: 134 start-page: 11 issue: Pt 1 year: 2011 ident: ref56 article-title: The pedunculopontine nucleus area: critical evaluation of interspecies differences relevant for its use as a target for deep brain stimulation publication-title: Brain doi: 10.1093/brain/awq322 – volume: 81 start-page: 1099 issue: 10 year: 2010 ident: ref49 article-title: The impact of low-frequency stimulation of the pedunculopontine nucleus region on reaction time in parkinsonism publication-title: Journal of neurology, neurosurgery, and psychiatry doi: 10.1136/jnnp.2009.189324 – volume: 421 start-page: 370 year: 2003 ident: ref41 article-title: Selective gating of visual signals by microstimulation of frontal cortex publication-title: Nature doi: 10.1038/nature01341 – volume: 123 start-page: 1767 issue: Pt 9 year: 2000 ident: ref15 article-title: The pedunculopontine nucleus and Parkinson's disease publication-title: Brain doi: 10.1093/brain/123.9.1767 – volume: 131 start-page: 1588 issue: Pt 6 year: 2008 ident: ref47 article-title: Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization publication-title: Brain doi: 10.1093/brain/awn075 – year: 1977 ident: ref46 article-title: Atlas for Stereotaxy of the Human Brain – volume: 133 start-page: 215 issue: Pt 1 year: 2010 ident: ref50 article-title: Unilateral pedunculopontine stimulation improves falls in Parkinson's disease publication-title: Brain doi: 10.1093/brain/awp261 – volume: 120 start-page: 2745 issue: 8 year: 2010 ident: ref18 article-title: Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease publication-title: J Clin Invest doi: 10.1172/JCI42642 – volume: 9 start-page: 170 issue: 2 year: 2002 ident: ref10 article-title: Deep brain stimulation of the pedunculopontine region in the normal non-human primate publication-title: Journal of clinical neuroscience: official journal of the Neurosurgical Society of Australasia doi: 10.1054/jocn.2001.0943 – volume: 81 start-page: 4586 issue: 14 year: 1984 ident: ref31 article-title: Function of the thalamic reticular complex: the searchlight hypothesis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.81.14.4586 – volume: 456 start-page: 391 issue: 7220 year: 2008 ident: ref33 article-title: Guarding the gateway to cortex with attention in visual thalamus publication-title: Nature doi: 10.1038/nature07382 – volume: 47 start-page: 551 issue: 6 year: 1998 ident: ref53 article-title: Frontal syndrome as a consequence of lesions in the pedunculopontine tegmental nucleus: a short theoretical review publication-title: Brain Res Bull doi: 10.1016/S0361-9230(98)00136-1 – volume: 36 start-page: 165 year: 2013 ident: ref37 article-title: Superior colliculus and visual spatial attention publication-title: Annu Rev Neurosci doi: 10.1146/annurev-neuro-062012-170249 – volume: 36 start-page: 363 issue: 5 year: 1991 ident: ref1 article-title: The pedunculopontine nucleus publication-title: Prog Neurobiol doi: 10.1016/0301-0082(91)90016-T – volume: 37 start-page: 694 issue: 3 year: 2007 ident: ref7 article-title: Topography of cortical and subcortical connections of the human pedunculopontine and subthalamic nuclei publication-title: Neuroimage doi: 10.1016/j.neuroimage.2007.05.050 – volume: 26 start-page: 41 issue: 1 year: 1989 ident: ref16 article-title: The pedunculopontine nucleus in Parkinson's disease publication-title: Ann Neurol doi: 10.1002/ana.410260106 – volume: 74 start-page: 713 issue: 2 year: 1995 ident: ref36 article-title: Covert orienting of attention in macaques. III. contributions of the superior colliculus publication-title: Journal of Neurophysiology doi: 10.1152/jn.1995.74.2.713 – volume: 515 start-page: 397 issue: 4 year: 2009 ident: ref54 article-title: GABAergic neuron distribution in the pedunculopontine nucleus defines functional subterritories publication-title: J Comp Neurol doi: 10.1002/cne.22065 – volume: 107 start-page: 814 issue: 4 year: 2007 ident: ref8 article-title: Connectivity of the human pedunculopontine nucleus region and diffusion tensor imaging in surgical targeting publication-title: Journal of neurosurgery doi: 10.3171/JNS-07/10/0814 – volume: 114 start-page: 285 issue: 2 year: 2000 ident: ref29 article-title: Pedunculopontine tegmental nucleus lesions impair stimulus—reward learning in autoshaping and conditioned reinforcement paradigms publication-title: Behav Neurosci doi: 10.1037/0735-7044.114.2.285 – volume: 82 start-page: 1642 issue: 3 year: 1999 ident: ref24 article-title: Injection of nicotine into the superior colliculus facilitates occurrence of express saccades in monkeys publication-title: J Neurophysiol doi: 10.1152/jn.1999.82.3.1642 – volume: 41 start-page: 782 year: 1967 ident: ref48 article-title: PEST: Efficient estimates on probability functions publication-title: Journalof the AcousticalSociety of America doi: 10.1121/1.1910407 – volume: 102 start-page: 524 issue: 3 year: 2005 ident: ref38 article-title: Microstimulation of the superior colliculus focuses attention without moving the eyes publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0408311101 – volume: 474 start-page: 372 year: 2011 ident: ref43 article-title: Control of visual cortical signals by prefrontal dopamine publication-title: Nature doi: 10.1038/nature09995 – volume: 42 start-page: 33 issue: 1 year: 2003 ident: ref57 article-title: The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes publication-title: Brain Res Brain Res Rev doi: 10.1016/S0165-0173(03)00143-7 – volume: 22 start-page: 1486 issue: 10 year: 2007 ident: ref44 article-title: Thirty days complication rate following surgery performed for deep-brain-stimulation publication-title: Movement disorders: official journal of the Movement Disorder Society doi: 10.1002/mds.21481 – volume: 16 start-page: 1877 issue: 17 year: 2005 ident: ref20 article-title: Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson's disease publication-title: Neuroreport doi: 10.1097/01.wnr.0000187629.38010.12 – reference: 26058355 - Conscious Cogn. 2015 Nov;36:414-25 – reference: 23761781 - Front Neurol. 2013 Jun 05;4:68 – reference: 9159502 - Neurosci Lett. 1997 Apr 25;226(2):111-4 – reference: 24880787 - J Neural Transm (Vienna). 2015 Feb;122(2):225-35 – reference: 16222438 - J Neurol. 2005 Oct;252 Suppl 4:IV5-IV12 – reference: 11399325 - Behav Brain Res. 2001 Sep 14;123(2):117-31 – reference: 22356461 - Eur J Neurosci. 2012 Mar;35(5):723-34 – reference: 19773356 - Brain. 2010 Jan;133(Pt 1):205-14 – reference: 16272872 - Neuroreport. 2005 Nov 28;16(17):1883-7 – reference: 12540901 - Nature. 2003 Jan 23;421(6921):370-3 – reference: 16624964 - J Neurosci. 2006 Apr 19;26(16):4444-50 – reference: 19846583 - Brain. 2010 Jan;133(Pt 1):215-24 – reference: 18849967 - Nature. 2008 Nov 20;456(7220):391-4 – reference: 7915727 - J Comp Neurol. 1994 Jun 8;344(2):232-41 – reference: 19459217 - J Comp Neurol. 2009 Aug 1;515(4):397-408 – reference: 16272871 - Neuroreport. 2005 Nov 28;16(17):1877-81 – reference: 15570164 - Neuroreport. 2004 Dec 3;15(17):2621-4 – reference: 21147837 - Brain. 2011 Jan;134(Pt 1):11-23 – reference: 11838801 - J Neurosurg. 2002 Feb;96(2):269-79 – reference: 12163524 - J Neurophysiol. 2002 Aug;88(2):715-31 – reference: 17937229 - J Neurosurg. 2007 Oct;107(4):814-20 – reference: 14622573 - Neuron. 2003 Nov 13;40(4):671-83 – reference: 23204606 - Sleep. 2012 Dec;35(12):1637-42 – reference: 21572439 - Nature. 2011 Jun 16;474(7351):372-5 – reference: 10960043 - Brain. 2000 Sep;123 ( Pt 9):1767-83 – reference: 17637800 - Nat Rev Neurosci. 2007 Aug;8(8):623-35 – reference: 14699418 - Nat Neurosci. 2004 Jan;7(1):56-64 – reference: 15601760 - Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):524-9 – reference: 17516483 - Mov Disord. 2007 Jul 30;22(10):1486-9 – reference: 15374668 - Trends Neurosci. 2004 Oct;27(10):585-8 – reference: 2442206 - J Comp Neurol. 1987 Aug 1;262(1):105-24 – reference: 10832790 - Behav Neurosci. 2000 Apr;114(2):285-94 – reference: 8077458 - J Comp Neurol. 1994 Jun 8;344(2):210-31 – reference: 8711130 - Prog Neurobiol. 1995 Oct;47(2):105-33 – reference: 20562469 - J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1099-104 – reference: 14653172 - Prog Brain Res. 2004;143:283-90 – reference: 2549845 - Ann Neurol. 1989 Jul;26(1):41-6 – reference: 19127584 - Ann Neurol. 2008 Dec;64 Suppl 2:S30-46 – reference: 20628197 - J Clin Invest. 2010 Aug;120(8):2745-54 – reference: 19320547 - J Cogn Neurosci. 2010 May;22(5):888-902 – reference: 7820134 - Brain Res Brain Res Rev. 1994 Aug;19(3):298-318 – reference: 8552245 - Neuroscience. 1995 Nov;69(2):507-17 – reference: 7472376 - J Neurophysiol. 1995 Aug;74(2):713-21 – reference: 3540040 - J Comp Neurol. 1986 Nov 22;253(4):525-38 – reference: 6589612 - Proc Natl Acad Sci U S A. 1984 Jul;81(14):4586-90 – reference: 11922707 - J Clin Neurosci. 2002 Mar;9(2):170-4 – reference: 18467343 - Brain. 2008 Jun;131(Pt 6):1588-98 – reference: 12668290 - Brain Res Brain Res Rev. 2003 Apr;42(1):33-84 – reference: 1887068 - Prog Neurobiol. 1991;36(5):363-89 – reference: 17644361 - Neuroimage. 2007 Sep 1;37(3):694-705 – reference: 10482780 - J Neurophysiol. 1999 Sep;82(3):1642-6 – reference: 24487235 - Nat Neurosci. 2014 Mar;17(3):449-54 – reference: 3038263 - Brain Res. 1987 May 26;412(1):169-74 – reference: 23682659 - Annu Rev Neurosci. 2013 Jul 8;36:165-82 – reference: 10078613 - Brain Res Bull. 1998 Dec;47(6):551-63 |
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| SubjectTerms | Aged Biology and Life Sciences Brain Brain stimulation Colliculus Contrast Sensitivity Deep brain stimulation Deep Brain Stimulation - methods Disease control Female Frequency dependence Gait Humans Influence Localization Male Medicine and Health Sciences Mesencephalon Middle Aged Motor skills Motor task performance Movement disorders Nerve Net - pathology Nerve Net - physiopathology Neural networks Neurobiology Neurodegenerative diseases Neurology Neuromodulation Neurons Neurosciences Neurosurgery Noise Nuclei Orientation Orientation behavior Parameter estimation Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson's disease Patients Pedunculopontine tegmental nucleus Pedunculopontine Tegmental Nucleus - pathology Pedunculopontine Tegmental Nucleus - physiopathology Physiological aspects Postural Balance Posture Pulvinar Social Sciences Spinal cord Stimulation Superior Colliculi - pathology Superior Colliculi - physiopathology Superior colliculus Tegmental nucleus Tegmentum Thalamus Thalamus - pathology Thalamus - physiopathology Thresholds Visual discrimination Visual observation Visual pathways Visual perception |
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| Title | Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus (PPN) Influences Visual Contrast Sensitivity in Human Observers |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27167979 https://www.proquest.com/docview/1788228619 https://www.proquest.com/docview/1789038032 https://pubmed.ncbi.nlm.nih.gov/PMC4864298 https://doaj.org/article/803dd83e86be4b518dd3efd81d0ad9e3 http://dx.doi.org/10.1371/journal.pone.0155206 |
| Volume | 11 |
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