Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus (PPN) Influences Visual Contrast Sensitivity in Human Observers
The parapontine nucleus of the thalamus (PPN) is a neuromodulatory midbrain structure with widespread connectivity to cortical and subcortical motor structures, as well as the spinal cord. The PPN also projects to the thalamus, including visual relay nuclei like the LGN and the pulvinar. Moreover, t...
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| Vydáno v: | PloS one Ročník 11; číslo 5; s. e0155206 |
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| Jazyk: | angličtina |
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United States
Public Library of Science
11.05.2016
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | The parapontine nucleus of the thalamus (PPN) is a neuromodulatory midbrain structure with widespread connectivity to cortical and subcortical motor structures, as well as the spinal cord. The PPN also projects to the thalamus, including visual relay nuclei like the LGN and the pulvinar. Moreover, there is intense connectivity with sensory structures of the tegmentum in particular with the superior colliculus (SC). Given the existence and abundance of projections to visual sensory structures, it is likely that activity in the PPN has some modulatory influence on visual sensory selection. Here we address this possibility by measuring the visual discrimination performance (luminance contrast thresholds) in a group of patients with Parkinson's Disease (PD) treated with deep-brain stimulation (DBS) of the PPN to control gait and postural motor deficits. In each patient we measured the luminance-contrast threshold of being able to discriminate an orientation-target (Gabor-grating) as a function of stimulation frequency (high 60Hz, low 8/10, no stimulation). Thresholds were determined using a standard staircase-protocol that is based on parameter estimation by sequential testing (PEST). We observed that under low frequency stimulation thresholds increased relative to no and high frequency stimulation in five out of six patients, suggesting that DBS of the PPN has a frequency-dependent impact on visual selection processes at a rather elementary perceptual level. |
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| AbstractList | The parapontine nucleus of the thalamus (PPN) is a neuromodulatory midbrain structure with widespread connectivity to cortical and subcortical motor structures, as well as the spinal cord. The PPN also projects to the thalamus, including visual relay nuclei like the LGN and the pulvinar. Moreover, there is intense connectivity with sensory structures of the tegmentum in particular with the superior colliculus (SC). Given the existence and abundance of projections to visual sensory structures, it is likely that activity in the PPN has some modulatory influence on visual sensory selection. Here we address this possibility by measuring the visual discrimination performance (luminance contrast thresholds) in a group of patients with Parkinson's Disease (PD) treated with deep-brain stimulation (DBS) of the PPN to control gait and postural motor deficits. In each patient we measured the luminance-contrast threshold of being able to discriminate an orientation-target (Gabor-grating) as a function of stimulation frequency (high 60Hz, low 8/10, no stimulation). Thresholds were determined using a standard staircase-protocol that is based on parameter estimation by sequential testing (PEST). We observed that under low frequency stimulation thresholds increased relative to no and high frequency stimulation in five out of six patients, suggesting that DBS of the PPN has a frequency-dependent impact on visual selection processes at a rather elementary perceptual level. |
| Audience | Academic |
| Author | Kaufmann, Joern Schoenfeld, Mircea Ariel Panther, Patricia Hopf, Jens-Max Noesselt, Toemme Voges, Jürgen Heinze, Hans-Jochen Strumpf, Hendrik |
| AuthorAffiliation | 3 Clinic for Neurology, Otto-von-Guericke University, Magdeburg, Germany 2 Institute for Biological Psychology, Otto-von-Guericke University, Magdeburg, Germany 1 Leibniz Institute for Neurobiology, Magdeburg, Germany 4 Clinic for Stereotactic Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany 5 Kliniken Schmieder, Allensbach, Germany University of Bologna, ITALY |
| AuthorAffiliation_xml | – name: University of Bologna, ITALY – name: 2 Institute for Biological Psychology, Otto-von-Guericke University, Magdeburg, Germany – name: 3 Clinic for Neurology, Otto-von-Guericke University, Magdeburg, Germany – name: 1 Leibniz Institute for Neurobiology, Magdeburg, Germany – name: 5 Kliniken Schmieder, Allensbach, Germany – name: 4 Clinic for Stereotactic Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany |
| Author_xml | – sequence: 1 givenname: Hendrik surname: Strumpf fullname: Strumpf, Hendrik – sequence: 2 givenname: Toemme surname: Noesselt fullname: Noesselt, Toemme – sequence: 3 givenname: Mircea Ariel surname: Schoenfeld fullname: Schoenfeld, Mircea Ariel – sequence: 4 givenname: Jürgen surname: Voges fullname: Voges, Jürgen – sequence: 5 givenname: Patricia surname: Panther fullname: Panther, Patricia – sequence: 6 givenname: Joern surname: Kaufmann fullname: Kaufmann, Joern – sequence: 7 givenname: Hans-Jochen surname: Heinze fullname: Heinze, Hans-Jochen – sequence: 8 givenname: Jens-Max surname: Hopf fullname: Hopf, Jens-Max |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27167979$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s00330_017_5299_5 crossref_primary_10_3389_fnins_2020_00367 crossref_primary_10_1016_j_neuroimage_2020_117627 crossref_primary_10_1093_brain_awaa374 |
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| Copyright | COPYRIGHT 2016 Public Library of Science 2016 Strumpf et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 Strumpf et al 2016 Strumpf et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: HS TN MAS H-JH J-MH. Performed the experiments: HS JV. Analyzed the data: HS TN PP J-MH JK. Contributed reagents/materials/analysis tools: JV PP H-JH JK. Wrote the paper: MAS TN J-MH. |
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| SubjectTerms | Aged Biology and Life Sciences Brain Brain stimulation Colliculus Contrast Sensitivity Deep brain stimulation Deep Brain Stimulation - methods Disease control Female Frequency dependence Gait Humans Influence Localization Male Medicine and Health Sciences Mesencephalon Middle Aged Motor skills Motor task performance Movement disorders Nerve Net - pathology Nerve Net - physiopathology Neural networks Neurobiology Neurodegenerative diseases Neurology Neuromodulation Neurons Neurosciences Neurosurgery Noise Nuclei Orientation Orientation behavior Parameter estimation Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson's disease Patients Pedunculopontine tegmental nucleus Pedunculopontine Tegmental Nucleus - pathology Pedunculopontine Tegmental Nucleus - physiopathology Physiological aspects Postural Balance Posture Pulvinar Social Sciences Spinal cord Stimulation Superior Colliculi - pathology Superior Colliculi - physiopathology Superior colliculus Tegmental nucleus Tegmentum Thalamus Thalamus - pathology Thalamus - physiopathology Thresholds Visual discrimination Visual observation Visual pathways Visual perception |
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| Title | Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus (PPN) Influences Visual Contrast Sensitivity in Human Observers |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27167979 https://www.proquest.com/docview/1788228619 https://www.proquest.com/docview/1789038032 https://pubmed.ncbi.nlm.nih.gov/PMC4864298 https://doaj.org/article/803dd83e86be4b518dd3efd81d0ad9e3 http://dx.doi.org/10.1371/journal.pone.0155206 |
| Volume | 11 |
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