Deep Brain Stimulation of the Pedunculopontine Tegmental Nucleus (PPN) Influences Visual Contrast Sensitivity in Human Observers

The parapontine nucleus of the thalamus (PPN) is a neuromodulatory midbrain structure with widespread connectivity to cortical and subcortical motor structures, as well as the spinal cord. The PPN also projects to the thalamus, including visual relay nuclei like the LGN and the pulvinar. Moreover, t...

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Vydáno v:	PloS one Ročník 11; číslo 5; s. e0155206
Hlavní autoři:	Strumpf, Hendrik, Noesselt, Toemme, Schoenfeld, Mircea Ariel, Voges, Jürgen, Panther, Patricia, Kaufmann, Joern, Heinze, Hans-Jochen, Hopf, Jens-Max
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 11.05.2016 Public Library of Science (PLoS)
Témata:	Aged Biology and Life Sciences Brain Brain stimulation Colliculus Contrast Sensitivity Deep brain stimulation Deep Brain Stimulation - methods Disease control Female Frequency dependence Gait Humans Influence Localization Male Medicine and Health Sciences Mesencephalon Middle Aged Motor skills Motor task performance Movement disorders Nerve Net - pathology Nerve Net - physiopathology Neural networks Neurobiology Neurodegenerative diseases Neurology Neuromodulation Neurons Neurosciences Neurosurgery Noise Nuclei Orientation Orientation behavior Parameter estimation Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson's disease Patients Pedunculopontine tegmental nucleus Pedunculopontine Tegmental Nucleus - pathology Pedunculopontine Tegmental Nucleus - physiopathology Physiological aspects Postural Balance Posture Pulvinar Social Sciences Spinal cord Stimulation Superior Colliculi - pathology Superior Colliculi - physiopathology Superior colliculus Tegmental nucleus Tegmentum Thalamus Thalamus - pathology Thalamus - physiopathology Thresholds Visual discrimination Visual observation Visual pathways Visual perception Germany
ISSN:	1932-6203, 1932-6203
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Shrnutí:	The parapontine nucleus of the thalamus (PPN) is a neuromodulatory midbrain structure with widespread connectivity to cortical and subcortical motor structures, as well as the spinal cord. The PPN also projects to the thalamus, including visual relay nuclei like the LGN and the pulvinar. Moreover, there is intense connectivity with sensory structures of the tegmentum in particular with the superior colliculus (SC). Given the existence and abundance of projections to visual sensory structures, it is likely that activity in the PPN has some modulatory influence on visual sensory selection. Here we address this possibility by measuring the visual discrimination performance (luminance contrast thresholds) in a group of patients with Parkinson's Disease (PD) treated with deep-brain stimulation (DBS) of the PPN to control gait and postural motor deficits. In each patient we measured the luminance-contrast threshold of being able to discriminate an orientation-target (Gabor-grating) as a function of stimulation frequency (high 60Hz, low 8/10, no stimulation). Thresholds were determined using a standard staircase-protocol that is based on parameter estimation by sequential testing (PEST). We observed that under low frequency stimulation thresholds increased relative to no and high frequency stimulation in five out of six patients, suggesting that DBS of the PPN has a frequency-dependent impact on visual selection processes at a rather elementary perceptual level.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: HS TN MAS H-JH J-MH. Performed the experiments: HS JV. Analyzed the data: HS TN PP J-MH JK. Contributed reagents/materials/analysis tools: JV PP H-JH JK. Wrote the paper: MAS TN J-MH.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0155206