Burden and risk factors for antenatal depression and its effect on preterm birth in South Asia: A population-based cohort study

Women experience high rates of depression, particularly during pregnancy and the postpartum periods. Using population-based data from Bangladesh and Pakistan, we estimated the burden of antenatal depression, its risk factors, and its effect on preterm birth. The study uses the following data: matern...

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Veröffentlicht in:	PloS one Jg. 17; H. 2; S. e0263091
Hauptverfasser:	Khanam, Rasheda, Applegate, Jennifer, Nisar, Imran, Dutta, Arup, Rahman, Sayedur, Nizar, Ambreen, Ali, Said Mohammed, Chowdhury, Nabidul Haque, Begum, Farzana, Dhingra, Usha, Tofail, Fahmida, Mehmood, Usma, Deb, Saikat, Ahmed, Salahuddin, Muhammad, Sajid, Das, Sayan, Ahmed, Saifuddin, Mittal, Harshita, Minckas, Nicole, Yoshida, Sachiyo, Bahl, Rajiv, Jehan, Fyezah, Sazawal, Sunil, Baqui, Abdullah H.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 07.02.2022 Public Library of Science (PLoS)
Schlagworte:	Adult Asia - epidemiology Bangladesh - epidemiology Birth Childrens health Cohort analysis Cohort Studies Confidence intervals Depression - complications Depression - epidemiology Diabetes Education Female Gestation Health risks Health surveillance Humans Infant, Newborn Infants (Premature) Medical laboratories Medicine and Health Sciences Mental depression Pakistan - epidemiology Parity Pediatrics Population Population studies Population-based studies Postpartum depression Postpartum period Pregnancy Pregnancy Complications - epidemiology Pregnancy Complications - psychology Pregnancy Outcome - epidemiology Pregnancy Outcome - psychology Premature birth Premature Birth - epidemiology Prenatal Care - statistics & numerical data Prenatal depression Psychological aspects Public health Risk analysis Risk Factors Socioeconomics Ultrasound Womens health Young Adult Asia Bangladesh Pakistan South Asia United States > US Tanzania Maryland Switzerland Baltimore Maryland Karachi Pakistan India
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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Zusammenfassung:	Women experience high rates of depression, particularly during pregnancy and the postpartum periods. Using population-based data from Bangladesh and Pakistan, we estimated the burden of antenatal depression, its risk factors, and its effect on preterm birth. The study uses the following data: maternal depression measured between 24 and 28 weeks of gestation using the 9-question Patient Health Questionnaire (PHQ-9); data on pregnancy including an ultrasound before 19 weeks of gestation; data on pregnancy outcomes; and data on woman's age, education, parity, weight, height, history of previous illness, prior miscarriage, stillbirth, husband's education, and household socioeconomic data collected during early pregnancy. Using PHQ-9 cutoff score of ≥12, women were categorized into none to mild depression or moderate to moderately severe depression. Using ultrasound data, preterm birth was defined as babies born <37 weeks of gestation. To identify risk ratios (RR) for antenatal depression, unadjusted and adjusted RR and 95% confidence intervals (CI) were calculated using log- binomial model. Log-binomial models were also used for determining the effect of antenatal depression on preterm birth adjusting for potential confounders. Data were analyzed using Stata version 16 (StataCorp LP). About 6% of the women reported moderate to moderately severe depressive symptoms during the antenatal period. A parity of ≥2 and the highest household wealth status were associated with an increased risk of depression. The overall incidence of preterm birth was 13.4%. Maternal antenatal depression was significantly associated with the risk of preterm birth (ARR, 95% CI: 1.34, 1.02-1.74). The increased risk of preterm birth in women with antenatal depression in conjunction with other significant risk factors suggests that depression likely occurs within a constellation of other risk factors. Thus, to effectively address the burden of preterm birth, programs require developing and providing integrated care addressing multiple risk factors.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0263091