Repair Pathway Choices and Consequences at the Double-Strand Break

DNA double-strand breaks (DSBs) are cytotoxic lesions that threaten genomic integrity. Failure to repair a DSB has deleterious consequences, including genomic instability and cell death. Indeed, misrepair of DSBs can lead to inappropriate end-joining events, which commonly underlie oncogenic transfo...

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Bibliographic Details
Published in:	Trends in cell biology Vol. 26; no. 1; pp. 52 - 64
Main Authors:	Ceccaldi, Raphael, Rondinelli, Beatrice, D’Andrea, Alan D.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.01.2016
Subjects:	alternative end joining Animals Cell Survival DNA Breaks, Double-Stranded DNA Repair Genomic Instability homologous recombination Humans Mutation Pathology Polθ synthetic lethality homologous recombination DNA repair Polθ alternative end joining synthetic lethality
ISSN:	0962-8924, 1879-3088
Online Access:	Get full text
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