Insights into the hyperglycosylation of human chorionic gonadotropin revealed by glycomics analysis

Human chorionic gonadotropin (hCG) is a glycoprotein hormone that is essential for the maintenance of pregnancy. Glycosylation of hCG is known to be essential for its biological activity. "Hyperglycosylated" variants secreted during early pregnancy have been proposed to be involved in init...

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Bibliographic Details
Published in:	PloS one Vol. 15; no. 2; p. e0228507
Main Authors:	Ibeto, Linda, Antonopoulos, Aristotelis, Grassi, Paola, Pang, Poh-Choo, Panico, Maria, Bobdiwala, Shabnam, Al-Memar, Maya, Davis, Paul, Davis, Mark, Norman Taylor, Julian, Almeida, Paula, Johnson, Mark R., Harvey, Richard, Bourne, Tom, Seckl, Michael, Clark, Gary, Haslam, Stuart M., Dell, Anne
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 11.02.2020 Public Library of Science (PLoS)
Subjects:	Antigenic determinants Antigens Biological activity Biology and Life Sciences Biomarkers Cancer Carbohydrate Sequence Chorionic gonadotropin Chorionic Gonadotropin, beta Subunit, Human - blood Chorionic Gonadotropin, beta Subunit, Human - metabolism Chorionic Gonadotropin, beta Subunit, Human - urine Chorionic gonadotropins Comparative analysis Cytotoxicity Diagnostic systems Diseases Embryo Embryos Epitopes Female Female identity Gestation Gestational Age Gestational Trophoblastic Disease - blood Gestational Trophoblastic Disease - metabolism Gestational Trophoblastic Disease - urine Glycan Glycomics - methods Glycoproteins Glycosylation Gonadotropins Gynecology Health aspects Hormones Humans Identity Implantation Killer cells Life sciences Mass spectrometry Mass spectroscopy Medicine and Health Sciences Miscarriage N-glycans Natural killer cells Novels Obstetrics Physical Sciences Pituitary (anterior) Pituitary hormones Placental hormones Polysaccharides Polysaccharides - metabolism Preeclampsia Pregnancy Pregnant women Protein Processing, Post-Translational Research and Analysis Methods Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Spectroscopy Tandem Mass Spectrometry Time Toxicity Trophoblastic disease Tumors Urine Womens health United Kingdom > UK United States > US Missouri
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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