MicroRNAs in the miR-17 and miR-15 families are downregulated in chronic kidney disease with hypertension

In older adults (aged 70-74 years), African-Americans have 4-fold higher risk of developing hypertension-attributed end-stage renal disease (ESRD) than European-Americans. A hypothesized mechanism linking hypertension and progressive chronic kidney disease (CKD) is the innate immune response and inf...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 8; p. e0176734
Main Authors:	Nandakumar, Priyanka, Tin, Adrienne, Grove, Megan L., Ma, Jianzhong, Boerwinkle, Eric, Coresh, Josef, Chakravarti, Aravinda
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 03.08.2017 Public Library of Science (PLoS)
Subjects:	Adults African Americans Albumin Atherosclerosis Biology and life sciences Blood Blood pressure Body mass Body mass index Complications Computer and Information Sciences Control methods Creatinine Diabetes mellitus Down-Regulation Drugs Elderly End-stage renal disease Environmental science Epidemiology Epidermal growth factor receptors Female Gene expression Gene Expression Profiling Gene Ontology Gene Regulatory Networks Gene sequencing Genes Genetics Genomics Glomerular filtration rate Health aspects Health risks Humans Hypertension Hypertension - complications Immune response Immune system Infections Innate immunity Kidney diseases Kidney transplantation Kidneys Male Medicine Medicine and Health Sciences MicroRNA MicroRNAs MicroRNAs - genetics Middle Aged Minority & ethnic groups miRNA Network analysis Older people Peripheral blood Public health Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - genetics Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism Sequence Analysis, RNA Urine United States > US Maryland Texas Baltimore Maryland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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