Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells

Expression and regulation of microRNAs is an emerging issue in erythroid differentiation and globin gene expression in hemoglobin disorders. In the first part of this study microarray analysis was performed both in mithramycin-induced K562 cells and erythroid precursors from healthy subjects or β-th...

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Vydané v:	PloS one Ročník 10; číslo 4; s. e0121567
Hlavní autori:	Bianchi, Nicoletta, Finotti, Alessia, Ferracin, Manuela, Lampronti, Ilaria, Zuccato, Cristina, Breveglieri, Giulia, Brognara, Eleonora, Fabbri, Enrica, Borgatti, Monica, Negrini, Massimo, Gambari, Roberto
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 07.04.2015 Public Library of Science (PLoS)
Predmet:	3' Untranslated regions Adaptor Proteins, Signal Transducing - biosynthesis Adaptor Proteins, Signal Transducing - genetics beta-Thalassemia - genetics beta-Thalassemia - metabolism Binding sites Biotechnology Breast cancer Cell cycle Cell Differentiation - drug effects Cell Differentiation - genetics Differentiation DNA microarrays Erythroid cells Erythroid Cells - metabolism Female Fetuses gamma-Globins - biosynthesis gamma-Globins - genetics Gene expression Gene Expression Regulation - drug effects Genes Hemoglobin Humans Hypoxia K562 Cells Laboratories Leukemia Life sciences Male Medical research MicroRNA MicroRNAs MicroRNAs - biosynthesis MicroRNAs - genetics miRNA Morphology Patients Plicamycin - pharmacology Proteins Rapamycin Regulatory-Associated Protein of mTOR Ribonucleic acid RNA Stem cells Thalassemia TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
ISSN:	1932-6203, 1932-6203
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