Angiopoietin-1 Requires Oxidant Signaling through p47phox to Promote Endothelial Barrier Defense

Reactive oxygen species (ROS) are largely considered to be pathogenic to normal endothelial function in disease states such as sepsis. We hypothesized that Angiopoietin-1 (Angpt-1), an endogenous agonist of the endothelial-specific receptor, Tie-2, promotes barrier defense by activating NADPH oxidas...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 3; p. e0119577
Main Authors:	Ghosh, Chandra C., Mukherjee, Aditi, David, Sascha, Milam, Katelyn E., Hunter, Jon T., Parikh, Samir M.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 11.03.2015 Public Library of Science (PLoS)
Subjects:	Actin Angiogenesis Angiopoietin Angiopoietin-1 - genetics Angiopoietin-1 - metabolism Animals Biology Cells, Cultured Cellular signal transduction Chemical inhibitors Contact stresses Endothelial cells Endothelium Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Gene expression Gene transfer Growth factors Guanosine triphosphatases Guanosinetriphosphatase Humans Hypertension Immunoglobulins Inflammation Intercellular Junctions Kinases Laboratory animals Lipopolysaccharides Lipopolysaccharides - pharmacology Medical research Medical schools Membrane Glycoproteins - antagonists & inhibitors Mice Microvasculature NAD(P)H oxidase NADPH Oxidase 2 NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - genetics NADPH Oxidases - metabolism Nephrology Oxidants Oxidative Stress - drug effects Oxidizing agents Oxygen Permeability Phosphorylation Proteins Rac1 protein Reactive oxygen species Reactive Oxygen Species - metabolism RhoA protein Sepsis Signal transduction Signaling siRNA Thrombin Thrombin - pharmacology Transduction United States
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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