Systemic Lupus Erythematosus and Vitamin D Deficiency Are Associated with Shorter Telomere Length among African Americans: A Case-Control Study

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that disproportionately affects African American females. The causes of SLE are unknown but postulated to be a combination of genetic predisposition and environmental triggers. Vitamin D deficiency is one of the possible env...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one Jg. 8; H. 5; S. e63725
Hauptverfasser:	Hoffecker, Brett M., Raffield, Laura M., Kamen, Diane L., Nowling, Tamara K.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 20.05.2013 Public Library of Science (PLoS)
Schlagworte:	25-Hydroxyvitamin D Adult African American women African Americans African Americans - genetics Aging Antibodies Autoimmune diseases Biology Biomarkers Case-Control Studies Chromosomes Chronic conditions Correlation Deoxyribonucleic acid Disease control DNA Enzyme-linked immunosorbent assay Female Females Humans Leukocytes (mononuclear) Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - genetics Medical research Medicine Middle Aged Minority & ethnic groups Multiplexing Patients Peripheral blood mononuclear cells Population studies Radioimmunoassay Systemic lupus erythematosus Telomere - genetics Telomere Homeostasis Telomeres Vitamin D Vitamin D - blood Vitamin D deficiency Vitamin D Deficiency - blood Vitamin D Deficiency - genetics Vitamin deficiency United States > US South Carolina
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that disproportionately affects African American females. The causes of SLE are unknown but postulated to be a combination of genetic predisposition and environmental triggers. Vitamin D deficiency is one of the possible environmental triggers. In this study we evaluated relationships between vitamin D status, cellular aging (telomere length) and anti-telomere antibodies among African American Gullah women with SLE. The study population included African American female SLE patients and unaffected controls from the Sea Island region of South Carolina. Serum 25-hydroxyvitamin D levels were measured using a nonchromatographic radioimmunoassay. Telomere length was measured in genomic DNA of peripheral blood mononuclear cells (PBMCs) by monochrome multiplex quantitative PCR. Anti-telomere antibody levels were measured by enzyme-linked immunosorbent assay (ELISA). Patients with SLE had significantly shorter telomeres and higher anti-telomere antibody titers compared to age- and gender-matched unaffected controls. There was a positive correlation between anti-telomere antibody levels and disease activity among patients and a significant correlation of shorter telomeres with lower 25-hydroxyvitamin D levels in both patients and controls. In follow-up examination of a subset of the patients, the patients who remained vitamin D deficient tended to have shorter telomeres than those patients whose 25-hydroxyvitamin D levels were repleted. Increasing 25-hydroxyvitamin D levels in African American patients with SLE may be beneficial in maintaining telomere length and preventing cellular aging. Moreover, anti-telomere antibody levels may be a promising biomarker of SLE status and disease activity.
AbstractList	Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that disproportionately affects African American females. The causes of SLE are unknown but postulated to be a combination of genetic predisposition and environmental triggers. Vitamin D deficiency is one of the possible environmental triggers. In this study we evaluated relationships between vitamin D status, cellular aging (telomere length) and anti-telomere antibodies among African American Gullah women with SLE. The study population included African American female SLE patients and unaffected controls from the Sea Island region of South Carolina. Serum 25-hydroxyvitamin D levels were measured using a nonchromatographic radioimmunoassay. Telomere length was measured in genomic DNA of peripheral blood mononuclear cells (PBMCs) by monochrome multiplex quantitative PCR. Anti-telomere antibody levels were measured by enzyme-linked immunosorbent assay (ELISA). Patients with SLE had significantly shorter telomeres and higher anti-telomere antibody titers compared to age- and gender-matched unaffected controls. There was a positive correlation between anti-telomere antibody levels and disease activity among patients and a significant correlation of shorter telomeres with lower 25-hydroxyvitamin D levels in both patients and controls. In follow-up examination of a subset of the patients, the patients who remained vitamin D deficient tended to have shorter telomeres than those patients whose 25-hydroxyvitamin D levels were repleted. Increasing 25-hydroxyvitamin D levels in African American patients with SLE may be beneficial in maintaining telomere length and preventing cellular aging. Moreover, anti-telomere antibody levels may be a promising biomarker of SLE status and disease activity. Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that disproportionately affects African American females. The causes of SLE are unknown but postulated to be a combination of genetic predisposition and environmental triggers. Vitamin D deficiency is one of the possible environmental triggers. In this study we evaluated relationships between vitamin D status, cellular aging (telomere length) and anti-telomere antibodies among African American Gullah women with SLE. The study population included African American female SLE patients and unaffected controls from the Sea Island region of South Carolina. Serum 25-hydroxyvitamin D levels were measured using a nonchromatographic radioimmunoassay. Telomere length was measured in genomic DNA of peripheral blood mononuclear cells (PBMCs) by monochrome multiplex quantitative PCR. Anti-telomere antibody levels were measured by enzyme-linked immunosorbent assay (ELISA). Patients with SLE had significantly shorter telomeres and higher anti-telomere antibody titers compared to age- and gender-matched unaffected controls. There was a positive correlation between anti-telomere antibody levels and disease activity among patients and a significant correlation of shorter telomeres with lower 25-hydroxyvitamin D levels in both patients and controls. In follow-up examination of a subset of the patients, the patients who remained vitamin D deficient tended to have shorter telomeres than those patients whose 25-hydroxyvitamin D levels were repleted. Increasing 25-hydroxyvitamin D levels in African American patients with SLE may be beneficial in maintaining telomere length and preventing cellular aging. Moreover, anti-telomere antibody levels may be a promising biomarker of SLE status and disease activity.Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that disproportionately affects African American females. The causes of SLE are unknown but postulated to be a combination of genetic predisposition and environmental triggers. Vitamin D deficiency is one of the possible environmental triggers. In this study we evaluated relationships between vitamin D status, cellular aging (telomere length) and anti-telomere antibodies among African American Gullah women with SLE. The study population included African American female SLE patients and unaffected controls from the Sea Island region of South Carolina. Serum 25-hydroxyvitamin D levels were measured using a nonchromatographic radioimmunoassay. Telomere length was measured in genomic DNA of peripheral blood mononuclear cells (PBMCs) by monochrome multiplex quantitative PCR. Anti-telomere antibody levels were measured by enzyme-linked immunosorbent assay (ELISA). Patients with SLE had significantly shorter telomeres and higher anti-telomere antibody titers compared to age- and gender-matched unaffected controls. There was a positive correlation between anti-telomere antibody levels and disease activity among patients and a significant correlation of shorter telomeres with lower 25-hydroxyvitamin D levels in both patients and controls. In follow-up examination of a subset of the patients, the patients who remained vitamin D deficient tended to have shorter telomeres than those patients whose 25-hydroxyvitamin D levels were repleted. Increasing 25-hydroxyvitamin D levels in African American patients with SLE may be beneficial in maintaining telomere length and preventing cellular aging. Moreover, anti-telomere antibody levels may be a promising biomarker of SLE status and disease activity.
Audience	Academic
Author	Hoffecker, Brett M. Raffield, Laura M. Nowling, Tamara K. Kamen, Diane L.
AuthorAffiliation	2 Medical Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina, United States of America University of Michigan, United States of America 1 Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America
AuthorAffiliation_xml	– name: 2 Medical Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina, United States of America – name: 1 Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, United States of America – name: University of Michigan, United States of America
Author_xml	– sequence: 1 givenname: Brett M. surname: Hoffecker fullname: Hoffecker, Brett M. – sequence: 2 givenname: Laura M. surname: Raffield fullname: Raffield, Laura M. – sequence: 3 givenname: Diane L. surname: Kamen fullname: Kamen, Diane L. – sequence: 4 givenname: Tamara K. surname: Nowling fullname: Nowling, Tamara K.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23700431$$D View this record in MEDLINE/PubMed
BookMark	eNqNk99u0zAUxiM0xP7AGyCwhITgoiWJ7cTZBVLUDahUaRIdu7Vc5yRxldjFdoA-Ba-Mu7aonSaEchH7-Pd9zjk55zw60UZDFL1M4nGC8-TD0gxWi268CuFxHGc4T-mT6CwpcDrK0hifHKxPo3PnlnFMMcuyZ9FpivM4Jjg5i37P185DrySaDavBoWu79i30whsXdkJX6E550SuNrtAV1Eoq0HKNSguodM5IJTxU6KfyLZq3xnqw6BY600MAZqCbEBe90Q0qa6uk0KgMR5uFu0QlmggHo4nR3poOzf1QrZ9HT2vROXixe19E3z5d306-jGY3n6eTcjaSWZH6EZZSkixhmFGKCRaMVYIQShkVrF5IWWRVkRCQkBWkoqE4NWCWE1HjrBYFVPgier31XXXG8V0tHU8wxTgpUoIDMd0SlRFLvrKqF3bNjVD8PmBsw4X1SnbAk5jQRYxBpikmC0wXaY4LqBeCZEwSyILXx91tw6KHSkLIWHRHpscnWrW8MT84zigrWBIM3u0MrPk-gPO8V05C1wkNZrj_bkrynNIioG8eoI9nt6MaERJQujbhXrkx5SXJWYAKQgI1foQKT7VpmdB4tQrxI8H7I0FgPPzyjRic49P51_9nb-6O2bcHbAui860z3eCV0e4YfHVY6b8l3nd8AC63gLTGOQs1l6HBNz4hNdWFf8k347UvGt-MF9-NVxCTB-K9_z9lfwBDsSmT
CitedBy_id	crossref_primary_10_1002_art_42313 crossref_primary_10_3390_nu13114127 crossref_primary_10_1111_1756_185x_70379 crossref_primary_10_1155_2017_5719461 crossref_primary_10_1186_2047_9158_3_16 crossref_primary_10_3390_genes7090060 crossref_primary_10_1136_lupus_2015_000144 crossref_primary_10_1177_0961203316629001 crossref_primary_10_1016_j_nut_2015_05_018 crossref_primary_10_1016_j_autrev_2019_102392 crossref_primary_10_3892_mmr_2019_10663 crossref_primary_10_1136_lupus_2022_000698 crossref_primary_10_3233_JAD_200926 crossref_primary_10_1017_S0007114516002075 crossref_primary_10_5937_arhfarm72_36376 crossref_primary_10_1007_s11065_023_09598_z crossref_primary_10_1586_1744666X_2013_850031 crossref_primary_10_1177_1753944720977715 crossref_primary_10_3390_biom14101261 crossref_primary_10_1113_JP274887 crossref_primary_10_1007_s12603_023_1948_3 crossref_primary_10_1111_nyas_12432 crossref_primary_10_1007_s00296_016_3497_0 crossref_primary_10_1016_j_dld_2013_11_008 crossref_primary_10_1016_j_autrev_2017_09_011 crossref_primary_10_3390_nu16152525 crossref_primary_10_1177_09612033231195953 crossref_primary_10_1515_cclm_2017_0870 crossref_primary_10_3390_nu16060906 crossref_primary_10_1177_0961203316662721 crossref_primary_10_1007_s00393_016_0209_9 crossref_primary_10_1111_1756_185X_13676 crossref_primary_10_1136_lupus_2023_000968 crossref_primary_10_1177_09612033221130976 crossref_primary_10_1111_mcn_12475 crossref_primary_10_3390_nu13124341 crossref_primary_10_1515_hmbci_2018_0064
Cites_doi	10.1196/annals.1392.001 10.1002/art.1780390303 10.1111/j.1474-9726.2008.00448.x 10.1002/art.1780400928 10.1002/art.1780350606 10.1001/archinternmed.2008.604 10.1006/clim.2001.5023 10.4049/jimmunol.0803736 10.1093/nar/gkn1027 10.1002/art.1780260226 10.1016/j.semarthrit.2008.10.007 10.1189/jlb.1011523 10.1056/NEJMra071297 10.1016/j.jacc.2011.02.051 10.1177/0961203307084299 10.1136/ard.2003.011890 10.2310/JIM.0b013e31821b8755 10.3945/ajcn.111.014779 10.1093/nar/30.10.e47 10.1136/ard.2010.148494 10.1097/HJH.0b013e32834e1f0a 10.1177/0961203310371161 10.1097/00124743-199510000-00002 10.1177/0961203311404915 10.1007/s11926-008-0044-3 10.1111/j.0105-2896.2005.00267.x 10.1191/0961203303lu426oa 10.1002/art.1780251101 10.1002/art.21955 10.1016/j.jim.2009.09.012 10.1016/j.exger.2005.12.002 10.1007/s00109-010-0590-9 10.1371/journal.pone.0009193 10.1002/1529-0131(200104)44:4<981::AID-ANR158>3.0.CO;2-0 10.1177/0961203307077155 10.1191/096120300678828343 10.1093/rheumatology/keh048 10.1002/art.23416 10.1093/ajcn/86.5.1420
ContentType	Journal Article
Copyright	COPYRIGHT 2013 Public Library of Science 2013 Hoffecker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Hoffecker et al 2013 Hoffecker et al
Copyright_xml	– notice: COPYRIGHT 2013 Public Library of Science – notice: 2013 Hoffecker et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2013 Hoffecker et al 2013 Hoffecker et al
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0063725
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & allied health premium. Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agriculture Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium ProQuest advanced technologies & aerospace journals ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals - NZ
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic Agricultural Science Database
Database_xml	– sequence: 1 dbid: DOA name: DOAJ : directory of open access journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Medicine Biology
DocumentTitleAlternate	Vitamin D Deficiency and Telomere Length in SLE
EISSN	1932-6203
ExternalDocumentID	1353319243 oai_doaj_org_article_1045b03ec2234b35b2739efba468c4e6 PMC3658981 2975251671 A478192944 23700431 10_1371_journal_pone_0063725
Genre	Research Support, U.S. Gov't, Non-P.H.S Journal Article Research Support, N.I.H., Extramural
GeographicLocations	United States--US South Carolina
GeographicLocations_xml	– name: South Carolina – name: United States--US
GrantInformation_xml	– fundername: NIAMS NIH HHS grantid: R03 AR053376 – fundername: NIAMS NIH HHS grantid: P60 AR062755 – fundername: NIAMS NIH HHS grantid: K23 AR052364 – fundername: NIAMS NIH HHS grantid: AR053376 – fundername: NCRR NIH HHS grantid: UL1 RR029882 – fundername: BLRD VA grantid: I01 BX000115
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RIG RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF NPM PV9 RZL BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM AAPBV ABPTK
ID	FETCH-LOGICAL-c692t-3ccc46183855343a88da445585a8fbcc96d914ece694d5063fe3874af36fa9ed3
IEDL.DBID	FPL
ISICitedReferencesCount	44
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000319966400028&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Sun Sep 03 00:14:17 EDT 2023 Fri Oct 03 12:52:42 EDT 2025 Tue Nov 04 01:59:24 EST 2025 Mon Sep 08 14:50:47 EDT 2025 Tue Oct 07 07:02:41 EDT 2025 Sat Nov 29 13:32:22 EST 2025 Sat Nov 29 09:55:36 EST 2025 Wed Nov 26 09:21:57 EST 2025 Wed Nov 26 10:41:51 EST 2025 Thu May 22 21:17:37 EDT 2025 Tue Aug 05 11:41:59 EDT 2025 Tue Nov 18 22:17:40 EST 2025 Sat Nov 29 02:24:55 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	5
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c692t-3ccc46183855343a88da445585a8fbcc96d914ece694d5063fe3874af36fa9ed3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. These authors also contributed equally to this work. Conceived and designed the experiments: DLK TKN. Performed the experiments: BMH LMR TKN. Analyzed the data: BMH LMR DLK TKN. Contributed reagents/materials/analysis tools: DLK TKN. Wrote the paper: BMH LMR DLK TKN.
OpenAccessLink	http://dx.doi.org/10.1371/journal.pone.0063725
PMID	23700431
PQID	1353319243
PQPubID	1436336
PageCount	e63725
ParticipantIDs	plos_journals_1353319243 doaj_primary_oai_doaj_org_article_1045b03ec2234b35b2739efba468c4e6 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3658981 proquest_miscellaneous_1355477559 proquest_journals_1353319243 gale_infotracmisc_A478192944 gale_infotracacademiconefile_A478192944 gale_incontextgauss_ISR_A478192944 gale_incontextgauss_IOV_A478192944 gale_healthsolutions_A478192944 pubmed_primary_23700431 crossref_citationtrail_10_1371_journal_pone_0063725 crossref_primary_10_1371_journal_pone_0063725
PublicationCentury	2000
PublicationDate	2013-05-20
PublicationDateYYYYMMDD	2013-05-20
PublicationDate_xml	– month: 05 year: 2013 text: 2013-05-20 day: 20
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2013
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	A Rahman (ref1) 2008; 358 S Bernatsky (ref2) 2006; 54 DL Kamen (ref22) 2008; 58 F Beier (ref17) 2007; 16 LL Ritterhouse (ref10) 2011; 70 DL Kamen (ref4) 2008; 10 LM Vila (ref9) 2004; 43 GS Alarcon (ref15) 1983; 26 J Calvo-Alen (ref13) 1995; 1 J Lin (ref39) 2010; 352 RM Cawthon (ref29) 2009; 37 D Gladman (ref26) 1996; 39 I Al Mheid (ref5) 2011; 58 MB Tew (ref12) 2001; 44 BW Hollis (ref27) 2000; 46 Q Ouyang (ref38) 2007; 1106 D Kurosaka (ref18) 2003; 12 G Gilkeson (ref31) 2011; 20 A Zittermann (ref8) 2012; 95 DJ Wallace (ref20) 2000; 9 L Kaszubowska (ref37) 2008; 59 AA Ginde (ref30) 2009; 169 EM Salonen (ref21) 2004; 63 GJ Pons-Estel (ref3) 2010; 39 C Bombardier (ref25) 1992; 35 G Obermoser (ref35) 2010; 19 JS Adams (ref34) 2009; 182 JJ Goronzy (ref36) 2006; 41 A Chebel (ref41) 2009; 8 M Honda (ref14) 2001; 99 DL Kamen (ref33) 2010; 88 G Zhao (ref6) 2012; 30 MC Hochberg (ref24) 1997; 40 CH Wu (ref16) 2007; 16 JB Richards (ref19) 2007; 86 RM Cawthon (ref28) 2002; 30 I Ben-Zvi (ref11) 2010; 5 EM Tan (ref23) 1982; 25 L Alvarez-Rodriguez (ref32) 2012; 91 KS Hathcock (ref40) 2005; 205 C Aranow (ref7) 2011; 59
References_xml	– volume: 1106 start-page: 240 year: 2007 ident: ref38 article-title: Telomere length in human natural killer cell subsets publication-title: Ann N Y Acad Sci doi: 10.1196/annals.1392.001 – volume: 39 start-page: 363 year: 1996 ident: ref26 article-title: The development and initial validation of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology damage index for systemic lupus erythematosus publication-title: Arthritis Rheum doi: 10.1002/art.1780390303 – volume: 8 start-page: 52 year: 2009 ident: ref41 article-title: Telomere uncapping during in vitro T-lymphocyte senescence publication-title: Aging Cell doi: 10.1111/j.1474-9726.2008.00448.x – volume: 40 start-page: 1725 year: 1997 ident: ref24 article-title: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus publication-title: Arthritis Rheum doi: 10.1002/art.1780400928 – volume: 35 start-page: 630 year: 1992 ident: ref25 article-title: Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE publication-title: Arthritis Rheum doi: 10.1002/art.1780350606 – volume: 169 start-page: 626 year: 2009 ident: ref30 article-title: Demographic differences and trends of vitamin D insufficiency in the US population, 1988–2004 publication-title: Arch Intern Med doi: 10.1001/archinternmed.2008.604 – volume: 99 start-page: 211 year: 2001 ident: ref14 article-title: Telomere shortening and decreased replicative potential, contrasted by continued proliferation of telomerase-positive CD8+CD28(lo) T cells in patients with systemic lupus erythematosus publication-title: Clin Immunol doi: 10.1006/clim.2001.5023 – volume: 182 start-page: 4289 year: 2009 ident: ref34 article-title: Vitamin d-directed rheostatic regulation of monocyte antibacterial responses publication-title: J Immunol doi: 10.4049/jimmunol.0803736 – volume: 37 start-page: e21 year: 2009 ident: ref29 article-title: Telomere length measurement by a novel monochrome multiplex quantitative PCR method publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn1027 – volume: 26 start-page: 238 year: 1983 ident: ref15 article-title: Systemic lupus erythematosus, gout and Paget's disease publication-title: Arthritis Rheum doi: 10.1002/art.1780260226 – volume: 39 start-page: 257 year: 2010 ident: ref3 article-title: Understanding the epidemiology and progression of systemic lupus erythematosus publication-title: Semin Arthritis Rheum doi: 10.1016/j.semarthrit.2008.10.007 – volume: 91 start-page: 829 year: 2012 ident: ref32 article-title: Age and low levels of circulating vitamin D are associated with impaired innate immune function publication-title: J Leukoc Biol doi: 10.1189/jlb.1011523 – volume: 358 start-page: 929 year: 2008 ident: ref1 article-title: Systemic lupus erythematosus publication-title: N Engl J Med doi: 10.1056/NEJMra071297 – volume: 58 start-page: 186 year: 2011 ident: ref5 article-title: Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans publication-title: Journal of the American College of Cardiology doi: 10.1016/j.jacc.2011.02.051 – volume: 16 start-page: 955 year: 2007 ident: ref17 article-title: Telomere length analysis in monocytes and lymphocytes from patients with systemic lupus erythematosus using multi-color flow-FISH publication-title: Lupus doi: 10.1177/0961203307084299 – volume: 63 start-page: 1250 year: 2004 ident: ref21 article-title: Anti-telomere antibodies in systemic lupus erythematosus (SLE): a comparison with five antinuclear antibody assays in 430 patients with SLE and other rheumatic diseases publication-title: Ann Rheum Dis doi: 10.1136/ard.2003.011890 – volume: 59 start-page: 881 year: 2011 ident: ref7 article-title: Vitamin D and the immune system publication-title: J Investig Med doi: 10.2310/JIM.0b013e31821b8755 – volume: 95 start-page: 91 year: 2012 ident: ref8 article-title: Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies publication-title: Am J Clin Nutr doi: 10.3945/ajcn.111.014779 – volume: 30 start-page: e47 year: 2002 ident: ref28 article-title: Telomere measurement by quantitative PCR publication-title: Nucleic Acids Res doi: 10.1093/nar/30.10.e47 – volume: 70 start-page: 1569 year: 2011 ident: ref10 article-title: Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus publication-title: Ann Rheum Dis doi: 10.1136/ard.2010.148494 – volume: 30 start-page: 284 year: 2012 ident: ref6 article-title: Serum 25-hydroxyvitamin D levels and all-cause and cardiovascular disease mortality among US adults with hypertension: the NHANES linked mortality study publication-title: J Hypertens doi: 10.1097/HJH.0b013e32834e1f0a – volume: 19 start-page: 1012 year: 2010 ident: ref35 article-title: The interferon-alpha signature of systemic lupus erythematosus publication-title: Lupus doi: 10.1177/0961203310371161 – volume: 1 start-page: 260 year: 1995 ident: ref13 article-title: Predictors of Renal Involvement in Patients with Recent Onset Systemic Lupus Erythematosus publication-title: J Clin Rheumatol doi: 10.1097/00124743-199510000-00002 – volume: 20 start-page: 1095 year: 2011 ident: ref31 article-title: The United States to Africa lupus prevalence gradient revisited publication-title: Lupus doi: 10.1177/0961203311404915 – volume: 10 start-page: 273 year: 2008 ident: ref4 article-title: The link between vitamin D deficiency and systemic lupus erythematosus publication-title: Curr Rheumatol Rep doi: 10.1007/s11926-008-0044-3 – volume: 46 start-page: 1657 year: 2000 ident: ref27 article-title: Comparison of commercially available (125)I-based RIA methods for the determination of circulating 25-hydroxyvitamin D. Clin Chem – volume: 205 start-page: 104 year: 2005 ident: ref40 article-title: In vivo regulation of telomerase activity and telomere length publication-title: Immunol Rev doi: 10.1111/j.0105-2896.2005.00267.x – volume: 12 start-page: 591 year: 2003 ident: ref18 article-title: Telomerase activity and telomere length of peripheral blood mononuclear cells in SLE patients publication-title: Lupus doi: 10.1191/0961203303lu426oa – volume: 25 start-page: 1271 year: 1982 ident: ref23 article-title: The 1982 revised criteria for the classification of systemic lupus erythematosus publication-title: Arthritis Rheum doi: 10.1002/art.1780251101 – volume: 54 start-page: 2550 year: 2006 ident: ref2 article-title: Mortality in systemic lupus erythematosus publication-title: Arthritis Rheum doi: 10.1002/art.21955 – volume: 59 start-page: 169 year: 2008 ident: ref37 article-title: Telomere shortening and ageing of the immune system publication-title: J Physiol Pharmacol – volume: 352 start-page: 71 year: 2010 ident: ref39 article-title: Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance publication-title: J Immunol Methods doi: 10.1016/j.jim.2009.09.012 – volume: 41 start-page: 246 year: 2006 ident: ref36 article-title: Telomeres, immune aging and autoimmunity publication-title: Exp Gerontol doi: 10.1016/j.exger.2005.12.002 – volume: 88 start-page: 441 year: 2010 ident: ref33 article-title: Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity publication-title: J Mol Med doi: 10.1007/s00109-010-0590-9 – volume: 5 start-page: e9193 year: 2010 ident: ref11 article-title: The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus publication-title: PLoS ONE doi: 10.1371/journal.pone.0009193 – volume: 44 start-page: 981 year: 2001 ident: ref12 article-title: Systemic lupus erythematosus in three ethnic groups. VIII. Lack of association of glutathione S-transferase null alleles with disease manifestations publication-title: Arthritis Rheum doi: 10.1002/1529-0131(200104)44:4<981::AID-ANR158>3.0.CO;2-0 – volume: 16 start-page: 265 year: 2007 ident: ref16 article-title: Premature telomere shortening in polymorphonuclear neutrophils from patients with systemic lupus erythematosus is related to the lupus disease activity publication-title: Lupus doi: 10.1177/0961203307077155 – volume: 9 start-page: 328 year: 2000 ident: ref20 article-title: Anti-telomere antibodies in systemic lupus erythematosus: a new ELISA test for anti-DNA with potential pathogenetic implications publication-title: Lupus doi: 10.1191/096120300678828343 – volume: 43 start-page: 358 year: 2004 ident: ref9 article-title: Early clinical manifestations, disease activity and damage of systemic lupus erythematosus among two distinct US Hispanic subpopulations publication-title: Rheumatology doi: 10.1093/rheumatology/keh048 – volume: 58 start-page: 1237 year: 2008 ident: ref22 article-title: Autoantibody prevalence and lupus characteristics in a unique African American population publication-title: Arthritis Rheum doi: 10.1002/art.23416 – volume: 86 start-page: 1420 year: 2007 ident: ref19 article-title: Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women publication-title: Am J Clin Nutr doi: 10.1093/ajcn/86.5.1420
SSID	ssj0053866
Score	2.294979
Snippet	Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that disproportionately affects African American females. The causes of SLE are...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e63725
SubjectTerms	25-Hydroxyvitamin D Adult African American women African Americans African Americans - genetics Aging Antibodies Autoimmune diseases Biology Biomarkers Case-Control Studies Chromosomes Chronic conditions Correlation Deoxyribonucleic acid Disease control DNA Enzyme-linked immunosorbent assay Female Females Humans Leukocytes (mononuclear) Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - genetics Medical research Medicine Middle Aged Minority & ethnic groups Multiplexing Patients Peripheral blood mononuclear cells Population studies Radioimmunoassay Systemic lupus erythematosus Telomere - genetics Telomere Homeostasis Telomeres Vitamin D Vitamin D - blood Vitamin D deficiency Vitamin D Deficiency - blood Vitamin D Deficiency - genetics Vitamin deficiency
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals - NZ dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQqgcuiJZHAwUMQgIOgfXacRxu5VGBhAriUfUWOY5DI22TVZKtxK_gLzNje6MNqlQO3HbjyWp3Hh7PZub7CHlaMMMqheQurBSxKOGVTqSKlbKpkIYz5ujbTj6lx8fq9DT7skX1hT1hHh7YKw6iWiTFnFsDeUwUPCkg32a2KrSQygjrwLbh1LMppvweDFEsZRiU4yl7FezyctU2Fju5eIrU2FuJyOH1j7vybLVs-8uOnH93Tm6loqOb5EY4Q9JD_913yTXb7JHdEKU9fR6gpF_cIr89IHlt6HK9WvfUdr88SmvbwzvdlPSiHvR53dB3tLQIJoGTmFR3lupgN1tS_K-W9mfYltvRwS7bcwsCSMEC1x1bEfV0Qw3dPADqX1NNDWTIOPTCU4dje5v8OHr__e2HOFAwxEZmiyHmxhghIexVknDBtVKlFiKBGkOrqjAmk2XGhDVWZqJMQLGV5SoVuuKy0pkt-R0ya0Dp-4RC4SILXs1LNjcC7swYFMcSJ30TKMG4jQjf2CM3AZ8caTKWuXvolkKd4tWboxXzYMWIxONdK4_PcYX8GzT1KIvo2u4C-FwefC6_yuci8ggdJfejquMekR_i3C6cN4WIyBMngQgbDbbw_NTrvs8_fj75B6FvXydCz4JQ1YI6jA5jE_CbELlrInkwkYR9wkyW99GtN1rpc2Q84Vh_c7hz4-qXLz8el_FDsS2vse3aySQiTaEqjchdHxmjZhccmRM4i0g6iZmJ6qcrTX3mAM45HIszxe79D1vdJ9cXjsEkgYRwQGZDt7YPyI65GOq-e-h2jT8C63M4 priority: 102 providerName: Directory of Open Access Journals – databaseName: ProQuest advanced technologies & aerospace journals dbid: P5Z link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELeg8MALY3wtY4BBSMBDWFN_xOEFlW4TSNWY2KgmXqLEcbpKXVKaFml_Bf8yd44TFjQBEm9tfLYS--58Z9_dj5AXaaCDXCG4S5Bxn2fwKxFS-UqZkEvNgsDCt03G4eGhOj2NjtyBW-XCKhudaBV1Vmo8I99FfAaG3gJ7t_jmI2oU3q46CI3r5AZWSUDBPBJfG00MsiylS5djYbDrVufNoiwMxnOxEAGyL21Htmp_q5t7i3lZXWV4_h4_eWlDOtj430-5Q247U5QOa97ZJNdMcZdsOmGv6CtXkfr1PfKjrms-03S8Xqwrur-8qIu9lhX8S4qMTmar5HxW0D26Z7AmBSZ0wsiGNstvMopHvvT4DKN7l_TEzMtzAwRjU0zhuQU9ojVqUUGbe6TqLR3SEWy0_qgOqacY93hxn3w52D8ZffAdkoOvZTRY-UxrzSVoDyUE4yxRKks4F-CqJCpPtY5kFgXcaCMjnglYmdwwFfIkZzJPIpOxB6RXwKptEQr-j0xZ3s-CvubQMwrAx5aYMCzAk2PGI6xZ0Fi7MueItjGP7d1dCO5OPb0xskHs2MAjfttrUZf5-Av9e-SVlhaLdNsH5XIaO5mHAbhI-8xoMMF4ykQKpmJk8jThUmlupEeeIqfFdcZrq2riIab_gtnKuUeeWwos1FFgJNA0WVdV_PHT5B-Ijj93iF46oryE6dCJy76Ab8ICYB3KnQ4lqBvdad5CuWhmpYp_cTP0bPj96uZnbTMOitF9hSnXlkbwMATn1iMPa9FqZ3bAEICBBR4JO0LXmfpuSzE7s3XSGVjXkQq2__xaj8itgYU4EbBj7JDeark2j8lN_X01q5ZPrEL5CUXBgA8 priority: 102 providerName: ProQuest
Title	Systemic Lupus Erythematosus and Vitamin D Deficiency Are Associated with Shorter Telomere Length among African Americans: A Case-Control Study
URI	https://www.ncbi.nlm.nih.gov/pubmed/23700431 https://www.proquest.com/docview/1353319243 https://www.proquest.com/docview/1355477559 https://pubmed.ncbi.nlm.nih.gov/PMC3658981 https://doaj.org/article/1045b03ec2234b35b2739efba468c4e6 http://dx.doi.org/10.1371/journal.pone.0063725
Volume	8
WOSCitedRecordID	wos000319966400028&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ : directory of open access journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlR1db9Mw0GIdD7wA42uFUQxCAh4ymtpxHN7arhXTuhK1oyq8RInjbJW6pGpapP0K_jJ3TlrItAl4OSXx2UrOvvNdfB-EvI1sZScSi7vYMbd4DFehI6QlpXa5UMy2Tfm2ycAdDuV06vm_DcVrJ_jMtT-WND1cZKlGLyzmtpwdsttiQqALV98fbCQv8K4QZXjcbT0r24_J0r-VxbXFPMtvUjSv-0v-sQH1H_zvqz8k90tVk7aLtbFH7uj0EdkrmTmn78uM0x8ek59F3vKZooP1Yp3T3vKqSOaa5XAXpjGdzFbh5SylR_RIY84JDNiEkTXdTK-OKf7SpeML9N5d0jM9zy41IAx0eg7PTVEjWlQlSunmnCj_RNu0Cxup1S1c5in6NV49IV_7vbPuZ6us1GAp4bVWFlNKcQHSQToO4yyUMg45d8AUCWUSKeWJ2LO5Vlp4PHaAEIlm0uVhwkQSejpmT0ktBSLtEwr2jYhY0oztpuLQ07PBhhYYEOyApcZ0nbDNBAaqTGOO1TTmgTmbc8GcKcgbINWDkup1Ym17LYo0Hn_B7-Da2OJiEm7zAKY3KHkaBuBO1GRagYrFI-ZEoAp6OolCLqTiWtTJK1xZQRHRuhUlQRvDe0Et5bxO3hgMTMSRoqfPebjO8-D4y-QfkMajCtK7EinJgBwqLKMr4JswwVcF86CCCeJEVZr3kQ82VMkDLIzC0Exn0HPDGzc3v94246DovZfqbG1wHO66YLzWybOClbaUbTEssMDsOnErTFYhfbUlnV2YPOgMtGdP2s9vf-MX5F7LlC9xYDc4ILXVcq1fkrvqx2qWLxtkxx1NEE5dAyVA2bUbZLfTG_qjhvk_0zAiBuBJ5xDgafMEoesbOAboO9-hh3986n_7BT5Beug
linkProvider	Public Library of Science
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1fb9MwELdGQYIXYPxbYDCDQMBDWFM7joOEUGk3rVopaCtV30LiOF2lLilNC-qn4JvwGbnLPxY0AS974C2Jz1Z6vTvfxXf3I-RpYCkrkgjuYoXc5CFc-baQppTa4UIxy8rg20Z9ZzCQ47H7cYP8KGthMK2ytImZoQ4Thd_IdxGfgWG0wN7Ov5iIGoWnqyWERi4Wh3r9DUK29E2vC__vs1Zrf2_YOTALVAFTCbe1NJlSiguQZGnbjDNfytDn3Aa32ZdRoJQrQtfiWmnh8tCGHTzSTDrcj5iIfFeHDNa9RC6DHXcwhcwZVwEe2A4hivI85li7hTS8miexxvwx5iAg95ntL0MJqPaCxnyWpOc5ur_na57ZAPdv_G-su0muF642bee6sUk2dHyLbBbGLKUvio7bL2-T73nf9qmi_dV8ldK9xTpvZpukcOfHIR1Nl_7pNKZd2tXYcwMLVmFlTUvx1iHFT9r0-ASzlxd0qGfJqQaCvo4n8DwDdaI5KlNMy3Oy9DVt0w44EmYnLxmgmNe5vkM-XQhj7pJGDFKyRSjEdyJgUTO0morDTNdikgksiLYhUmXaIKwUIE8VbdwRTWTmZWeTDoRzOXs9FDuvEDuDmNWsed7G5C_071A2K1psQp49SBYTr7BpsAC3gybTClxMHjA7AFfY1VHgcyEV18IgOyjZXl7RW5lSr43lzeCWc26QJxkFNiKJMdNp4q_S1Ot9GP0D0fFRjeh5QRQlwA7lF9Ul8JuwwVmNcrtGCeZU1Ya3UA9LrqTeL-2BmaV-nT_8uBrGRTF7MdbJKqOxueNA8G6Qe7kqV5xtMQSYYJZBnJqS11hfH4mnJ1kfeAbRgyut-39-rR1y9WD4vu_1e4PDB-RaK4NzsWF33CaN5WKlH5Ir6utymi4eZcaMks8XbQJ-AqyD3P8
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VgBAXoLxqKHRBIMrBJM6u12skhELSiKhRqGiJKi7GXq_TSKkd4gSUX8H_4dcx4xc1qoBLD9wS73gVT-bpnZmPkKeBpaxIIriLFXKTh_DJt4U0pdQOF4pZVgbfNh46o5E8PnYPNsiPshcGyypLm5gZ6jBR-I68ifgMDLMF1oyKsoiDXv_N_IuJCFJ40lrCaeQisq_X3yB9S18PevBfP2u3-3tH3XdmgTBgKuG2lyZTSnEBUi1tm3HmSxn6nNsQQvsyCpRyRehaXCstXB7a4M0jzaTD_YiJyHd1yGDfS-QyPJWLid-B_an0AmBHhCha9ZhjNQvJeDlPYo21ZMxBcO4zrjBDDKj8QmM-S9Lzgt7fazfPOMP-jf-ZjTfJ9SIEp51cZzbJho5vkc3CyKV0t5jE_eI2-Z7Pc58qOlzNVyndW6zzIbdJCt_8OKTj6dI_nca0R3saZ3FgIyvsrGkp9jqk-KqbHp5gVfOCHulZcqqBYKjjCVzPwJ5ojtYU0_L8LH1FO7QLAYbZzVsJKNZ7ru-QjxfCmLukEYPEbBEKeZ8IWNQKrZbicKdrMckENkrbkMEybRBWCpOnivHuiDIy87IzSwfSvJy9HoqgV4igQczqrnk-3uQv9G9RTitaHE6eXUgWE6-wdbABt4MW0wpCTx4wO4AQ2dVR4HMhFdfCIDso5V7e6VuZWK-Dbc8QrnNukCcZBQ4oiVFGJ_4qTb3B-_E_EB1-qBE9L4iiBNih_KLrBJ4JB5_VKLdrlGBmVW15C3Wy5Erq_dIkuLPUtfOXH1fLuClWNcY6WWU0NnccSOoNci9X64qzbYbAE8wyiFNT-Brr6yvx9CSbD88gq3Cldf_PP2uHXAXN94aD0f4Dcq2dobzY4DS3SWO5WOmH5Ir6upymi0eZXaPk80VbgJ9HauXy
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Systemic+Lupus+Erythematosus+and+Vitamin+D+Deficiency+Are+Associated+with+Shorter+Telomere+Length+among+African+Americans%3A+A+Case-Control+Study&rft.jtitle=PloS+one&rft.au=Hoffecker%2C+Brett+M&rft.au=Raffield%2C+Laura+M&rft.au=Kamen%2C+Diane+L&rft.au=Nowling%2C+Tamara+K&rft.date=2013-05-20&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=8&rft.issue=5&rft.spage=e63725&rft_id=info:doi/10.1371%2Fjournal.pone.0063725&rft.externalDBID=IOV&rft.externalDocID=A478192944
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon