Temporal Trends in the Characteristics of Children at Antiretroviral Therapy Initiation in Southern Africa: The IeDEA-SA Collaboration

Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	PloS one Ročník 8; číslo 12; s. e81037
Hlavní autoři:	Davies, Mary-Ann, Phiri, Sam, Wood, Robin, Wellington, Maureen, Cox, Vivian, Bolton-Moore, Carolyn, Timmerman, Venessa, Moultrie, Harry, Ndirangu, James, Rabie, Helena, Technau, Karl, Giddy, Janet, Maxwell, Nicola, Boulle, Andrew, Keiser, Olivia, Egger, Matthias, Eley, Brian
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 09.12.2013 Public Library of Science (PLoS)
Témata:	Acquired immune deficiency syndrome Africa, Southern - epidemiology Age AIDS Anemia Anemia - epidemiology Anemia - etiology Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy CD4 antigen CD4 Lymphocyte Count Child Child health Child, Preschool Children Collaboration Continuity (mathematics) Databases, Factual Diagnostic systems Female Guidelines Highly active antiretroviral therapy HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - immunology HIV tests Human immunodeficiency virus Humans Immunodeficiency Immunosuppression Immunotherapy Infant Infants Logistic Models Male Medical diagnosis Mortality Preventive medicine Regression analysis Therapy Time Factors Africa, Southern South Africa Zambia
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration. Data from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and ≥10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the percentage with severe immunosuppression (81 to 63%), WHO Stage III/IV disease (75 to 62%), severe anemia (12 to 7%) and weight-for-age z-score<-3 (31 to 28%). Similar results were seen when restricting to infants with significant declines in the proportion with severe immunodeficiency (98 to 82%) and Stage III/IV disease (81 to 63%). First-line regimen use followed country guidelines. Between 2005 and 2010 increasing numbers of children have initiated ART with a decline in disease severity at start of therapy. However, even in 2010, a substantial number of infants and children started ART with advanced disease. These results highlight the importance of efforts to improve access to HIV diagnostic testing and ART in children.
AbstractList	Background Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration. Methodology/Principal Findings Data from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and [greater than or equal to]10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the percentage with severe immunosuppression (81 to 63%), WHO Stage III/IV disease (75 to 62%), severe anemia (12 to 7%) and weight-for-age z-score<-3 (31 to 28%). Similar results were seen when restricting to infants with significant declines in the proportion with severe immunodeficiency (98 to 82%) and Stage III/IV disease (81 to 63%). First-line regimen use followed country guidelines. Conclusions/Significance Between 2005 and 2010 increasing numbers of children have initiated ART with a decline in disease severity at start of therapy. However, even in 2010, a substantial number of infants and children started ART with advanced disease. These results highlight the importance of efforts to improve access to HIV diagnostic testing and ART in children. Background Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration. Methodology/Principal Findings Data from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and ≥10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the percentage with severe immunosuppression (81 to 63%), WHO Stage III/IV disease (75 to 62%), severe anemia (12 to 7%) and weight-for-age z-score<−3 (31 to 28%). Similar results were seen when restricting to infants with significant declines in the proportion with severe immunodeficiency (98 to 82%) and Stage III/IV disease (81 to 63%). First-line regimen use followed country guidelines. Conclusions/Significance Between 2005 and 2010 increasing numbers of children have initiated ART with a decline in disease severity at start of therapy. However, even in 2010, a substantial number of infants and children started ART with advanced disease. These results highlight the importance of efforts to improve access to HIV diagnostic testing and ART in children. Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration.BACKGROUNDSince 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration.Data from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and ≥10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the percentage with severe immunosuppression (81 to 63%), WHO Stage III/IV disease (75 to 62%), severe anemia (12 to 7%) and weight-for-age z-score<-3 (31 to 28%). Similar results were seen when restricting to infants with significant declines in the proportion with severe immunodeficiency (98 to 82%) and Stage III/IV disease (81 to 63%). First-line regimen use followed country guidelines.METHODOLOGY/PRINCIPAL FINDINGSData from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and ≥10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the percentage with severe immunosuppression (81 to 63%), WHO Stage III/IV disease (75 to 62%), severe anemia (12 to 7%) and weight-for-age z-score<-3 (31 to 28%). Similar results were seen when restricting to infants with significant declines in the proportion with severe immunodeficiency (98 to 82%) and Stage III/IV disease (81 to 63%). First-line regimen use followed country guidelines.Between 2005 and 2010 increasing numbers of children have initiated ART with a decline in disease severity at start of therapy. However, even in 2010, a substantial number of infants and children started ART with advanced disease. These results highlight the importance of efforts to improve access to HIV diagnostic testing and ART in children.CONCLUSIONS/SIGNIFICANCEBetween 2005 and 2010 increasing numbers of children have initiated ART with a decline in disease severity at start of therapy. However, even in 2010, a substantial number of infants and children started ART with advanced disease. These results highlight the importance of efforts to improve access to HIV diagnostic testing and ART in children. Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration.Data from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and ≥10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the percentage with severe immunosuppression (81 to 63%), WHO Stage III/IV disease (75 to 62%), severe anemia (12 to 7%) and weight-for-age z-score<-3 (31 to 28%). Similar results were seen when restricting to infants with significant declines in the proportion with severe immunodeficiency (98 to 82%) and Stage III/IV disease (81 to 63%). First-line regimen use followed country guidelines.Between 2005 and 2010 increasing numbers of children have initiated ART with a decline in disease severity at start of therapy. However, even in 2010, a substantial number of infants and children started ART with advanced disease. These results highlight the importance of efforts to improve access to HIV diagnostic testing and ART in children. Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration. Data from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and [greater than or equal to]10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the percentage with severe immunosuppression (81 to 63%), WHO Stage III/IV disease (75 to 62%), severe anemia (12 to 7%) and weight-for-age z-score<-3 (31 to 28%). Similar results were seen when restricting to infants with significant declines in the proportion with severe immunodeficiency (98 to 82%) and Stage III/IV disease (81 to 63%). First-line regimen use followed country guidelines. Between 2005 and 2010 increasing numbers of children have initiated ART with a decline in disease severity at start of therapy. However, even in 2010, a substantial number of infants and children started ART with advanced disease. These results highlight the importance of efforts to improve access to HIV diagnostic testing and ART in children. Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration. Data from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and ≥10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the percentage with severe immunosuppression (81 to 63%), WHO Stage III/IV disease (75 to 62%), severe anemia (12 to 7%) and weight-for-age z-score<-3 (31 to 28%). Similar results were seen when restricting to infants with significant declines in the proportion with severe immunodeficiency (98 to 82%) and Stage III/IV disease (81 to 63%). First-line regimen use followed country guidelines. Between 2005 and 2010 increasing numbers of children have initiated ART with a decline in disease severity at start of therapy. However, even in 2010, a substantial number of infants and children started ART with advanced disease. These results highlight the importance of efforts to improve access to HIV diagnostic testing and ART in children. Background Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment guidelines have recommended ART initiation for all infants and very young children, and at higher CD4 thresholds for older children. We examined temporal changes in patient and regimen characteristics at ART start using data from 12 cohorts in 4 countries participating in the IeDEA-SA collaboration. Methodology/Principal Findings Data from 30,300 ART-naïve children aged <16 years at ART initiation who started therapy between 2005 and 2010 were analysed. We examined changes in median values for continuous variables using the Cuzick's test for trend over time. We also examined changes in the proportions of patients with particular disease severity characteristics (expressed as a binary variable e.g. WHO Stage III/IV vs I/II) using logistic regression. Between 2005 and 2010 the number of children starting ART each year increased and median age declined from 63 months (2006) to 56 months (2010). Both the proportion of children <1 year and ≥10 years of age increased from 12 to 19% and 18 to 22% respectively. Children had less severe disease at ART initiation in later years with significant declines in the percentage with severe immunosuppression (81 to 63%), WHO Stage III/IV disease (75 to 62%), severe anemia (12 to 7%) and weight-for-age z-score<−3 (31 to 28%). Similar results were seen when restricting to infants with significant declines in the proportion with severe immunodeficiency (98 to 82%) and Stage III/IV disease (81 to 63%). First-line regimen use followed country guidelines. Conclusions/Significance Between 2005 and 2010 increasing numbers of children have initiated ART with a decline in disease severity at start of therapy. However, even in 2010, a substantial number of infants and children started ART with advanced disease. These results highlight the importance of efforts to improve access to HIV diagnostic testing and ART in children.
Audience	Academic
Author	Rabie, Helena Giddy, Janet Keiser, Olivia Egger, Matthias Maxwell, Nicola Eley, Brian Phiri, Sam Bolton-Moore, Carolyn Cox, Vivian Timmerman, Venessa Moultrie, Harry Boulle, Andrew Davies, Mary-Ann Technau, Karl Ndirangu, James Wellington, Maureen Wood, Robin
AuthorAffiliation	9 Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa 12 Sinikithemba Clinic, McCord Hospital, Durban, South Africa 3 Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa 13 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland 7 Knowledge Translation Unit, University of Cape Town Lung Institute, Cape Town, South Africa 10 Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa 2 Lighthouse Trust Clinic, Kamuzu Central Hospital, Lilongwe, Malawi 11 Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital and University of Witwatersrand, Johannesburg, South Africa 5 Médecins Sans Frontières South Africa and Khayelitsha ART Programme, Khayelitsha, Cape Town, South Africa 4 Newlands Clinic, Harare, Zimbabwe 14 Red Cross Children's Hospital and School of
AuthorAffiliation_xml	– name: 9 Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Somkhele, South Africa – name: 5 Médecins Sans Frontières South Africa and Khayelitsha ART Programme, Khayelitsha, Cape Town, South Africa – name: 3 Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa – name: 6 Centre for Infectious Disease Research in Zambia, Lusaka, Zambia and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America – name: 7 Knowledge Translation Unit, University of Cape Town Lung Institute, Cape Town, South Africa – name: 11 Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital and University of Witwatersrand, Johannesburg, South Africa – name: 12 Sinikithemba Clinic, McCord Hospital, Durban, South Africa – name: 1 School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa – name: 4 Newlands Clinic, Harare, Zimbabwe – name: 13 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland – name: 10 Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa – name: 14 Red Cross Children's Hospital and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa – name: 8 Wits Reproductive Health and HIV Institute, Harriet Shezi Children's Clinic, Chris Hani Baragwanath Hospital, Faculty of Health Sciences, University of Witwatersrand, Soweto, Johannesburg, South Africa – name: UNAIDS, Trinidad and Tobago – name: 2 Lighthouse Trust Clinic, Kamuzu Central Hospital, Lilongwe, Malawi
Author_xml	– sequence: 1 givenname: Mary-Ann surname: Davies fullname: Davies, Mary-Ann – sequence: 2 givenname: Sam surname: Phiri fullname: Phiri, Sam – sequence: 3 givenname: Robin surname: Wood fullname: Wood, Robin – sequence: 4 givenname: Maureen surname: Wellington fullname: Wellington, Maureen – sequence: 5 givenname: Vivian surname: Cox fullname: Cox, Vivian – sequence: 6 givenname: Carolyn surname: Bolton-Moore fullname: Bolton-Moore, Carolyn – sequence: 7 givenname: Venessa surname: Timmerman fullname: Timmerman, Venessa – sequence: 8 givenname: Harry surname: Moultrie fullname: Moultrie, Harry – sequence: 9 givenname: James surname: Ndirangu fullname: Ndirangu, James – sequence: 10 givenname: Helena surname: Rabie fullname: Rabie, Helena – sequence: 11 givenname: Karl surname: Technau fullname: Technau, Karl – sequence: 12 givenname: Janet surname: Giddy fullname: Giddy, Janet – sequence: 13 givenname: Nicola surname: Maxwell fullname: Maxwell, Nicola – sequence: 14 givenname: Andrew surname: Boulle fullname: Boulle, Andrew – sequence: 15 givenname: Olivia surname: Keiser fullname: Keiser, Olivia – sequence: 16 givenname: Matthias surname: Egger fullname: Egger, Matthias – sequence: 17 givenname: Brian surname: Eley fullname: Eley, Brian
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/24363808$$D View this record in MEDLINE/PubMed
BookMark	eNqNk99q2zAUxs3oWP9sbzA2w2BsF8kkS5HtXgxM1m2BQmHJdiuOZTlWcaRUksv6AnvuyYlb4lLG8IXN8e_7jvX5nNPoSBsto-g1RlNMUvzp2nRWQzvdhvIUoQwjkj6LTnBOkglLEDk6eD6OTp27RmhGMsZeRMcJJYxkKDuJ_qzkZmsstPHKSl25WOnYNzKeN2BBeGmV80q42NShpNoqQDH4uNBeWemtuVU7bSMtbO_ihVZegVdG9z5L0wUrq-OitkrAeY_FC_nlopgsi3hu2hbK0LrHX0bPa2idfDXcz6KfXy9W8--Ty6tvi3lxOREsT_yElAhTKZgoKS6rLE0EoiSnKGfZLKWsFFXCSF7XGGiJqllJBIVEyhooQQQSTM6it3vfbWscHyJ0HFPGcJqEHoFY7InKwDXfWrUBe8cNKL4rGLvmYEMkreQZoARSqPO6ymmFy3KWyjKv8pqVQDCG4PV56NaVG1kJqX1Ia2Q6fqNVw9fmlofflCYZDQYfBgNrbjrpPN8oJ2QITkvT9d-do3SGCMsC-u4R-vTpBmoN4QBK1yb0Fb0pL2iakVlGaN92-gQVrkpulAjzVqtQHwk-jgSB8fK3X0PnHF8sf_w_e_VrzL4_YBsJrW-cabt-ZNwYfHOY9EPE94MeALoHhDXOWVk_IBjxfp_u4-L9PvFhn4Ls_JFMKL-b2JCIav8t_gujQyby
CitedBy_id	crossref_primary_10_1097_MD_0000000000010901 crossref_primary_10_1097_INF_0000000000000214 crossref_primary_10_1371_journal_pone_0155510 crossref_primary_10_1186_s12981_020_00277_0 crossref_primary_10_1080_09540121_2016_1176676 crossref_primary_10_2174_18746136_v17_2305300_2022_20 crossref_primary_10_1093_cid_cix099 crossref_primary_10_1016_S2352_3018_21_00004_7 crossref_primary_10_2989_16085906_2017_1380677 crossref_primary_10_7448_IAS_20_4_21520 crossref_primary_10_1097_MD_0000000000021410 crossref_primary_10_1111_tmi_12830 crossref_primary_10_1097_INF_0000000000002516 crossref_primary_10_1097_QAI_0000000000003137 crossref_primary_10_1097_INF_0000000000001745 crossref_primary_10_1111_tmi_12834 crossref_primary_10_1371_journal_pone_0291523 crossref_primary_10_1111_hiv_70015 crossref_primary_10_3390_diagnostics11030567 crossref_primary_10_1371_journal_pone_0230205 crossref_primary_10_3389_fpubh_2020_00096 crossref_primary_10_7448_IAS_18_7_20296 crossref_primary_10_7448_IAS_18_7_20770 crossref_primary_10_1093_cid_ciy013 crossref_primary_10_1097_COH_0000000000000303 crossref_primary_10_1097_QAD_0000000000000672 crossref_primary_10_1002_jia2_25200 crossref_primary_10_1371_journal_pone_0169871
Cites_doi	10.1097/QAD.0b013e32833d45c5 10.1371/journal.pone.0033611 10.1097/INF.0b013e31817acf7b 10.1097/QAD.0b013e32833016ce 10.1097/QAI.0b013e31820a7f2f 10.1016/S1473-3099(08)70180-4 10.1097/INF.0b013e3181e753a8 10.1128/JCM.00431-12 10.1371/journal.pone.0029656 10.1056/NEJMoa1113249 10.1097/QAI.0b013e3182427029 10.1097/QAI.0b013e3181e0c4cf 10.1542/peds.2009-2701 10.1097/QAD.0b013e32832d84fd 10.1086/656361 10.1093/tropej/fmn036 10.1111/j.1365-3156.2010.02504.x 10.1097/QAI.0b013e3182303c7e 10.1097/QAD.0b013e328318f148 10.1097/QAD.0b013e32831c54bd 10.2471/BLT.09.066126 10.1097/QAI.0b013e3182167f0d 10.1086/521116 10.1186/1758-2652-13-46 10.1056/NEJMoa0800971 10.1097/QAI.0b013e318198a8a4 10.1111/j.1365-3156.2008.02178.x 10.1186/1471-2431-10-54 10.1371/journal.pone.0028510 10.2174/157016207780077002 10.1371/journal.pmed.1000178 10.1097/QAD.0b013e328355d0ce 10.1016/S0140-6736(11)60363-2 10.1097/QAI.0b013e31819c173f 10.1186/1471-2431-9-80 10.1136/adc.2009.169367 10.2471/BLT.09.068015 10.1186/1471-2431-10-44 10.1371/journal.pone.0044914 10.1371/journal.pmed.1000227
ContentType	Journal Article
Contributor	Giddy, Janet Fritz, Christiane Chi, Benjamin Eley, Brian Heinrich, Sabine Hoffmann, Christopher Phiri, Sam Stinson, Kathryn Fox, Matthew van Oosterhout, Joep Moultrie, Harry Prozesky, Hans Technau, Karl Ndirangu, James Wellington, Maureen Pestilli, Sabrina Wood, Robin
Contributor_xml	– sequence: 1 givenname: Maureen surname: Wellington fullname: Wellington, Maureen – sequence: 2 givenname: Brian surname: Eley fullname: Eley, Brian – sequence: 3 givenname: Christiane surname: Fritz fullname: Fritz, Christiane – sequence: 4 givenname: Kathryn surname: Stinson fullname: Stinson, Kathryn – sequence: 5 givenname: Janet surname: Giddy fullname: Giddy, Janet – sequence: 6 givenname: Matthew surname: Fox fullname: Fox, Matthew – sequence: 7 givenname: Sabine surname: Heinrich fullname: Heinrich, Sabine – sequence: 8 givenname: Christopher surname: Hoffmann fullname: Hoffmann, Christopher – sequence: 9 givenname: Harry surname: Moultrie fullname: Moultrie, Harry – sequence: 10 givenname: James surname: Ndirangu fullname: Ndirangu, James – sequence: 11 givenname: Joep surname: van Oosterhout fullname: van Oosterhout, Joep – sequence: 12 givenname: Sabrina surname: Pestilli fullname: Pestilli, Sabrina – sequence: 13 givenname: Sam surname: Phiri fullname: Phiri, Sam – sequence: 14 givenname: Hans surname: Prozesky fullname: Prozesky, Hans – sequence: 15 givenname: Benjamin surname: Chi fullname: Chi, Benjamin – sequence: 16 givenname: Karl surname: Technau fullname: Technau, Karl – sequence: 17 givenname: Robin surname: Wood fullname: Wood, Robin
Copyright	COPYRIGHT 2013 Public Library of Science 2013 Davies et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/3.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Davies et al 2013 Davies et al
Copyright_xml	– notice: COPYRIGHT 2013 Public Library of Science – notice: 2013 Davies et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/3.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2013 Davies et al 2013 Davies et al
CorporateAuthor	IeDEA Southern Africa Steering Group
CorporateAuthor_xml	– name: IeDEA Southern Africa Steering Group
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0081037
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central One Sustainability ProQuest Central UK/Ireland ProQuest SciTech Premium Collection Technology Collection Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium ProQuest advanced technologies & aerospace journals ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Agricultural Science Database
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General)
DocumentTitleAlternate	Characteristics at ART Initiation in Children
EISSN	1932-6203
ExternalDocumentID	1466172692 oai_doaj_org_article_8a02a7af9fd94d1bb57eb9d9f6ba311a PMC3867284 3150579451 A478358344 24363808 10_1371_journal_pone_0081037
Genre	Journal Article Research Support, N.I.H., Extramural
GeographicLocations	Africa, Southern South Africa Zambia
GeographicLocations_xml	– name: Africa, Southern – name: South Africa – name: Zambia
GrantInformation_xml	– fundername: NIAID NIH HHS grantid: 2U01AI069924 – fundername: NIAID NIH HHS grantid: U01 AI069924
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RIG RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF NPM PV9 RZL BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM AAPBV ABPTK N95
ID	FETCH-LOGICAL-c692t-3b014ec6cb41bd872c0439409685746bcd2639ff1a4b0d5b3c4a2eefa4303a213
IEDL.DBID	FPL
ISICitedReferencesCount	29
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000328705200015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Sun Apr 02 01:15:53 EDT 2023 Mon Nov 10 04:31:32 EST 2025 Tue Nov 04 02:05:22 EST 2025 Thu Oct 02 10:54:09 EDT 2025 Tue Oct 07 07:01:38 EDT 2025 Sat Nov 29 13:10:09 EST 2025 Sat Nov 29 09:56:00 EST 2025 Wed Nov 26 10:13:14 EST 2025 Wed Nov 26 10:11:54 EST 2025 Thu May 22 21:19:32 EDT 2025 Mon Jul 21 05:53:02 EDT 2025 Tue Nov 18 20:54:36 EST 2025 Sat Nov 29 02:43:39 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	12
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c692t-3b014ec6cb41bd872c0439409685746bcd2639ff1a4b0d5b3c4a2eefa4303a213
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Membership of the IeDEA Southern Africa Steering Group is provided in the Acknowledgments. Conceived and designed the experiments: MD SP RW MW VC CB VT HM JN HR KT JG NM AB OK ME BE. Performed the experiments: MD SP RW MW VC CB VT HM JN HR KT JG NM AB OK ME BE. Analyzed the data: MD AB NM BE. Wrote the paper: MD SP RW MW VC CB VT HM JN HR KT JG NM AB OK ME BE.
OpenAccessLink	http://dx.doi.org/10.1371/journal.pone.0081037
PMID	24363808
PQID	1466172692
PQPubID	1436336
PageCount	e81037
ParticipantIDs	plos_journals_1466172692 doaj_primary_oai_doaj_org_article_8a02a7af9fd94d1bb57eb9d9f6ba311a pubmedcentral_primary_oai_pubmedcentral_nih_gov_3867284 proquest_miscellaneous_1490750368 proquest_journals_1466172692 gale_infotracmisc_A478358344 gale_infotracacademiconefile_A478358344 gale_incontextgauss_ISR_A478358344 gale_incontextgauss_IOV_A478358344 gale_healthsolutions_A478358344 pubmed_primary_24363808 crossref_primary_10_1371_journal_pone_0081037 crossref_citationtrail_10_1371_journal_pone_0081037
PublicationCentury	2000
PublicationDate	2013-12-09
PublicationDateYYYYMMDD	2013-12-09
PublicationDate_xml	– month: 12 year: 2013 text: 2013-12-09 day: 09
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2013
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	ref58 JN Mutanga (ref53) 2012; 7 ref19 DE Bourne (ref56) 2009; 23 I Inwani (ref48) 2009; 50 G Fatti (ref35) 2010; 13 GE Gray (ref41) 2010; 7 S Khamadi (ref49) 2008; 54 N Rollins (ref45) 2009; 23 ref46 R Ferrand (ref42) 2010; 88 A Calmy (ref4) 2011; 377 A Violari (ref57) 2012; 366 R Becquet (ref6) 2012; 7 M McGuire (ref38) 2010; 15 Suppl 1 N Janssen (ref34) 2010; 95 RA Ferrand (ref40) 2010; 7 R Weigel (ref44) 2009; 9 CG Sutcliffe (ref7) 2008; 8 M Braun (ref50) 2011; 56 B Laughton (ref12) 2012; 26 A Kiboneka (ref32) 2008; 22 P Braitstein (ref37) 2011; 57 RR Lilian (ref55) 2012; 50 CG Sutcliffe (ref36) 2010; 29 BC Zanoni (ref11) 2012; 7 (ref26) 2004 H Nuwagaba-Biribonwoha (ref54) 2010; 10 G Fatti (ref13) 2011; 58 S Heidari (ref3) 2012; 59 ref2 M Davies (ref9) 2009; 99 ref1 (ref30) 2012 T Meyers (ref51) 2007; 196 Suppl 3 (ref27) 2005 E Peacock-Villada (ref8) 2011; 127 CG Sutcliffe (ref14) 2010; 10 B Eley (ref10) 2006; 96 M Cornell (ref15) 2010; 24 HB Jaspan (ref31) 2008; 27 RA Ferrand (ref43) 2010; 51 K Little (ref5) 2007; 5 ref24 ref23 ref25 MF Anaky (ref33) 2010; 88 ref22 L Fenner (ref20) 2010; 54 ref21 P Iliff (ref47) 2008; 13 ref28 ref29 RA Ferrand (ref39) 2009; 23 A Violari (ref18) 2008; 359 M Cornell (ref17) 2009; 99 C Kankasa (ref52) 2009; 51 SD Patel (ref16) 2012; 7 19504732 - J Acquir Immune Defic Syndr. 2009 Jun 1;51(2):202-8 22536311 - PLoS One. 2012;7(4):e29656 19065753 - AIDS. 2009 Jan 2;23(1):101-6 20073292 - S Afr Med J. 2009 Sep;99(9):653-60 20021641 - BMC Pediatr. 2009;9:80 18818556 - Pediatr Infect Dis J. 2008 Nov;27(11):993-8 22438965 - PLoS One. 2012;7(3):e33611 20673355 - BMC Pediatr. 2010;10:54 20804412 - Clin Infect Dis. 2010 Oct 1;51(7):844-51 20616968 - Bull World Health Organ. 2010 Jul 1;88(7):490-9 20526227 - Pediatr Infect Dis J. 2010 Sep;29(9):849-54 21407085 - J Acquir Immune Defic Syndr. 2011 Jul 1;57(3):e40-6 19225401 - J Acquir Immune Defic Syndr. 2009 Apr 15;50(5):492-8 18181697 - J Infect Dis. 2007 Dec 1;196 Suppl 3:S474-81 19020325 - N Engl J Med. 2008 Nov 20;359(21):2233-44 19055624 - Trop Med Int Health. 2008 Dec;13(12):1459-69 19880392 - Arch Dis Child. 2010 Jun;95(6):414-21 20586961 - Trop Med Int Health. 2010 Jun;15 Suppl 1:55-62 20126383 - PLoS Med. 2010 Feb;7(2):e1000178 20539856 - Bull World Health Organ. 2010 Jun;88(6):428-34 20565786 - BMC Pediatr. 2010;10:44 21224736 - J Acquir Immune Defic Syndr. 2011 Apr 15;56(5):e122-8 20683318 - AIDS. 2010 Sep 10;24(14):2263-70 22138766 - J Acquir Immune Defic Syndr. 2012 Feb 1;59(2):161-9 17077930 - S Afr Med J. 2006 Sep;96(9 Pt 2):988-93 19491653 - AIDS. 2009 Sep 10;23(14):1851-7 20128272 - S Afr Med J. 2009 Oct;99(10):730-7 22383946 - PLoS One. 2012;7(2):e28510 22518871 - J Clin Microbiol. 2012 Jul;50(7):2373-7 23028677 - PLoS One. 2012;7(9):e44914 18511477 - J Trop Pediatr. 2008 Dec;54(6):370-4 22614886 - AIDS. 2012 Aug 24;26(13):1685-90 21262891 - Pediatrics. 2011 Feb;127(2):e423-41 18652994 - Lancet Infect Dis. 2008 Aug;8(8):477-89 20588185 - J Acquir Immune Defic Syndr. 2010 Aug;54(5):524-32 21857355 - J Acquir Immune Defic Syndr. 2011 Nov 1;58(3):e60-7 21108804 - J Int AIDS Soc. 2010;13:46 21511331 - Lancet. 2011 May 7;377(9777):1546-8 17346131 - Curr HIV Res. 2007 Mar;5(2):139-53 19005272 - AIDS. 2008 Nov 30;22(18):2493-9 19684508 - AIDS. 2009 Sep 24;23(15):2039-46 20161804 - PLoS Med. 2010 Feb;7(2):e1000227 22716976 - N Engl J Med. 2012 Jun 21;366(25):2380-9
References_xml	– volume: 24 start-page: 2263 year: 2010 ident: ref15 article-title: Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002–2007 publication-title: AIDS doi: 10.1097/QAD.0b013e32833d45c5 – ident: ref1 – year: 2005 ident: ref27 article-title: Guidelines for the management of HIV-infected children in South Africa publication-title: Jacana – volume: 7 start-page: e33611 year: 2012 ident: ref11 article-title: Predictors of poor CD4 and weight recovery in HIV-infected children initiating ART in South Africa publication-title: PLoS One doi: 10.1371/journal.pone.0033611 – ident: ref24 – volume: 99 start-page: 730 year: 2009 ident: ref9 article-title: Outcomes of the South African National Antiretroviral Treatment (ART) programme for children - The IeDEA Southern Africa Collaboration publication-title: South African Medical Journal – volume: 27 start-page: 993 year: 2008 ident: ref31 article-title: Two-year outcomes of children on non-nucleoside reverse transcriptase inhibitor and protease inhibitor regimens in a South African pediatric antiretroviral program publication-title: Pediatric Infectious Disease Journal doi: 10.1097/INF.0b013e31817acf7b – volume: 23 start-page: 2039 year: 2009 ident: ref39 article-title: AIDS among older children and adolescents in Southern Africa: projecting the time course and magnitude of the epidemic publication-title: AIDS doi: 10.1097/QAD.0b013e32833016ce – volume: 56 start-page: e122 year: 2011 ident: ref50 article-title: Inadequate coordination of maternal and infant HIV services detrimentally affects early infant diagnosis outcomes in Lilongwe, Malawi publication-title: Journal of Acquired Immune Deficiency Syndromes doi: 10.1097/QAI.0b013e31820a7f2f – volume: 8 start-page: 477 year: 2008 ident: ref7 article-title: Effectiveness of antiretroviral therapy among HIV-infected children in sub-Saharan Africa publication-title: Lancet Infectious Diseases doi: 10.1016/S1473-3099(08)70180-4 – volume: 29 start-page: 849 year: 2010 ident: ref36 article-title: Differences in presentation, treatment initiation, and response among children infected with human immunodeficiency virus in urban and rural Zambia publication-title: Pediatric Infectious Disease Journal doi: 10.1097/INF.0b013e3181e753a8 – volume: 50 start-page: 2373 year: 2012 ident: ref55 article-title: Early diagnosis of in utero and intrapartum HIV infection in infants prior to 6 weeks of age publication-title: Journal of Clinical Microbiology doi: 10.1128/JCM.00431-12 – volume: 7 start-page: e29656 year: 2012 ident: ref53 article-title: Institutionalizing provider-initiated HIV testing and counselling for children: an observational case study from Zambia publication-title: PLoS One doi: 10.1371/journal.pone.0029656 – volume: 366 start-page: 2380 year: 2012 ident: ref57 article-title: Nevirapine versus ritonavir-boosted lopinavir for HIV-infected children publication-title: New England Journal of Medicine doi: 10.1056/NEJMoa1113249 – ident: ref2 – volume: 59 start-page: 161 year: 2012 ident: ref3 article-title: Unresolved antiretroviral treatment management issues in HIV-infected children publication-title: Journal of Acquired Immune Deficiency Syndromes doi: 10.1097/QAI.0b013e3182427029 – volume: 54 start-page: 524 year: 2010 ident: ref20 article-title: Early mortality and loss to follow-up in HIV-infected children starting antiretroviral therapy in Southern Africa publication-title: Journal of Acquired Immune Deficiency Syndromes doi: 10.1097/QAI.0b013e3181e0c4cf – volume: 127 start-page: e423 year: 2011 ident: ref8 article-title: Post-HAART outcomes in pediatric populations: comparison of resource-limited and developed countries publication-title: Pediatrics doi: 10.1542/peds.2009-2701 – volume: 23 start-page: 1851 year: 2009 ident: ref45 article-title: Universal HIV testing of infants at immunization clinics: an acceptable and feasible approach for early infant diagnosis in high HIV prevalence settings publication-title: AIDS doi: 10.1097/QAD.0b013e32832d84fd – volume: 51 start-page: 844 year: 2010 ident: ref43 article-title: Undiagnosed HIV infection among adolescents seeking primary health care in Zimbabwe publication-title: Clinical Infectious Diseases doi: 10.1086/656361 – volume: 54 start-page: 370 year: 2008 ident: ref49 article-title: Rapid identification of infants for antiretroviral therapy in a resource poor setting: the Kenya experience publication-title: Journal of Tropical Pediatrics doi: 10.1093/tropej/fmn036 – ident: ref23 – volume: 15 Suppl 1 start-page: 55 year: 2010 ident: ref38 article-title: Vital status of pre-ART and ART patients defaulting from care in rural Malawi publication-title: Tropical Medicine and International Health doi: 10.1111/j.1365-3156.2010.02504.x – volume: 58 start-page: e60 year: 2011 ident: ref13 article-title: Temporal trends in baseline characteristics and treatment outcomes of children starting antiretroviral treatment: an analysis in four provinces in South Africa, 2004–2009 publication-title: Journal of Acquired Immune Deficiency Syndromes doi: 10.1097/QAI.0b013e3182303c7e – volume: 22 start-page: 2493 year: 2008 ident: ref32 article-title: Clinical and immunological outcomes of a national paediatric cohort receiving combination antiretroviral therapy in Uganda publication-title: AIDS doi: 10.1097/QAD.0b013e328318f148 – volume: 23 start-page: 101 year: 2009 ident: ref56 article-title: Emergence of a peak in early infant mortality due to HIV/AIDS in South Africa publication-title: AIDS doi: 10.1097/QAD.0b013e32831c54bd – volume: 88 start-page: 428 year: 2010 ident: ref42 article-title: Survey of children accessing HIV services in a high prevalence setting: time for adolescents to count? publication-title: Bulletin of the World Health Organization doi: 10.2471/BLT.09.066126 – volume: 57 start-page: e40 year: 2011 ident: ref37 article-title: “Wamepotea” (they have become lost): outcomes of HIV-positive and HIV-exposed children lost to follow-up from a large HIV treatment program in western Kenya publication-title: Journal of Acquired Immune Deficiency Syndromes doi: 10.1097/QAI.0b013e3182167f0d – volume: 196 Suppl 3 start-page: S474 year: 2007 ident: ref51 article-title: Challenges to pediatric HIV care and treatment in South Africa publication-title: Journal of Infectious Diseases doi: 10.1086/521116 – ident: ref58 – volume: 99 start-page: 653 year: 2009 ident: ref17 article-title: Monitoring the South African National Antiretroviral Treatment Programme, 2003–2007: the IeDEA Southern Africa collaboration publication-title: South African Medical Journal – volume: 13 start-page: 46 year: 2010 ident: ref35 article-title: Increased vulnerability of rural children on antiretroviral therapy attending public health facilities in South Africa: a retrospective cohort study publication-title: Journal of the International AIDS Society doi: 10.1186/1758-2652-13-46 – volume: 359 start-page: 2233 year: 2008 ident: ref18 article-title: Early antiretroviral therapy and mortality among HIV-infected infants publication-title: New England Journal of Medicine doi: 10.1056/NEJMoa0800971 – ident: ref29 – volume: 50 start-page: 492 year: 2009 ident: ref48 article-title: Performance of clinical algorithms for HIV-1 diagnosis and antiretroviral initiation among HIV-1-exposed children aged less than 18 months in Kenya publication-title: Journal of Acquired Immune Deficiency Syndromes doi: 10.1097/QAI.0b013e318198a8a4 – ident: ref22 – ident: ref25 – volume: 96 start-page: 988 year: 2006 ident: ref10 article-title: Antiretroviral treatment for children publication-title: South African Medical Journal – volume: 13 start-page: 1459 year: 2008 ident: ref47 article-title: Making a working clinical diagnosis of HIV infection in infants in Zimbabwe publication-title: Tropical Medicine and International Health doi: 10.1111/j.1365-3156.2008.02178.x – ident: ref19 – year: 2012 ident: ref30 article-title: Circular minute 2 of 2012: Initiation of antiretroviral treatment to all HIV positive children aged 5 years and under regardless of CD4 count and/or WHO clinical staging publication-title: Pretoria – volume: 10 start-page: 54 year: 2010 ident: ref14 article-title: Secular trends in pediatric antiretroviral treatment programs in rural and urban Zambia: a retrospective cohort study publication-title: BMC Pediatrics doi: 10.1186/1471-2431-10-54 – volume: 7 start-page: e28510 year: 2012 ident: ref6 article-title: Children who acquire HIV infection perinatally are at higher risk of early death than those acquiring infection through breastmilk: a meta-analysis publication-title: PLoS One doi: 10.1371/journal.pone.0028510 – volume: 5 start-page: 139 year: 2007 ident: ref5 article-title: Disease progression in children with vertically-acquired HIV infection in sub-Saharan Africa: reviewing the need for HIV treatment publication-title: Current HIV Research doi: 10.2174/157016207780077002 – volume: 7 start-page: e1000178 year: 2010 ident: ref40 article-title: Causes of acute hospitalization in adolescence: burden and spectrum of HIV-related morbidity in a country with an early-onset and severe HIV epidemic: a prospective survey publication-title: PLoS Medicine doi: 10.1371/journal.pmed.1000178 – year: 2004 ident: ref26 article-title: National Antiretroviral Treatment Guidelines publication-title: Jacana – volume: 26 start-page: 1685 year: 2012 ident: ref12 article-title: Early antiretroviral therapy improves neurodevelopmental outcomes in infants publication-title: AIDS doi: 10.1097/QAD.0b013e328355d0ce – ident: ref46 – volume: 377 start-page: 1546 year: 2011 ident: ref4 article-title: Improving treatment outcomes for children with HIV publication-title: Lancet doi: 10.1016/S0140-6736(11)60363-2 – ident: ref28 – volume: 51 start-page: 202 year: 2009 ident: ref52 article-title: Routine offering of HIV testing to hospitalized pediatric patients at university teaching hospital, Lusaka, Zambia: acceptability and feasibility publication-title: Journal of Acquired Immune Deficiency Syndromes doi: 10.1097/QAI.0b013e31819c173f – ident: ref21 – volume: 9 start-page: 80 year: 2009 ident: ref44 article-title: Effect of provider-initiated testing and counselling and integration of ART services on access to HIV diagnosis and treatment for children in Lilongwe, Malawi: a pre- post comparison publication-title: BMC Pediatrics doi: 10.1186/1471-2431-9-80 – volume: 95 start-page: 414 year: 2010 ident: ref34 article-title: Successful paediatric HIV treatment in rural primary care in Africa publication-title: Archives of Diseases in Childhood doi: 10.1136/adc.2009.169367 – volume: 88 start-page: 490 year: 2010 ident: ref33 article-title: Scaling up antiretroviral therapy for HIV-infected children in Cote d'Ivoire: determinants of survival and loss to programme publication-title: Bulletin of the World Health Organization doi: 10.2471/BLT.09.068015 – volume: 10 start-page: 44 year: 2010 ident: ref54 article-title: Introducing a multi-site program for early diagnosis of HIV infection among HIV-exposed infants in Tanzania publication-title: BMC Pediatrics doi: 10.1186/1471-2431-10-44 – volume: 7 start-page: e44914 year: 2012 ident: ref16 article-title: Increases in pediatric antiretroviral treatment, South Africa 2005–2010 publication-title: PLoS One doi: 10.1371/journal.pone.0044914 – volume: 7 start-page: e1000227 year: 2010 ident: ref41 article-title: Adolescent HIV–cause for concern in Southern Africa publication-title: PLoS Medicine doi: 10.1371/journal.pmed.1000227 – reference: 22138766 - J Acquir Immune Defic Syndr. 2012 Feb 1;59(2):161-9 – reference: 19005272 - AIDS. 2008 Nov 30;22(18):2493-9 – reference: 20073292 - S Afr Med J. 2009 Sep;99(9):653-60 – reference: 21857355 - J Acquir Immune Defic Syndr. 2011 Nov 1;58(3):e60-7 – reference: 19504732 - J Acquir Immune Defic Syndr. 2009 Jun 1;51(2):202-8 – reference: 20539856 - Bull World Health Organ. 2010 Jun;88(6):428-34 – reference: 20128272 - S Afr Med J. 2009 Oct;99(10):730-7 – reference: 20616968 - Bull World Health Organ. 2010 Jul 1;88(7):490-9 – reference: 20588185 - J Acquir Immune Defic Syndr. 2010 Aug;54(5):524-32 – reference: 22438965 - PLoS One. 2012;7(3):e33611 – reference: 22383946 - PLoS One. 2012;7(2):e28510 – reference: 21262891 - Pediatrics. 2011 Feb;127(2):e423-41 – reference: 17077930 - S Afr Med J. 2006 Sep;96(9 Pt 2):988-93 – reference: 21407085 - J Acquir Immune Defic Syndr. 2011 Jul 1;57(3):e40-6 – reference: 19684508 - AIDS. 2009 Sep 24;23(15):2039-46 – reference: 19055624 - Trop Med Int Health. 2008 Dec;13(12):1459-69 – reference: 20673355 - BMC Pediatr. 2010;10:54 – reference: 20021641 - BMC Pediatr. 2009;9:80 – reference: 20126383 - PLoS Med. 2010 Feb;7(2):e1000178 – reference: 21108804 - J Int AIDS Soc. 2010;13:46 – reference: 19065753 - AIDS. 2009 Jan 2;23(1):101-6 – reference: 20586961 - Trop Med Int Health. 2010 Jun;15 Suppl 1:55-62 – reference: 21511331 - Lancet. 2011 May 7;377(9777):1546-8 – reference: 19491653 - AIDS. 2009 Sep 10;23(14):1851-7 – reference: 22518871 - J Clin Microbiol. 2012 Jul;50(7):2373-7 – reference: 18818556 - Pediatr Infect Dis J. 2008 Nov;27(11):993-8 – reference: 20565786 - BMC Pediatr. 2010;10:44 – reference: 18652994 - Lancet Infect Dis. 2008 Aug;8(8):477-89 – reference: 22536311 - PLoS One. 2012;7(4):e29656 – reference: 20161804 - PLoS Med. 2010 Feb;7(2):e1000227 – reference: 19880392 - Arch Dis Child. 2010 Jun;95(6):414-21 – reference: 21224736 - J Acquir Immune Defic Syndr. 2011 Apr 15;56(5):e122-8 – reference: 20526227 - Pediatr Infect Dis J. 2010 Sep;29(9):849-54 – reference: 23028677 - PLoS One. 2012;7(9):e44914 – reference: 22716976 - N Engl J Med. 2012 Jun 21;366(25):2380-9 – reference: 17346131 - Curr HIV Res. 2007 Mar;5(2):139-53 – reference: 18181697 - J Infect Dis. 2007 Dec 1;196 Suppl 3:S474-81 – reference: 19020325 - N Engl J Med. 2008 Nov 20;359(21):2233-44 – reference: 19225401 - J Acquir Immune Defic Syndr. 2009 Apr 15;50(5):492-8 – reference: 22614886 - AIDS. 2012 Aug 24;26(13):1685-90 – reference: 18511477 - J Trop Pediatr. 2008 Dec;54(6):370-4 – reference: 20683318 - AIDS. 2010 Sep 10;24(14):2263-70 – reference: 20804412 - Clin Infect Dis. 2010 Oct 1;51(7):844-51
SSID	ssj0053866
Score	2.2734292
Snippet	Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country treatment... Background Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country... Background Since 2005, increasing numbers of children have started antiretroviral therapy (ART) in sub-Saharan Africa and, in recent years, WHO and country...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e81037
SubjectTerms	Acquired immune deficiency syndrome Africa, Southern - epidemiology Age AIDS Anemia Anemia - epidemiology Anemia - etiology Anti-HIV Agents - therapeutic use Antiretroviral agents Antiretroviral drugs Antiretroviral therapy CD4 antigen CD4 Lymphocyte Count Child Child health Child, Preschool Children Collaboration Continuity (mathematics) Databases, Factual Diagnostic systems Female Guidelines Highly active antiretroviral therapy HIV HIV Infections - complications HIV Infections - drug therapy HIV Infections - epidemiology HIV Infections - immunology HIV tests Human immunodeficiency virus Humans Immunodeficiency Immunosuppression Immunotherapy Infant Infants Logistic Models Male Medical diagnosis Mortality Preventive medicine Regression analysis Therapy Time Factors
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQigMXRHk1pYBBSMAhdJM4L25LaUUlVBAtVW_R-BFYaZWsmiw_gd_NjO1EG1SpHLiux1Z2Xp5JZr5h7JXSeGkJmIdQJCYUEm0OapGFKgdtFGDabBFvLj7np6fF5WX5dWvUF9WEOXhgx7iDAuYx5FCXtS6FjqRMcyNLXdaZhCSKbGiEUc-QTDkfjFacZb5RLsmjAy-Xd-u2MQRoSs1xk4vI4vWPXnm2XrXddSHn35WTW1fR8T1218eQfOGefYfdMs19tuOttONvPJT02wfs97lDnlrx3ta-8mXDMeLjagrTzNuaD13dHHqO3EZP2NPbBrvXIQ_g5mXvJEnndK0tjm-4GzX03h58Yj4eLcKzBT_c1q-H7Pvx0fnhp9BPXghVVsZ9mEjMnIzKlBSR1EUeK9tBi-lOkeYik0rHGNnUdQQoXZ3KRAmIjalB4I0IcZQ8YrMGeb3LuEgTUHGsI4IizEBLBVmqNIgI5hiL1AFLBjFUysOS03SMVWW_teWYnjiuViS8ygsvYOG4a-1gOW6g_0ASHmkJVNv-gKpWeVWrblK1gD0n_ahch-roGqqFoNdnNLAkYC8tBQFrNFS58wM2XVedfLn4B6KzbxOi156obpEdCny3BP4nAuyaUO5PKNE9qMnyLmnzwJWOcj2KWlHOuHPQ8OuXX4zLdChV4zWm3RBNab9_Z0XAHjuDGDkbiwRd-hxX8ompTFg_XWmWPy2uORptjo5j73_I6gm7E9PgEio8KvfZrL_amKfstvrVL7urZ9ZZ_AFLe3PD priority: 102 providerName: Directory of Open Access Journals – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZg4cAFKK8uFDAICTik3STOiwsKSytWQqWipeotGj9SVlolyybLT-B3M-N4Q4MqQOK6M47W9rxsz3zD2Aul0WkJmHiQhsYTEnUOShF7KgFtFOCx2SLenH5MDg_Ts7PsyF24NS6tcmMTraHWtaI78j3UaHK2cRa8XX7zqGsUva66FhpX2TVCSQht6t7RxhKjLsexK5cLE3_P7c7usq4MwZpSidzAHVnU_t42j5aLurks8Pw9f_KCQzq49b9Tuc1uulCU553sbLErprrDtpyyN_yVQ6R-fZf9OOkArBa8S6Hl84pj4MinQ7RnXpd86orDObQ8r1o0qC1dWtixHYABn1G-khUI-o7t4WdWFe86Fr0hNj4z7_dz7zjn04tieo99Odg_mX7wXAMHT-HkWi-UeAAzKlZS-FKnSaBsIS6emtIoEbFUOsAAqSx9QCHRkQyVgMCYEgQ6Vgj88D4bVbhZ24yLKAQVBNonRMMYtFQQR0qD8GGCIU05ZuFmHwvl0M2pycaisE92CZ5yulUtaPcLt_tj5vWjlh26x1_435GI9LyEzW1_qFfnhVP1IoVJAAmUWakzoX0po8TITGdlLCH0fRizpyRgRVfo2luYIhd0C0d9T8bsueUgfI6KEoDOYd00xezT6T8wHX8eML10TGWNy6HAFV3gnAj3a8C5M-BEK6MG5G1Sh82qNMUvIcaRGzG_nPysJ9NHKamvMvWaeDL7jB6nY_ag06h-ZQMRomeYICUZ6Npg6YeUav7VwqOj1idofx7--W89YjcC6mxCmUnZDhu1q7V5zK6r7-28WT2xduQnqd5_TA priority: 102 providerName: ProQuest
Title	Temporal Trends in the Characteristics of Children at Antiretroviral Therapy Initiation in Southern Africa: The IeDEA-SA Collaboration
URI	https://www.ncbi.nlm.nih.gov/pubmed/24363808 https://www.proquest.com/docview/1466172692 https://www.proquest.com/docview/1490750368 https://pubmed.ncbi.nlm.nih.gov/PMC3867284 https://doaj.org/article/8a02a7af9fd94d1bb57eb9d9f6ba311a http://dx.doi.org/10.1371/journal.pone.0081037
Volume	8
WOSCitedRecordID	wos000328705200015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agriculture Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (ProQuest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1fb9MwELdYxwMvwPi3wigGIQEPGU3ixAlvbelEta1E7agKL5HjOFCpSqsm5SPwublz3LBMm4CXe6jPUXq-O5-du98R8lqmsGkx0bVE4CqLJWBzImO-JblIlRRwbNaIN7MzPh4H83kY_TkoXvmC73L7vZHp8XqVKwQjxcK2PbLvuL6PKVwn0dnO84Lt-r4pj7tpZmP70Sj9tS9urZer4rpA82q-5KUN6OTe_776fXLXhJq0V-nGAbml8gfkwBhzQd8axOl3D8mviwqgakmrFFm6yCkEhnTQRHOmq4wOTPE3FSXt5SU4zBIvJfTcCqCAjjAfSS84Pkf36FObnFYdiT4gGx2pj8OeNe3RwWU1fES-nAwvBp8s06DBkn7olJabwAFLSV8mzE7SgDtSF9rCqSjwOPMTmToQAGWZLUAJUi9xJROOUplgsHEKx3Yfk1YOsjkklHmukI6T2ohY6Is0kcL3ZCqYLboQsmRt4u7WLZYGvRybaCxj_UmOwymmkmqMwo6NsNvEqmetK_SOv_D3USVqXsTe1j_AqsbGlONAdB3BRRZmachSO0k8rpIwDTM_Ea5tizZ5gQoVV4WstQeJewxv2bCvSZu80hyIv5Fjgs93sS2KePR59g9M00mD6Y1hylYgDilMUQX8J8T1anAeNTjBi8jG8CGq_04qBR4JMbiFdYaZO5O4fvhlPYwPxaS9XK22yBPqz-R-0CZPKguqJeswFzx_F0Z4w7Yaom-O5IsfGv4crJyDf3l68xs_I3cc7FqCWUfhEWmVm616Tm7Ln-Wi2HTIHp_MkM65pgHQYGB3yH5_OI4mHX0t09GeBehp_xjoefcUKY80nQKNvG8wIxqdR19_A5PAeh0
linkProvider	Public Library of Science
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1fb9MwELdGQYIXYPxbYTCDQMBDWOO4-YOEUOk2rVopaCvV3oJjO6NSlZSmBfEF-Dh8Ru4cJyxoAl72wGt9ttLL3e9s5-53hDyWCoIWFx1HhJ52eAI-J1LuOzIQSksBx2bDeDMZBqNReHwcvV8jP6paGEyrrDDRALXKJd6Rb4NHY7D1I_Z6_tnBrlH4dbVqoVGaxYH-9hWObMWrwQ683yeM7e2O-_uO7SrgSJi8dLwETgVa-jLhbqLCgElTHQpb-bAbcD-RikHUTlNXwJOrbuJJLpjWqeCA9oK5Hqx7gVwEHHcxhSw4nFTID9jh-7Y8zwvcbWsNL-Z5ppFGFUvyGuHPdAmoY0FrPsuLsza6v-drngqAe9f-N9VdJ1ftVpv2St9YJ2s6u0HWLZgV9Jll3H5-k3wflwRdM1qmCNNpRmFjTPtNNmuap7Rvi9-pWNJetoSAscRLGTO3JGigA8zHMgaP65gehXqR0bIj00sUowO9s9tzjnq0f9oNb5EP56KP26SVgXFsEMq7npCMKRcZG32hEin8rlSCu6IDW7a0TbzKbmJp2duxicgsNp8kAzjFlVqN0dpia21t4tSz5iV7yV_k36BJ1rLIPW5-yBcnsYWyOBQdJgKRRqmKuHKTpBvoJFJR6ifCc13RJlto0HFZyFsjaNzjeMuIfV3a5JGRQP6RDBOcTsSqKOLBu8k_CB0dNoSeWqE0B3VIYYtK4D8hr1lDcrMhCSgqG8Mb6H6VVor4l9PAzMqtzh5-WA_jopi0mOl8hTKRSRPwwza5U3pwrVnGPYh8HRgJGr7dUH1zJJt-MvTvgDIB4OvdPz_WFrm8P347jIeD0cE9coVhFxfMwoo2SWu5WOn75JL8spwWiwcGwyj5eN6e_xOOQ9u2
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1fb9MwELdGQYgXYPxbYTCDQMBDaOO4-YOEUGk3UW0qExvT3oJjO6NSlZQmBfEF-FB8Ou4cJyxoAl72wGt9tprL_e5s5-53hDyWCoIWF31HhJ52eAKYEyn3HRkIpaWAY7NhvDnaC6bT8Pg42l8jP-paGEyrrH2icdQql3hH3gNEY7D1I9ZLbVrE_njn9eKzgx2k8Etr3U6jMpFd_e0rHN-KV5MxvOsnjO1sH47eOrbDgCNhodLxEjghaOnLhLuJCgMmTaUobOvDQcD9RCoGETxNXQFPoQaJJ7lgWqeCg-cXzPVg3QvkYuCBFWOV-qhJLwE_4vu2VM8L3J61jBeLPNNIqYrlea1QaDoGNHGhs5jnxVmb3t9zN08Fw51r_7Mar5OrdgtOhxVm1smazm6QdevkCvrMMnE_v0m-H1bEXXNapQ7TWUZhw0xHbZZrmqd0ZIviqSjpMCshkJR4WWPmVsQNdIJ5WgYIuI7pXaiXGa06Nb1EMTrR4-2hczCko9PwvEU-nIs-bpNOBoayQSgfeEIyplxkcvSFSqTwB1IJ7oo-bOXSLvFqG4qlZXXH5iLz2HyqDOB0V2k1RsuLreV1idPMWlSsJn-Rf4Pm2cgiJ7n5IV-exNbFxaHoMxGINEpVxJWbJINAJ5GKUj8RnuuKLtlC446rAt_Gs8ZDjreP2O-lSx4ZCeQlydA0T8SqKOLJu6N_EDp43xJ6aoXSHNQhhS02gWdCvrOW5GZLEryrbA1vIBRrrRTxLwDBzBpiZw8_bIZxUUxmzHS-QpnIpA_4YZfcqdDcaJZx9CV9GAlaOG-pvj2SzT4ZWnjwOAH43bt__ltb5DIAPt6bTHfvkSsMm7tgcla0STrlcqXvk0vySzkrlg-MO6Pk43kD_ydCQOQR
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Temporal+Trends+in+the+Characteristics+of+Children+at+Antiretroviral+Therapy+Initiation+in+Southern+Africa%3A+The+IeDEA-SA+Collaboration&rft.jtitle=PloS+one&rft.au=Davies%2C+Mary-Ann&rft.au=Phiri%2C+Sam&rft.au=Wood%2C+Robin&rft.au=Wellington%2C+Maureen&rft.date=2013-12-09&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=8&rft.issue=12&rft.spage=e81037&rft_id=info:doi/10.1371%2Fjournal.pone.0081037&rft.externalDBID=IOV&rft.externalDocID=A478358344
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon