A Unified Framework for Association Analysis with Multiple Related Phenotypes

We consider the problem of assessing associations between multiple related outcome variables, and a single explanatory variable of interest. This problem arises in many settings, including genetic association studies, where the explanatory variable is genotype at a genetic variant. We outline a fram...

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Vydáno v:	PloS one Ročník 8; číslo 7; s. e65245
Hlavní autor:	Stephens, Matthew
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 05.07.2013 Public Library of Science (PLoS)
Témata:	Algorithms Association analysis Bayes Theorem Bayesian analysis Biology Cholesterol Computer Simulation Enzymes Genetic aspects Genetic Association Studies Genetic diversity Genetic variance Genome-wide association studies Genomes Genomics Genotype Humans Hypotheses Lipid Metabolism Lipids Mathematics Medicine Models, Genetic Models, Statistical Multivariate Analysis Phenotype Phenotypes Regression Analysis Statistics
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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