Incidence and Geographic Distribution of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa

South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012. XD...

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Veröffentlicht in:	PloS one Jg. 10; H. 7; S. e0132076
Hauptverfasser:	Lim, Jennifer R., Gandhi, Neel R., Mthiyane, Thuli, Mlisana, Koleka, Moodley, Julie, Jaglal, Prenika, Ramdin, Neeshan, Brust, James C. M., Ismail, Nazir, Rustomjee, Roxana, Shah, N. Sarita
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 06.07.2015 Public Library of Science (PLoS)
Schlagworte:	Adolescent Adult Aged Antitubercular agents Child Child, Preschool Disease control Drug resistance Drug therapy Drug wholesalers Epidemics Extensively Drug-Resistant Tuberculosis - epidemiology Female Geographical distribution Health aspects Health surveillance HIV Human immunodeficiency virus Humans Incidence Infectious diseases Laboratories Male Medical research Medicine Microbial drug resistance Middle Aged Mortality Population Public health South Africa - epidemiology Studies Tuberculosis South Africa
ISSN:	1932-6203, 1932-6203
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Abstract	South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012. XDR-TB cases are widely distributed geographically, with the majority of districts experiencing a rise in incidence.
AbstractList	South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012. XDR-TB cases are widely distributed geographically, with the majority of districts experiencing a rise in incidence. South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012. XDR-TB cases are widely distributed geographically, with the majority of districts experiencing a rise in incidence.South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012. XDR-TB cases are widely distributed geographically, with the majority of districts experiencing a rise in incidence.
Audience	Academic
Author	Lim, Jennifer R. Jaglal, Prenika Moodley, Julie Shah, N. Sarita Mlisana, Koleka Ramdin, Neeshan Rustomjee, Roxana Brust, James C. M. Mthiyane, Thuli Gandhi, Neel R. Ismail, Nazir
AuthorAffiliation	4 National Health Laboratory Service, Durban, South Africa 1 Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America 7 Medical Research Council, Cape Town, South Africa 2 Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America 6 Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa 3 University of KwaZulu-Natal, Durban, South Africa 5 Centre for Tuberculosis, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa Institut de Génétique et Microbiologie, FRANCE
AuthorAffiliation_xml	– name: 1 Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America – name: Institut de Génétique et Microbiologie, FRANCE – name: 2 Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America – name: 3 University of KwaZulu-Natal, Durban, South Africa – name: 5 Centre for Tuberculosis, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa – name: 6 Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa – name: 7 Medical Research Council, Cape Town, South Africa – name: 4 National Health Laboratory Service, Durban, South Africa
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CitedBy_id	crossref_primary_10_1186_s12916_018_1178_4 crossref_primary_10_3390_ijerph21091137 crossref_primary_10_1093_infdis_jiy394 crossref_primary_10_1136_bmjopen_2019_031663 crossref_primary_10_1186_s12879_016_1906_3 crossref_primary_10_1371_journal_pone_0181797 crossref_primary_10_1136_bmjopen_2023_082129 crossref_primary_10_1016_j_aogh_2017_05_007 crossref_primary_10_1093_aje_kwaa028
Cites_doi	10.1164/rccm.200907-0989OC 10.1016/S0140-6736(13)62675-6 10.1038/nrmicro2048 10.3201/eid1903.120998 10.1016/S0140-6736(09)60916-8 10.1056/NEJM199507273330406 10.1371/journal.pone.0017513 10.3201/eid1710.100952 10.1371/journal.pone.0034156 10.1128/JCM.05832-11 10.1016/S0140-6736(06)69573-1
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Copyright	COPYRIGHT 2015 Public Library of Science 2015 Lim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2015 Lim et al 2015 Lim et al
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 Conceived and designed the experiments: NRG JCMB NSS. Performed the experiments: JM NR. Analyzed the data: JRL PJ. Contributed reagents/materials/analysis tools: TM KM NI RR. Wrote the paper: JRL NRG TM KM JCMB RR NSS. Competing Interests: The authors have declared that no competing interests exist.
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Snippet	South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds...
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SubjectTerms	Adolescent Adult Aged Antitubercular agents Child Child, Preschool Disease control Drug resistance Drug therapy Drug wholesalers Epidemics Extensively Drug-Resistant Tuberculosis - epidemiology Female Geographical distribution Health aspects Health surveillance HIV Human immunodeficiency virus Humans Incidence Infectious diseases Laboratories Male Medical research Medicine Microbial drug resistance Middle Aged Mortality Population Public health South Africa - epidemiology Studies Tuberculosis
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Title	Incidence and Geographic Distribution of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa
URI	https://www.ncbi.nlm.nih.gov/pubmed/26147963 https://www.proquest.com/docview/1694520498 https://www.proquest.com/docview/1694963206 https://pubmed.ncbi.nlm.nih.gov/PMC4493033 https://doaj.org/article/6ac52e5d64844e1b8238b8d70a125562 http://dx.doi.org/10.1371/journal.pone.0132076
Volume	10
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