Uptake and release of amino acids in the fetal-placental unit in human pregnancies
The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to determine and assess the paired relationships between concentrations and arteriovenous differences of 19 amino acids on the maternal and fetal sides...
Uložené v:
| Vydané v: | PloS one Ročník 12; číslo 10; s. e0185760 |
|---|---|
| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
Public Library of Science
05.10.2017
Public Library of Science (PLoS) |
| Predmet: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to determine and assess the paired relationships between concentrations and arteriovenous differences of 19 amino acids on the maternal and fetal sides of the human placenta in a large study sample.
This cross-sectional in vivo study included 179 healthy women with uncomplicated term pregnancies. During planned cesarean section, we sampled blood from incoming and outgoing vessels on the maternal (radial artery and uterine vein) and fetal (umbilical vein and artery) sides of the placenta. Amino acid concentrations were measured by liquid chromatography-tandem mass spectrometry. We calculated paired arteriovenous differences and performed Wilcoxon signed-rank tests and Spearman's correlations.
In the umbilical circulation, we observed a positive venoarterial difference (fetal uptake) for 14 amino acids and a negative venoarterial difference (fetal release) for glutamic acid (p<0.001). In the maternal circulation, we observed a positive arteriovenous difference (uteroplacental uptake) for leucine (p = 0.005), isoleucine (p = 0.01), glutamic acid (p<0.001) and arginine (p = 0.04) and a negative arteriovenous difference (uteroplacental release) for tyrosine (p = 0.002), glycine (p = 0.01) and glutamine (p = 0.02). The concentrations in the maternal artery and umbilical vein were correlated for all amino acids except tryptophan, but we observed no correlations between the uteroplacental uptake and the fetal uptake or the umbilical vein concentration. Two amino acids showed a correlation between the maternal artery concentration and the fetal uptake.
Our human in vivo study expands the current insight into fetal-placental amino acid exchange, and discloses some differences from what has been previously described in animals. Our findings are consistent with the concept that the fetal supply of amino acids in the human is the result of a dynamic interplay between fetal and placental amino acid metabolism and interconversions. |
|---|---|
| AbstractList | OBJECTIVES:The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to determine and assess the paired relationships between concentrations and arteriovenous differences of 19 amino acids on the maternal and fetal sides of the human placenta in a large study sample. METHODS:This cross-sectional in vivo study included 179 healthy women with uncomplicated term pregnancies. During planned cesarean section, we sampled blood from incoming and outgoing vessels on the maternal (radial artery and uterine vein) and fetal (umbilical vein and artery) sides of the placenta. Amino acid concentrations were measured by liquid chromatography-tandem mass spectrometry. We calculated paired arteriovenous differences and performed Wilcoxon signed-rank tests and Spearman's correlations. RESULTS:In the umbilical circulation, we observed a positive venoarterial difference (fetal uptake) for 14 amino acids and a negative venoarterial difference (fetal release) for glutamic acid (p<0.001). In the maternal circulation, we observed a positive arteriovenous difference (uteroplacental uptake) for leucine (p = 0.005), isoleucine (p = 0.01), glutamic acid (p<0.001) and arginine (p = 0.04) and a negative arteriovenous difference (uteroplacental release) for tyrosine (p = 0.002), glycine (p = 0.01) and glutamine (p = 0.02). The concentrations in the maternal artery and umbilical vein were correlated for all amino acids except tryptophan, but we observed no correlations between the uteroplacental uptake and the fetal uptake or the umbilical vein concentration. Two amino acids showed a correlation between the maternal artery concentration and the fetal uptake. CONCLUSIONS:Our human in vivo study expands the current insight into fetal-placental amino acid exchange, and discloses some differences from what has been previously described in animals. Our findings are consistent with the concept that the fetal supply of amino acids in the human is the result of a dynamic interplay between fetal and placental amino acid metabolism and interconversions. Objectives The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to determine and assess the paired relationships between concentrations and arteriovenous differences of 19 amino acids on the maternal and fetal sides of the human placenta in a large study sample. Methods This cross-sectional in vivo study included 179 healthy women with uncomplicated term pregnancies. During planned cesarean section, we sampled blood from incoming and outgoing vessels on the maternal (radial artery and uterine vein) and fetal (umbilical vein and artery) sides of the placenta. Amino acid concentrations were measured by liquid chromatography—tandem mass spectrometry. We calculated paired arteriovenous differences and performed Wilcoxon signed-rank tests and Spearman’s correlations. Results In the umbilical circulation, we observed a positive venoarterial difference (fetal uptake) for 14 amino acids and a negative venoarterial difference (fetal release) for glutamic acid (p<0.001). In the maternal circulation, we observed a positive arteriovenous difference (uteroplacental uptake) for leucine (p = 0.005), isoleucine (p = 0.01), glutamic acid (p<0.001) and arginine (p = 0.04) and a negative arteriovenous difference (uteroplacental release) for tyrosine (p = 0.002), glycine (p = 0.01) and glutamine (p = 0.02). The concentrations in the maternal artery and umbilical vein were correlated for all amino acids except tryptophan, but we observed no correlations between the uteroplacental uptake and the fetal uptake or the umbilical vein concentration. Two amino acids showed a correlation between the maternal artery concentration and the fetal uptake. Conclusions Our human in vivo study expands the current insight into fetal-placental amino acid exchange, and discloses some differences from what has been previously described in animals. Our findings are consistent with the concept that the fetal supply of amino acids in the human is the result of a dynamic interplay between fetal and placental amino acid metabolism and interconversions. The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to determine and assess the paired relationships between concentrations and arteriovenous differences of 19 amino acids on the maternal and fetal sides of the human placenta in a large study sample.OBJECTIVESThe current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to determine and assess the paired relationships between concentrations and arteriovenous differences of 19 amino acids on the maternal and fetal sides of the human placenta in a large study sample.This cross-sectional in vivo study included 179 healthy women with uncomplicated term pregnancies. During planned cesarean section, we sampled blood from incoming and outgoing vessels on the maternal (radial artery and uterine vein) and fetal (umbilical vein and artery) sides of the placenta. Amino acid concentrations were measured by liquid chromatography-tandem mass spectrometry. We calculated paired arteriovenous differences and performed Wilcoxon signed-rank tests and Spearman's correlations.METHODSThis cross-sectional in vivo study included 179 healthy women with uncomplicated term pregnancies. During planned cesarean section, we sampled blood from incoming and outgoing vessels on the maternal (radial artery and uterine vein) and fetal (umbilical vein and artery) sides of the placenta. Amino acid concentrations were measured by liquid chromatography-tandem mass spectrometry. We calculated paired arteriovenous differences and performed Wilcoxon signed-rank tests and Spearman's correlations.In the umbilical circulation, we observed a positive venoarterial difference (fetal uptake) for 14 amino acids and a negative venoarterial difference (fetal release) for glutamic acid (p<0.001). In the maternal circulation, we observed a positive arteriovenous difference (uteroplacental uptake) for leucine (p = 0.005), isoleucine (p = 0.01), glutamic acid (p<0.001) and arginine (p = 0.04) and a negative arteriovenous difference (uteroplacental release) for tyrosine (p = 0.002), glycine (p = 0.01) and glutamine (p = 0.02). The concentrations in the maternal artery and umbilical vein were correlated for all amino acids except tryptophan, but we observed no correlations between the uteroplacental uptake and the fetal uptake or the umbilical vein concentration. Two amino acids showed a correlation between the maternal artery concentration and the fetal uptake.RESULTSIn the umbilical circulation, we observed a positive venoarterial difference (fetal uptake) for 14 amino acids and a negative venoarterial difference (fetal release) for glutamic acid (p<0.001). In the maternal circulation, we observed a positive arteriovenous difference (uteroplacental uptake) for leucine (p = 0.005), isoleucine (p = 0.01), glutamic acid (p<0.001) and arginine (p = 0.04) and a negative arteriovenous difference (uteroplacental release) for tyrosine (p = 0.002), glycine (p = 0.01) and glutamine (p = 0.02). The concentrations in the maternal artery and umbilical vein were correlated for all amino acids except tryptophan, but we observed no correlations between the uteroplacental uptake and the fetal uptake or the umbilical vein concentration. Two amino acids showed a correlation between the maternal artery concentration and the fetal uptake.Our human in vivo study expands the current insight into fetal-placental amino acid exchange, and discloses some differences from what has been previously described in animals. Our findings are consistent with the concept that the fetal supply of amino acids in the human is the result of a dynamic interplay between fetal and placental amino acid metabolism and interconversions.CONCLUSIONSOur human in vivo study expands the current insight into fetal-placental amino acid exchange, and discloses some differences from what has been previously described in animals. Our findings are consistent with the concept that the fetal supply of amino acids in the human is the result of a dynamic interplay between fetal and placental amino acid metabolism and interconversions. The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to determine and assess the paired relationships between concentrations and arteriovenous differences of 19 amino acids on the maternal and fetal sides of the human placenta in a large study sample. This cross-sectional in vivo study included 179 healthy women with uncomplicated term pregnancies. During planned cesarean section, we sampled blood from incoming and outgoing vessels on the maternal (radial artery and uterine vein) and fetal (umbilical vein and artery) sides of the placenta. Amino acid concentrations were measured by liquid chromatography-tandem mass spectrometry. We calculated paired arteriovenous differences and performed Wilcoxon signed-rank tests and Spearman's correlations. In the umbilical circulation, we observed a positive venoarterial difference (fetal uptake) for 14 amino acids and a negative venoarterial difference (fetal release) for glutamic acid (p<0.001). In the maternal circulation, we observed a positive arteriovenous difference (uteroplacental uptake) for leucine (p = 0.005), isoleucine (p = 0.01), glutamic acid (p<0.001) and arginine (p = 0.04) and a negative arteriovenous difference (uteroplacental release) for tyrosine (p = 0.002), glycine (p = 0.01) and glutamine (p = 0.02). The concentrations in the maternal artery and umbilical vein were correlated for all amino acids except tryptophan, but we observed no correlations between the uteroplacental uptake and the fetal uptake or the umbilical vein concentration. Two amino acids showed a correlation between the maternal artery concentration and the fetal uptake. Our human in vivo study expands the current insight into fetal-placental amino acid exchange, and discloses some differences from what has been previously described in animals. Our findings are consistent with the concept that the fetal supply of amino acids in the human is the result of a dynamic interplay between fetal and placental amino acid metabolism and interconversions. The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to determine and assess the paired relationships between concentrations and arteriovenous differences of 19 amino acids on the maternal and fetal sides of the human placenta in a large study sample. This cross-sectional in vivo study included 179 healthy women with uncomplicated term pregnancies. During planned cesarean section, we sampled blood from incoming and outgoing vessels on the maternal (radial artery and uterine vein) and fetal (umbilical vein and artery) sides of the placenta. Amino acid concentrations were measured by liquid chromatography-tandem mass spectrometry. We calculated paired arteriovenous differences and performed Wilcoxon signed-rank tests and Spearman's correlations. In the umbilical circulation, we observed a positive venoarterial difference (fetal uptake) for 14 amino acids and a negative venoarterial difference (fetal release) for glutamic acid (p<0.001). In the maternal circulation, we observed a positive arteriovenous difference (uteroplacental uptake) for leucine (p = 0.005), isoleucine (p = 0.01), glutamic acid (p<0.001) and arginine (p = 0.04) and a negative arteriovenous difference (uteroplacental release) for tyrosine (p = 0.002), glycine (p = 0.01) and glutamine (p = 0.02). The concentrations in the maternal artery and umbilical vein were correlated for all amino acids except tryptophan, but we observed no correlations between the uteroplacental uptake and the fetal uptake or the umbilical vein concentration. Two amino acids showed a correlation between the maternal artery concentration and the fetal uptake. Our human in vivo study expands the current insight into fetal-placental amino acid exchange, and discloses some differences from what has been previously described in animals. Our findings are consistent with the concept that the fetal supply of amino acids in the human is the result of a dynamic interplay between fetal and placental amino acid metabolism and interconversions. |
| Audience | Academic |
| Author | Bastani, Nasser Ezzatkhah Jansson, Thomas Holm, Maia Blomhoff Zucknick, Manuela Holme, Ane Moe Refsum, Helga Mørkrid, Lars Henriksen, Tore Blomhoff, Rune Michelsen, Trond Melbye |
| AuthorAffiliation | 1 Department of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway 3 Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway 5 Division of Reproductive Sciences, Department of OB/GYN University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America 6 Analytic Unit of Metabolic Diseases, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway 7 Department of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway 4 Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway Johns Hopkins University, UNITED STATES 2 Institute of Clinical Medicine, University of Oslo, Oslo, Norway 8 Norwegian Advisory Unit on Women’s Health, Oslo University Hospital, Oslo, Norway |
| AuthorAffiliation_xml | – name: 8 Norwegian Advisory Unit on Women’s Health, Oslo University Hospital, Oslo, Norway – name: 1 Department of Obstetrics, Division of Obstetrics and Gynecology, Oslo University Hospital, Oslo, Norway – name: 6 Analytic Unit of Metabolic Diseases, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway – name: 2 Institute of Clinical Medicine, University of Oslo, Oslo, Norway – name: Johns Hopkins University, UNITED STATES – name: 3 Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway – name: 4 Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway – name: 5 Division of Reproductive Sciences, Department of OB/GYN University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America – name: 7 Department of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway |
| Author_xml | – sequence: 1 givenname: Maia Blomhoff orcidid: 0000-0002-3680-0259 surname: Holm fullname: Holm, Maia Blomhoff – sequence: 2 givenname: Nasser Ezzatkhah surname: Bastani fullname: Bastani, Nasser Ezzatkhah – sequence: 3 givenname: Ane Moe surname: Holme fullname: Holme, Ane Moe – sequence: 4 givenname: Manuela surname: Zucknick fullname: Zucknick, Manuela – sequence: 5 givenname: Thomas surname: Jansson fullname: Jansson, Thomas – sequence: 6 givenname: Helga surname: Refsum fullname: Refsum, Helga – sequence: 7 givenname: Lars surname: Mørkrid fullname: Mørkrid, Lars – sequence: 8 givenname: Rune surname: Blomhoff fullname: Blomhoff, Rune – sequence: 9 givenname: Tore surname: Henriksen fullname: Henriksen, Tore – sequence: 10 givenname: Trond Melbye surname: Michelsen fullname: Michelsen, Trond Melbye |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28982184$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk22L1DAQx4uceA_6DUQLguiLXZMmbVNfCMfhw8LBwen5NkzT6W7WNOk1rei3N73tyvY4RAppmPzmn5k_mdPoyDqLUfSckiVlOX23dUNnwSzbEF4SKtI8I4-iE1qwZJElhB0d7I-jU--3hKRMZNmT6DgRhUio4CfR9U3bww-MwVZxhwbBY-zqGBptXQxKVz7WNu43GNfYg1m0BhTasIsHq_vxbDM0YOO2w7UFqzT6p9HjGozHZ9P_LLr59PHbxZfF5dXn1cX55UJlRdIvKIbqkNBQlCpYLRQrQRRZBilgUtU5U0xRoVTGVQ68SvKKlnVSFLRMWa04sLPo5U63Nc7LyQ4vaUBESklWBGK1IyoHW9l2uoHut3Sg5V3AdWsJXa-VQZlQrsoKueJVynlZCqDIUlEyUoeVqqD1YbptKBusRhM6MDPR-YnVG7l2P2WaBbcTFgTeTAKdux3Q97LRXqExYNENY91c5Gme3qGv7qEPdzdRawgNaFu7cK8aReV5SkRChMh4oJYPUOGrsNEqvJ1ah_gs4e0sITA9_urXMHgvV1-v_5-9-j5nXx-wGwTTb7wzQ6-d9XPwxaHTfy3eP9oAvN8BqnPed1hLpXsYdUJr2khK5Dghe9PkOCFympCQzO8l7_X_mfYHyvgUPg |
| CitedBy_id | crossref_primary_10_1080_13813455_2020_1846204 crossref_primary_10_1113_JP278226 crossref_primary_10_1016_j_jnutbio_2021_108760 crossref_primary_10_1080_01443615_2024_2379498 crossref_primary_10_1002_btm2_10595 crossref_primary_10_1016_j_bbalip_2018_12_007 crossref_primary_10_1186_s12916_022_02415_z crossref_primary_10_1007_s00726_018_2576_9 crossref_primary_10_1053_j_semperi_2019_06_002 crossref_primary_10_1111_apha_14157 crossref_primary_10_3390_ani13101708 crossref_primary_10_1210_jc_2019_00166 crossref_primary_10_1016_j_metabol_2025_156330 crossref_primary_10_3390_metabo10090350 crossref_primary_10_1093_jn_nxaa263 crossref_primary_10_3390_ijms20153654 crossref_primary_10_1038_s41390_020_1033_0 crossref_primary_10_1098_rstb_2024_0173 crossref_primary_10_1186_s12884_021_03734_4 crossref_primary_10_1016_j_isci_2023_108021 crossref_primary_10_1093_jas_skad383 crossref_primary_10_1038_s41390_020_01181_z crossref_primary_10_1016_j_ajog_2024_03_012 crossref_primary_10_1096_fj_201801193R crossref_primary_10_3390_biomedicines10010166 crossref_primary_10_3390_ijerph182111545 crossref_primary_10_1038_s41390_021_01672_7 crossref_primary_10_1093_nutrit_nuac015 crossref_primary_10_1016_j_placenta_2019_09_001 crossref_primary_10_1017_S2040174420000884 crossref_primary_10_1002_ijgo_13151 crossref_primary_10_1080_14767058_2021_1922378 crossref_primary_10_1038_s41598_025_12856_0 crossref_primary_10_3390_metabo12020175 crossref_primary_10_1016_j_devcel_2022_02_003 crossref_primary_10_1016_j_ebiom_2023_104441 crossref_primary_10_1016_j_ijpp_2019_12_007 |
| Cites_doi | 10.1016/S0143-4004(05)80287-5 10.1136/adc.2008.147256 10.1016/j.placenta.2013.10.003 10.1016/j.ajog.2004.08.011 10.1016/S0002-9378(96)70609-9 10.1016/S0002-9378(99)70230-9 10.1203/00006450-198501000-00024 10.1385/ENDO:19:1:23 10.1111/j.1365-2826.2008.01662.x 10.1152/ajpendo.00428.2003 10.1016/0002-9378(89)90670-4 10.1159/000243392 10.1155/2012/179827 10.1203/PDR.0b013e31823214d1 10.1159/000241099 10.1203/00006450-199505000-00002 10.1159/000240845 10.1111/j.1471-0528.1969.tb05855.x 10.1016/S0143-4004(96)80080-4 10.1152/physrev.1990.70.1.43 10.1210/jcem.86.11.8036 10.1016/S0002-9378(16)33136-2 10.1007/s00726-007-0006-5 10.1371/journal.pone.0117084 10.1016/j.nut.2009.09.017 10.1111/j.2517-6161.1995.tb02031.x 10.1016/S0002-9378(99)70581-8 10.1016/0140-6736(93)91224-A 10.1016/0002-9378(88)90792-2 10.1016/S0301-2115(03)00172-6 10.1016/0028-2243(93)90201-M 10.1053/plac.2000.0612 10.1016/j.ajog.2008.06.054 10.1097/GRF.0b013e31829cb9ca |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Holm et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2017 Holm et al 2017 Holm et al |
| Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Holm et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2017 Holm et al 2017 Holm et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0185760 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Science in Context ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Agricultural Science Database MEDLINE |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine |
| DocumentTitleAlternate | Uptake and release of amino acids in the human fetal-placental unit |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1991851069 oai_doaj_org_article_214cbde4c4d544bb8a1e358b30f58b1c PMC5628923 A508208864 28982184 10_1371_journal_pone_0185760 |
| Genre | Journal Article |
| GeographicLocations | Norway |
| GeographicLocations_xml | – name: Norway |
| GrantInformation_xml | – fundername: ; grantid: 2013043 – fundername: ; grantid: 2016066 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 5PM - 02 AAPBV ABPTK ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c692t-1e932e01053c93f8c3ba8966a5ae2df73c3c18cc64c7a4d27d1bf2991b53fc4a3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 45 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000412360300067&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:14:07 EST 2021 Fri Oct 03 12:52:36 EDT 2025 Tue Nov 04 01:34:45 EST 2025 Fri Sep 05 11:10:01 EDT 2025 Tue Oct 07 08:08:43 EDT 2025 Sat Nov 29 13:24:26 EST 2025 Sat Nov 29 09:59:30 EST 2025 Wed Nov 26 10:33:56 EST 2025 Wed Nov 26 09:24:14 EST 2025 Thu May 22 21:14:40 EDT 2025 Thu Apr 03 06:57:19 EDT 2025 Sat Nov 29 02:40:54 EST 2025 Tue Nov 18 21:19:21 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-1e932e01053c93f8c3ba8966a5ae2df73c3c18cc64c7a4d27d1bf2991b53fc4a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: RB is a chair holder in AS VITAS. Otherwise, the authors declare that they have no conflicts of interests. This does not alter our adherence to all PLOS ONE policies on sharing data and materials. |
| ORCID | 0000-0002-3680-0259 |
| OpenAccessLink | https://doaj.org/article/214cbde4c4d544bb8a1e358b30f58b1c |
| PMID | 28982184 |
| PQID | 1991851069 |
| PQPubID | 1436336 |
| PageCount | e0185760 |
| ParticipantIDs | plos_journals_1991851069 doaj_primary_oai_doaj_org_article_214cbde4c4d544bb8a1e358b30f58b1c pubmedcentral_primary_oai_pubmedcentral_nih_gov_5628923 proquest_miscellaneous_1948757523 proquest_journals_1991851069 gale_infotracmisc_A508208864 gale_infotracacademiconefile_A508208864 gale_incontextgauss_ISR_A508208864 gale_incontextgauss_IOV_A508208864 gale_healthsolutions_A508208864 pubmed_primary_28982184 crossref_citationtrail_10_1371_journal_pone_0185760 crossref_primary_10_1371_journal_pone_0185760 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-10-05 |
| PublicationDateYYYYMMDD | 2017-10-05 |
| PublicationDate_xml | – month: 10 year: 2017 text: 2017-10-05 day: 05 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2017 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | AF Philipps (ref32) 1978; 131 CL Paolini (ref26) 2001; 86 M Jozwik (ref28) 1999; 180 G Geddie (ref37) 1996; 17 A Velazquez (ref14) 1976; 29 I Cetin (ref19) 1991; 60 MA Alterman (ref39) 2011 I Cetin (ref25) 1995; 37 S Lager (ref9) 2012; 2012 FC Battaglia (ref10) 2001; 22 I Cetin (ref12) 2003; 110 HL Galan (ref27) 2009; 200 I Cetin (ref4) 1988; 158 MA Prenton (ref13) 1969; 76 AK Elshorbagy (ref23) 2010; 26 G Soltesz (ref31) 1985; 19 M Chung (ref34) 1998; 274 M Jozwik (ref30) 2004; 286 S Ronzoni (ref29) 1999; 181 PE Day (ref36) 2013; 34 A Schaefer (ref20); 14 DJ Barker (ref2) 1993; 341 CH van den Akker (ref33) 2011; 70 S Hayashi (ref15) 1978; 34 DJ Barker (ref1) 2013; 56 K Benirschke (ref11) 2012 Y Benjamini (ref24) 1995 T Steingrimsdottir (ref16) 1993; 50 H Tsuchiya (ref18) 2009; 94 AM Holme (ref22) 2017 IR Holzman (ref35) 1979; 1 TR Regnault (ref6) 2002; 19 I Cetin (ref17) 2005; 192 MA Grillo (ref7) 2008; 34 DL Economides (ref5) 1989; 161 HN Christensen (ref38) 1990; 70 JK Cleal (ref8) 2008; 20 I Cetin (ref3) 1996; 174 AM Holme (ref21) 2015; 10 |
| References_xml | – volume: 14 start-page: 103 ident: ref20 article-title: Placenta-fetal “alanine-lactate cycle” in the human during late gestation publication-title: Placenta doi: 10.1016/S0143-4004(05)80287-5 – volume: 94 start-page: F155 year: 2009 ident: ref18 article-title: Differences between the amino acid concentrations of umbilical venous and arterial blood publication-title: Arch Dis Child Fetal Neonatal Ed doi: 10.1136/adc.2008.147256 – volume: 34 start-page: 1223 year: 2013 ident: ref36 article-title: Partitioning of glutamine synthesised by the isolated perfused human placenta between the maternal and fetal circulations publication-title: Placenta doi: 10.1016/j.placenta.2013.10.003 – volume: 192 start-page: 610 year: 2005 ident: ref17 article-title: Maternal and fetal amino acid concentrations in normal pregnancies and in pregnancies with gestational diabetes mellitus publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2004.08.011 – volume: 174 start-page: 1575 year: 1996 ident: ref3 article-title: Maternal concentrations and fetal-maternal concentration differences of plasma amino acids in normal and intrauterine growth-restricted pregnancies publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(96)70609-9 – volume: 180 start-page: 447 year: 1999 ident: ref28 article-title: Fetal supply of amino acids and amino nitrogen after maternal infusion of amino acids in pregnant sheep publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(99)70230-9 – year: 2017 ident: ref22 article-title: The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo publication-title: J Vis Exp – volume: 19 start-page: 91 year: 1985 ident: ref31 article-title: The metabolic and endocrine milieu of the human fetus and mother at 18–21 weeks of gestation. I. Plasma amino acid concentrations publication-title: Pediatr Res doi: 10.1203/00006450-198501000-00024 – volume: 19 start-page: 23 year: 2002 ident: ref6 article-title: Transport and metabolism of amino acids in placenta publication-title: Endocrine doi: 10.1385/ENDO:19:1:23 – volume: 20 start-page: 419 year: 2008 ident: ref8 article-title: The mechanisms and regulation of placental amino acid transport to the human foetus publication-title: J Neuroendocrinol doi: 10.1111/j.1365-2826.2008.01662.x – volume: 274 start-page: E13 year: 1998 ident: ref34 article-title: Production and utilization of amino acids by ovine placenta in vivo publication-title: Am J Physiol – volume: 286 start-page: E376 year: 2004 ident: ref30 article-title: Reciprocal inhibition of umbilical uptake within groups of amino acids publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00428.2003 – volume: 1 start-page: 137 year: 1979 ident: ref35 article-title: Uterine uptake of amino acids and placental glutamine—glutamate balance in the pregnant ewe publication-title: J Dev Physiol – volume: 161 start-page: 1219 year: 1989 ident: ref5 article-title: Plasma amino acids in appropriate- and small-for-gestational-age fetuses publication-title: Am J Obstet Gynecol doi: 10.1016/0002-9378(89)90670-4 – volume: 60 start-page: 83 year: 1991 ident: ref19 article-title: Plasma and erythrocyte amino acids in mother and fetus publication-title: Biol Neonate doi: 10.1159/000243392 – volume: 2012 start-page: 179827 year: 2012 ident: ref9 article-title: Regulation of nutrient transport across the placenta publication-title: J Pregnancy doi: 10.1155/2012/179827 – volume: 70 start-page: 566 year: 2011 ident: ref33 article-title: Amino acid metabolism in the human fetus at term: leucine, valine, and methionine kinetics publication-title: Pediatr Res doi: 10.1203/PDR.0b013e31823214d1 – year: 2011 ident: ref39 article-title: Amino Acid Analysis: Methods and Protocols – volume: 34 start-page: 11 year: 1978 ident: ref15 article-title: Umbilical vein-artery differences of plasma amino acids in the last trimester of human pregnancy publication-title: Biol Neonate doi: 10.1159/000241099 – volume: 37 start-page: 571 year: 1995 ident: ref25 article-title: In vivo placental transport of glycine and leucine in human pregnancies publication-title: Pediatr Res doi: 10.1203/00006450-199505000-00002 – volume: 29 start-page: 28 year: 1976 ident: ref14 article-title: Amino acid pools in the feto-maternal system publication-title: Biol Neonate doi: 10.1159/000240845 – volume: 76 start-page: 404 year: 1969 ident: ref13 article-title: Umbilical vein-artery and uterine arterio-venous plasma amino acid differences (in the human subject) publication-title: J Obstet Gynaecol Br Commonw doi: 10.1111/j.1471-0528.1969.tb05855.x – volume: 17 start-page: 619 year: 1996 ident: ref37 article-title: Comparison of leucine, serine and glycine transport across the ovine placenta publication-title: Placenta doi: 10.1016/S0143-4004(96)80080-4 – volume: 70 start-page: 43 year: 1990 ident: ref38 article-title: Role of amino acid transport and countertransport in nutrition and metabolism publication-title: Physiol Rev doi: 10.1152/physrev.1990.70.1.43 – volume: 86 start-page: 5427 year: 2001 ident: ref26 article-title: Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.86.11.8036 – volume: 131 start-page: 881 year: 1978 ident: ref32 article-title: Tissue concentrations of free amino acids in term human placentas publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(16)33136-2 – volume: 34 start-page: 517 year: 2008 ident: ref7 article-title: Transport of amino acids through the placenta and their role publication-title: Amino Acids doi: 10.1007/s00726-007-0006-5 – volume: 10 start-page: e0117084 year: 2015 ident: ref21 article-title: Placental glucose transfer: a human in vivo study publication-title: PLoS One doi: 10.1371/journal.pone.0117084 – volume: 26 start-page: 1201 year: 2010 ident: ref23 article-title: Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemia publication-title: Nutrition doi: 10.1016/j.nut.2009.09.017 – start-page: 289 year: 1995 ident: ref24 article-title: Controlling the false discovery rate: a practical and powerful approach to multiple testing publication-title: Journal of the Royal Statistical Society Series B (Methodological) doi: 10.1111/j.2517-6161.1995.tb02031.x – volume: 181 start-page: 477 year: 1999 ident: ref29 article-title: Umbilical amino acid uptake at increasing maternal amino acid concentrations: effect of a maternal amino acid infusate publication-title: Am J Obstet Gynecol doi: 10.1016/S0002-9378(99)70581-8 – volume: 341 start-page: 938 year: 1993 ident: ref2 article-title: Fetal nutrition and cardiovascular disease in adult life publication-title: Lancet doi: 10.1016/0140-6736(93)91224-A – start-page: 941 year: 2012 ident: ref11 article-title: Pathology of the Human Placenta – volume: 158 start-page: 120 year: 1988 ident: ref4 article-title: Umbilical amino acid concentrations in appropriate and small for gestational age infants: a biochemical difference present in utero publication-title: Am J Obstet Gynecol doi: 10.1016/0002-9378(88)90792-2 – volume: 110 start-page: S50 issue: Suppl 1 year: 2003 ident: ref12 article-title: Placental transport of amino acids in normal and growth-restricted pregnancies publication-title: Eur J Obstet Gynecol Reprod Biol doi: 10.1016/S0301-2115(03)00172-6 – volume: 50 start-page: 197 year: 1993 ident: ref16 article-title: Balance of amino acids in the pregnant human uterus at term publication-title: Eur J Obstet Gynecol Reprod Biol doi: 10.1016/0028-2243(93)90201-M – volume: 22 start-page: 145 year: 2001 ident: ref10 article-title: Placental transport and metabolism of amino acids publication-title: Placenta doi: 10.1053/plac.2000.0612 – volume: 200 start-page: 91 e91 year: 2009 ident: ref27 article-title: The transplacental transport of essential amino acids in uncomplicated human pregnancies publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2008.06.054 – volume: 56 start-page: 511 year: 2013 ident: ref1 article-title: The obstetric origins of health for a lifetime publication-title: Clin Obstet Gynecol doi: 10.1097/GRF.0b013e31829cb9ca |
| SSID | ssj0053866 |
| Score | 2.443905 |
| Snippet | The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed to... Objectives The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed... OBJECTIVES:The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed... Objectives The current concepts of human fetal-placental amino acid exchange and metabolism are mainly based on animal-, in vitro- and ex vivo models. We aimed... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0185760 |
| SubjectTerms | Adult Amino acids Amino Acids - blood Amino Acids - metabolism Analysis Arginine Biology and Life Sciences Blood vessels Cesarean section Chromatography Clinical medicine Correlation Cross-Sectional Studies Female Fetuses Glutamic acid Glutamine Glycine Gynecology Health aspects Hospitals Humans In Vitro Techniques In vivo methods and tests Isoleucine Leucine Liquid chromatography Mass spectrometry Mass spectroscopy Maternal-Fetal Exchange Medicine Medicine and Health Sciences Metabolism Nutrition Obstetrics Physical Sciences Physiological aspects Placenta Placenta - metabolism Pregnancy Pregnant women Rank tests Studies Tryptophan Tyrosine Umbilical vein Uterus Uterus - metabolism Women's health Womens health |
| SummonAdditionalLinks | – databaseName: Biological Science Database dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZgQYgL0PJooIBBSNBD2jjOwzmhgqjgQKkKRb1FtmMvESUJm11-PzOONyWoAiQuOcSTKJmXZ-zxN4Q8k1wWJgYJ8LiIwkRJ8IMQJoSpZZVQguUiUq7ZRH54KE5PiyO_4Nb7ssq1T3SOumo1rpHvYYkORAdRVrzsvofYNQp3V30LjcvkCqIkcFe6d7T2xGDLWeaPy_Gc7Xnp7HZtY3YjBEFywJTn05FD7R9986w7a_uLAs_f6yd_mZAObv7vr9wiN3woSvcH3dkgl0yzSa6995vtm2TD231PX3hw6p3b5PikW8qvhsqmothvBSZB2loqv9VNS6Wuq57WDYWokloDcX3oar7wxCVdgfPAMdcVkHYLMx86A_d3yMnBm0-v34a-L0OosyJehsyANA221uS64FZorqSAtEmm0sSVzbnmmgmts0TnMqnivGLKwrTHVMqtTiS_S2YNyGCLUG24zQqZCZmLRKRKyNRGmcqEYm4LOSB8LZ5Se9By7J1xVrqduBySl4FZJQq19EINSDg-1Q2gHX-hf4WSH2kRctvdaBfz0ltwGbNEq8okOqnSJFHwqczwVCgeWbgyHZDHqDflcH51dBzlfopRlhBZEpCnjgJhNxqs65nLVd-X7z58_geij8cToueeyLbADi39WQr4J4TzmlBuTyjBeejJ8BZq-ZorfXmum_DkWnsvHn4yDuNLsVavMe0KaTAJztOYB-TeYCgjZyG9F7ioEJB8YkIT1k9HmvqLQz2HQF1ANnL_z5_1gFyPMfByJR7bZLZcrMxDclX_WNb94pFzDz8BaJVuog priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Rb9QwDI7QgRAvwAZsHQMCQgIeOpomTdPHgTiBBGMaDO2tStJ0nNja0_WO34-d5gqdNgEvfTg7VWrHjn1xPhPyXHNduBQ0wNMiiYXR4AchTIizmlXKKJarxPhmE_nBgTo5KQ5_J4oXTvB5zl4Hme7N28btJQhdJCFFv55yKbGEa3r4ce15wXalDNfjrho52n48Sv_giyfzs7a7LNC8WC_5xwY0vfO_U79LbodQk-73a2ODXHPNJrn5KRymb5KNYNcdfRnAp1_dI0fH86X-4ahuKor9VGCTo21N9fmsaam2s6qjs4ZC1EhrB3F77Gu68EYlXYFzQJrv-kfnC3fad_7t7pPj6buvb9_Hoe9CbGWRLmPmQFsOW2dyW_BaWW60grRIZ9qlVZ1zyy1T1kphcy2qNK-YqWFbYybjtRWaPyCTBj55m1DreC0LLZXOlVCZUTqrE2mkMswfEUeEr9VR2gBKjr0xzkp_0pZDctILq0QZlkGGEYmHUfMelOMv_G9Q0wMvQmr7H0BZZbDQMmXCmsoJK6pMCANTZY5nyvCkhiezEXmC66Ts76cOjqHczzCKUkqKiDzzHAir0WDdzqledV354fO3f2D6cjRiehGY6hbEYXW4KwHfhHBdI87dESc4Bzsib-OqXkulK7HSDYLsRBYwcr3SLyc_Hcj4UqzFa1y7Qh5McvMs5RHZ6g1jkCyk7wr_NIhIPjKZkejHlGb23aOaQyCuINvYuXrGD8mtFIMqX76xSybLxco9Ijfsz-WsWzz2ruAXBxRc6g priority: 102 providerName: Public Library of Science |
| Title | Uptake and release of amino acids in the fetal-placental unit in human pregnancies |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28982184 https://www.proquest.com/docview/1991851069 https://www.proquest.com/docview/1948757523 https://pubmed.ncbi.nlm.nih.gov/PMC5628923 https://doaj.org/article/214cbde4c4d544bb8a1e358b30f58b1c http://dx.doi.org/10.1371/journal.pone.0185760 |
| Volume | 12 |
| WOSCitedRecordID | wos000412360300067&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELeg8MALYnwtMIpBSMBDuiROYudxnVYxjZWoY9PYS2Q7zqgYSdW0_P3cOWlY0KTxwMs91OeqvS_fJeffEfJOMpmYADTAgsRzQyUhDkKa4EaFnwslfC48ZYdN8OlUnJ8n6bVRX9gT1sADN4LbDfxQq9yEOsyjMFRKSN-wSCjmFUB9jdEXsp5NMdXEYPDiOG4vyjHu77Z6GS2q0ow8hD-ykJR_DiKL199F5cHiqqpvSjn_7py8dhRNHpGHbQ5J95rfvkXumPIx2Wq9tKYfWijpj0_I7HSxkj8MlWVOcToKHFm0Kqj8OS8rKvU8r-m8pJAD0sJAFu7aDi28H0nX4Oq4Zmf40cXSXDZzfOun5HRy8HX_k9tOUXB1nAQr1zcge4ODMJlOWCE0U1JAkSMjaYK84Ewz7Qut41BzGeYBz31VwCHlq4gVOpTsGRmUILdtQrVhRZzIWEguQhGBLqLCi1UMerAvfB3CNiLNdAsxjpMurjL73oxDqdFIKENFZK0iHOJ2uxYNxMYt_GPUVseLANn2AzCbrDWb7Dazcchr1HXW3Dbt3DzbizAnEiIOHfLWciBIRoldOJdyXdfZ4Zezf2A6mfWY3rdMRQXi0LK9-QD_CcG3epw7PU5wdd1b3kbL3EilzrBvDVJmL05g58Zab15-0y3jl2JnXWmqNfJgycqjgDnkeWPcnWShGBf4CMAhvGf2PdH3V8r5d4tRDmm1gNrhxf_Q1UvyIMBkyrZt7JDBark2r8h9_Ws1r5dDcpfPzpCec0sFULHvD8m98cE0nQ1tYAA6ST8DPRqPgB57R0h5aukJ0DS6gB3p4XH67TdRmWqQ |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELbKgoAL0PJooFCDQMAhbRLn4RwQKo-qqz5A24d6C7bjLCtKEja7IP4Uv5EZ51GCKuDSA5cc4knkjGc-z8TzIOSxYCLWHqwA82LH9qUAHAQzwQ4yN-WSuxF3pGk2Ee3t8ePj-P0C-dHmwmBYZYuJBqjTQuE_8nUM0QHrwAnjl-UXG7tG4elq20KjFott_f0buGzVi-EbWN8nnrf59uD1lt10FbBVGHsz29UwF42NIZmKWcYVk4KD0S8Cob00i5hiyuVKhb6KhJ96UerKDEDblQHLlC8YvPcCuQg47mIIWTQ6apEfsCMMm_Q8FrnrjTSslUWu1xwsumQKYZ5uf6ZLQLcXDMqTojrL0P09XvOXDXDz-v_GuhvkWmNq041aNxbJgs6XyOXdJphgiSw2uFbRZ03x7ec3yeiwnIlPmoo8pdhPBjZ5WmRUfJ7kBRVqklZ0klOwmmmmwW-xTUwbZpTSOYAjjpmuh7Sc6nHd-bi6RQ7P5TNvk0EOa75MqNIsC2MRchFxnweSiyBzQhly6ZojcouwVhwS1RRlx94gJ4k5aYzAOauZlaAQJY0QWcTunirroiR_oX-FktbRYklxc6OYjpMGoRLP9ZVMta_8NPB9CVN1NQu4ZE4GV1dZZBXlNKnzcztgTDYCtCI5D32LPDIUWFYkx7ilsZhXVTJ8d_QPRPujHtHThigrgB1KNLki8E1YrqxHudKjBHBUveFl1KqWK1VyqgvwZKstZw8_7IbxpRiLmOtijjTo5EeBxyxyp1bMjrMejzn-NLFI1FPZHuv7I_nko6nqDo4IB2_r7p-ntUqubB3s7iQ7w73te-Sqh0amCWdZIYPZdK7vk0vq62xSTR8YaKLkw3kr9E-Jlsx6 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELbKgiouQMujgUINAgGHdJM4D-eAUGlZURWWqqWot-A4zrKiJGGzC-Kv8euYcZyUoAq49MAlh3gSOeOZzzPxPAh5KJiIlQcrwLzYsf1UAA6CmWAHuZvxlLsRd1LdbCIaj_nxcby_RH60uTAYVtliogbqrJT4j3yIITpgHThhPMxNWMT-zuh59cXGDlJ40tq202hEZE99_wbuW_1sdwfW-pHnjV6-235lmw4Dtgxjb267CualsEkkkzHLuWSp4OAAiEAoL8sjJpl0uZShLyPhZ16UuWkOAO6mAculLxi89wK5GDGQYsxS3-7CSwBHwtCk6rHIHRrJ2KzKQm06WIBJF8U83Qp1x4BuXxhUJ2V9ltH7e-zmL5vh6Or_zMZr5IoxwelWozMrZEkVq2T5jQkyWCUrBu9q-sQU5X56nRwcVXPxSVFRZBT7zMDmT8ucis_ToqRCTrOaTgsK1jTNFfgzto51w0xTugDQxDHdDZFWMzVpOiLXN8jRuXzmTTIoYP3XCJWK5WEsQi4i7vMg5SLInTANeerqo3OLsFY0EmmKtWPPkJNEn0BG4LQ1zEpQoBIjUBaxu6eqpljJX-hfoNR1tFhqXN8oZ5PEIFfiub5MM-VLPwt8P4WpuooFPGVODldXWmQDZTZp8nY7wEy2ArQuOQ99izzQFFhupECJm4hFXSe7b9__A9HhQY_osSHKS2CHFCaHBL4Jy5j1KNd7lACasje8hhrWcqVOTvUCnmw15-zh-90wvhRjFAtVLpAGnf8o8JhFbjVK2nHW4zHHnykWiXrq22N9f6SYftTV3sFB4eCF3f7ztDbIMuhx8np3vHeHXPbQ9tRRLutkMJ8t1F1ySX6dT-vZPY1SlHw4b33-CdLj1NU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Uptake+and+release+of+amino+acids+in+the+fetal-placental+unit+in+human+pregnancies&rft.jtitle=PloS+one&rft.au=Maia+Blomhoff+Holm&rft.au=Nasser+Ezzatkhah+Bastani&rft.au=Ane+Moe+Holme&rft.au=Manuela+Zucknick&rft.date=2017-10-05&rft.pub=Public+Library+of+Science+%28PLoS%29&rft.eissn=1932-6203&rft.volume=12&rft.issue=10&rft.spage=e0185760&rft_id=info:doi/10.1371%2Fjournal.pone.0185760&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_214cbde4c4d544bb8a1e358b30f58b1c |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |