Differential In Vitro Inhibition of Thrombin Generation by Anticoagulant Drugs in Plasma from Patients with Cirrhosis

Treatment and prevention of thrombotic complications is frequently required in patients with cirrhosis. However anticoagulant therapy is often withheld from these patients, because of the perceived bleeding diathesis. As a result of the limited clinical experience, the anticoagulant of choice for th...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 2; p. e88390
Main Authors:	Potze, Wilma, Arshad, Freeha, Adelmeijer, Jelle, Blokzijl, Hans, van den Berg, Arie P., Meijers, Joost C. M., Porte, Robert J., Lisman, Ton
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 04.02.2014 Public Library of Science (PLoS)
Subjects:	Anticoagulants Anticoagulants - therapeutic use Benzimidazoles - therapeutic use beta-Alanine - analogs & derivatives beta-Alanine - therapeutic use Bleeding Blood Coagulation Tests - methods Care and treatment Cirrhosis Complications Congenital diseases Dabigatran Drugs Female Gastroenterology Heparin Heparin, Low-Molecular-Weight - therapeutic use Hepatology Humans Laboratories Liver cirrhosis Liver Cirrhosis - metabolism Liver diseases Low molecular weight heparin Low molecular weights Male Medical research Medicine Middle Aged Molecular weight Morpholines - therapeutic use Patients Pharmacokinetics Pharmacology Plasma Polysaccharides - therapeutic use Rivaroxaban Surgery Thiophenes - therapeutic use Thrombin Thrombin - metabolism Thrombosis Veins & arteries Weight reduction
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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