Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation
Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (...
Uloženo v:
| Vydáno v: | PloS one Ročník 12; číslo 4; s. e0175278 |
|---|---|
| Hlavní autoři: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Public Library of Science
06.04.2017
Public Library of Science (PLoS) |
| Témata: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT).
Prospective measurements of CRP and ferritin, used as readouts of systemic inflammation, were performed in cryopreserved serum samples from 165 Brazilian patients with active PTB initiating ATT. Associations between levels of these laboratory parameters with mycobacterial loads in sputum as well as with sputum conversion at day 60 of ATT were tested.
Circulating levels of both ferritin and CRP gradually decreased over time on ATT. At pre-treatment, concentrations of these parameters were unable to distinguish patients with positive from those with negative acid-fast bacilli (AFB) in sputum cultures. However, patients who remained with positive cultures at day 60 of ATT exhibited heightened levels of these inflammatory markers compared to those with negative cultures at that time point.
CRP and Ferritin levels in serum may be useful to identify patients with positive cultures at day 60 of ATT. |
|---|---|
| AbstractList | Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT). Circulating levels of both ferritin and CRP gradually decreased over time on ATT. At pre-treatment, concentrations of these parameters were unable to distinguish patients with positive from those with negative acid-fast bacilli (AFB) in sputum cultures. However, patients who remained with positive cultures at day 60 of ATT exhibited heightened levels of these inflammatory markers compared to those with negative cultures at that time point. CRP and Ferritin levels in serum may be useful to identify patients with positive cultures at day 60 of ATT. Background Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT). Methods Prospective measurements of CRP and ferritin, used as readouts of systemic inflammation, were performed in cryopreserved serum samples from 165 Brazilian patients with active PTB initiating ATT. Associations between levels of these laboratory parameters with mycobacterial loads in sputum as well as with sputum conversion at day 60 of ATT were tested. Results Circulating levels of both ferritin and CRP gradually decreased over time on ATT. At pre-treatment, concentrations of these parameters were unable to distinguish patients with positive from those with negative acid-fast bacilli (AFB) in sputum cultures. However, patients who remained with positive cultures at day 60 of ATT exhibited heightened levels of these inflammatory markers compared to those with negative cultures at that time point. Conclusions CRP and Ferritin levels in serum may be useful to identify patients with positive cultures at day 60 of ATT. Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT).Prospective measurements of CRP and ferritin, used as readouts of systemic inflammation, were performed in cryopreserved serum samples from 165 Brazilian patients with active PTB initiating ATT. Associations between levels of these laboratory parameters with mycobacterial loads in sputum as well as with sputum conversion at day 60 of ATT were tested.Circulating levels of both ferritin and CRP gradually decreased over time on ATT. At pre-treatment, concentrations of these parameters were unable to distinguish patients with positive from those with negative acid-fast bacilli (AFB) in sputum cultures. However, patients who remained with positive cultures at day 60 of ATT exhibited heightened levels of these inflammatory markers compared to those with negative cultures at that time point.CRP and Ferritin levels in serum may be useful to identify patients with positive cultures at day 60 of ATT. Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT). Prospective measurements of CRP and ferritin, used as readouts of systemic inflammation, were performed in cryopreserved serum samples from 165 Brazilian patients with active PTB initiating ATT. Associations between levels of these laboratory parameters with mycobacterial loads in sputum as well as with sputum conversion at day 60 of ATT were tested. Circulating levels of both ferritin and CRP gradually decreased over time on ATT. At pre-treatment, concentrations of these parameters were unable to distinguish patients with positive from those with negative acid-fast bacilli (AFB) in sputum cultures. However, patients who remained with positive cultures at day 60 of ATT exhibited heightened levels of these inflammatory markers compared to those with negative cultures at that time point. CRP and Ferritin levels in serum may be useful to identify patients with positive cultures at day 60 of ATT. Background Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT). Methods Prospective measurements of CRP and ferritin, used as readouts of systemic inflammation, were performed in cryopreserved serum samples from 165 Brazilian patients with active PTB initiating ATT. Associations between levels of these laboratory parameters with mycobacterial loads in sputum as well as with sputum conversion at day 60 of ATT were tested. Results Circulating levels of both ferritin and CRP gradually decreased over time on ATT. At pre-treatment, concentrations of these parameters were unable to distinguish patients with positive from those with negative acid-fast bacilli (AFB) in sputum cultures. However, patients who remained with positive cultures at day 60 of ATT exhibited heightened levels of these inflammatory markers compared to those with negative cultures at that time point. Conclusions CRP and Ferritin levels in serum may be useful to identify patients with positive cultures at day 60 of ATT. Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT).BACKGROUNDClinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis infection and the lack of early biomarkers that predict treatment outcomes. Host Inflammation markers have been associated with tuberculosis (TB) pathogenesis. In the present study, we tested if circulating levels of C-reactive protein (CRP) and ferritin reflect mycobacterial loads and inflammation in pulmonary TB (PTB) patients undergoing anti-tuberculous therapy (ATT).Prospective measurements of CRP and ferritin, used as readouts of systemic inflammation, were performed in cryopreserved serum samples from 165 Brazilian patients with active PTB initiating ATT. Associations between levels of these laboratory parameters with mycobacterial loads in sputum as well as with sputum conversion at day 60 of ATT were tested.METHODSProspective measurements of CRP and ferritin, used as readouts of systemic inflammation, were performed in cryopreserved serum samples from 165 Brazilian patients with active PTB initiating ATT. Associations between levels of these laboratory parameters with mycobacterial loads in sputum as well as with sputum conversion at day 60 of ATT were tested.Circulating levels of both ferritin and CRP gradually decreased over time on ATT. At pre-treatment, concentrations of these parameters were unable to distinguish patients with positive from those with negative acid-fast bacilli (AFB) in sputum cultures. However, patients who remained with positive cultures at day 60 of ATT exhibited heightened levels of these inflammatory markers compared to those with negative cultures at that time point.RESULTSCirculating levels of both ferritin and CRP gradually decreased over time on ATT. At pre-treatment, concentrations of these parameters were unable to distinguish patients with positive from those with negative acid-fast bacilli (AFB) in sputum cultures. However, patients who remained with positive cultures at day 60 of ATT exhibited heightened levels of these inflammatory markers compared to those with negative cultures at that time point.CRP and Ferritin levels in serum may be useful to identify patients with positive cultures at day 60 of ATT.CONCLUSIONSCRP and Ferritin levels in serum may be useful to identify patients with positive cultures at day 60 of ATT. |
| Audience | Academic |
| Author | Gil-Santana, Leonardo Oliveira, Marina G. Andrade, Bruno B. Rauwerdink, Anneloek Cobelens, Frank Miranda, Pryscila Mesquita, Eliene D. D. Kritski, Afrânio Silva, Elisangela Oliveira, Martha M. |
| AuthorAffiliation | 1 Tuberculosis Academic Program, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil 2 Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil 9 Development Center for Technology on Health (CDTS) Fundação Oswaldo Cruz, Rio de Janeiro, Brazil 8 Amsterdam Institute for Global Health and Development, Academic Medical Centre, Amsterdam, The Netherlands Institut de Pharmacologie et de Biologie Structurale, FRANCE 4 Curso de Medicina, Faculdade de Tecnologia e Ciências (FTC), Salvador, Brazil 3 Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, Salvador, Brazil 6 Recognize the Biology Laboratory, Center of Bioscience and Biotechnology, State University of North Fluminense Darcy Ribeiro, Rio de Janeiro, Brazil 11 Universidade Salvador (UNIFACS), Laureate International Universities, Salvador, Brazil 5 Ary Parreira Institute, State Secretary of Health of Rio de Janeiro, Rio de Janeiro, B |
| AuthorAffiliation_xml | – name: 2 Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil – name: 11 Universidade Salvador (UNIFACS), Laureate International Universities, Salvador, Brazil – name: 3 Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, Salvador, Brazil – name: 5 Ary Parreira Institute, State Secretary of Health of Rio de Janeiro, Rio de Janeiro, Brazil – name: 9 Development Center for Technology on Health (CDTS) Fundação Oswaldo Cruz, Rio de Janeiro, Brazil – name: 10 Escola Bahiana de Medicina e Saúde Pública, Salvador, Brazil – name: 6 Recognize the Biology Laboratory, Center of Bioscience and Biotechnology, State University of North Fluminense Darcy Ribeiro, Rio de Janeiro, Brazil – name: 8 Amsterdam Institute for Global Health and Development, Academic Medical Centre, Amsterdam, The Netherlands – name: 1 Tuberculosis Academic Program, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil – name: Institut de Pharmacologie et de Biologie Structurale, FRANCE – name: 7 Rede Brasileira de Pesquisas em Tuberculose (Rede TB), Rio de Janeiro, Brazil – name: 4 Curso de Medicina, Faculdade de Tecnologia e Ciências (FTC), Salvador, Brazil |
| Author_xml | – sequence: 1 givenname: Pryscila surname: Miranda fullname: Miranda, Pryscila – sequence: 2 givenname: Leonardo surname: Gil-Santana fullname: Gil-Santana, Leonardo – sequence: 3 givenname: Marina G. surname: Oliveira fullname: Oliveira, Marina G. – sequence: 4 givenname: Eliene D. D. surname: Mesquita fullname: Mesquita, Eliene D. D. – sequence: 5 givenname: Elisangela surname: Silva fullname: Silva, Elisangela – sequence: 6 givenname: Anneloek surname: Rauwerdink fullname: Rauwerdink, Anneloek – sequence: 7 givenname: Frank surname: Cobelens fullname: Cobelens, Frank – sequence: 8 givenname: Martha M. surname: Oliveira fullname: Oliveira, Martha M. – sequence: 9 givenname: Bruno B. orcidid: 0000-0001-6833-3811 surname: Andrade fullname: Andrade, Bruno B. – sequence: 10 givenname: Afrânio surname: Kritski fullname: Kritski, Afrânio |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28384354$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk22L1DAQx4uceA_6DUQLguiLXdumj74QjsWHhYMDT30bpul0N0ea9JJ00e_hB3Z2tyvb4xBpIcnkN__MTCbnwYk2GoPgeRzNY1bE727NYDWoeU_meRQXWVKUj4KzuGLJLE8idnI0Pw3OnbuNooyVef4kOE1KVqYsS8-C3zeD8yA1NiEq3ICnCY2oXGjacDGzCMLLDYa9NR6lDkE3YYvWSk8L-vtBdUaD_RX6oUYrBmWcdGEPXqL2LrTYkbzUq5C2_GBJiYCd5EChh55O8B2hJEZmcjP6afC4BeXw2TheBN8_ffy2-DK7uv68XFxezUReJX4W17EQEEXQ5nGSQJ0A5VfXZS5yTKEtEwFlU9VCNEnTCkCIU6hZ1EYsKkWGyC6Cl3vdnoLmY0Edj8syi6osLioilnuiMXDLeys7ypQbkHxnMHbFwXopFHKWtlVVF0UjoEqbKq9TuhQE1iTYMMwYaX0YTxvqDhtBOVtQE9HpjpZrvjIbTlkxujESeDMKWHM3oPO8k06gUqDRDPu4KWyWZoS-uoc-nN1IrYASkLo1dK7YivLLtGJFnhZZSdT8AYq-BjspqPtaSfaJw9uJAzEef_oVDM7x5c3X_2evf0zZ10fsGkH5tTNq2LaMm4Ivjiv9t8SHtifg_R4Q1jhnseVC-l3rUWpS8Tji2zd2KBrfvjE-vjFyTu85H_T_6fYHtTcw6Q |
| CitedBy_id | crossref_primary_10_1183_13993003_01089_2018 crossref_primary_10_1371_journal_pgph_0004873 crossref_primary_10_1038_s41598_021_93059_1 crossref_primary_10_3389_fcimb_2021_595554 crossref_primary_10_1111_resp_14230 crossref_primary_10_3389_fimmu_2020_00586 crossref_primary_10_1111_crj_13677 crossref_primary_10_1186_s13052_024_01664_3 crossref_primary_10_1371_journal_pone_0233426 crossref_primary_10_1016_j_nmni_2025_101582 crossref_primary_10_1093_infdis_jiaf069 crossref_primary_10_1128_jcm_01859_21 crossref_primary_10_1016_j_dld_2017_12_008 crossref_primary_10_1080_14787210_2021_1898945 crossref_primary_10_1186_s12879_024_10228_z crossref_primary_10_4103_ijmy_ijmy_244_21 crossref_primary_10_1016_j_ijtb_2020_09_013 crossref_primary_10_1016_j_cyto_2019_154759 crossref_primary_10_1016_j_amjms_2021_12_014 crossref_primary_10_1097_MD_0000000000029297 crossref_primary_10_7759_cureus_27746 crossref_primary_10_1038_s41598_018_37860_5 crossref_primary_10_3390_antibiotics13121216 crossref_primary_10_1016_j_ijid_2020_05_109 crossref_primary_10_1111_imm_13023 |
| Cites_doi | 10.1371/journal.pone.0037350 10.1016/j.cyto.2016.02.004 10.1093/cid/ciu945 10.1155/2015/385402 10.1128/JB.05553-11 10.1186/1471-2334-13-48 10.1016/j.tube.2015.01.003 10.1017/S0007114508162122 10.1097/CCM.0000000000001607 10.1176/ajp.131.10.1121 10.1590/S1806-37132014000400008 10.1038/nature13489 10.1186/1758-2652-14-19 10.1007/s10517-013-2013-8 10.1016/j.tube.2015.02.042 10.1016/S1473-3099(14)71055-2 10.1093/trstmh/trs005 10.1038/bmt.2015.17 10.1016/S1473-3099(16)00070-0 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2017 Public Library of Science 2017 Miranda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2017 Miranda et al 2017 Miranda et al |
| Copyright_xml | – notice: COPYRIGHT 2017 Public Library of Science – notice: 2017 Miranda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2017 Miranda et al 2017 Miranda et al |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0175278 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) One Sustainability ProQuest Central UK/Ireland ProQuest SciTech Premium Collection Technology Collection Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials - QC ProQuest SciTech Premium Collection Natural Science Collection Biological Science Collection ProQuest Central ProQuest Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database Health & Medical Collection (Alumni Edition) Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE Agricultural Science Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals - Not for CDI Discovery url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| DocumentTitleAlternate | CRP and ferritin in TB patients undergoing treatment |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1885095179 oai_doaj_org_article_34f99b77dca94d96b4017ea3d2ed3e53 PMC5383283 A493764758 28384354 10_1371_journal_pone_0175278 |
| Genre | Journal Article |
| GeographicLocations | Brazil Rio de Janeiro Brazil |
| GeographicLocations_xml | – name: Rio de Janeiro Brazil – name: Brazil |
| GrantInformation_xml | – fundername: ; grantid: E-26/110.974/2011 – fundername: ; grantid: INCT 573548/2008-0 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM 3V. ALIPV BBORY CGR CUY CVF ECM EIF IPNFZ NPM RIG 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI RC3 7X8 PUEGO 5PM AAPBV ABPTK N95 |
| ID | FETCH-LOGICAL-c692t-1b1cca00af6122ab2a538bb86c6e4af82ca8d9bccd2dfcaea14ab30f0308c5ee3 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 30 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000399371900145&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Sun May 07 16:28:26 EDT 2023 Mon Nov 10 04:35:57 EST 2025 Tue Nov 04 01:55:17 EST 2025 Mon Sep 08 10:49:08 EDT 2025 Tue Oct 07 07:24:24 EDT 2025 Sat Nov 29 13:00:05 EST 2025 Sat Nov 29 09:53:19 EST 2025 Wed Nov 26 09:51:38 EST 2025 Wed Nov 26 09:24:12 EST 2025 Thu May 22 21:19:24 EDT 2025 Wed Feb 19 02:15:15 EST 2025 Tue Nov 18 22:26:20 EST 2025 Sat Nov 29 06:20:15 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c692t-1b1cca00af6122ab2a538bb86c6e4af82ca8d9bccd2dfcaea14ab30f0308c5ee3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceptualization: LG-S BBA AK.Data curation: PM LG-S MGO EDDM ES AR.Formal analysis: LG-S BBA.Funding acquisition: AK FC MMO.Investigation: PM MGO EDDM ES AR FC MMO AK.Methodology: LG-S BBA.Project administration: MMO AK.Resources: PM LG-S MGO EDDM FC MMO AK BBA.Software: LG-S BBA.Supervision: AK BBA.Validation: BBA.Visualization: LG-S BBA.Writing – original draft: LG-S BBA.Writing – review & editing: PM LG-S ES FC BBA AK. These authors also contributed equally to this work |
| ORCID | 0000-0001-6833-3811 |
| OpenAccessLink | https://www.proquest.com/docview/1885095179?pq-origsite=%requestingapplication% |
| PMID | 28384354 |
| PQID | 1885095179 |
| PQPubID | 1436336 |
| PageCount | e0175278 |
| ParticipantIDs | plos_journals_1885095179 doaj_primary_oai_doaj_org_article_34f99b77dca94d96b4017ea3d2ed3e53 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5383283 proquest_miscellaneous_1885951345 proquest_journals_1885095179 gale_infotracmisc_A493764758 gale_infotracacademiconefile_A493764758 gale_incontextgauss_ISR_A493764758 gale_incontextgauss_IOV_A493764758 gale_healthsolutions_A493764758 pubmed_primary_28384354 crossref_citationtrail_10_1371_journal_pone_0175278 crossref_primary_10_1371_journal_pone_0175278 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-04-06 |
| PublicationDateYYYYMMDD | 2017-04-06 |
| PublicationDate_xml | – month: 04 year: 2017 text: 2017-04-06 day: 06 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2017 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | (ref25) 1998 S Isanaka (ref19) 2012; 7 IA Kuznetsov (ref8) 2013; 154 H Friis (ref15) 2009; 102 ref2 RS Wallis (ref6) 2016; 16 ref1 JR Koethe (ref11) 2011; 14 MG Oliveira (ref17) 2014; 40 PA Minchella (ref9) 2015; 60 S Subbian (ref18) 2015; 2015 R Jacobs (ref7) 2016; 81 F Tacke (ref12) 2016; 44 GP Kubica (ref24) 1963; 87 H Bouharras El Idrissi (ref10) 2015; 32 PV Reddy (ref13) 2012; 194 V Clifford (ref4) 2015; 95 M Tanaka (ref14) 2015; 50 KD Mayer-Barber (ref22) 2014; 511 PA Minchella (ref20) 2015; 95 ML Plit (ref23) 1998; 2 G Walzl (ref5) 2014; 5 S Sivakolundu (ref21) 2013; 107 E Petersen (ref3) 2015; 15 DG Mayfield (ref26) 1974; 131 JM McDermid (ref16) 2013; 13 22101841 - J Bacteriol. 2012 Feb;194(3):567-75 27036358 - Lancet Infect Dis. 2016 Apr;16(4):e34-46 22606361 - PLoS One. 2012;7(5):e37350 25730191 - Bone Marrow Transplant. 2015 May;50(5):727-33 4416585 - Am J Psychiatry. 1974 Oct;131(10):1121-3 25210963 - J Bras Pneumol. 2014 Jul-Aug;40(4):403-10 26339659 - J Immunol Res. 2015;2015:385402 26878648 - Cytokine. 2016 May;81:50-6 25797612 - Tuberculosis (Edinb). 2015 May;95(3):217-28 25428413 - Clin Infect Dis. 2015 Mar 1;60(5):764-72 19175946 - Br J Nutr. 2009 Jul;102(2):310-7 23360117 - BMC Infect Dis. 2013 Jan 29;13:48 24990750 - Nature. 2014 Jul 3;511(7507):99-103 23658882 - Bull Exp Biol Med. 2013 Mar;154(5):618-21 26667743 - Nutr Hosp. 2015 Dec 01;32(6):2848-54 25477023 - Lancet Infect Dis. 2015 Jan;15(1):6-8 13927224 - Am Rev Respir Dis. 1963 May;87:775-9 26934143 - Crit Care Med. 2016 Jun;44(6):1049-58 25475107 - Cold Spring Harb Perspect Med. 2014 Dec 04;5(4):null 9661828 - Int J Tuberc Lung Dis. 1998 Jul;2(7):590-6 23222944 - Trans R Soc Trop Med Hyg. 2013 Jan;107(1):43-50 25764944 - Tuberculosis (Edinb). 2015 May;95(3):288-93 21477359 - J Int AIDS Soc. 2011 Apr 10;14:19 |
| References_xml | – volume: 7 start-page: e37350 year: 2012 ident: ref19 article-title: Iron status predicts treatment failure and mortality in tuberculosis patients: a prospective cohort study from Dar es Salaam, Tanzania publication-title: PLoS One doi: 10.1371/journal.pone.0037350 – ident: ref1 – volume: 81 start-page: 50 year: 2016 ident: ref7 article-title: Host biomarkers detected in saliva show promise as markers for the diagnosis of pulmonary tuberculosis disease and monitoring of the response to tuberculosis treatment publication-title: Cytokine doi: 10.1016/j.cyto.2016.02.004 – volume: 60 start-page: 764 year: 2015 ident: ref9 article-title: Complex anemia in tuberculosis: the need to consider causes and timing when designing interventions publication-title: Clin Infect Dis doi: 10.1093/cid/ciu945 – volume: 2015 year: 2015 ident: ref18 article-title: Vaccination with an Attenuated Ferritin Mutant Protects Mice against Virulent Mycobacterium tuberculosis publication-title: J Immunol Res doi: 10.1155/2015/385402 – volume: 2 start-page: 590 year: 1998 ident: ref23 article-title: Influence of antimicrobial chemotherapy and smoking status on the plasma concentrations of vitamin C, vitamin E, beta-carotene, acute phase reactants, iron and lipid peroxides in patients with pulmonary tuberculosis publication-title: Int J Tuberc Lung Dis – volume: 194 start-page: 567 year: 2012 ident: ref13 article-title: Iron storage proteins are essential for the survival and pathogenesis of Mycobacterium tuberculosis in THP-1 macrophages and the guinea pig model of infection publication-title: J Bacteriol doi: 10.1128/JB.05553-11 – volume: 13 start-page: 48 year: 2013 ident: ref16 article-title: Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11-year retrospective cohort study publication-title: BMC Infect Dis doi: 10.1186/1471-2334-13-48 – volume: 95 start-page: 217 year: 2015 ident: ref4 article-title: Cytokines for monitoring anti-tuberculous therapy: A systematic review publication-title: Tuberculosis (Edinb) doi: 10.1016/j.tube.2015.01.003 – volume: 102 start-page: 310 year: 2009 ident: ref15 article-title: Acute- phase response and iron status markers among pulmonary tuberculosis patients: a cross-sectional study in Mwanza, Tanzania publication-title: Br J Nutr doi: 10.1017/S0007114508162122 – volume: 32 start-page: 2848 year: 2015 ident: ref10 article-title: Imbalances in Protein Metabolism in Critical Care Patient with Systemic Inflammatory Response Syndrome at Admission in Intensive Care Unit publication-title: Nutr Hosp – volume: 44 start-page: 1049 year: 2016 ident: ref12 article-title: Iron Parameters Determine the Prognosis of Critically Ill Patients publication-title: Crit Care Med doi: 10.1097/CCM.0000000000001607 – volume: 131 start-page: 1121 year: 1974 ident: ref26 article-title: The CAGE questionnaire validation of a new alcoholism screening instrument publication-title: Am J Psychiatry doi: 10.1176/ajp.131.10.1121 – volume: 40 start-page: 403 year: 2014 ident: ref17 article-title: Anemia in hospitalized patients with pulmonary tuberculosis publication-title: J Bras Pneumol doi: 10.1590/S1806-37132014000400008 – ident: ref2 – year: 1998 ident: ref25 article-title: Laboratory Services in Tuberculosis Control, Part II – volume: 511 start-page: 99 year: 2014 ident: ref22 article-title: Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk publication-title: Nature doi: 10.1038/nature13489 – volume: 14 start-page: 19 year: 2011 ident: ref11 article-title: Nutrition and inflammation serum biomarkers are associated with 12-week mortality among malnourished adults initiating antiretroviral therapy in Zambia publication-title: J Int AIDS Soc doi: 10.1186/1758-2652-14-19 – volume: 154 start-page: 618 year: 2013 ident: ref8 article-title: Iron-containing proteins lactoferrin and ferritin in biological media of patients with pulmonary tuberculosis publication-title: Bull Exp Biol Med doi: 10.1007/s10517-013-2013-8 – volume: 95 start-page: 288 year: 2015 ident: ref20 article-title: Iron homeostasis and progression to pulmonary tuberculosis disease among household contacts publication-title: Tuberculosis (Edinb) doi: 10.1016/j.tube.2015.02.042 – volume: 15 start-page: 6 year: 2015 ident: ref3 article-title: Reflections on travel-associated infections in Europe publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(14)71055-2 – volume: 107 start-page: 43 year: 2013 ident: ref21 article-title: Serum iron profile and ELISA-based detection of antibodies against the iron-regulated protein HupB of Mycobacterium tuberculosis in TB patients and household contacts in Hyderabad (Andhra Pradesh), India publication-title: Trans R Soc Trop Med Hyg doi: 10.1093/trstmh/trs005 – volume: 87 start-page: 775 year: 1963 ident: ref24 article-title: Sputum digestion and decontamination with N-acetyl-L-cysteine-sodium hydroxide for culture of mycobacteria publication-title: Am Rev Respir Dis – volume: 50 start-page: 727 year: 2015 ident: ref14 article-title: Clinical significance of pretransplant serum ferritin on the outcome of allogeneic hematopoietic SCT: a prospective cohort study by the Kanto Study Group for Cell Therapy publication-title: Bone Marrow Transplant doi: 10.1038/bmt.2015.17 – volume: 5 year: 2014 ident: ref5 article-title: Clinical immunology and multiplex biomarkers of human tuberculosis publication-title: Cold Spring Harb Perspect Med – volume: 16 start-page: e34 year: 2016 ident: ref6 article-title: Tuberculosis—advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(16)00070-0 – reference: 24990750 - Nature. 2014 Jul 3;511(7507):99-103 – reference: 25210963 - J Bras Pneumol. 2014 Jul-Aug;40(4):403-10 – reference: 23222944 - Trans R Soc Trop Med Hyg. 2013 Jan;107(1):43-50 – reference: 4416585 - Am J Psychiatry. 1974 Oct;131(10):1121-3 – reference: 25428413 - Clin Infect Dis. 2015 Mar 1;60(5):764-72 – reference: 25764944 - Tuberculosis (Edinb). 2015 May;95(3):288-93 – reference: 23658882 - Bull Exp Biol Med. 2013 Mar;154(5):618-21 – reference: 26934143 - Crit Care Med. 2016 Jun;44(6):1049-58 – reference: 22606361 - PLoS One. 2012;7(5):e37350 – reference: 26339659 - J Immunol Res. 2015;2015:385402 – reference: 25730191 - Bone Marrow Transplant. 2015 May;50(5):727-33 – reference: 13927224 - Am Rev Respir Dis. 1963 May;87:775-9 – reference: 25477023 - Lancet Infect Dis. 2015 Jan;15(1):6-8 – reference: 25797612 - Tuberculosis (Edinb). 2015 May;95(3):217-28 – reference: 26667743 - Nutr Hosp. 2015 Dec 01;32(6):2848-54 – reference: 9661828 - Int J Tuberc Lung Dis. 1998 Jul;2(7):590-6 – reference: 22101841 - J Bacteriol. 2012 Feb;194(3):567-75 – reference: 19175946 - Br J Nutr. 2009 Jul;102(2):310-7 – reference: 26878648 - Cytokine. 2016 May;81:50-6 – reference: 25475107 - Cold Spring Harb Perspect Med. 2014 Dec 04;5(4):null – reference: 27036358 - Lancet Infect Dis. 2016 Apr;16(4):e34-46 – reference: 23360117 - BMC Infect Dis. 2013 Jan 29;13:48 – reference: 21477359 - J Int AIDS Soc. 2011 Apr 10;14:19 |
| SSID | ssj0053866 |
| Score | 2.3845222 |
| Snippet | Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium tuberculosis... Background Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium... Background Clinical trials that evaluate new anti-tubercular drugs and treatment regimens take years to complete due to the slow clearance of Mycobacterium... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0175278 |
| SubjectTerms | Acute phase proteins Acute phase substances Adult Alcoholism Anemia Animal models Antibodies Antiinfectives and antibacterials Antitubercular Agents - therapeutic use Ascorbic acid Attenuation Autoimmune diseases Bacilli Bacteria Biochemistry Biology and Life Sciences Biomarkers Biotechnology Bone marrow Bone marrow transplantation C-reactive protein C-Reactive Protein - metabolism Cages Care and treatment Carotene Cell culture Cell survival Chemotherapy Clinical outcomes Clinical trials Decontamination Diagnosis Digestion Drug abuse Drug resistance Female Ferritin Ferritins - metabolism Genetic aspects Health aspects Health risk assessment HIV Homeostasis Human immunodeficiency virus Humans Infections Inflammation Interferon Interleukin 1 Loads (forces) Lung diseases Male Malignancy Medicine and Health Sciences Middle Aged Mortality Patients Proteins Psychiatry Tuberculosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - metabolism Vitamin E |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Li9RAEG5k8OBFXF8bXbUVQT1kd5LudNLHdXFRkFVclb2FflR0YMwMyUTwf_iDrX5MmMjCehBySbq6yVRVV75mqr4i5LnlplSiMClkwFKuoUw1L2SaWdBFBbi9wBcKvy_PzqqLC_lxp9WXywkL9MBBcUeMN1LqsrRGSW6l0HggKEExm4NlUHieT0Q928NUiMG4i4WIhXKszI6iXQ7XqxYOcX6Ru7ZqOx8iz9c_RuXZernqL4Ocf2dO7nyKTm-RmxFD0uPw7nvkGrS3yV7cpT19GamkX90hv89DfRRY6urIEVdaunRpQj1dNfQkRcTo4x31dA2LlqrW0saRNW7wBq_1sEQ_Vd0vuhk0dGbAV170NLKx9rSDH6HFBA0UHriSzwLDJQdUAx3z2HExfOzd4C75cvrm88nbNPZhSI2Q-SbNdIZ2ns9Vg3AoVzpXqF-tK2EEcNVUuVGVldoYm9vGKFAZV5rNG0eFYwoAdo_MWtT8PqEM4Z9ttMoFSA6y0bZAAVVlRgsDSiWEbY1Sm0hS7nplLGv_z1uJh5Wg49qZso6mTEg6zloHko4r5F87e4-yjmLbP0DHq6Pj1Vc5XkKeOG-pQ73qGCjqY46IT3A8hyXkmZdwNButy-P5poa-r999-PoPQuefJkIvolCzQnUYFWsn8Dc5-q6J5MFEEoOFmQzvO9_eaqWvs6oqHMouJc7c-vvlw0_HYbeoy81rYTUEGRRhvEjI_bA9Rs0ieK0QkPOElJONM1H9dKRdfPcs5-hjDKc_-B-2ekhu5A6OuYwrcUBmm26AR-S6-blZ9N1jHzr-AOSLfQo priority: 102 providerName: Directory of Open Access Journals – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZg4cAFKK8GChiEBBxSNrFjx8dSUYFUlYoC6i3yYwIrLdnVZoPE_-AHM3a8gVStACmXxGPLGc9MPisznwl55riVWhQ2hQxYyg3I1PBCpZkDU5SA7gWhUPhQHh2Vp6fq-PdG8cwffCazV1Gnu8tFA7toP0Uuy8vkSs6E8ClcB8eHm8iLvitELI-7qOfo8xNY-odYPFnOF-15QPNsvuQfH6CDG_879ZvkeoSadK-3jS1yCZpbZCs6c0tfRMbpl7fJz5O-jAoc9eXmCD8dnftsopYuarqfIrAMYZEGVodZQ3XjaO05Hdd4g9eym6M569UPuu4MrGyH7zhraSRtbekKvvUnUdCe6QNHCsliOGSH06ZDujsOho-Dtdwhnw7efNx_m8bjGlIrVL5OM5OhOUynukbUlGuTa1wQY0phBXBdl7nVpVPGWpe72mrQGdeGTWvPmGMLAHaXTBrU1DahDFGiq43OBSgOqjauQAFdZtYIC1onhG1WsbKRy9wfqTGvwg86iXuaXseVV30VVZ-QdOi17Lk8_iL_2hvIIOuZuMMDXOMqOnbFeK2UkdJZrbhTwuCGVYJmLgfHoGAJeezNq-rLWod4Uu1xBIaC43YtIU-DhGfjaHy6zxfdtW317v3nfxA6-TASeh6F6gWqw-pYYoHv5Fm-RpI7I0mMKXbUvO2dYaOVtsrKsvBgXCrsuXGQ85ufDM1-UJ_C18Ci62VQhPEiIfd6fxo0ixi3RNzOEyJHnjZS_bilmX0NZOhoYwy73794xg_ItdxjMZ9uJXbIZL3q4CG5ar-vZ-3qUYggvwCcs3j8 priority: 102 providerName: Public Library of Science |
| Title | Sustained elevated levels of C-reactive protein and ferritin in pulmonary tuberculosis patients remaining culture positive upon treatment initiation |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/28384354 https://www.proquest.com/docview/1885095179 https://www.proquest.com/docview/1885951345 https://pubmed.ncbi.nlm.nih.gov/PMC5383283 https://doaj.org/article/34f99b77dca94d96b4017ea3d2ed3e53 http://dx.doi.org/10.1371/journal.pone.0175278 |
| Volume | 12 |
| WOSCitedRecordID | wos000399371900145&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals - Not for CDI Discovery customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database (Proquest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdYxwMvwPhaYBSDkICHdE2czye0VquYtpWog6njJfJXRqWSlKRB4v_gD-bsuGFBEyAhVSc1PrvN-e5ydu5-Ruil8HhIA5_b0pHE9pgMbeb5se0IyfxIgnlJXSh8Ek6n0XweJ2bDrTJplRufqB21KLjaI993oshX4UAYv119tdWpUertqjlCYwttK5QEolP3ko0nBlsOAlMuR0Jn38zOYFXkcgCa6LvqcLUrjyON2t_65t5qWVTXBZ6_509eeSBN7vzvrdxFt00oig8a3dlBN2R-D-0YY6_wa4NI_eY--nHWlFlJgVU5OoSnAi9VtlGFiwyPbQg8tdvEGvVhkWOaC5wpzMc1fIHPql7Cj9LyO17XTJa8hnteVNiAula4lF-akypwgwQCI-lkMhiyBjniNh0eBoPLWpseoI-Tww_jd7Y5zsHmQeyubYc5oC7DIc0gqnIpcylMEGNRwAPp0SxyOY1EzDgXrsg4ldTxKCPDTCHqcF9K8hD1cpi6XYQJRJEiY9QNZOzJOGPCBwYaOZwFXFJqIbKZ1ZQbrHN15MYy1S_wQljzNDJOlS6kRhcsZLe9Vg3Wx1_4R0phWl6F1K0vFOVlagw_JV4WxywMBaexJ-KAwYI2lJQIVwoifWKhZ0rd0qbstfU36YEHgWPgwXLOQi80h0LryFU60CWtqyo9en_-D0xnsw7TK8OUFSAOTk0JBtyTQgHrcO51OMHn8E7zrjKOjVSq9JdKQ8-N0l_f_LxtVoOqFL9cFnXDAyzE8y30qLGvVrIQA0cQ13sWCjuW1xF9tyVffNZg6aBjBLo__vPfeoJuuSpeUylZwR7qrctaPkU3-bf1oir7aCucnSs6DzWNgEZjp4-2R4fTZNbXGzlAJ8kJ0OPRAOjp8LivvZGmZ0AT_xP0SI5Ok4ufBQuXUw |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELbKggQXoLwaKNQgEHBIu4md1wGhUqi66rKgtlS9Bb9SVlqSJdmA-j_4HfxGxo4TGlQBlx6Qckk8HiWTmfE4mfkGoceSioiFgXCVp4hLuYpcToPE9aTiQazAvJQpFB5Hk0l8dJS8X0I_2loYnVbZ-kTjqGUh9DfyDS-OAx0ORMnL-RdXd43Sf1fbFhqNWuyqk2-wZatejF7D-33i-9tvDrZ2XNtVwBVh4i9cj3tw18Mhy2Bx9xn3Gdg853EoQkVZFvuCxTLhQkhfZoIp5lHGyTDTwC4iUIoA3wvoIvhxT6eQRXuHrecHPmFoy_NI5G1YbVifF7laB80PfN3M7dTyZ7oEdGvBYD4rqrMC3d_zNU8tgNvX_jfRXUdXbaiNNxvbWEZLKr-Blq0zq_Azi7j9_Cb6vt-UkSmJdbk9hN8Sz3Q2VYWLDG-5EFibZQEbVItpjlkucaYxLRdwAse8nsFDsvIEL2quSlGDjKcVtqC1FS7V56YTB26QToCTSZYDljW8N9yl-wMzuGys5Rb6cC7SuY0GOajKCsIEomSZceaHKqEqybgMgIDFnuChUIw5iLRalAqL5a5bisxS84Mygj1dI-NU615qdc9Bbjdr3mCZ_IX-lVbQjlYjkZsLRXmcWseWEpolCY8iKVhCZRJy2LBHihHpK0lUQBy0ptU7bcp6O3-ablIIjEMK21UHPTIUGo0k1-lOx6yuqnT07vAfiPb3ekRPLVFWgDgEsyUm8Ewa5axHudqjBJ8qesMr2hhbqVTpLxOCma2RnT38sBvWTHUKY66KuqEBEkIDB91p7LmTLMT4MexbqIOinqX3RN8fyaefDBg86BiB6Xf_fFtr6PLOwdtxOh5Ndu-hK76OTXX6WbiKBouyVvfRJfF1Ma3KB8ajYfTxvP3ATyXB7IQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELbKghAXoLwaKNQgEHBIdxM7rwNCZUvFqtVS0YJ6C36lrLQkS7IB9X_wa_h1jB0nNKgCLj0g5ZJ4PFpPZsbjzcw3CD2WVEQsDISrPEVcylXkchokricVD2IF5qVMofBeNJ3GR0fJ_gr60dbC6LTK1icaRy0Lof8jH3pxHOhwIEqGmU2L2N_eebn44uoOUvpLa9tOo1GRXXXyDY5v1YvJNrzrJ76_8_pw_Ma1HQZcESb-0vW4BysYjVgGG73PuM_A_jmPQxEqyrLYFyyWCRdC-jITTDGPMk5GmQZ5EYFSBPheQBcjAlqsq9THXXoJ8AlDW6pHIm9oNWNzUeRqE6wg8HVjt1NboekY0O0Lg8W8qM4Ken_P3Ty1Ge5c-5_FeB1dtSE43mpsZhWtqPwGWrVOrsLPLBL385vo-0FTXqYk1mX4EJZLPNdZVhUuMjx2IeA22wU2aBezHLNc4kxjXS7hBq5FPYdFsvIEL2uuSlGDvGcVtmC2FS7V56ZDB24QUICTSaIDljW8Q9yVAQAzeGys6BZ6fy7SuY0GOajNGsIEomeZceaHKqEqybgMgIDFnuChUIw5iLQalQqL8a5bjcxT8-EygrNeI-NU62Fq9dBBbjdr0WCc_IX-lVbWjlYjlJsHRXmcWoeXEpolCY8iKVhCZRJyOMhHihHpK0lUQBy0oVU9bcp9Oz-bblEImEMKx1gHPTIUGqUk14p6zOqqSidvP_wD0cG7HtFTS5QVIA7BbOkJrEmjn_Uo13uU4GtFb3hNG2YrlSr9ZU4wszW4s4cfdsOaqU5tzFVRNzRAQmjgoDuNbXeShdg_hvMMdVDUs_qe6Psj-eyTAYkHHSMw_e6ff9YGugzmn-5Nprv30BVfh6w6Ky1cR4NlWav76JL4upxV5QPj3DD6eN5u4CdmAvTf |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Sustained+elevated+levels+of+C-reactive+protein+and+ferritin+in+pulmonary+tuberculosis+patients+remaining+culture+positive+upon+treatment+initiation&rft.jtitle=PloS+one&rft.au=Miranda%2C+Pryscila&rft.au=Gil-Santana%2C+Leonardo&rft.au=Oliveira%2C+Marina+G&rft.au=Mesquita%2C+Eliene+D.+D&rft.date=2017-04-06&rft.pub=Public+Library+of+Science&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=12&rft.issue=4&rft.spage=e0175278&rft_id=info:doi/10.1371%2Fjournal.pone.0175278&rft.externalDBID=IOV&rft.externalDocID=A493764758 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |