Vitamin B12 and Folic Acid Improve Gross Motor and Problem-Solving Skills in Young North Indian Children: A Randomized Placebo-Controlled Trial

Deficiencies of vitamin B12 and folate are associated with delayed development and neurological manifestations. The objective of this study was to measure the effect of daily supplementation of vitamin B12 and/or folic acid on development in young North Indian children. In a randomized, double blind...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one Jg. 10; H. 6; S. e0129915
Hauptverfasser: Kvestad, Ingrid, Taneja, Sunita, Kumar, Tivendra, Hysing, Mari, Refsum, Helga, Yajnik, Chittaranjan S., Bhandari, Nita, Strand, Tor A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 22.06.2015
Public Library of Science (PLoS)
Schlagworte:
Acids
Anemia
Brain research
Child development
Child welfare
Child, Preschool
Children
Clinical trials
Consent
Cyanocobalamin
Delayed
Developmental delays
Developmental Disabilities - drug therapy
Dietary Supplements
Enrollments
Ethics
Factorial design
Female
Folic acid
Folic Acid - therapeutic use
Folic Acid Deficiency - drug therapy
Homocysteine
Humans
India
Infant
Male
Mental health
Motor skill
Motor Skills - drug effects
Nutrition
Pediatrics
Placebos
Problem solving
Problem Solving - drug effects
Randomization
Registration
Social Skills
Society
Studies
Subgroups
Supplements
Vitamin B
Vitamin B 12 - therapeutic use
Vitamin B 12 Deficiency - drug therapy
Vitamin B12
Vitamins
India
Norway
United States > US
Baltimore Maryland
ISSN:1932-6203, 1932-6203
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Deficiencies of vitamin B12 and folate are associated with delayed development and neurological manifestations. The objective of this study was to measure the effect of daily supplementation of vitamin B12 and/or folic acid on development in young North Indian children. In a randomized, double blind trial, children aged six to 30 months, received supplement with placebo or vitamin B12 and/or folic acid for six months. Children were allocated in a 1:1:1:1 ratio in a factorial design and in blocks of 16. We measured development in 422 children by the Ages and Stages Questionnaire 3rd ed. at the end of the intervention. Compared to placebo, children who received both vitamin B12 and folic acid had 0.45 (95% CI 0.19, 0.73) and 0.28 (95% CI 0.02, 0.54) higher SD-units in the domains of gross motor and problem solving functioning, respectively. The effect was highest in susceptible subgroups consisting of stunted children, those with high plasma homocysteine (> 10 μmol/L) or in those who were younger than 24 at end study. With the exception of a significant improvement on gross motor scores by vitamin B12 alone, supplementation of either vitamin alone had no effect on any of the outcomes. Our findings suggest that supplementation of vitamin B12 and folic acid benefit development in North Indian Children. ClinicalTrials.gov NCT00717730.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
Membership of the Folate and Vitamin B12 Study Group is listed in the Acknowledgments.
Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: IK ST TK HR CSY NB TAS. Performed the experiments: ST TK. Analyzed the data: IK HR TAS. Contributed reagents/materials/analysis tools: CSY. Wrote the paper: IK MH HR TAS.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0129915