Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin

Antigen exposure to oral mucosa is generally thought to lead to immune tolerance induction. However, very little is known about the subset composition and function of dendritic cells (DC) migrating from human oral mucosa. Here we show that migratory DC from healthy human gingival explants consist of...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 7; p. e0180333
Main Authors:	Kosten, Ilona Jennifer, van de Ven, Rieneke, Thon, Maria, Gibbs, Susan, de Gruijl, Tanja D.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 13.07.2017 Public Library of Science (PLoS)
Subjects:	Analysis Antigens Antigens, CD1 - metabolism Bacteria Biology and Life Sciences Cell Differentiation Cell Movement Chemokines CXCR4 protein Cytokines Cytokines - metabolism Dendritic cells Dendritic Cells - cytology Dendritic Cells - immunology Dermatology Differentiation (biology) Explants Frequency distribution Functional analysis Gingiva Health aspects Humans Immunity Immunization Immunological tolerance Inflammation Langerhans Cells - cytology Langerhans Cells - immunology Lymphatic system Lymphocytes Lymphocytes T Medicine and Health Sciences Mouth Mucosa - cytology Mouth Mucosa - metabolism Mucosa Mucous membrane Oral mucosa Phenotype Receptors, CXCR4 - metabolism Risk factors Skin Skin - cytology Skin - metabolism Steady state T cell receptors T-Lymphocytes - immunology Netherlands
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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