Global Gene Expression and Systems Biology Analysis of Bovine Monocyte-Derived Macrophages in Response to In Vitro Challenge with Mycobacterium bovis

Mycobacterium bovis, the causative agent of bovine tuberculosis, is a major cause of mortality in global cattle populations. Macrophages are among the first cell types to encounter M. bovis following exposure and the response elicited by these cells is pivotal in determining the outcome of infection...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 2; p. e32034
Main Authors:	Magee, David A., Taraktsoglou, Maria, Killick, Kate E., Nalpas, Nicolas C., Browne, John A., Park, Stephen D. E., Conlon, Kevin M., Lynn, David J., Hokamp, Karsten, Gordon, Stephen V., Gormley, Eamonn, MacHugh, David E.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 22.02.2012 Public Library of Science (PLoS)
Subjects:	Animal genetics Animal populations Animals Apoptosis Biology Biomedical research Cattle Cellular signal transduction Chemokines Cytokines Female Females Food science Gene expression Gene Expression Profiling Gene Expression Regulation Genes Genetic research Genome Genomes Genomics Granuloma - metabolism Health aspects HIV Human immunodeficiency virus Immunology In Vitro Techniques Infection Infections Inflammation Inflammatory response Intracellular Intracellular signalling Kinases Laboratories Macrophages Macrophages - cytology Macrophages - microbiology Medical research Monocytes Monocytes - cytology Monocytes - microbiology Multiplicity of infection Mycobacterium Mycobacterium avium Mycobacterium bovis Mycobacterium bovis - metabolism Mycobacterium tuberculosis MyD88 protein Neutrophils Oligonucleotide Array Sequence Analysis Receptors Ribonucleic acid RNA RNA - metabolism Rodents Signal Transduction Systems analysis Systems Biology Toll-like receptors Transcriptome Tuberculosis Tuberculosis, Bovine - microbiology Veterinary colleges Veterinary medicine Ireland
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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