IL-27 Imparts Immunoregulatory Function to Human NK Cell Subsets

Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on sti...

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Vydáno v:PloS one Ročník 6; číslo 10; s. e26173
Hlavní autoři: Laroni, Alice, Gandhi, Roopali, Beynon, Vanessa, Weiner, Howard L.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 19.10.2011
Public Library of Science (PLoS)
Témata:
Arthritis
Autoimmune diseases
Autoimmunity
Biology
Cell Proliferation
Cytokines
Cytotoxicity
Genotype & phenotype
Glycoproteins
Growth factors
Hospitals
Humans
Immune response
Immune system
Immunoregulation
Immunotherapy
Interferon
Interferon-gamma - metabolism
Interleukin 10
Interleukin 27
Interleukin-10 - metabolism
Interleukin-17 - physiology
Interleukins
Killer cells
Killer Cells, Natural - cytology
Killer Cells, Natural - immunology
Ligands
Lymphocyte receptors
Lymphocytes
Lymphocytes T
Medical research
Medical schools
Medicine
Multiple sclerosis
Natural killer cells
Real-Time Polymerase Chain Reaction
T cell receptors
T cells
Toxicity
Viability
Womens health
γ-Interferon
United States > US
Massachusetts
ISSN:1932-6203, 1932-6203
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Shrnutí:Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on stimulating factors. We found that IL-27 treatment results in increased IL-10 and IFN-γ expression, increased viability and decreased proliferation in both CD56(bright) and CD56(dim) NK cell subsets. More importantly, IL-27 treatment imparts regulatory activity to CD56(bright) NK cells, which mediates its suppressive function on T cells in a contact-dependent manner. There is growing evidence that CD56(bright) NK cell-mediated immunoregulation plays an important role in the control of autoimmunity. Thus, understanding the role of IL-27 in NK cell function has important implications for treatment of autoimmune disorders.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Conceived and designed the experiments: AL RG HLW. Performed the experiments: AL RG VB. Analyzed the data: AL RG. Contributed reagents/materials/analysis tools: HLW. Wrote the paper: AL RG HLW.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0026173