IL-27 Imparts Immunoregulatory Function to Human NK Cell Subsets

Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on sti...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 10; p. e26173
Main Authors:	Laroni, Alice, Gandhi, Roopali, Beynon, Vanessa, Weiner, Howard L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 19.10.2011 Public Library of Science (PLoS)
Subjects:	Arthritis Autoimmune diseases Autoimmunity Biology Cell Proliferation Cytokines Cytotoxicity Genotype & phenotype Glycoproteins Growth factors Hospitals Humans Immune response Immune system Immunoregulation Immunotherapy Interferon Interferon-gamma - metabolism Interleukin 10 Interleukin 27 Interleukin-10 - metabolism Interleukin-17 - physiology Interleukins Killer cells Killer Cells, Natural - cytology Killer Cells, Natural - immunology Ligands Lymphocyte receptors Lymphocytes Lymphocytes T Medical research Medical schools Medicine Multiple sclerosis Natural killer cells Real-Time Polymerase Chain Reaction T cell receptors T cells Toxicity Viability Womens health γ-Interferon United States > US Massachusetts
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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