IL-27 Imparts Immunoregulatory Function to Human NK Cell Subsets
Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on sti...
Saved in:
| Published in: | PloS one Vol. 6; no. 10; p. e26173 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Public Library of Science
19.10.2011
Public Library of Science (PLoS) |
| Subjects: | |
| ISSN: | 1932-6203, 1932-6203 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on stimulating factors. We found that IL-27 treatment results in increased IL-10 and IFN-γ expression, increased viability and decreased proliferation in both CD56(bright) and CD56(dim) NK cell subsets. More importantly, IL-27 treatment imparts regulatory activity to CD56(bright) NK cells, which mediates its suppressive function on T cells in a contact-dependent manner. There is growing evidence that CD56(bright) NK cell-mediated immunoregulation plays an important role in the control of autoimmunity. Thus, understanding the role of IL-27 in NK cell function has important implications for treatment of autoimmune disorders. |
|---|---|
| AbstractList | Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56bright and CD56dim NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on stimulating factors. We found that IL-27 treatment results in increased IL-10 and IFN-γ expression, increased viability and decreased proliferation in both CD56bright and CD56dim NK cell subsets. More importantly, IL-27 treatment imparts regulatory activity to CD56bright NK cells, which mediates its suppressive function on T cells in a contact-dependent manner. There is growing evidence that CD56bright NK cell-mediated immunoregulation plays an important role in the control of autoimmunity. Thus, understanding the role of IL-27 in NK cell function has important implications for treatment of autoimmune disorders. Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56.sup.bright and CD56.sup.dim NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on stimulating factors. We found that IL-27 treatment results in increased IL-10 and IFN-[gamma] expression, increased viability and decreased proliferation in both CD56.sup.bright and CD56.sup.dim NK cell subsets. More importantly, IL-27 treatment imparts regulatory activity to CD56.sup.bright NK cells, which mediates its suppressive function on T cells in a contact-dependent manner. There is growing evidence that CD56.sup.bright NK cell-mediated immunoregulation plays an important role in the control of autoimmunity. Thus, understanding the role of IL-27 in NK cell function has important implications for treatment of autoimmune disorders. Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on stimulating factors. We found that IL-27 treatment results in increased IL-10 and IFN-γ expression, increased viability and decreased proliferation in both CD56(bright) and CD56(dim) NK cell subsets. More importantly, IL-27 treatment imparts regulatory activity to CD56(bright) NK cells, which mediates its suppressive function on T cells in a contact-dependent manner. There is growing evidence that CD56(bright) NK cell-mediated immunoregulation plays an important role in the control of autoimmunity. Thus, understanding the role of IL-27 in NK cell function has important implications for treatment of autoimmune disorders. Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on stimulating factors. We found that IL-27 treatment results in increased IL-10 and IFN-γ expression, increased viability and decreased proliferation in both CD56(bright) and CD56(dim) NK cell subsets. More importantly, IL-27 treatment imparts regulatory activity to CD56(bright) NK cells, which mediates its suppressive function on T cells in a contact-dependent manner. There is growing evidence that CD56(bright) NK cell-mediated immunoregulation plays an important role in the control of autoimmunity. Thus, understanding the role of IL-27 in NK cell function has important implications for treatment of autoimmune disorders.Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on stimulating factors. We found that IL-27 treatment results in increased IL-10 and IFN-γ expression, increased viability and decreased proliferation in both CD56(bright) and CD56(dim) NK cell subsets. More importantly, IL-27 treatment imparts regulatory activity to CD56(bright) NK cells, which mediates its suppressive function on T cells in a contact-dependent manner. There is growing evidence that CD56(bright) NK cell-mediated immunoregulation plays an important role in the control of autoimmunity. Thus, understanding the role of IL-27 in NK cell function has important implications for treatment of autoimmune disorders. |
| Audience | Academic |
| Author | Laroni, Alice Gandhi, Roopali Beynon, Vanessa Weiner, Howard L. |
| AuthorAffiliation | University of Nebraska Medical Center, United States of America Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America |
| AuthorAffiliation_xml | – name: University of Nebraska Medical Center, United States of America – name: Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America |
| Author_xml | – sequence: 1 givenname: Alice surname: Laroni fullname: Laroni, Alice – sequence: 2 givenname: Roopali surname: Gandhi fullname: Gandhi, Roopali – sequence: 3 givenname: Vanessa surname: Beynon fullname: Beynon, Vanessa – sequence: 4 givenname: Howard L. surname: Weiner fullname: Weiner, Howard L. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22039443$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNk19v0zAUxSM0xP7AN0AQCWmIhxbbN7XjPSCmirGKikkMeLUcx2ldJXGxnYl9exyaTc00IZQHRze_c27u0fVxctDaVifJS4ymGBh-v7Gda2U93cbyFCFCMYMnyRHmQCaUIDjYez9Mjr3fIDSDnNJnySGJNZ5lcJR8XCwnhKWLZitd8PFsutY6vepqGay7TS-6VgVj2zTY9LJrZJt-_ZLOdV2n113hdfDPk6eVrL1-MZwnyY-LT9_nl5Pl1efF_Hw5UZTjMNEcMlQQXnAqmZ4RBiWmOlMAFcPFjJWUapIDx4RRTvIZVhg4JzQHDFXUwknyeue7ra0Xw_BeYMBxdM7znljsiNLKjdg600h3K6w04m_BupWIMxpVa0GqCpMCZVmJdQYV5AwVrOSAMq4l4Sh6fRi6dUWjS6Xb4GQ9Mh1_ac1arOyNAMzzGHI0eDsYOPur0z6IxngVc5Ottp0XHGFAAHgWyTcPyMeHG6iVjP9v2srGtqr3FOcZozllGcGRmj5CxafUjVFxUSoT6yPBu5EgMkH_DivZeS8W19_-n736OWZP99i1lnVYe1t3_Sr5MfhqP-j7hO82NALZDlDOeu90dY9gJPqLcBeX6C-CGC5ClJ09kCkTZN8-JmLqf4v_AKoKCaY |
| CitedBy_id | crossref_primary_10_1038_srep25782 crossref_primary_10_1111_ajt_12351 crossref_primary_10_1002_eji_201444699 crossref_primary_10_3389_fimmu_2016_00694 crossref_primary_10_3389_fimmu_2024_1366377 crossref_primary_10_1016_j_jaci_2013_07_030 crossref_primary_10_1007_s00011_020_01337_x crossref_primary_10_3389_fimmu_2018_01869 crossref_primary_10_3390_cells9030615 crossref_primary_10_1016_j_jhep_2015_12_020 crossref_primary_10_1155_2014_671431 crossref_primary_10_1016_j_bbi_2017_06_011 crossref_primary_10_3389_fimmu_2017_00025 crossref_primary_10_3389_fimmu_2021_622306 crossref_primary_10_1080_08820139_2024_2337025 crossref_primary_10_1038_s41598_019_41478_6 crossref_primary_10_1155_2014_938561 crossref_primary_10_4049_jimmunol_1500591 crossref_primary_10_1016_j_sleep_2017_11_1150 crossref_primary_10_1007_s00281_019_00765_0 crossref_primary_10_1146_annurev_immunol_032414_112134 crossref_primary_10_4049_jimmunol_1302656 crossref_primary_10_1016_j_cellimm_2022_104497 crossref_primary_10_3390_cells10081955 crossref_primary_10_1084_jem_20141678 crossref_primary_10_3389_fimmu_2020_621225 crossref_primary_10_3390_cells8121527 crossref_primary_10_1177_1352458518800776 crossref_primary_10_1002_eji_201444903 crossref_primary_10_3389_fimmu_2021_645850 crossref_primary_10_1016_j_humimm_2019_07_283 crossref_primary_10_3390_jcm9051450 crossref_primary_10_1016_j_jaut_2012_05_006 crossref_primary_10_1038_s41598_017_16702_w crossref_primary_10_1016_j_imlet_2013_03_001 crossref_primary_10_1038_s41435_020_0102_z crossref_primary_10_1016_j_jaut_2016_04_003 crossref_primary_10_1186_s40425_019_0652_7 crossref_primary_10_3389_fimmu_2016_00606 crossref_primary_10_1155_2016_6903496 crossref_primary_10_1016_j_intimp_2021_108374 crossref_primary_10_1016_j_envpol_2016_02_004 |
| Cites_doi | 10.1016/j.coi.2009.09.012 10.1007/s00109-007-0164-7 10.1038/ni1541 10.1073/pnas.97.7.3400 10.4049/jimmunol.0900568 10.1186/ar2336 10.1007/s10072-007-0803-3 10.1038/nri1001 10.1016/S1474-4422(10)70033-8 10.1016/j.coi.2008.09.003 10.1016/j.chom.2009.11.003 10.1182/blood-2002-09-2876 10.4049/jimmunol.174.12.7684 10.4049/jimmunol.172.4.2225 10.1016/S1359-6101(01)00021-1 10.1182/blood.V97.10.3146 10.1038/sj.cdd.4402170 10.1038/ni1138 10.1073/pnas.0601335103 10.1016/S1074-7613(02)00324-2 10.1038/ni1582 10.1158/0008-5472.CAN-08-2793 10.1016/S1074-7613(03)00300-5 |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2011 Public Library of Science 2011 Laroni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Laroni et al. 2011 |
| Copyright_xml | – notice: COPYRIGHT 2011 Public Library of Science – notice: 2011 Laroni et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Laroni et al. 2011 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA |
| DOI | 10.1371/journal.pone.0026173 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Proquest Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central ProQuest Advanced Technologies & Aerospace Collection Agricultural & Environmental Science Collection ProQuest Central Essentials ProQuest Biological Science Collection ProQuest Central Technology collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database (Proquest) Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database (Proquest) Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database (ProQuest) Materials Science Collection ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine Biology |
| DocumentTitleAlternate | Immunoregulatory Function of IL-27 on NK Cells |
| EISSN | 1932-6203 |
| ExternalDocumentID | 1310269984 oai_doaj_org_article_2ff12b044d1e43f3870b7d93049ea290 PMC3198386 2900282571 A476867421 22039443 10_1371_journal_pone_0026173 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | United States--US Massachusetts |
| GeographicLocations_xml | – name: Massachusetts – name: United States--US |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RIG RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF NPM PV9 RZL BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 5PM ESTFP AAPBV ABPTK |
| ID | FETCH-LOGICAL-c691t-e9340b29b96a7e5273d16e4c33f71b57d66e2839127692851c1399268313f9343 |
| IEDL.DBID | FPL |
| ISICitedReferencesCount | 45 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000296507500037&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Sun Sep 03 00:14:07 EDT 2023 Fri Oct 03 12:42:37 EDT 2025 Tue Nov 04 01:31:01 EST 2025 Wed Dec 03 15:19:04 EST 2025 Sat Nov 29 14:38:06 EST 2025 Sat Nov 29 13:12:19 EST 2025 Sat Nov 29 09:52:22 EST 2025 Wed Nov 26 09:23:24 EST 2025 Wed Nov 26 09:26:19 EST 2025 Thu May 22 21:19:53 EDT 2025 Mon Jul 21 06:04:43 EDT 2025 Tue Nov 18 20:38:44 EST 2025 Sat Nov 29 02:24:22 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c691t-e9340b29b96a7e5273d16e4c33f71b57d66e2839127692851c1399268313f9343 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: AL RG HLW. Performed the experiments: AL RG VB. Analyzed the data: AL RG. Contributed reagents/materials/analysis tools: HLW. Wrote the paper: AL RG HLW. |
| OpenAccessLink | http://dx.doi.org/10.1371/journal.pone.0026173 |
| PMID | 22039443 |
| PQID | 1310269984 |
| PQPubID | 1436336 |
| PageCount | e26173 |
| ParticipantIDs | plos_journals_1310269984 doaj_primary_oai_doaj_org_article_2ff12b044d1e43f3870b7d93049ea290 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3198386 proquest_miscellaneous_901303315 proquest_journals_1310269984 gale_infotracmisc_A476867421 gale_infotracacademiconefile_A476867421 gale_incontextgauss_ISR_A476867421 gale_incontextgauss_IOV_A476867421 gale_healthsolutions_A476867421 pubmed_primary_22039443 crossref_primary_10_1371_journal_pone_0026173 crossref_citationtrail_10_1371_journal_pone_0026173 |
| PublicationCentury | 2000 |
| PublicationDate | 2011-10-19 |
| PublicationDateYYYYMMDD | 2011-10-19 |
| PublicationDate_xml | – month: 10 year: 2011 text: 2011-10-19 day: 19 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2011 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | B Bielekova (ref6) 2006; 103 TA Fehniger (ref5) 2003; 101 D Wynn (ref24) 2010; 9 AV Villarino (ref14) 2005; 174 A Villarino (ref21) 2003; 19 TA Fehniger (ref19) 2002; 13 G Perona-Wright (ref17) 2009; 6 E Vivier (ref22) 2008; 9 A Moretta (ref1) 2008; 15 M Saraste (ref7) 2007; 28 A Awasthi (ref10) 2007; 8 A Martin-Fontecha (ref2) 2004; 5 M Flodstrom-Tullberg (ref16) 2009; 21 C de Rham (ref20) 2007; 9 C Diveu (ref9) 2008; 20 S Pflanz (ref12) 2002; 16 G Ferlazzo (ref4) 2008; 415 G Murugaiyan (ref11) 2009; 183 M Matsui (ref13) 2009; 69 MA Cooper (ref3) 2001; 97 M Batten (ref8) 2007; 85 S Pflanz (ref15) 2004; 172 G Trinchieri (ref18) 2003; 3 P Andre (ref23) 2000; 97 19892538 - Curr Opin Immunol. 2009 Dec;21(6):634-40 17294231 - J Mol Med (Berl). 2007 Jul;85(7):661-72 10725346 - Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3400-5 15531883 - Nat Immunol. 2004 Dec;5(12):1260-5 14614852 - Immunity. 2003 Nov;19(5):645-55 19625647 - J Immunol. 2009 Aug 15;183(4):2435-43 14764690 - J Immunol. 2004 Feb 15;172(4):2225-31 11900992 - Cytokine Growth Factor Rev. 2002 Apr;13(2):169-83 18425107 - Nat Immunol. 2008 May;9(5):503-10 20006839 - Cell Host Microbe. 2009 Dec 17;6(6):503-12 12480696 - Blood. 2003 Apr 15;101(8):3052-7 17603762 - Neurol Sci. 2007 Jun;28(3):121-6 17994022 - Nat Immunol. 2007 Dec;8(12):1380-9 12563297 - Nat Rev Immunol. 2003 Feb;3(2):133-46 15944269 - J Immunol. 2005 Jun 15;174(12):7684-91 16585503 - Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5941-6 17541426 - Cell Death Differ. 2008 Feb;15(2):226-33 18053164 - Arthritis Res Ther. 2007;9(6):R125 19244121 - Cancer Res. 2009 Mar 15;69(6):2523-30 11342442 - Blood. 2001 May 15;97(10):3146-51 20163990 - Lancet Neurol. 2010 Apr;9(4):381-90 12121660 - Immunity. 2002 Jun;16(6):779-90 18834938 - Curr Opin Immunol. 2008 Dec;20(6):663-8 18370156 - Methods Mol Biol. 2008;415:197-213 |
| References_xml | – volume: 21 start-page: 634 year: 2009 ident: ref16 article-title: Natural killer cells in human autoimmunity. publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2009.09.012 – volume: 85 start-page: 661 year: 2007 ident: ref8 article-title: The biology and therapeutic potential of interleukin 27. publication-title: J Mol Med doi: 10.1007/s00109-007-0164-7 – volume: 8 start-page: 1380 year: 2007 ident: ref10 article-title: A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. publication-title: Nat Immunol doi: 10.1038/ni1541 – volume: 97 start-page: 3400 year: 2000 ident: ref23 article-title: Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.97.7.3400 – volume: 183 start-page: 2435 year: 2009 ident: ref11 article-title: IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. publication-title: J Immunol doi: 10.4049/jimmunol.0900568 – volume: 9 start-page: R125 year: 2007 ident: ref20 article-title: The proinflammatory cytokines IL-2, IL-15 and IL-21 modulate the repertoire of mature human natural killer cell receptors. publication-title: Arthritis Res Ther doi: 10.1186/ar2336 – volume: 28 start-page: 121 year: 2007 ident: ref7 article-title: Expansion of CD56Bright natural killer cells in the peripheral blood of multiple sclerosis patients treated with interferon-beta. publication-title: Neurol Sci doi: 10.1007/s10072-007-0803-3 – volume: 3 start-page: 133 year: 2003 ident: ref18 article-title: Interleukin-12 and the regulation of innate resistance and adaptive immunity. publication-title: Nat Rev Immunol doi: 10.1038/nri1001 – volume: 415 start-page: 197 year: 2008 ident: ref4 article-title: Isolation and analysis of human natural killer cell subsets. publication-title: Methods Mol Biol – volume: 9 start-page: 381 year: 2010 ident: ref24 article-title: Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta. publication-title: Lancet Neurol doi: 10.1016/S1474-4422(10)70033-8 – volume: 20 start-page: 663 year: 2008 ident: ref9 article-title: Cytokines that regulate autoimmunity. publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2008.09.003 – volume: 6 start-page: 503 year: 2009 ident: ref17 article-title: Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells. publication-title: Cell Host Microbe doi: 10.1016/j.chom.2009.11.003 – volume: 101 start-page: 3052 year: 2003 ident: ref5 article-title: CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. publication-title: Blood doi: 10.1182/blood-2002-09-2876 – volume: 174 start-page: 7684 year: 2005 ident: ref14 article-title: Positive and Negative Regulation of the IL-27 Receptor during Lymphoid Cell Activation. publication-title: The Journal of Immunology doi: 10.4049/jimmunol.174.12.7684 – volume: 172 start-page: 2225 year: 2004 ident: ref15 article-title: WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. publication-title: J Immunol doi: 10.4049/jimmunol.172.4.2225 – volume: 13 start-page: 169 year: 2002 ident: ref19 article-title: Interleukin-2 and interleukin-15: immunotherapy for cancer. publication-title: Cytokine Growth Factor Rev doi: 10.1016/S1359-6101(01)00021-1 – volume: 97 start-page: 3146 year: 2001 ident: ref3 article-title: Human natural killer cells: a unique innate immunoregulatory role for the CD56(bright) subset. publication-title: Blood doi: 10.1182/blood.V97.10.3146 – volume: 15 start-page: 226 year: 2008 ident: ref1 article-title: NK cells at the interface between innate and adaptive immunity. publication-title: Cell Death Differ doi: 10.1038/sj.cdd.4402170 – volume: 5 start-page: 1260 year: 2004 ident: ref2 article-title: Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. publication-title: Nat Immunol doi: 10.1038/ni1138 – volume: 103 start-page: 5941 year: 2006 ident: ref6 article-title: Regulatory CD56(bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0601335103 – volume: 16 start-page: 779 year: 2002 ident: ref12 article-title: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. publication-title: Immunity doi: 10.1016/S1074-7613(02)00324-2 – volume: 9 start-page: 503 year: 2008 ident: ref22 article-title: Functions of natural killer cells. publication-title: Nat Immunol doi: 10.1038/ni1582 – volume: 69 start-page: 2523 year: 2009 ident: ref13 article-title: Interleukin-27 activates natural killer cells and suppresses NK-resistant head and neck squamous cell carcinoma through inducing antibody-dependent cellular cytotoxicity. publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-2793 – volume: 19 start-page: 645 year: 2003 ident: ref21 article-title: The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. publication-title: Immunity doi: 10.1016/S1074-7613(03)00300-5 – reference: 18053164 - Arthritis Res Ther. 2007;9(6):R125 – reference: 14764690 - J Immunol. 2004 Feb 15;172(4):2225-31 – reference: 16585503 - Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5941-6 – reference: 11342442 - Blood. 2001 May 15;97(10):3146-51 – reference: 14614852 - Immunity. 2003 Nov;19(5):645-55 – reference: 15531883 - Nat Immunol. 2004 Dec;5(12):1260-5 – reference: 19892538 - Curr Opin Immunol. 2009 Dec;21(6):634-40 – reference: 17603762 - Neurol Sci. 2007 Jun;28(3):121-6 – reference: 11900992 - Cytokine Growth Factor Rev. 2002 Apr;13(2):169-83 – reference: 20006839 - Cell Host Microbe. 2009 Dec 17;6(6):503-12 – reference: 10725346 - Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3400-5 – reference: 17994022 - Nat Immunol. 2007 Dec;8(12):1380-9 – reference: 17541426 - Cell Death Differ. 2008 Feb;15(2):226-33 – reference: 12121660 - Immunity. 2002 Jun;16(6):779-90 – reference: 17294231 - J Mol Med (Berl). 2007 Jul;85(7):661-72 – reference: 20163990 - Lancet Neurol. 2010 Apr;9(4):381-90 – reference: 15944269 - J Immunol. 2005 Jun 15;174(12):7684-91 – reference: 19244121 - Cancer Res. 2009 Mar 15;69(6):2523-30 – reference: 18370156 - Methods Mol Biol. 2008;415:197-213 – reference: 18425107 - Nat Immunol. 2008 May;9(5):503-10 – reference: 19625647 - J Immunol. 2009 Aug 15;183(4):2435-43 – reference: 12563297 - Nat Rev Immunol. 2003 Feb;3(2):133-46 – reference: 12480696 - Blood. 2003 Apr 15;101(8):3052-7 – reference: 18834938 - Curr Opin Immunol. 2008 Dec;20(6):663-8 |
| SSID | ssj0053866 |
| Score | 2.2490454 |
| Snippet | Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets... Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56.sup.bright and CD56.sup.dim NK cell... Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56bright and CD56dim NK cell subsets is... |
| SourceID | plos doaj pubmedcentral proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e26173 |
| SubjectTerms | Arthritis Autoimmune diseases Autoimmunity Biology Cell Proliferation Cytokines Cytotoxicity Genotype & phenotype Glycoproteins Growth factors Hospitals Humans Immune response Immune system Immunoregulation Immunotherapy Interferon Interferon-gamma - metabolism Interleukin 10 Interleukin 27 Interleukin-10 - metabolism Interleukin-17 - physiology Interleukins Killer cells Killer Cells, Natural - cytology Killer Cells, Natural - immunology Ligands Lymphocyte receptors Lymphocytes Lymphocytes T Medical research Medical schools Medicine Multiple sclerosis Natural killer cells Real-Time Polymerase Chain Reaction T cell receptors T cells Toxicity Viability Womens health γ-Interferon |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELbQigMXRHl1oYCFkIBD2vUj9vpGQVRUVAvipd6sOLGhUklWcRaJf89M4o0aVKkcOK0Uj6PdzzP2zHrmG0KeyeBKp2WecZ8rbGFWZEtRBYhSlJC6CIYv-kLhE71aLU9PzccLrb4wJ2ygBx6AO-AhMO4WUlbMSxEE6JfTlcHbIV9w00fr4PVsg6lhDwYrVioVygnNDtK67K-b2u8PLORichD1fP3jrjxbnzfxMpfz78zJC0fR0S1yM_mQ9HD47jvkmq9vk51kpZG-SFTSL--QV8cnGdcUSyHbLsLnz03dtEP7-ab9TfFUw5WhXUP7bn109Z7if_k0wobiu3iXfD16--XNuyz1TMhKZViXeSPkwnHjjCq0R3a1iikvSyGCZi7XlVIePArDuFaGg7tVMqSmVUvBRIC54h6Z1YDSLqGAd3B4SczASeFlKFyowPmqGDPO51LMidgCaMtEKI59Lc5tf0umIbAY8LAIu02wz0k2zloPhBpXyL_GtRllkQ67fwBKYpOS2KuUZE6e4MraobZ0NGp7KCHaUlpyNidPewmkxKgx5-Z7sYnRHn_49g9Cnz9NhJ4nodAAHGWR6hzgNyHV1kRybyIJhl1OhndRD7eoRMAIvEEF8bGEmVvdvHyYjsP4Usyjq32zidbgRbUQLJ-T-4Mmj8ByvsAiaQBcT3R8gvx0pD770ROSwza-BIt78D-W6iG5wVOaJTN7ZNa1G_-IXC9_dWexfdxb-R96QFNl priority: 102 providerName: Directory of Open Access Journals – databaseName: Biological Science Database (Proquest) dbid: M7P link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZg4cAFKK9uKWAhJOCQdv2IvT5BqVixoloqXurNysMulZZkm2SR-PfMJN5AUAVInCLF4yiZl8eZ8TeEPJE-zVIt44i7WGELsySaitzDLkUJqRNv-KQ9KHykF4vpyYk5Dj_c6lBWufGJraPOywz_ke8ziEO4gs2BfLE6j7BrFGZXQwuNy-QKoiSItnTveOOJwZaVCsflhGb7QTp7q7Jwex0WuRgsRy1qf--bR6tlWV8UeP5eP_nLgjS78b-fcpNcD6EoPeh0Z4tccsUtshWMvabPAiL189vk5fwo4prOsVy9qeH6dV2UVdfFvqy-0xksjihg2pS0zQrQxVt66JZLin7JNfUd8mn2-uPhmyi0XogyZVgTOSPkJOUmNSrRDkHacqaczITwmqWxzpVyEJgYxrUyHKK2jCHCrZoKJjzMFXfJqAA2bxPKHOgD5poZxDo880nqc4jhcsZM6mIpxkRsJGCzgEuO7TGWtk22adifdPywKDcb5DYmUT9r1eFy_IX-FQq3p0VU7fZGWZ3aYKSWe894OpEyh5cWXoAvS3VuMBPpEm4mY_IIVcN2R1R732APJGzalJacjcnjlgKRNQos3TlN1nVt5-8-_wPRh_cDoqeByJfAjiwJxyXgmxCxa0C5O6AE_5ANhrdRkTdcqe1P9YOZGwW9eJj2w_hQLMcrXLmurcF8txAsHpN7nSn0jOV8gmetgeF6YCQDzg9HirMvLa45rAZTMNmdP7_VfXKNhzpMZnbJqKnW7gG5mn1rzurqYesAfgCW_mF3 priority: 102 providerName: ProQuest |
| Title | IL-27 Imparts Immunoregulatory Function to Human NK Cell Subsets |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/22039443 https://www.proquest.com/docview/1310269984 https://www.proquest.com/docview/901303315 https://pubmed.ncbi.nlm.nih.gov/PMC3198386 https://doaj.org/article/2ff12b044d1e43f3870b7d93049ea290 http://dx.doi.org/10.1371/journal.pone.0026173 |
| Volume | 6 |
| WOSCitedRecordID | wos000296507500037&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database (ProQuest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database (Proquest) customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Proquest Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3db9MwELdYxwMvwPhaYZQIIQEPKbGd2PEba7WKql2JOpg6XqJ8ODCpJFWTIvHfc5e4hUybgJeLVJ8r52ff-RyffybklZvFSSxdz2baE3iFWWT7PM1glSK4K6NMMac-KDyVs5m_WKjg90Lxyg4-l_SdwbS_KnLdbxjE-R7ZZ1wITOEaBdOt5wXbFcIcj7upZmv6qVn6d764s1oW5XWB5tV8yT8moNG9_236fXLXhJrWcTM2DsgtnT8gB8aYS-uNYZx--5C8H09tJq0xpqNXJTy_b_Ji3dxSX6x_WiOY_LADraqw6q_-1mxiDfVyaaHf0VX5iHwenXwafrDN1Qp2IhStbK2468RMxUpEUiMJW0qFdhPOM0ljT6ZCaAg8FGVSKAZRWUKRwVb4nPIM6vLHpJPDWx0Si2rob9xLphDLsCSL4iyFGC2lVMXac3mX8C3iYWJ4x_H6i2VYb6ZJWH80eIQIU2hg6hJ7V2vV8G78RX-AnbnTRdbs-gfoj9AYYciyjLLYcd0UGs0zDr4qlqnCnUYdMeV0yQscCmFzBHVn--GxC4syIV1Gu-RlrYHMGTmm5nyNNmUZjj-e_4PS2byl9NooZQXAkUTmOAS8EzJytTSPWppg_0mr-BAH7haVEjCCoFHAMtqFmtvBfH2xtSvGP8V0u1wXmzJUuJ_NOfW65Ekz9HfAMubgWWoAXLaMooV8uyS__FbzloO398FEn97c4GfkDjM5llQdkU613ujn5Hbyo7os1z2yJ-fnKBeylj5If0h7ZH9wMgvmvfp7Sq92CSAngz7IU2eCUga1PAMZeF-gRjA-DS5-AaOOXEo |
| linkProvider | Public Library of Science |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELdGQYIXYHytMJiFQMBDttpO7foBwRhMq1oK2sa0N5MPp0wqSWlS0P4p_kbuEicQNAEve-CpUn2JkvPd7865L0Ie-UkYhcrve9z2JY4wC7yBiBM4pUjhqyDRvFcWCo_VZDI4PtbvV8j3uhYG0yprTCyBOs4i_Ea-xcAP4RIOB_6L-RcPp0ZhdLUeoVGJxciefoMjW_58-Br29zHnu28Od_Y8N1XAi6RmhWe18Hsh16GWgbLYfyxm0vqREIliYV_FUlqwuZpxJTUHhyRi2LxVDgQTCVwr4L4XyEXAcYYpZGr_qEZ-wA4pXXmeUGzLScPmPEvtZtX7XLTMXzkloLEFnfksy89ydH_P1_zFAO5e-99Yd51cda423a50Y5Ws2PQGWXVgltOnruP2s5vk5XDscUWHmI5f5PD7eZlmCzvF0WbZ4pTugvFHAaZFRsuoB52M6I6dzSjiri3yW-TDubzJbdJJYVvXCGUW5B1j6Qx8OR4lQZjE4KPGjOnQ9n3RJaLecRO5vus4_mNmymCigvNXxQ-DcmKcnHSJ11w1r_qO_IX-FQpTQ4tdw8s_ssXUOBAyPEkYD3u-H8NDi0QAVocq1hhptQHXvS7ZQFE0VQlug31m24dDqVQ-Z13ysKTAziEppiZNg2Wem-G7o38gOthvET1xREkG7IgCVw4C74QdyVqU6y1KwL-otbyGilNzJTc_xR2urBXi7GXaLONNMd0wtdkyNxrj-UKwfpfcqVSvYSznPawlB4arllK2ON9eSU8-lX3bwdoNACLu_vmpNsjlvcO3YzMeTkb3yBXuck6ZXiedYrG098ml6Gtxki8elOBDycfzVtkfANy4-w |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELdGQYgXYHytMFiEQMBD1tpO7foBweioqDqViS_tzeTDLpNKUpoUtH-Nv467xAkETcDLHniKFJ-j5Hz38zn3RciDwEZxJIOBz8xAYAuz0B_yxMIpRfBAhlaxfpkofCBns-HRkTrcIN_rXBgMq6wxsQTqJIvxH3mPgh3CBBwOgp51YRGH--Nnyy8-dpBCT2vdTqMSkak5-QbHt_zpZB_W-iFj45fvRq9812HAj4WihW8UD_oRU5ESoTRYiyyhwgQx51bSaCATIQzsv4oyKRQD4ySmWMhVDDnlFuZyeO45cl5ykGLMUh814SWAI0K4VD0uac9Jxu4yS81uVQedt7bCsmNAsy90lossP83o_T1285fNcHzlf2bjVXLZmeDeXqUzm2TDpNfIpgO53HvsKnE_uU6eTw58Jr0JhukXOVw_r9NsZebY8ixbnXhjMApQsL0i80pviDebeiOzWHiIx6bIb5D3Z_IlN0knhSXeIh41oAfoY6dg47HYhpFNwHZNKFWRGQS8S3i9-jp29dixLchCl05GCeeyih8aZUY7mekSv5m1rOqR_IX-BQpWQ4vVxMsb2WquHThpZi1lUT8IEnhpbjlgeCQThR5YEzLV75IdFEtdpeY2mKj3AjisChkw2iX3SwqsKJKiUM3DdZ7ryesP_0D09k2L6JEjshmwIw5dmgh8E1Yqa1FutygBF-PW8BYqUc2VXP8UfZhZK8fpw14zjA_FMMTUZOtcK_Tzc04HXXKrUsOGsYz1McccGC5bCtrifHskPf5U1nOHXXAIcHH7z2-1Qy6CpuqDyWx6h1xiLhSVqm3SKVZrc5dciL8Wx_nqXolDHvl41hr7Az7owVY |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IL-27+imparts+immunoregulatory+function+to+human+NK+cell+subsets&rft.jtitle=PloS+one&rft.au=Laroni%2C+Alice&rft.au=Gandhi%2C+Roopali&rft.au=Beynon%2C+Vanessa&rft.au=Weiner%2C+Howard+L&rft.date=2011-10-19&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=6&rft.issue=10&rft.spage=e26173&rft_id=info:doi/10.1371%2Fjournal.pone.0026173&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |