IL-27 Imparts Immunoregulatory Function to Human NK Cell Subsets

Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on sti...

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Vydané v:	PloS one Ročník 6; číslo 10; s. e26173
Hlavní autori:	Laroni, Alice, Gandhi, Roopali, Beynon, Vanessa, Weiner, Howard L.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 19.10.2011 Public Library of Science (PLoS)
Predmet:	Arthritis Autoimmune diseases Autoimmunity Biology Cell Proliferation Cytokines Cytotoxicity Genotype & phenotype Glycoproteins Growth factors Hospitals Humans Immune response Immune system Immunoregulation Immunotherapy Interferon Interferon-gamma - metabolism Interleukin 10 Interleukin 27 Interleukin-10 - metabolism Interleukin-17 - physiology Interleukins Killer cells Killer Cells, Natural - cytology Killer Cells, Natural - immunology Ligands Lymphocyte receptors Lymphocytes Lymphocytes T Medical research Medical schools Medicine Multiple sclerosis Natural killer cells Real-Time Polymerase Chain Reaction T cell receptors T cells Toxicity Viability Womens health γ-Interferon United States > US Massachusetts
ISSN:	1932-6203, 1932-6203
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Popis
Shrnutí:	Interleukin-27 (IL-27) is a cytokine with multiple roles in regulating the immune response, but its effect on human CD56(bright) and CD56(dim) NK cell subsets is unknown. NK cell subsets interact with other components of the immune system, leading to cytotoxicity or immunoregulation depending on stimulating factors. We found that IL-27 treatment results in increased IL-10 and IFN-γ expression, increased viability and decreased proliferation in both CD56(bright) and CD56(dim) NK cell subsets. More importantly, IL-27 treatment imparts regulatory activity to CD56(bright) NK cells, which mediates its suppressive function on T cells in a contact-dependent manner. There is growing evidence that CD56(bright) NK cell-mediated immunoregulation plays an important role in the control of autoimmunity. Thus, understanding the role of IL-27 in NK cell function has important implications for treatment of autoimmune disorders.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: AL RG HLW. Performed the experiments: AL RG VB. Analyzed the data: AL RG. Contributed reagents/materials/analysis tools: HLW. Wrote the paper: AL RG HLW.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0026173