Epigenetic Changes of CXCR4 and Its Ligand CXCL12 as Prognostic Factors for Sporadic Breast Cancer

Chemokines and their receptors are involved in the development and cancer progression. The chemokine CXCL12 interacts with its receptor, CXCR4, to promote cellular adhesion, survival, proliferation and migration. The CXCR4 gene is upregulated in several types of cancers, including skin, lung, pancre...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 12; p. e29461
Main Authors:	Ramos, Edneia A. S., Grochoski, Mariana, Braun-Prado, Karin, Seniski, Gerusa G., Cavalli, Iglenir J., Ribeiro, Enilze M. S. F., Camargo, Anamaria A., Costa, Fabrício F., Klassen, Giseli
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 29.12.2011 Public Library of Science (PLoS)
Subjects:	Adult Aged Aged, 80 and over Biology Biomarkers Biotechnology Bisulfite Brain Brain tumors Brazil Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cancer metastasis Cancer therapies Cancer treatment Cell Line, Tumor Cell survival Chemokine CXCL12 - genetics Chemokines Cloning CpG islands CXCL12 protein CXCR4 protein Cytosine Decision making Deoxyribonucleic acid Development and progression DNA DNA methylation DNA Methylation - genetics DNA sequencing Epigenesis, Genetic Epigenetic inheritance Epigenetics ESR1 protein Female Gene expression Gene Expression Regulation, Neoplastic Gene sequencing Gene Silencing Genes Genomics Humans Kaplan-Meier Estimate Laboratories Leukocyte migration Ligands Lungs Lymph nodes Lymphatic system Medical prognosis Medical research Medicine Melanoma Metastases Metastasis Methylation Middle Aged Molecular biology Mortality Pancreas Pancreatic cancer Pathology Patients Polymerase chain reaction Prognosis Promoter Regions, Genetic - genetics Public health Receptors Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Reverse Transcriptase Polymerase Chain Reaction Sequence Analysis, DNA Skin Sodium Sulfites Survival Tumor cell lines Tumors Brazil
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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