Hemagglutinin from the H5N1 Virus Activates Janus Kinase 3 to Dysregulate Innate Immunity

Highly pathogenic avian influenza viruses (HPAIVs) cause severe disease in humans. There are no effective vaccines or antiviral therapies currently available to control fatal outbreaks due in part to the lack of understanding of virus-mediated immunopathology. In our study, we used hemagglutinin (HA...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 2; p. e31721
Main Authors:	Xu, Wei, Chen, Minhui, Ge, Nanhai, Xu, Jun
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 16.02.2012 Public Library of Science (PLoS)
Subjects:	Animals Antigens Antiviral agents Avian flu Avian influenza Avian influenza viruses Biology Cell cycle Chemokines Cytokine receptors Cytokines Development and progression Disease Ebola virus Epithelial cells Epithelial Cells - virology Fatalities Gene expression Hemagglutinins Hemagglutinins - immunology Hemagglutinins - pharmacology Hospitals Immunity Immunity, Innate - drug effects Infections Influenza Influenza A Virus, H5N1 Subtype - immunology Influenza vaccines Inhibitors Innate immunity Janus kinase 3 Janus Kinase 3 - metabolism Kinases Laboratories Lectins Lung - virology Lungs Lymphocytes Medicine Mice Mice, Knockout Mutual fund industry Outbreaks Proteins Psoriasis Receptors Respiratory diseases Rheumatoid arthritis Rodents Signal transduction Signal Transduction - immunology Signaling Transgenic animals Vaccines Viruses China
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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