A miR-1207-5p Binding Site Polymorphism Abolishes Regulation of HBEGF and Is Associated with Disease Severity in CFHR5 Nephropathy

Heparin binding epidermal growth factor (HBEGF) is expressed in podocytes and was shown to play a role in glomerular physiology. MicroRNA binding sites on the 3'UTR of HBEGF were predicted using miRWalk algorithm and followed by DNA sequencing in 103 patients diagnosed with mild or severe glome...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 2; p. e31021
Main Authors:	Papagregoriou, Gregory, Erguler, Kamil, Dweep, Harsh, Voskarides, Konstantinos, Koupepidou, Panayiota, Athanasiou, Yiannis, Pierides, Alkis, Gretz, Norbert, Felekkis, Kyriacos N., Deltas, Constantinos
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02.02.2012 Public Library of Science (PLoS)
Subjects:	3' Untranslated regions Algorithms Alleles Anticoagulants Binding Sites Biology Breast cancer Chromosomes Chronic kidney failure Complement System Proteins - genetics Deoxyribonucleic acid Development and progression Diabetes Disease Progression DNA DNA sequencing Epidermal growth factor Gene expression Gene Expression Regulation Gene sequencing Genetic aspects Genetic Therapy Genetics Genomes Glomerulonephritis, Membranous - genetics Glomerulonephritis, Membranous - therapy Health aspects Heparin Heparin-binding EGF-like Growth Factor Heredity Humans Intercellular Signaling Peptides and Proteins - genetics Kidney diseases Kidney Failure, Chronic Laboratories Luciferase Lymphoma Medical research Medicine MicroRNA MicroRNAs MicroRNAs - genetics miRNA Mutation Nephrology Nephropathy Patients Physiological aspects Polymorphism Polymorphism, Genetic Renal failure Ribonucleic acid RNA Rodents Severity of Illness Index Single nucleotide polymorphisms Single-nucleotide polymorphism Target recognition Cyprus
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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