The Forkhead Transcription Factor Foxl2 Is Sumoylated in Both Human and Mouse: Sumoylation Affects Its Stability, Localization, and Activity

The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure. Inactivation of Foxl2 in mice demonstrated its indispensability for female gona...

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Bibliographic Details
Published in:	PloS one Vol. 5; no. 3; p. e9477
Main Authors:	Marongiu, Mara, Deiana, Manila, Meloni, Alessandra, Marcia, Loredana, Puddu, Alessandro, Cao, Antonio, Schlessinger, David, Crisponi, Laura
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02.03.2010 Public Library of Science (PLoS)
Subjects:	Animal care Animal tissues Animals Antagonism Blepharophimosis Cell lines Chlorocebus aethiops Cloning COS Cells Deactivation Deoxyribonucleic acid DNA Forkhead Box Protein L2 Forkhead protein Forkhead Transcription Factors - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation Genetics and Genomics/Animal Genetics Genetics and Genomics/Gene Function Granulosa cells Humans Inactivation Localization Male Mice Mice, Inbred C57BL Molecular Biology/Post-Translational Regulation of Gene Expression Mutation Penicillin Protein Inhibitors of Activated STAT - metabolism Proteins Reproductive status Sex determination Sox9 protein Spermatogenesis Stability SUMO protein SUMO-1 Protein Transcription factors Ubiquitin-Conjugating Enzyme UBC9 Ubiquitin-Conjugating Enzymes - metabolism Yeast Italy
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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