Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41

A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope. Here we describe a HIV-1 envelope (Env) gp140 oligomer...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	PloS one Ročník 6; číslo 11; s. e27824
Hlavní autori:	Dennison, S. Moses, Sutherland, Laura L., Jaeger, Frederick H., Anasti, Kara M., Parks, Robert, Stewart, Shelley, Bowman, Cindy, Xia, Shi-Mao, Zhang, Ruijun, Shen, Xiaoying, Scearce, Richard M., Ofek, Gilad, Yang, Yongping, Kwong, Peter D., Santra, Sampa, Liao, Hua-Xin, Tomaras, Georgia, Letvin, Norman L., Chen, Bing, Alam, S. Munir, Haynes, Barton F.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 30.11.2011 Public Library of Science (PLoS)
Predmet:	Animals Antibodies Antibody Formation - immunology Antibody response Antibody Specificity - immunology Antigenic determinants Antigens B cells Binding sites Biology Children & youth Cross-Priming - immunology Deoxyribonucleic acid DNA Epitopes Epitopes - immunology Fusion protein Glycoprotein gp41 Glycoproteins Guinea Pigs HIV HIV Antibodies - blood HIV Antibodies - immunology HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - immunology HIV-1 - immunology Hospitals Human immunodeficiency virus Immunization Immunoglobulins Infections Infectious diseases Lipids Liposomes Liposomes - chemistry Macaca mulatta - immunology Medicine Neutralization Neutralization Tests Neutralizing Peptides Peptides - chemistry Peptides - immunology Physicians Protein binding Protein Structure, Quaternary Proteins Recombinant Fusion Proteins - metabolism Scaffolds Strategy Well construction Yang, Cindy North Carolina United States > US Maryland Massachusetts
ISSN:	1932-6203, 1932-6203
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope. Here we describe a HIV-1 envelope (Env) gp140 oligomer prime followed by MPER peptide-liposomes boost strategy for eliciting serum antibody responses in rhesus macaques that bind to a gp41 fusion intermediate protein. This Env-liposome immunization strategy induced antibodies to the 2F5 neutralizing epitope ⁶⁶⁴DKW residues, and these antibodies preferentially bound to a gp41 fusion intermediate construct as well as to MPER scaffolds stabilized in the 2F5-bound conformation. However, no serum lipid binding activity was observed nor was serum neutralizing activity for HIV-1 pseudoviruses present. Nonetheless, the Env-liposome prime-boost immunization strategy induced antibodies that recognized a gp41 fusion intermediate protein and was successful in focusing the antibody response to the desired epitope.
AbstractList	A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope. Here we describe a HIV-1 envelope (Env) gp140 oligomer prime followed by MPER peptide-liposomes boost strategy for eliciting serum antibody responses in rhesus macaques that bind to a gp41 fusion intermediate protein. This Env-liposome immunization strategy induced antibodies to the 2F5 neutralizing epitope 664DKW residues, and these antibodies preferentially bound to a gp41 fusion intermediate construct as well as to MPER scaffolds stabilized in the 2F5-bound conformation. However, no serum lipid binding activity was observed nor was serum neutralizing activity for HIV-1 pseudoviruses present. Nonetheless, the Env-liposome prime-boost immunization strategy induced antibodies that recognized a gp41 fusion intermediate protein and was successful in focusing the antibody response to the desired epitope. A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope. Here we describe a HIV-1 envelope (Env) gp140 oligomer prime followed by MPER peptide-liposomes boost strategy for eliciting serum antibody responses in rhesus macaques that bind to a gp41 fusion intermediate protein. This Env-liposome immunization strategy induced antibodies to the 2F5 neutralizing epitope ⁶⁶⁴DKW residues, and these antibodies preferentially bound to a gp41 fusion intermediate construct as well as to MPER scaffolds stabilized in the 2F5-bound conformation. However, no serum lipid binding activity was observed nor was serum neutralizing activity for HIV-1 pseudoviruses present. Nonetheless, the Env-liposome prime-boost immunization strategy induced antibodies that recognized a gp41 fusion intermediate protein and was successful in focusing the antibody response to the desired epitope.A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope. Here we describe a HIV-1 envelope (Env) gp140 oligomer prime followed by MPER peptide-liposomes boost strategy for eliciting serum antibody responses in rhesus macaques that bind to a gp41 fusion intermediate protein. This Env-liposome immunization strategy induced antibodies to the 2F5 neutralizing epitope ⁶⁶⁴DKW residues, and these antibodies preferentially bound to a gp41 fusion intermediate construct as well as to MPER scaffolds stabilized in the 2F5-bound conformation. However, no serum lipid binding activity was observed nor was serum neutralizing activity for HIV-1 pseudoviruses present. Nonetheless, the Env-liposome prime-boost immunization strategy induced antibodies that recognized a gp41 fusion intermediate protein and was successful in focusing the antibody response to the desired epitope. A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope. Here we describe a HIV-1 envelope (Env) gp140 oligomer prime followed by MPER peptide-liposomes boost strategy for eliciting serum antibody responses in rhesus macaques that bind to a gp41 fusion intermediate protein. This Env-liposome immunization strategy induced antibodies to the 2F5 neutralizing epitope .sup.664 DKW residues, and these antibodies preferentially bound to a gp41 fusion intermediate construct as well as to MPER scaffolds stabilized in the 2F5-bound conformation. However, no serum lipid binding activity was observed nor was serum neutralizing activity for HIV-1 pseudoviruses present. Nonetheless, the Env-liposome prime-boost immunization strategy induced antibodies that recognized a gp41 fusion intermediate protein and was successful in focusing the antibody response to the desired epitope. A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody response to the transiently exposed MPER pre-hairpin intermediate neutralization epitope. Here we describe a HIV-1 envelope (Env) gp140 oligomer prime followed by MPER peptide-liposomes boost strategy for eliciting serum antibody responses in rhesus macaques that bind to a gp41 fusion intermediate protein. This Env-liposome immunization strategy induced antibodies to the 2F5 neutralizing epitope ⁶⁶⁴DKW residues, and these antibodies preferentially bound to a gp41 fusion intermediate construct as well as to MPER scaffolds stabilized in the 2F5-bound conformation. However, no serum lipid binding activity was observed nor was serum neutralizing activity for HIV-1 pseudoviruses present. Nonetheless, the Env-liposome prime-boost immunization strategy induced antibodies that recognized a gp41 fusion intermediate protein and was successful in focusing the antibody response to the desired epitope.
Audience	Academic
Author	Sutherland, Laura L. Shen, Xiaoying Parks, Robert Chen, Bing Ofek, Gilad Dennison, S. Moses Jaeger, Frederick H. Xia, Shi-Mao Scearce, Richard M. Yang, Yongping Kwong, Peter D. Stewart, Shelley Tomaras, Georgia Alam, S. Munir Santra, Sampa Zhang, Ruijun Letvin, Norman L. Bowman, Cindy Liao, Hua-Xin Anasti, Kara M. Haynes, Barton F.
AuthorAffiliation	University of Alabama, United States of America 3 Division of Molecular Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America 1 Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America 2 Department of Medicine, Beth Israel Deaconess Medical Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America 4 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
AuthorAffiliation_xml	– name: 3 Division of Molecular Medicine, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America – name: 1 Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, United States of America – name: 2 Department of Medicine, Beth Israel Deaconess Medical Center, Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America – name: University of Alabama, United States of America – name: 4 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Author_xml	– sequence: 1 givenname: S. Moses surname: Dennison fullname: Dennison, S. Moses – sequence: 2 givenname: Laura L. surname: Sutherland fullname: Sutherland, Laura L. – sequence: 3 givenname: Frederick H. surname: Jaeger fullname: Jaeger, Frederick H. – sequence: 4 givenname: Kara M. surname: Anasti fullname: Anasti, Kara M. – sequence: 5 givenname: Robert surname: Parks fullname: Parks, Robert – sequence: 6 givenname: Shelley surname: Stewart fullname: Stewart, Shelley – sequence: 7 givenname: Cindy surname: Bowman fullname: Bowman, Cindy – sequence: 8 givenname: Shi-Mao surname: Xia fullname: Xia, Shi-Mao – sequence: 9 givenname: Ruijun surname: Zhang fullname: Zhang, Ruijun – sequence: 10 givenname: Xiaoying surname: Shen fullname: Shen, Xiaoying – sequence: 11 givenname: Richard M. surname: Scearce fullname: Scearce, Richard M. – sequence: 12 givenname: Gilad surname: Ofek fullname: Ofek, Gilad – sequence: 13 givenname: Yongping surname: Yang fullname: Yang, Yongping – sequence: 14 givenname: Peter D. surname: Kwong fullname: Kwong, Peter D. – sequence: 15 givenname: Sampa surname: Santra fullname: Santra, Sampa – sequence: 16 givenname: Hua-Xin surname: Liao fullname: Liao, Hua-Xin – sequence: 17 givenname: Georgia surname: Tomaras fullname: Tomaras, Georgia – sequence: 18 givenname: Norman L. surname: Letvin fullname: Letvin, Norman L. – sequence: 19 givenname: Bing surname: Chen fullname: Chen, Bing – sequence: 20 givenname: S. Munir surname: Alam fullname: Alam, S. Munir – sequence: 21 givenname: Barton F. surname: Haynes fullname: Haynes, Barton F.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22140469$$D View this record in MEDLINE/PubMed
BookMark	eNqNk12L1DAUhousuB_6D0QLguJFxyT9SOuFMCyuW1hZGNe9Daf5mMnQScYmFfXXm-50lumyiPSi5eR535y8PTmNjow1MopeYjTDKcUf1rbvDLSzbSjPECK0JNmT6ARXKUkKgtKjg-_j6NS5NUJ5WhbFs-iYEJyhrKhOonVtRM-9tia2Kp4brxsrtHSxNvFiJV3v4q_A4UcfSjcr8PFCcrs0-o-MIb7oXRAmtfGy20ihwcv43Bpluw3sLS_r2wTHy22Gn0dPFbROvhjfZ9H3i88355fJ1fWX-nx-lfCiwj4BKnDDQ6cpxxzTXChSKEFzLCuCiMQipQrySuQqLXmDBYFMkIbmCiPVqDxLz6LXO99tax0bY3IMp5hWOA8nD0S9I4SFNdt2egPdb2ZBs7uC7ZYMOq95K5koEYaqbIauMgKqyqWsGkQBEIeUkuD1adytb0IGXBrfQTsxna4YvWJL-5OlhNACFcHg3WjQ2SFmzzbacdm2YKTtHatQSTMUGg_kmwfk44cbqSWE_nX4G2FbPniyeUaLssBpWQVq9ggVHiE3moeRUjrUJ4L3E0FgvPzll9A7x-pvi_9nr2-n7NsDdiWh9Stn236YHzcFXx0GfZ_wfpYDkO0A3lnnOqnuEYzYcGX2cbHhyrDxygTZxwcyrv3d-IZEdPtv8V9Iuhv8
CitedBy_id	crossref_primary_10_1002_jps_23773 crossref_primary_10_1517_14712598_2013_761969 crossref_primary_10_1016_j_immuni_2019_02_008 crossref_primary_10_1016_j_virol_2016_01_002 crossref_primary_10_1016_j_virol_2014_03_015 crossref_primary_10_1038_ncomms7565 crossref_primary_10_1126_scitranslmed_aaf0618 crossref_primary_10_1074_jbc_M113_494609 crossref_primary_10_3389_fimmu_2024_1484029 crossref_primary_10_1371_journal_pone_0151842 crossref_primary_10_1074_jbc_M113_527747 crossref_primary_10_1038_s41577_022_00753_w crossref_primary_10_1016_j_coi_2015_05_007 crossref_primary_10_3390_v10030100 crossref_primary_10_3390_v12111210 crossref_primary_10_1128_JVI_01089_16 crossref_primary_10_3389_fimmu_2018_02194 crossref_primary_10_1371_journal_ppat_1008373 crossref_primary_10_1097_COH_0000000000000360 crossref_primary_10_1134_S0026893316030110 crossref_primary_10_1016_j_bbamem_2014_07_007 crossref_primary_10_1016_j_vaccine_2017_03_039 crossref_primary_10_1016_j_cell_2024_04_033 crossref_primary_10_1038_srep40800 crossref_primary_10_1371_journal_ppat_1003202 crossref_primary_10_1016_j_immuni_2015_12_001 crossref_primary_10_1128_JVI_02664_13 crossref_primary_10_1371_journal_pone_0072205 crossref_primary_10_1016_j_virol_2015_09_010 crossref_primary_10_1097_COH_0000000000000049 crossref_primary_10_1007_s13238_018_0534_7 crossref_primary_10_1128_JVI_00005_21 crossref_primary_10_1586_14760584_2016_1129905 crossref_primary_10_1016_j_vaccine_2014_12_045 crossref_primary_10_1084_jem_20121977 crossref_primary_10_1016_j_tim_2012_08_011 crossref_primary_10_3389_fimmu_2023_1049673 crossref_primary_10_1016_j_cell_2024_10_003 crossref_primary_10_1128_JVI_01193_20 crossref_primary_10_1074_jbc_M114_569566 crossref_primary_10_1016_j_virol_2020_06_016 crossref_primary_10_3389_fimmu_2017_01154 crossref_primary_10_1016_j_smim_2021_101470 crossref_primary_10_1371_journal_pone_0052740 crossref_primary_10_1128_microbiolspec_AID_0025_2014 crossref_primary_10_3390_vaccines2010001 crossref_primary_10_1371_journal_ppat_1002806 crossref_primary_10_1128_JVI_00718_12 crossref_primary_10_1084_jem_20121827 crossref_primary_10_1074_jbc_M115_644351 crossref_primary_10_4049_jimmunol_1800323 crossref_primary_10_1186_s12977_018_0457_7 crossref_primary_10_1016_j_sbi_2024_102897 crossref_primary_10_1016_j_bbamem_2023_184235 crossref_primary_10_1111_imr_12075 crossref_primary_10_12688_gatesopenres_14743_1 crossref_primary_10_1097_COH_0000000000000820 crossref_primary_10_1128_mSphere_00320_19 crossref_primary_10_12688_gatesopenres_14743_2 crossref_primary_10_4049_jimmunol_1302511 crossref_primary_10_4049_jimmunol_1300971
Cites_doi	10.1128/JVI.00239-07 10.1016/j.vaccine.2009.05.059 10.1073/pnas.0912914107 10.1128/JVI.74.13.6186-6192.2000 10.1126/science.1111781 10.4049/jimmunol.178.7.4424 10.1038/nsmb.1944 10.1016/S0264-410X(00)00267-X 10.1097/QAD.0b013e32832faea5 10.1128/MMBR.00020-07 10.1128/JVI.02631-08 10.1016/S0022-2836(03)00611-9 10.1074/jbc.M205862200 10.1128/JVI.73.3.2469-2480.1999 10.1021/bi026952u 10.4049/jimmunol.181.9.5875 10.1016/j.virol.2007.11.005 10.1016/j.immuni.2004.12.011 10.1016/j.virol.2009.05.015 10.1073/pnas.0912381107 10.1128/JVI.78.19.10724-10737.2004 10.1128/JVI.00571-09 10.1016/j.immuni.2008.06.009 10.1016/j.virol.2006.04.043 10.1016/S0264-410X(99)00125-5 10.1073/pnas.0901474106 10.1016/j.clim.2003.08.012 10.1128/JVI.73.7.6089-6092.1999 10.1038/nsmb.1950 10.1016/j.coi.2011.04.003 10.1128/JVI.02036-08 10.1128/JVI.00184-09 10.1089/08892220152741450 10.1016/j.immuni.2007.11.018 10.1371/journal.pone.0018233 10.1021/bi0509245 10.1128/JVI.01680-10 10.1016/j.vaccine.2004.09.037 10.1016/j.vaccine.2005.01.099 10.1073/pnas.1004728107 10.1371/journal.pone.0016074 10.1099/0022-1317-77-9-2001 10.1073/pnas.0908713106 10.1073/pnas.0800255105 10.1371/journal.pone.0014813 10.1089/aid.2008.0213 10.1016/j.jmb.2008.09.024 10.1021/bi010640u 10.1128/JVI.78.15.8342-8348.2004 10.1016/j.immuni.2007.12.004 10.1128/JVI.01272-09 10.1128/JVI.00927-07
ContentType	Journal Article
Copyright	COPYRIGHT 2011 Public Library of Science 2011 Dennison et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Dennison et al. 2011
Copyright_xml	– notice: COPYRIGHT 2011 Public Library of Science – notice: 2011 Dennison et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Dennison et al. 2011
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PTHSS PYCSY RC3 7X8 5PM DOA
DOI	10.1371/journal.pone.0027824
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	Agricultural Science Database MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Medicine Biology
DocumentTitleAlternate	Induction of MPER Antibodies in Rhesus
EISSN	1932-6203
ExternalDocumentID	1317915214 oai_doaj_org_article_d801a98ba7d142af95ee9b07aa0ca372 PMC3227606 2921475951 A476861389 22140469 10_1371_journal_pone_0027824
Genre	Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GeographicLocations	North Carolina United States--US Maryland Massachusetts
GeographicLocations_xml	– name: Maryland – name: North Carolina – name: United States--US – name: Massachusetts
GrantInformation_xml	– fundername: NIAID NIH HHS grantid: U19 AI067854 – fundername: NIAID NIH HHS grantid: AI067854 – fundername: NIAID NIH HHS grantid: P30 AI060354 – fundername: NIAID NIH HHS grantid: U01 AI067854
GroupedDBID	--- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV ADRAZ AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAWUL BBNVY BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPNFZ IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PYCSY RIG RNS RPM SV3 TR2 UKHRP WOQ WOW ~02 ~KM ALIPV CGR CUY CVF ECM EIF NPM PV9 RZL BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO ESTFP FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI PRINS RC3 7X8 5PM AAPBV ABPTK BBAFP
ID	FETCH-LOGICAL-c691t-a7d1bc5383c1c175df26fd751e9202e1d37fa59d5f38cb1d2a4d2b75f10fbf543
IEDL.DBID	FPL
ISICitedReferencesCount	65
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000298168100019&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1932-6203
IngestDate	Sun Oct 02 00:11:00 EDT 2022 Fri Oct 03 12:53:35 EDT 2025 Tue Nov 04 01:56:44 EST 2025 Sun Nov 09 10:21:28 EST 2025 Tue Oct 07 06:51:55 EDT 2025 Sat Nov 29 13:03:58 EST 2025 Sat Nov 29 09:52:15 EST 2025 Wed Nov 26 10:24:15 EST 2025 Wed Nov 26 09:26:14 EST 2025 Thu May 22 21:19:51 EDT 2025 Mon Jul 21 06:05:29 EDT 2025 Sat Nov 29 02:37:10 EST 2025 Tue Nov 18 22:28:58 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	11
Language	English
License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. Creative Commons Attribution License
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c691t-a7d1bc5383c1c175df26fd751e9202e1d37fa59d5f38cb1d2a4d2b75f10fbf543
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: SMD SMA H-XL NLL BFH. Performed the experiments: SMD LLS CB RMS FHJ KMA SS RP S-MX XS RZ SS. Analyzed the data: SMD FHJ KMA RP S-MX GT H-XL SMA BFH. Contributed reagents/materials/analysis tools: YY PDK GO BC. Wrote the paper: SMD SMA BFH.
OpenAccessLink	http://dx.doi.org/10.1371/journal.pone.0027824
PMID	22140469
PQID	1317915214
PQPubID	1436336
PageCount	e27824
ParticipantIDs	plos_journals_1317915214 doaj_primary_oai_doaj_org_article_d801a98ba7d142af95ee9b07aa0ca372 pubmedcentral_primary_oai_pubmedcentral_nih_gov_3227606 proquest_miscellaneous_908740152 proquest_journals_1317915214 gale_infotracmisc_A476861389 gale_infotracacademiconefile_A476861389 gale_incontextgauss_ISR_A476861389 gale_incontextgauss_IOV_A476861389 gale_healthsolutions_A476861389 pubmed_primary_22140469 crossref_primary_10_1371_journal_pone_0027824 crossref_citationtrail_10_1371_journal_pone_0027824
PublicationCentury	2000
PublicationDate	2011-11-30
PublicationDateYYYYMMDD	2011-11-30
PublicationDate_xml	– month: 11 year: 2011 text: 2011-11-30 day: 30
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States – name: San Francisco – name: San Francisco, USA
PublicationTitle	PloS one
PublicationTitleAlternate	PLoS One
PublicationYear	2011
Publisher	Public Library of Science Public Library of Science (PLoS)
Publisher_xml	– name: Public Library of Science – name: Public Library of Science (PLoS)
References	A Hinz (ref12) 2009; 390 Z Biron (ref23) 2005; 44 M Montero (ref25) 2008; 72 X Shen (ref15) 2010; 107 X Shen (ref9) 2009; 83 L Morris (ref45) 2011 H Zhang (ref36) 2004; 78 MB Uccellini (ref50) 2008; 181 G Ofek (ref3) 2004; 78 BK Chakrabarti (ref38) 2005; 23 I Munoz-Barroso (ref5) 1999; 73 G Stiegler (ref4) 2001; 17 RA Herlands (ref47) 2008; 29 G Ofek (ref27) 2010; 107 JP Julien (ref2) 2008; 384 DJ Schibli (ref26) 2001; 40 J Ho (ref39) 2005; 23 W Yuan (ref30) 2009; 25 E Coeffier (ref10) 2000; 19 L Song (ref20) 2009; 106 MJ Shlomchik (ref48) 2008; 28 L Verkoczy (ref46) 2011; 23 J Wang (ref42) 2011; 6 SM Alam (ref29) 2009; 106 L Verkoczy (ref16) 2010; 107 MK Gorny (ref31) 2000; 74 G Barbato (ref22) 2003; 330 L Ye (ref43) 2011; 6 GR Matyas (ref51) 2009; 23 SM Dennison (ref53) 2011; 85 AJ Hessell (ref7) 2010; 84 X Liang (ref37) 1999; 17 TT Tran (ref49) 2003; 109 G Frey (ref14) 2008; 105 ZY Sun (ref21) 2008; 28 K Salzwedel (ref6) 1999; 73 G Frey (ref32) 2010; 17 DS Watson (ref41) 2009; 27 HX Liao (ref52) 2006; 353 RM Cardoso (ref1) 2005; 22 GB McGaughey (ref40) 2003; 42 BF Haynes (ref34) 2005; 308 SM Alam (ref18) 2007; 178 SM Alam (ref17) 2008; 82 GF Arnold (ref35) 2009; 83 JG Joyce (ref24) 2002; 277 L Eckhart (ref11) 1996; 77 ES Gray (ref44) 2007; 81 SM Dennison (ref19) 2009; 83 DN Sather (ref8) 2009; 83 S Phogat (ref13) 2008; 373 NI Nicely (ref28) 2010; 17 J Guenaga (ref33) 2011; 6 18322034 - Microbiol Mol Biol Rev. 2008 Mar;72(1):54-84, table of contents 19906907 - J Virol. 2010 Feb;84(3):1302-13 19640992 - J Virol. 2009 Oct;83(19):10211-23 19539967 - Virology. 2009 Aug 1;390(2):221-7 19292593 - AIDS Res Hum Retroviruses. 2009 Mar;25(3):319-28 19458040 - Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9057-62 21524897 - Curr Opin Immunol. 2011 Jun;23(3):383-90 15254206 - J Virol. 2004 Aug;78(15):8342-8 15694508 - Vaccine. 2005 Feb 18;23(13):1559-73 19279101 - J Virol. 2009 May;83(10):5087-100 20876137 - Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17880-7 12641452 - Biochemistry. 2003 Mar 25;42(11):3214-23 21980336 - PLoS One. 2011;6(9):e23532 19193787 - J Virol. 2009 Apr;83(8):3617-25 18199415 - Immunity. 2008 Jan;28(1):18-28 8810996 - J Gen Virol. 1996 Sep;77 ( Pt 9):2001-8 18155743 - Virology. 2008 Mar 30;373(1):72-84 11115689 - Vaccine. 2000 Nov 22;19(7-8):684-93 15837367 - Vaccine. 2005 May 16;23(26):3434-45 9971832 - J Virol. 1999 Mar;73(3):2469-80 18987148 - J Virol. 2009 Jan;83(2):757-69 19906992 - Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20234-9 17942537 - J Virol. 2008 Jan;82(1):115-25 15367639 - J Virol. 2004 Oct;78(19):10724-37 10438057 - Vaccine. 1999 Jul 16;17(22):2862-72 20231447 - Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5972-7 18941176 - J Immunol. 2008 Nov 1;181(9):5875-84 21483871 - PLoS One. 2011;6(3):e18233 19710597 - AIDS. 2009 Oct 23;23(16):2069-77 14697742 - Clin Immunol. 2003 Dec;109(3):278-87 17409164 - J Virol. 2007 Jun;81(12):6187-96 18322015 - Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3739-44 18691914 - Immunity. 2008 Aug 15;29(2):249-60 21076402 - Nat Struct Mol Biol. 2010 Dec;17(12):1486-91 11583156 - Biochemistry. 2001 Aug 14;40(32):9570-8 21625584 - PLoS One. 2011;6(5):e14813 11788027 - AIDS Res Hum Retroviruses. 2001 Dec 10;17(18):1757-65 21106741 - J Virol. 2011 Feb;85(3):1340-7 17039602 - Virology. 2006 Sep 30;353(2):268-82 10846104 - J Virol. 2000 Jul;74(13):6186-92 21297864 - PLoS One. 2011;6(1):e16074 16216084 - Biochemistry. 2005 Oct 18;44(41):13602-11 18191596 - Immunity. 2008 Jan;28(1):52-63 15723805 - Immunity. 2005 Feb;22(2):163-73 19520200 - Vaccine. 2009 Jul 23;27(34):4672-83 17372000 - J Immunol. 2007 Apr 1;178(7):4424-35 21076400 - Nat Struct Mol Biol. 2010 Dec;17(12):1492-4 12237296 - J Biol Chem. 2002 Nov 29;277(48):45811-20 15860590 - Science. 2005 Jun 24;308(5730):1906-8 12860131 - J Mol Biol. 2003 Jul 25;330(5):1101-15 10364363 - J Virol. 1999 Jul;73(7):6089-92 18824005 - J Mol Biol. 2008 Dec 12;384(2):377-92 20018688 - Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):181-6
References_xml	– volume: 81 start-page: 6187 year: 2007 ident: ref44 article-title: Neutralizing antibody responses in acute human immunodeficiency virus type 1 subtype C infection. publication-title: J Virol doi: 10.1128/JVI.00239-07 – volume: 27 start-page: 4672 year: 2009 ident: ref41 article-title: Role of lipid structure in the humoral immune response in mice to covalent lipid-peptides from the membrane proximal region of HIV-1 gp41. publication-title: Vaccine doi: 10.1016/j.vaccine.2009.05.059 – volume: 107 start-page: 181 year: 2010 ident: ref16 article-title: Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0912914107 – volume: 74 start-page: 6186 year: 2000 ident: ref31 article-title: Recognition by human monoclonal antibodies of free and complexed peptides representing the prefusogenic and fusogenic forms of human immunodeficiency virus type 1 gp41. publication-title: J Virol doi: 10.1128/JVI.74.13.6186-6192.2000 – volume: 308 start-page: 1906 year: 2005 ident: ref34 article-title: Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. publication-title: Science doi: 10.1126/science.1111781 – volume: 178 start-page: 4424 year: 2007 ident: ref18 article-title: The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes. publication-title: J Immunol doi: 10.4049/jimmunol.178.7.4424 – volume: 17 start-page: 1492 year: 2010 ident: ref28 article-title: Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region. publication-title: Nat Struct Mol Biol doi: 10.1038/nsmb.1944 – volume: 19 start-page: 684 year: 2000 ident: ref10 article-title: Antigenicity and immunogenicity of the HIV-1 gp41 epitope ELDKWA inserted into permissive sites of the MalE protein. publication-title: Vaccine doi: 10.1016/S0264-410X(00)00267-X – volume: 23 start-page: 2069 year: 2009 ident: ref51 article-title: Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes. publication-title: AIDS doi: 10.1097/QAD.0b013e32832faea5 – volume: 72 start-page: 54 year: 2008 ident: ref25 article-title: The membrane-proximal external region of the human immunodeficiency virus type 1 envelope: dominant site of antibody neutralization and target for vaccine design. publication-title: Microbiol Mol Biol Rev doi: 10.1128/MMBR.00020-07 – volume: 83 start-page: 3617 year: 2009 ident: ref9 article-title: In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth. publication-title: J Virol doi: 10.1128/JVI.02631-08 – volume: 330 start-page: 1101 year: 2003 ident: ref22 article-title: Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusion. publication-title: J Mol Biol doi: 10.1016/S0022-2836(03)00611-9 – volume: 277 start-page: 45811 year: 2002 ident: ref24 article-title: Enhancement of alpha -helicity in the HIV-1 inhibitory peptide DP178 leads to an increased affinity for human monoclonal antibody 2F5 but does not elicit neutralizing responses in vitro. Implications for vaccine design. publication-title: J Biol Chem doi: 10.1074/jbc.M205862200 – volume: 73 start-page: 2469 year: 1999 ident: ref6 article-title: A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity. publication-title: J Virol doi: 10.1128/JVI.73.3.2469-2480.1999 – volume: 42 start-page: 3214 year: 2003 ident: ref40 article-title: HIV-1 vaccine development: constrained peptide immunogens show improved binding to the anti-HIV-1 gp41 MAb. publication-title: Biochemistry doi: 10.1021/bi026952u – volume: 181 start-page: 5875 year: 2008 ident: ref50 article-title: Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-alpha. publication-title: J Immunol doi: 10.4049/jimmunol.181.9.5875 – volume: 373 start-page: 72 year: 2008 ident: ref13 article-title: Analysis of the human immunodeficiency virus type 1 gp41 membrane proximal external region arrayed on hepatitis B surface antigen particles. publication-title: Virology doi: 10.1016/j.virol.2007.11.005 – volume: 22 start-page: 163 year: 2005 ident: ref1 article-title: Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. publication-title: Immunity doi: 10.1016/j.immuni.2004.12.011 – volume: 390 start-page: 221 year: 2009 ident: ref12 article-title: Characterization of a trimeric MPER containing HIV-1 gp41 antigen. publication-title: Virology doi: 10.1016/j.virol.2009.05.015 – volume: 107 start-page: 5972 year: 2010 ident: ref15 article-title: Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0912381107 – volume: 78 start-page: 10724 year: 2004 ident: ref3 article-title: Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope. publication-title: J Virol doi: 10.1128/JVI.78.19.10724-10737.2004 – volume: 83 start-page: 10211 year: 2009 ident: ref19 article-title: Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions. publication-title: J Virol doi: 10.1128/JVI.00571-09 – volume: 29 start-page: 249 year: 2008 ident: ref47 article-title: T cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells. publication-title: Immunity doi: 10.1016/j.immuni.2008.06.009 – volume: 353 start-page: 268 year: 2006 ident: ref52 article-title: A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. publication-title: Virology doi: 10.1016/j.virol.2006.04.043 – volume: 17 start-page: 2862 year: 1999 ident: ref37 article-title: Epitope insertion into variable loops of HIV-1 gp120 as a potential means to improve immunogenicity of viral envelope protein. publication-title: Vaccine doi: 10.1016/S0264-410X(99)00125-5 – volume: 106 start-page: 9057 year: 2009 ident: ref20 article-title: Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0901474106 – volume: 109 start-page: 278 year: 2003 ident: ref49 article-title: Specificity and immunochemical properties of anti-DNA antibodies induced in normal mice by immunization with mammalian DNA with a CpG oligonucleotide as adjuvant. publication-title: Clin Immunol doi: 10.1016/j.clim.2003.08.012 – volume: 73 start-page: 6089 year: 1999 ident: ref5 article-title: Role of the membrane-proximal domain in the initial stages of human immunodeficiency virus type 1 envelope glycoprotein-mediated membrane fusion. publication-title: J Virol doi: 10.1128/JVI.73.7.6089-6092.1999 – volume: 17 start-page: 1486 year: 2010 ident: ref32 article-title: Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies. publication-title: Nat Struct Mol Biol doi: 10.1038/nsmb.1950 – volume: 23 start-page: 383 year: 2011 ident: ref46 article-title: Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. publication-title: Curr Opin Immunol doi: 10.1016/j.coi.2011.04.003 – volume: 83 start-page: 757 year: 2009 ident: ref8 article-title: Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection. publication-title: J Virol doi: 10.1128/JVI.02036-08 – volume: 83 start-page: 5087 year: 2009 ident: ref35 article-title: Broad neutralization of human immunodeficiency virus type 1 (HIV-1) elicited from human rhinoviruses that display the HIV-1 gp41 ELDKWA epitope. publication-title: J Virol doi: 10.1128/JVI.00184-09 – volume: 17 start-page: 1757 year: 2001 ident: ref4 article-title: A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1. publication-title: AIDS Res Hum Retroviruses doi: 10.1089/08892220152741450 – volume: 28 start-page: 52 year: 2008 ident: ref21 article-title: HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. publication-title: Immunity doi: 10.1016/j.immuni.2007.11.018 – volume: 6 start-page: e18233 year: 2011 ident: ref42 article-title: HIV-1 gp41 core with exposed membrane-proximal external region inducing broad HIV-1 neutralizing antibodies. publication-title: PLoS One doi: 10.1371/journal.pone.0018233 – volume: 44 start-page: 13602 year: 2005 ident: ref23 article-title: The 2F5 epitope is helical in the HIV-1 entry inhibitor T-20. publication-title: Biochemistry doi: 10.1021/bi0509245 – volume: 85 start-page: 1340 year: 2011 ident: ref53 article-title: Nonneutralizing HIV-1 gp41 envelope cluster II human monoclonal antibodies show polyreactivity for binding to phospholipids and protein autoantigens. publication-title: J Virol doi: 10.1128/JVI.01680-10 – volume: 23 start-page: 1559 year: 2005 ident: ref39 article-title: Conformational constraints imposed on a pan-neutralizing HIV-1 antibody epitope result in increased antigenicity but not neutralizing response. publication-title: Vaccine doi: 10.1016/j.vaccine.2004.09.037 – volume: 23 start-page: 3434 year: 2005 ident: ref38 article-title: Expanded breadth of virus neutralization after immunization with a multiclade envelope HIV vaccine candidate. publication-title: Vaccine doi: 10.1016/j.vaccine.2005.01.099 – volume: 107 start-page: 17880 year: 2010 ident: ref27 article-title: Elicitation of structure-specific antibodies by epitope scaffolds. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1004728107 – volume: 6 start-page: e16074 year: 2011 ident: ref33 article-title: Heterologous Epitope-Scaffold Prime∶Boosting Immuno-Focuses B Cell Responses to the HIV-1 gp41 2F5 Neutralization Determinant. publication-title: PLoS ONE doi: 10.1371/journal.pone.0016074 – volume: 77 start-page: 2001 issue: Pt 9 year: 1996 ident: ref11 article-title: Immunogenic presentation of a conserved gp41 epitope of human immunodeficiency virus type 1 on recombinant surface antigen of hepatitis B virus. publication-title: J Gen Virol doi: 10.1099/0022-1317-77-9-2001 – volume: 106 start-page: 20234 year: 2009 ident: ref29 article-title: Role of HIV membrane in neutralization by two broadly neutralizing antibodies. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0908713106 – volume: 105 start-page: 3739 year: 2008 ident: ref14 article-title: A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies. publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0800255105 – volume: 6 start-page: e14813 year: 2011 ident: ref43 article-title: Induction of HIV Neutralizing Antibodies against the MPER of the HIV Envelope Protein by HA/gp41 Chimeric Protein-Based DNA and VLP Vaccines. publication-title: PLoS One doi: 10.1371/journal.pone.0014813 – volume: 25 start-page: 319 year: 2009 ident: ref30 article-title: Oligomer-specific conformations of the human immunodeficiency virus (HIV-1) gp41 envelope glycoprotein ectodomain recognized by human monoclonal antibodies. publication-title: AIDS Res Hum Retroviruses doi: 10.1089/aid.2008.0213 – volume: 384 start-page: 377 year: 2008 ident: ref2 article-title: Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site. publication-title: J Mol Biol doi: 10.1016/j.jmb.2008.09.024 – volume: 40 start-page: 9570 year: 2001 ident: ref26 article-title: The membrane-proximal tryptophan-rich region of the HIV glycoprotein, gp41, forms a well-defined helix in dodecylphosphocholine micelles. publication-title: Biochemistry doi: 10.1021/bi010640u – volume: 78 start-page: 8342 year: 2004 ident: ref36 article-title: Induction of mucosal and systemic neutralizing antibodies against human immunodeficiency virus type 1 (HIV-1) by oral immunization with bovine Papillomavirus-HIV-1 gp41 chimeric virus-like particles. publication-title: J Virol doi: 10.1128/JVI.78.15.8342-8348.2004 – volume: 28 start-page: 18 year: 2008 ident: ref48 article-title: Sites and stages of autoreactive B cell activation and regulation. publication-title: Immunity doi: 10.1016/j.immuni.2007.12.004 – volume: 84 start-page: 1302 year: 2010 ident: ref7 article-title: Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. publication-title: J Virol doi: 10.1128/JVI.01272-09 – volume: 82 start-page: 115 year: 2008 ident: ref17 article-title: Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection. publication-title: J Virol doi: 10.1128/JVI.00927-07 – year: 2011 ident: ref45 article-title: Isolation of a Human Anti-HIV gp41 Membrane Proximal Region Neutralizing Antibody by Antigen-Specific Single B Cell Sorting. publication-title: PLoS One – reference: 15694508 - Vaccine. 2005 Feb 18;23(13):1559-73 – reference: 20231447 - Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5972-7 – reference: 21076400 - Nat Struct Mol Biol. 2010 Dec;17(12):1492-4 – reference: 19906907 - J Virol. 2010 Feb;84(3):1302-13 – reference: 11583156 - Biochemistry. 2001 Aug 14;40(32):9570-8 – reference: 18199415 - Immunity. 2008 Jan;28(1):18-28 – reference: 12860131 - J Mol Biol. 2003 Jul 25;330(5):1101-15 – reference: 19906992 - Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20234-9 – reference: 10364363 - J Virol. 1999 Jul;73(7):6089-92 – reference: 18987148 - J Virol. 2009 Jan;83(2):757-69 – reference: 18155743 - Virology. 2008 Mar 30;373(1):72-84 – reference: 15254206 - J Virol. 2004 Aug;78(15):8342-8 – reference: 21625584 - PLoS One. 2011;6(5):e14813 – reference: 18322034 - Microbiol Mol Biol Rev. 2008 Mar;72(1):54-84, table of contents – reference: 21076402 - Nat Struct Mol Biol. 2010 Dec;17(12):1486-91 – reference: 11788027 - AIDS Res Hum Retroviruses. 2001 Dec 10;17(18):1757-65 – reference: 19279101 - J Virol. 2009 May;83(10):5087-100 – reference: 19640992 - J Virol. 2009 Oct;83(19):10211-23 – reference: 10846104 - J Virol. 2000 Jul;74(13):6186-92 – reference: 19710597 - AIDS. 2009 Oct 23;23(16):2069-77 – reference: 17372000 - J Immunol. 2007 Apr 1;178(7):4424-35 – reference: 16216084 - Biochemistry. 2005 Oct 18;44(41):13602-11 – reference: 15367639 - J Virol. 2004 Oct;78(19):10724-37 – reference: 21980336 - PLoS One. 2011;6(9):e23532 – reference: 19458040 - Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):9057-62 – reference: 18322015 - Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3739-44 – reference: 18941176 - J Immunol. 2008 Nov 1;181(9):5875-84 – reference: 19292593 - AIDS Res Hum Retroviruses. 2009 Mar;25(3):319-28 – reference: 8810996 - J Gen Virol. 1996 Sep;77 ( Pt 9):2001-8 – reference: 20018688 - Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):181-6 – reference: 18691914 - Immunity. 2008 Aug 15;29(2):249-60 – reference: 19520200 - Vaccine. 2009 Jul 23;27(34):4672-83 – reference: 19539967 - Virology. 2009 Aug 1;390(2):221-7 – reference: 18824005 - J Mol Biol. 2008 Dec 12;384(2):377-92 – reference: 19193787 - J Virol. 2009 Apr;83(8):3617-25 – reference: 15837367 - Vaccine. 2005 May 16;23(26):3434-45 – reference: 17409164 - J Virol. 2007 Jun;81(12):6187-96 – reference: 17942537 - J Virol. 2008 Jan;82(1):115-25 – reference: 12641452 - Biochemistry. 2003 Mar 25;42(11):3214-23 – reference: 21106741 - J Virol. 2011 Feb;85(3):1340-7 – reference: 21524897 - Curr Opin Immunol. 2011 Jun;23(3):383-90 – reference: 17039602 - Virology. 2006 Sep 30;353(2):268-82 – reference: 21297864 - PLoS One. 2011;6(1):e16074 – reference: 11115689 - Vaccine. 2000 Nov 22;19(7-8):684-93 – reference: 15860590 - Science. 2005 Jun 24;308(5730):1906-8 – reference: 21483871 - PLoS One. 2011;6(3):e18233 – reference: 9971832 - J Virol. 1999 Mar;73(3):2469-80 – reference: 12237296 - J Biol Chem. 2002 Nov 29;277(48):45811-20 – reference: 10438057 - Vaccine. 1999 Jul 16;17(22):2862-72 – reference: 20876137 - Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17880-7 – reference: 15723805 - Immunity. 2005 Feb;22(2):163-73 – reference: 18191596 - Immunity. 2008 Jan;28(1):52-63 – reference: 14697742 - Clin Immunol. 2003 Dec;109(3):278-87
RelatedPersons	Yang, Cindy
RelatedPersons_xml	– fullname: Yang, Cindy
SSID	ssj0053866
Score	2.3134334
Snippet	A component to the problem of inducing broad neutralizing HIV-1 gp41 membrane proximal external region (MPER) antibodies is the need to focus the antibody...
SourceID	plos doaj pubmedcentral proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	e27824
SubjectTerms	Animals Antibodies Antibody Formation - immunology Antibody response Antibody Specificity - immunology Antigenic determinants Antigens B cells Binding sites Biology Children & youth Cross-Priming - immunology Deoxyribonucleic acid DNA Epitopes Epitopes - immunology Fusion protein Glycoprotein gp41 Glycoproteins Guinea Pigs HIV HIV Antibodies - blood HIV Antibodies - immunology HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - immunology HIV-1 - immunology Hospitals Human immunodeficiency virus Immunization Immunoglobulins Infections Infectious diseases Lipids Liposomes Liposomes - chemistry Macaca mulatta - immunology Medicine Neutralization Neutralization Tests Neutralizing Peptides Peptides - chemistry Peptides - immunology Physicians Protein binding Protein Structure, Quaternary Proteins Recombinant Fusion Proteins - metabolism Scaffolds Strategy Well construction Yang, Cindy
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQxYELory6sICFkIBD2vgVx8eCqNpLQTyq3iLHj-5WJVltshz49Xgcb9SgSuXANZ5Nst-Mx5545huE3rC6lLYsRWao5RmX1GVK5CzztrBUE6JrrmOzCXl6Wp6fqy_XWn1BTthADzwAd2CDC9WqrLW0hFPtlXBO1bnUOjeayeh9c6m2wdTgg8MsLopUKMckOUh62V-1jduPh22UTxaiyNc_euWd1VXb3bTl_Dtz8tpSdPQA3U97SHw4vPsuuuOah2g3zdIOv0tU0u8foUvozBErF3DrcQBxWbeQNoiXDV4vXLfp8E9tNDwe9wvd45RP9Nthjf0GvqRlQCixjgUmvcMheh7LHeGWxydnGcEXK04eox9Hn75_PM5Sd4XMFIr0GQBam4AUM8SETYT1tPBWCuIUzakjlkmvhbLCs9LUJGiOW1pL4Unuay84e4J2moDnHsLSFZYUpSos49xwoYXOufFhL1Ayr6WYIbaFujKJehw6YFxV8TxNhhBkQK4CBVVJQTOUjb9aDdQbt8h_AC2OskCcHS8Ec6qSOVW3mdMMvQIbqIYq1HH6V4c8xGUFnOrO0OsoAeQZDWTnXOhN11Unn8_-Qejb14nQ2yTk2wCH0akiIvwnIOWaSM4nksEFmMnwHljsFpUuYASss2FnFkCZb6345mE8DsNNIeOuce2mq1QemzWKgMjTweZHYCkFTqYiPFZOZsME-elIs1xE6vKwfMgQMj_7H6p6ju7FD_yRh3OOdvr1xr1Ad82vftmtX0Z_8Ae1xWdO priority: 102 providerName: Directory of Open Access Journals – databaseName: Nursing & Allied Health Database dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELegIMQLsMFYYYCFkICHbLHjxMkTKohqe9hAZVR7ixx_tEVTUpqUB_56fI4TCJoAidf6ksbn893Zd_c7hF5ERcpVmsaBpIoFjFMdZHEYBUYligpCRMGEazbBz87Si4vso79wq31aZacTnaJWlYQ78iMSAZCmNTbszfprAF2jILrqW2hcRzcI-MZWnvls3mliu5eTxJfLRZwc-dU5XFelPnQhN8oG5sih9ve6ebS-rOqrHM_f8yd_MUjTu_87lXvojndF8aSVnR10TZe76NapD7bvoh2_72v8yoNTv76PvkCvD1cLgSuDJ2WzKipIRMSrEs-Wut7W-FRIAZ-Dz5eiwbM2Q-m7xgJPt3A3F7hbSFey0mgMJYddASW88vhkHhC8WDPyAH2evj9_dxz4fg2BTDLSBIIrUkjL9UgSad0SZWhiFI-JzmhINVERNyLOVGyiVBbEygJTtOCxIaEpTMyiPTQq7drsI8x1okiSZomKGJMsFrEImTTWu0gjI3g8RlG3bLn0YObQU-MydxE6bg81LRNzWOzcL_YYBf1T6xbM4y_0b0EielqA4nY_VJtF7nd2rqyNF1lawOwZFSaLtc6KkAsRShFxOkbPQJ7ytq61Vyj5hNmTXgJx4jF67igAjqOEfJ-F2NZ1fvJh_g9En2YDopeeyFSWHVL4Ggs7J4D5GlAeDCitUpGD4X2Q_o4rdf5TZu2TnVRfPYz7YXgp5PCVutrWeRa69o-x5cjDdv_0jKUUUJ4S-7d8sLMGnB-OlKulA0O3BonbQ_ijP3_VY3TbBQMcZucBGjWbrX6CbspvzarePHVa4weQaHbe priority: 102 providerName: ProQuest
Title	Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41
URI	https://www.ncbi.nlm.nih.gov/pubmed/22140469 https://www.proquest.com/docview/1317915214 https://www.proquest.com/docview/908740152 https://pubmed.ncbi.nlm.nih.gov/PMC3227606 https://doaj.org/article/d801a98ba7d142af95ee9b07aa0ca372 http://dx.doi.org/10.1371/journal.pone.0027824
Volume	6
WOSCitedRecordID	wos000298168100019&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3Nb9MwFLfYhhAXYONjhVEshAQcUmLHjpPjOq1aNVqiblQbl8jxx1Y0pdXScuCv59lNC5k2AZd3iJ8T52c_f7_fQ-hdVCRCJwkPFNUsYIKaIOVhFFgdayoJkQWTPtiEGA6Ts7M0-71QvHGCHwnyqca0M5uWpuMPyijbQFs0imMXqqGXfV71vGC7cVy7x92VszH8eJb-dV-8ObuaVrdNNG_el_xjAOo9_t-iP0GP6qkm3l-2jW10z5Q76MGgPkzfQdu1XVf4Q00-_fEp-u5ieXhfBzy1eL-cT4qpu2iIJyUeXZpqUeGBVNIVHZ9eyjkeLW8g_TRY4t7C7b0FfpfRu6TMDXYuhSsHSffKo_44IPhixsgz9LV3eHpwFNTxGAIVp2QeSKFJoQDlSBEF0w5taWy14MSkNKSG6EhYyVPNbZSogkBdM00LwS0JbWE5i56jzRKg2EVYmFiTOEljHTGmGJdchkxZmD0kkZWCt1C0qqZc1WTlLmbGVe5P4AQsWpYg5g7bvMa2hYJ1rtmSrOMv-l3XAta6jmrbP4BKzGvLzTWM4TJNCvf3jEqbcmPSIhRShkpGgrbQG9d-8qXf6rrDyPcZrORidw7cQm-9hqPbKN19ngu5qKq8_2X8D0ono4bS-1rJTgEOJWsfCvgnR-PV0NxraEKnoRrJu661r1CpACPHUwtzOQBlb2UBtyfjdbJ7qbujV5rposrT0Id35IDIi6W9rIGl1LE4xfBZ0bCkBvLNlHJy6cnOYcARsMh-eXeBX6GHfqPf83Huoc359cK8RvfVj_mkum6jDTEaO3kmvExAJgekjba6h8Ns1PabMG3fj4A87nZADsJjJ0Xm5QnIjH-DHFl_kJ3_AjU1caM
linkProvider	Public Library of Science
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKQcAFaHl0oVALgYBD2viRODkgVApVV32AylL1Fhw_2kVVsjS7IPhR_EY8zgOCKuDSA9f1xBtP5mF7Zr5B6BHLE6GTJAoU1TzggpogjUIWWB1rKgmROZe-2YTY20sOD9O3c-h7WwsDaZWtTfSGWpcK7sjXCAMgTeds-IvJpwC6RkF0tW2hUYvFtvn6xR3ZqufDV-77PqZ08_VoYytougoEKk7JNJBCk1w5PWeKKOc8taWx1SIiJqUhNUQzYWWU6siyROXEvTHXNBeRJaHNbcSZm_cCusgZZaBFyUaXUuLmjOOmPI8JstZIw-qkLMyqD_FR3nN_vktA5wvmJydlddZG9_d8zV8c4Ob1_411N9C1ZquN12vdWEBzplhEl3ebZIJFtNDYtQo_bcC3n91EH6GXia_1wKXF68V0nJeQaInHBd4_NtWswrtSSVg-Hh3LKd6vM7C-GSzx5gzuHgN_y-pLcqYGQ0llWyAKU24NDwKCjyac3ELvz2X5t9F84WRhCWFhYk3iJI0141zxSEYy5Mq63VPCrBTRALFWTDLVgLVDz5CTzEcghTu01UzMQLiyRrgGKOiemtRgJX-hfwkS2NEC1Lj_oTw9yhrLlWm3h5FpksPqOZU2jYxJ81BIGSrJBB2gFZDfrK7b7Qxmts7dSTaGOPgAPfQUADdSQD7TkZxVVTZ8c_APRO_2e0RPGiJbOnYo2dSQuDUBjFmPcrlH6Yym6g0vgba1XKmynzrinmy16Oxh3A3DpJCjWJhyVmVp6NtbRo4jd2p97RhLKaBYxe5vRU-Te5zvjxTjYw_27hyuiMP47p_fagVd2Rrt7mQ7w73te-iqD3x4fNJlND89nZn76JL6PB1Xpw-8xcLow3nr-Q-O89Sr
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwELZKQRUXoOXRhUItBAIOaWPHsZMDQgtl1VXpsiql6i04frSLqmTZZEHw0_h12I6zEFQBlx64rifeeDIP2zPzDQCPojxhMkniQGBJAsKwCtI4jAItqcQcIZ4T7ppNsNEoOT5Ox0vge1sLY9MqW5voDLUshb0j30aRBdI0zoZsa58WMd4ZvJh-CmwHKRtpbdtpNCKyp75-Mce36vlwx3zrxxgPXh--2g18h4FA0BTVAWcS5cLofCSQMI5Uaky1ZDFSKQ6xQjJimsepjHWUiByZtycS5yzWKNS5jklk5r0ELjNCQ-zSBsetFzBzUupL9SKGtr1kbE3LQm25cB8mHVfoOgYs_MLy9Kysztv0_p67-YszHFz_n9l4A1zzW3DYb3RmFSypYg2s7PskgzWw6u1dBZ96UO5nN8FH2-PE1YDAUsN-UU_y0iZgwkkBD05VNa_gPhfcsgIenvIaHjSZWd8U5HAwt3eSgbt9daU6tYK21LItHLVT7g6PAgRPpgTdAu8vZPm3wXJh5GIdQKaoRDRJqYwIESTmMQ-J0GZXlUSas7gHolZkMuFB3G0vkbPMRSaZOcw1TMysoGVe0HogWDw1bUBM_kL_0krjgtZCkLsfytlJ5i1aJs3ehqdJbldPMNdprFSah4zzUPCI4R7YtLKcNfW8C0Oa9Yk54VIbH--Bh47CwpAUVhJP-LyqsuHbo38genfQIXriiXRp2CG4ry0xa7LwZh3KjQ6lMaaiM7xuNa_lSpX91BfzZKtR5w_DxbCd1OYuFqqcV1kauraXseHInUZ3F4zF2KJbUfO3rKPVHc53R4rJqQOBN46Y0ZDe_fNbbYIVo97Zm-Fo7x646uIhDrZ0AyzXs7m6D66Iz_Wkmj1wxguCDxet5j8Ag4Hdtw
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Induction+of+Antibodies+in+Rhesus+Macaques+That+Recognize+a+Fusion-Intermediate+Conformation+of+HIV-1+gp41&rft.jtitle=PloS+one&rft.au=Dennison%2C+S.+Moses&rft.au=Sutherland%2C+Laura+L.&rft.au=Jaeger%2C+Frederick+H.&rft.au=Anasti%2C+Kara+M.&rft.date=2011-11-30&rft.issn=1932-6203&rft.eissn=1932-6203&rft.volume=6&rft.issue=11&rft.spage=e27824&rft_id=info:doi/10.1371%2Fjournal.pone.0027824&rft.externalDBID=n%2Fa&rft.externalDocID=10_1371_journal_pone_0027824
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon