Vascular Endothelial Growth Factor in the Circulation in Cancer Patients May Not Be a Relevant Biomarker

Levels of circulating vascular endothelial growth factor (VEGF) have widely been used as biomarker for angiogenic activity in cancer. For this purpose, non-standardized measurements in plasma and serum were used, without correction for artificial VEGF release by platelets activated ex vivo. We hypot...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 5; p. e19873
Main Authors:	Niers, Tatjana M. H., Richel, Dick J., Meijers, Joost C. M., Schlingemann, Reinier O.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 26.05.2011 Public Library of Science (PLoS)
Subjects:	Activation Aged Angiogenesis Background levels Baseline studies beta-Thromboglobulin - metabolism Bevacizumab Biomarkers Biomarkers, Tumor - blood Blood Blood platelets Blood Platelets - metabolism Cancer Cancer metastasis Cancer patients Care and treatment Case-Control Studies Citric acid Colorectal cancer Granulocytes Humans Kidney cancer Medicine Metastases Metastasis Middle Aged Monoclonal antibodies Neoplasms - blood Neoplasms - physiopathology Neutrophils Patients Platelet Activation Platelet Factor 4 - metabolism Platelets Renal cell carcinoma Studies Targeted cancer therapy Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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