The Fanconi Anemia Core Complex Is Dispensable during Somatic Hypermutation and Class Switch Recombination

To generate high affinity antibodies during an immune response, B cells undergo somatic hypermutation (SHM) of their immunoglobulin genes. Error-prone translesion synthesis (TLS) DNA polymerases have been reported to be responsible for all mutations at template A/T and at least a fraction of G/C tra...

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Vydáno v:	PloS one Ročník 5; číslo 12; s. e15236
Hlavní autoři:	Krijger, Peter H. L., Wit, Niek, van den Berk, Paul C. M., Jacobs, Heinz
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 29.12.2010 Public Library of Science (PLoS)
Témata:	Analysis Anemia Animals Antibodies Antigens B cells B-Lymphocytes - cytology Biology Cancer Chemical synthesis Cisplatin - pharmacology Class switching Cross-Linking Reagents - pharmacology Crosslinking Deoxyribonucleic acid DNA DNA - chemistry DNA biosynthesis DNA Mutational Analysis DNA polymerases DNA repair DNA-directed DNA polymerase Fanconi Anemia - metabolism Fanconi syndrome Fanconi's anemia Fibroblasts - cytology Genes Genotype Immune response Immune system Immunoglobulin Class Switching Immunoglobulins Immunology Lymphocytes B Mice Mutagenesis Mutation Phenotype Proliferating cell nuclear antigen Recombination Rodents Somatic hypermutation Ubiquitin - chemistry Ubiquitination Ultraviolet Rays Netherlands
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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