Susceptibility of Domestic Swine to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease, has been shown to infect several species. The role of domestic livestock and associated risks for humans in close contact with food production animals remains unknown for many species. Determinin...

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Vydáno v:	Emerging infectious diseases Ročník 27; číslo 1; s. 104 - 112
Hlavní autoři:	Pickering, Brad S., Smith, Greg, Pinette, Mathieu M., Embury-Hyatt, Carissa, Moffat, Estella, Marszal, Peter, Lewis, Charles E.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States U.S. National Center for Infectious Diseases 01.01.2021 Centers for Disease Control and Prevention
Témata:	Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Canada Control coronavirus disease Coronavirus Infections - veterinary Coronavirus Infections - virology Coronaviruses COVID-19 Disease susceptibility Disease Susceptibility - veterinary Disease transmission Diseases Domestic animals Epidemics Female Food production Hematology Hemoglobin Hogs Housing conditions Human-animal relationships Livestock Lymph Nodes - virology Lymphatic system Male Medical research Medicine, Experimental Mouth - virology Nasal Cavity - virology Pandemics Proteins Public health Reagents Rectum - virology respiratory infections RNA, Viral - blood SARS SARS-CoV-2 SARS-CoV-2 - immunology SARS-CoV-2 - isolation & purification SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Susceptibility of Domestic Swine to Experimental Infection with Severe Acute Respiratory Syndrome Coronavirus 2 Swine Virus Shedding Zoonoses Canada viruses SARS coronavirus zoonoses respiratory infections COVID-19 swine SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 livestock antibodies coronavirus disease pandemics public health One Health
ISSN:	1080-6040, 1080-6059, 1080-6059
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Shrnutí:	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease, has been shown to infect several species. The role of domestic livestock and associated risks for humans in close contact with food production animals remains unknown for many species. Determining the susceptibility of pigs to SARS-CoV-2 is critical to a One Health approach to manage potential risk for zoonotic transmission. We found that pigs are susceptible to SARS-CoV-2 after oronasal inoculation. Among 16 animals, we detected viral RNA in group oral fluids and in nasal wash from 2 pigs, but live virus was isolated from only 1 pig. Antibodies also were detected in only 2 animals at 11 and 13 days postinoculation but were detected in oral fluid samples at 6 days postinoculation, indicating antibody secretion. These data highlight the need for additional livestock assessment to determine the potential role of domestic animals in the SARS-CoV-2 pandemic.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author contributions: B.P. conceived the research. B.P, G.S., M.M.P., E.M, P.M., and C.E.L. performed the experiments. B.P, G.S., M.M.P., C.E.H., and C.E.L. analyzed the data. B.P. wrote the manuscript with input from B.P, G.S., M.M.P., E.M., and C.E.L. All authors discussed the results and reviewed the manuscript.
ISSN:	1080-6040 1080-6059 1080-6059
DOI:	10.3201/eid2701.203399