Influence of bacterial interactions on pneumococcal colonization of the nasopharynx

► Streptococcus pneumoniae is a member of a complex microbial community in the nasopharynx. ► Co-colonization with ≥2 strains is common, facilitating recombination and affecting density. ► Interactions with other nasopharyngeal bacteria influence carriage prevalence and virulence. ► Interspecies quo...

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Published in:Trends in microbiology (Regular ed.) Vol. 21; no. 3; pp. 129 - 135
Main Authors: Shak, Joshua R., Vidal, Jorge E., Klugman, Keith P.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.03.2013
Subjects:
bacteremia
Bacteria
biofilm
carriage
Carrier State - microbiology
co-colonization
Coinfection - microbiology
diagnostic techniques
ecosystems
Humans
interaction
Internal Medicine
meningitis
Microbial Interactions
nasopharynx
Nasopharynx - microbiology
otitis media
Pneumococcal Infections - microbiology
pneumonia
serotypes
Streptococcus pneumoniae
Streptococcus pneumoniae - growth & development
the pneumococcus
vaccines
virulence
interaction
the pneumococcus
co-colonization
carriage
nasopharynx
Streptococcus pneumoniae
ISSN:0966-842X, 1878-4380, 1878-4380
Online Access:Get full text
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Summary:► Streptococcus pneumoniae is a member of a complex microbial community in the nasopharynx. ► Co-colonization with ≥2 strains is common, facilitating recombination and affecting density. ► Interactions with other nasopharyngeal bacteria influence carriage prevalence and virulence. ► Interspecies quorum-sensing may regulate nasopharyngeal bacterial biofilm formation. Streptococcus pneumoniae (the pneumococcus) is a common commensal inhabitant of the nasopharynx and a frequent etiologic agent in serious diseases such as pneumonia, otitis media, bacteremia, and meningitis. Multiple pneumococcal strains can colonize the nasopharynx, which is also home to many other bacterial species. Intraspecies and interspecies interactions influence pneumococcal carriage in important ways. Co-colonization by two or more pneumococcal strains has implications for vaccine serotype replacement, carriage detection, and pneumonia diagnostics. Interactions between the pneumococcus and other bacterial species alter carriage prevalence, modulate virulence, and affect biofilm formation. By examining these interactions, this review highlights how the bacterial ecosystem of the nasopharynx changes the nature and course of pneumococcal carriage.
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ISSN:0966-842X
1878-4380
1878-4380
DOI:10.1016/j.tim.2012.11.005