BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents 1 – 5 . Here we show that se...

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Vydáno v:	Nature (London) Ročník 596; číslo 7871; s. 273 - 275
Hlavní autoři:	Liu, Jianying, Liu, Yang, Xia, Hongjie, Zou, Jing, Weaver, Scott C., Swanson, Kena A., Cai, Hui, Cutler, Mark, Cooper, David, Muik, Alexander, Jansen, Kathrin U., Sahin, Ugur, Xie, Xuping, Dormitzer, Philip R., Shi, Pei-Yong
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 12.08.2021 Nature Publishing Group
Témata:	13 38/23 38/77 38/90 631/326/590/2293 631/326/596/4130 Animals Antibodies Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Binding sites BNT162 Vaccine Causes of Chemical compounds Chlorocebus aethiops Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 - virology COVID-19 vaccines COVID-19 Vaccines - genetics COVID-19 Vaccines - immunology Disease transmission Glycoproteins Health aspects Humanities and Social Sciences Humans Immunization Medical research Medicine, Experimental mRNA Vaccines multidisciplinary Mutation Neutralization Neutralization Tests Pandemics Pathogenicity Pathogens Pharmacology SARS-CoV-2 - genetics SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Vaccines Vaccines, Synthetic - genetics Vero Cells Viral diseases Viruses United States United Kingdom > UK Nigeria United States > US India
ISSN:	0028-0836, 1476-4687, 1476-4687
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Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents 1 – 5 . Here we show that serum samples taken from twenty human volunteers, two or four weeks after their second dose of the BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020) and spike glycoproteins from the recently identified B.1.617.1, B.1.617.2, B.1.618 (all of which were first identified in India) or B.1.525 (first identified in Nigeria) lineages. Geometric mean plaque reduction neutralization titres against the variant viruses—particularly the B.1.617.1 variant—seemed to be lower than the titre against the USA-WA1/2020 virus, but all sera tested neutralized the variant viruses at titres of at least 1:40. The susceptibility of the variant strains to neutralization elicited by the BNT162b2 vaccine supports mass immunization as a central strategy to end the coronavirus disease 2019 (COVID-19) pandemic globally. Samples of serum from individuals immunized with the BNT162b2 vaccine show neutralization activity against engineered SARS-CoV-2s bearing the spike mutations from B.1.617 and other variants.
AbstractList	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents.sup.1-5. Here we show that serum samples taken from twenty human volunteers, two or four weeks after their second dose of the BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020) and spike glycoproteins from the recently identified B.1.617.1, B.1.617.2, B.1.618 (all of which were first identified in India) or B.1.525 (first identified in Nigeria) lineages. Geometric mean plaque reduction neutralization titres against the variant viruses--particularly the B.1.617.1 variant--seemed to be lower than the titre against the USA-WA1/2020 virus, but all sera tested neutralized the variant viruses at titres of at least 1:40. The susceptibility of the variant strains to neutralization elicited by the BNT162b2 vaccine supports mass immunization as a central strategy to end the coronavirus disease 2019 (COVID-19) pandemic globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents . Here we show that serum samples taken from twenty human volunteers, two or four weeks after their second dose of the BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020) and spike glycoproteins from the recently identified B.1.617.1, B.1.617.2, B.1.618 (all of which were first identified in India) or B.1.525 (first identified in Nigeria) lineages. Geometric mean plaque reduction neutralization titres against the variant viruses-particularly the B.1.617.1 variant-seemed to be lower than the titre against the USA-WA1/2020 virus, but all sera tested neutralized the variant viruses at titres of at least 1:40. The susceptibility of the variant strains to neutralization elicited by the BNT162b2 vaccine supports mass immunization as a central strategy to end the coronavirus disease 2019 (COVID-19) pandemic globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents.sup.1-5. Here we show that serum samples taken from twenty human volunteers, two or four weeks after their second dose of the BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020) and spike glycoproteins from the recently identified B.1.617.1, B.1.617.2, B.1.618 (all of which were first identified in India) or B.1.525 (first identified in Nigeria) lineages. Geometric mean plaque reduction neutralization titres against the variant viruses--particularly the B.1.617.1 variant--seemed to be lower than the titre against the USA-WA1/2020 virus, but all sera tested neutralized the variant viruses at titres of at least 1:40. The susceptibility of the variant strains to neutralization elicited by the BNT162b2 vaccine supports mass immunization as a central strategy to end the coronavirus disease 2019 (COVID-19) pandemic globally. Samples of serum from individuals immunized with the BNT162b2 vaccine show neutralization activity against engineered SARS-CoV-2s bearing the spike mutations from B.1.617 and other variants. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents 1 – 5 . Here we show that serum samples taken from twenty human volunteers, two or four weeks after their second dose of the BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020) and spike glycoproteins from the recently identified B.1.617.1, B.1.617.2, B.1.618 (all of which were first identified in India) or B.1.525 (first identified in Nigeria) lineages. Geometric mean plaque reduction neutralization titres against the variant viruses—particularly the B.1.617.1 variant—seemed to be lower than the titre against the USA-WA1/2020 virus, but all sera tested neutralized the variant viruses at titres of at least 1:40. The susceptibility of the variant strains to neutralization elicited by the BNT162b2 vaccine supports mass immunization as a central strategy to end the coronavirus disease 2019 (COVID-19) pandemic globally. Samples of serum from individuals immunized with the BNT162b2 vaccine show neutralization activity against engineered SARS-CoV-2s bearing the spike mutations from B.1.617 and other variants. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents1-5. Here we show that serum samples taken from twenty human volunteers, two or four weeks after their second dose of the BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020) and spike glycoproteins from the recently identified B.1.617.1, B.1.617.2, B.1.618 (all of which were first identified in India) or B.1.525 (first identified in Nigeria) lineages. Geometric mean plaque reduction neutralization titres against the variant viruses-particularly the B.1.617.1 variant-seemed to be lower than the titre against the USA-WA1/2020 virus, but all sera tested neutralized the variant viruses at titres of at least 1:40. The susceptibility of the variant strains to neutralization elicited by the BNT162b2 vaccine supports mass immunization as a central strategy to end the coronavirus disease 2019 (COVID-19) pandemic globally.Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents1-5. Here we show that serum samples taken from twenty human volunteers, two or four weeks after their second dose of the BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020) and spike glycoproteins from the recently identified B.1.617.1, B.1.617.2, B.1.618 (all of which were first identified in India) or B.1.525 (first identified in Nigeria) lineages. Geometric mean plaque reduction neutralization titres against the variant viruses-particularly the B.1.617.1 variant-seemed to be lower than the titre against the USA-WA1/2020 virus, but all sera tested neutralized the variant viruses at titres of at least 1:40. The susceptibility of the variant strains to neutralization elicited by the BNT162b2 vaccine supports mass immunization as a central strategy to end the coronavirus disease 2019 (COVID-19) pandemic globally. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis of their potential for altered transmissibility, pathogenicity, and coverage by vaccines and therapeutic agents1-5. Here we show that serum samples taken from twenty human volunteers, two or four weeks after their second dose of the BNT162b2 vaccine, neutralize engineered SARS-CoV-2 with a USA-WA1/2020 genetic background (a virus strain isolated in January 2020) and spike glycoproteins from the recently identified B.1.617.1, B.1.617.2, B.1.618 (all of which were first identified in India) or B.1.525 (first identified in Nigeria) lineages. Geometric mean plaque reduction neutralization titres against the variant viruses-particularly the B.1.617.1 variant-seemed to be lower than the titre against the USA-WA1/2020 virus, but all sera tested neutralized the variant viruses at titres of at least 1:40. The susceptibility of the variant strains to neutralization elicited by the BNT162b2 vaccine supports mass immunization as a central strategy to end the coronavirus disease 2019 (COV1D-19) pandemic globally.
Audience	Academic
Author	Xia, Hongjie Dormitzer, Philip R. Liu, Jianying Zou, Jing Weaver, Scott C. Liu, Yang Cai, Hui Xie, Xuping Jansen, Kathrin U. Sahin, Ugur Muik, Alexander Shi, Pei-Yong Cutler, Mark Cooper, David Swanson, Kena A.
Author_xml	– sequence: 1 givenname: Jianying surname: Liu fullname: Liu, Jianying organization: Department of Microbiology and Immunology, University of Texas Medical Branch, Institute for Human Infections and Immunity, University of Texas Medical Branch – sequence: 2 givenname: Yang surname: Liu fullname: Liu, Yang organization: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch – sequence: 3 givenname: Hongjie orcidid: 0000-0002-2520-7038 surname: Xia fullname: Xia, Hongjie organization: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch – sequence: 4 givenname: Jing surname: Zou fullname: Zou, Jing organization: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch – sequence: 5 givenname: Scott C. orcidid: 0000-0001-8016-8556 surname: Weaver fullname: Weaver, Scott C. organization: Department of Microbiology and Immunology, University of Texas Medical Branch, Institute for Human Infections and Immunity, University of Texas Medical Branch, Institute for Translational Sciences, University of Texas Medical Branch, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Sealy Institute for Vaccine Sciences, University of Texas Medical Branch – sequence: 6 givenname: Kena A. orcidid: 0000-0002-3389-8414 surname: Swanson fullname: Swanson, Kena A. organization: Pfizer Vaccine Research and Development – sequence: 7 givenname: Hui surname: Cai fullname: Cai, Hui organization: Pfizer Vaccine Research and Development – sequence: 8 givenname: Mark surname: Cutler fullname: Cutler, Mark organization: Pfizer Vaccine Research and Development – sequence: 9 givenname: David surname: Cooper fullname: Cooper, David organization: Pfizer Vaccine Research and Development – sequence: 10 givenname: Alexander orcidid: 0000-0003-4561-2273 surname: Muik fullname: Muik, Alexander organization: BioNTech – sequence: 11 givenname: Kathrin U. surname: Jansen fullname: Jansen, Kathrin U. organization: Pfizer Vaccine Research and Development – sequence: 12 givenname: Ugur surname: Sahin fullname: Sahin, Ugur email: ugur.sahin@biontech.de organization: BioNTech – sequence: 13 givenname: Xuping orcidid: 0000-0003-0918-016X surname: Xie fullname: Xie, Xuping email: xuxie@utmb.edu organization: Department of Biochemistry and Molecular Biology, University of Texas Medical Branch – sequence: 14 givenname: Philip R. orcidid: 0000-0003-0671-6360 surname: Dormitzer fullname: Dormitzer, Philip R. email: philip.dormitzer@pfizer.com organization: Pfizer Vaccine Research and Development – sequence: 15 givenname: Pei-Yong orcidid: 0000-0001-5553-1616 surname: Shi fullname: Shi, Pei-Yong email: peshi@utmb.edu organization: Institute for Human Infections and Immunity, University of Texas Medical Branch, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Institute for Translational Sciences, University of Texas Medical Branch, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Sealy Institute for Vaccine Sciences, University of Texas Medical Branch
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34111888$$D View this record in MEDLINE/PubMed
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Snippet	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuing to evolve around the world, generating new variants that are of concern on the basis...
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SubjectTerms	13 38/23 38/77 38/90 631/326/590/2293 631/326/596/4130 Animals Antibodies Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Binding sites BNT162 Vaccine Causes of Chemical compounds Chlorocebus aethiops Coronaviruses COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 - virology COVID-19 vaccines COVID-19 Vaccines - genetics COVID-19 Vaccines - immunology Disease transmission Glycoproteins Health aspects Humanities and Social Sciences Humans Immunization Medical research Medicine, Experimental mRNA Vaccines multidisciplinary Mutation Neutralization Neutralization Tests Pandemics Pathogenicity Pathogens Pharmacology SARS-CoV-2 - genetics SARS-CoV-2 - immunology Science Science (multidisciplinary) Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Vaccines Vaccines, Synthetic - genetics Vero Cells Viral diseases Viruses
Title	BNT162b2-elicited neutralization of B.1.617 and other SARS-CoV-2 variants
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Volume	596
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