Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia
Charles Mullighan and colleagues report a recurrent rearrangement of CRLF2 in B-progenitor and Down syndrome-associated acute lymphoblastic leukemia. Their genetic and functional evidence indicates that CRLF2 cooperates with activated JAK2 to promote leukemogenesis. Aneuploidy and translocations are...
Gespeichert in:
| Veröffentlicht in: | Nature genetics Jg. 41; H. 11; S. 1243 - 1246 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
New York
Nature Publishing Group US
01.11.2009
Nature Publishing Group |
| Schlagworte: | |
| ISSN: | 1061-4036, 1546-1718, 1546-1718 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Charles Mullighan and colleagues report a recurrent rearrangement of
CRLF2
in B-progenitor and Down syndrome-associated acute lymphoblastic leukemia. Their genetic and functional evidence indicates that CRLF2 cooperates with activated JAK2 to promote leukemogenesis.
Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, noncoding exon of
P2RY8
with the coding region of
CRLF2
. We identified the
P2RY8-CRLF2
fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome.
CRLF2
alteration was associated with activating
JAK
mutations, and expression of human
P2RY8-CRLF2
together with mutated mouse
Jak2
resulted in constitutive Jak-Stat activation and cytokine-independent growth of Ba/F3 cells overexpressing interleukin-7 receptor alpha. Our findings indicate that these two genetic lesions together contribute to leukemogenesis in B-progenitor ALL. |
|---|---|
| AbstractList | Charles Mullighan and colleagues report a recurrent rearrangement of
CRLF2
in B-progenitor and Down syndrome-associated acute lymphoblastic leukemia. Their genetic and functional evidence indicates that CRLF2 cooperates with activated JAK2 to promote leukemogenesis.
Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, noncoding exon of
P2RY8
with the coding region of
CRLF2
. We identified the
P2RY8-CRLF2
fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome.
CRLF2
alteration was associated with activating
JAK
mutations, and expression of human
P2RY8-CRLF2
together with mutated mouse
Jak2
resulted in constitutive Jak-Stat activation and cytokine-independent growth of Ba/F3 cells overexpressing interleukin-7 receptor alpha. Our findings indicate that these two genetic lesions together contribute to leukemogenesis in B-progenitor ALL. Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, noncoding exon of P2RY8 with the coding region of CRLF2. We identified the P2RY8-CRLF2 fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome. CRLF2 alteration was associated with activating JAK mutations, and expression of human P2RY8-CRLF2 together with mutated mouse Jak2 resulted in constitutive Jak-Stat activation and cytokine-independent growth of Ba/F3 cells overexpressing interleukin-7 receptor alpha. Our findings indicate that these two genetic lesions together contribute to leukemogenesis in B-progenitor ALL.Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, noncoding exon of P2RY8 with the coding region of CRLF2. We identified the P2RY8-CRLF2 fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome. CRLF2 alteration was associated with activating JAK mutations, and expression of human P2RY8-CRLF2 together with mutated mouse Jak2 resulted in constitutive Jak-Stat activation and cytokine-independent growth of Ba/F3 cells overexpressing interleukin-7 receptor alpha. Our findings indicate that these two genetic lesions together contribute to leukemogenesis in B-progenitor ALL. Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, noncoding exon of P2RY8 with the coding region of CRLF2. We identified the P2RY8-CRLF2 fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome. CRLF2 alteration was associated with activating JAK mutations, and expression of human P2RY8-CRLF2 together with mutated mouse Jak2 resulted in constitutive Jak-Stat activation and cytokine-independent growth of Ba/F3 cells overexpressing interleukin-7 receptor alpha. Our findings indicate that these two genetic lesions together contribute to leukemogenesis in B-progenitor ALL. [PUBLICATION ABSTRACT] Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring chromosomal alterations. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, noncoding exon of P2RY8 with the coding region of CRLF2. We identified the P2RY8-CRLF2 fusion in 7% of individuals with B-progenitor ALL and 53% of individuals with ALL associated with Down syndrome. CRLF2 alteration was associated with activating JAK mutations, and expression of human P2RY8-CRLF2 together with mutated mouse Jak2 resulted in constitutive Jak-Stat activation and cytokine-independent growth of Ba/F3 cells overexpressing interleukin-7 receptor alpha. Our findings indicate that these two genetic lesions together contribute to leukemogenesis in B-progenitor ALL. Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many patients lack a recurring chromosomal alteration. Here we report a recurring interstitial deletion of the pseudoautosomal region 1 of chromosomes X and Y in B-progenitor ALL that juxtaposes the first, non-coding exon of P2RY8 to the coding region of CRLF2 (which encodes cytokine receptor like factor 2, or thymic stromal lymphopoietin receptor). The P2RY8-CRLF2 fusion was identified in 7% of B-progenitor ALL cases, and was identified in over 50% of ALL cases arising in patients with Down syndrome (53% of 75 cases). CRLF2 alteration was associated with the presence of activating JAK mutations, and expression of P2RY8-CRLF2 together with JAK2 mutants resulted in constitutive Jak-Stat activation and cytokine-independent growth of Ba/F3-IL7R cells, indicating that these two genetic lesions together contribute to leukemogenesis in B-progenitor ALL. |
| Audience | Academic |
| Author | Harvey, Richard C Raimondi, Susana C Basso, Giuseppe Downing, James R Liu, Wei Cheng, Jinjun Willman, Cheryl L Heerema, Nyla A Williams, Richard T Collins-Underwood, J Racquel Meyer, Julia Pui, Ching-Hon Carroll, Andrew J Rabin, Karen R Phillips, Letha A A Zhang, Jinghui Coustan-Smith, Elaine Ma, Jing Pession, Andrea Hunger, Stephen P Loudin, Michael G Mikhail, Fady M Carroll, William L Mullighan, Charles G |
| AuthorAffiliation | 4 Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Rockville, MD 8 Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 9 New York University Cancer Institute, New York University Langone Medical Center, New York, NY 10 Pathology, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH 6 Department of Oncology, St Jude Children’s Research Hospital, Memphis, TN 11 Department of Pediatrics, University of Padua, Padua, Italy 3 Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN 2 Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX 12 Department of Pediatrics, University of Bologna, Hematology and Oncology Unit “Lalla Seragnoli”, Bologna, Italy 7 University of New Mexico Cancer Research & Treatment Center, UNM Cancer Research Facility, Albuquerque, NM 13 Section of Pediatric Hematology/Oncology/Bone Mar |
| AuthorAffiliation_xml | – name: 10 Pathology, College of Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH – name: 13 Section of Pediatric Hematology/Oncology/Bone Marrow Transplantation and Center for Cancer and Blood Disorders, University of Colorado Denver School of Medicine, The Children’s Hospital, Aurora, CO – name: 5 The Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, Memphis, TN – name: 9 New York University Cancer Institute, New York University Langone Medical Center, New York, NY – name: 12 Department of Pediatrics, University of Bologna, Hematology and Oncology Unit “Lalla Seragnoli”, Bologna, Italy – name: 8 Department of Genetics, University of Alabama at Birmingham, Birmingham, AL – name: 4 Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health, Rockville, MD – name: 11 Department of Pediatrics, University of Padua, Padua, Italy – name: 1 Department of Pathology, St Jude Children’s Research Hospital, Memphis, TN – name: 3 Department of Biostatistics, St Jude Children’s Research Hospital, Memphis, TN – name: 7 University of New Mexico Cancer Research & Treatment Center, UNM Cancer Research Facility, Albuquerque, NM – name: 2 Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, TX – name: 6 Department of Oncology, St Jude Children’s Research Hospital, Memphis, TN |
| Author_xml | – sequence: 1 givenname: Charles G surname: Mullighan fullname: Mullighan, Charles G email: charles.mullighan@stjude.org organization: Department of Pathology, St. Jude Children's Research Hospital – sequence: 2 givenname: J Racquel surname: Collins-Underwood fullname: Collins-Underwood, J Racquel organization: Department of Pathology, St. Jude Children's Research Hospital – sequence: 3 givenname: Letha A A surname: Phillips fullname: Phillips, Letha A A organization: Department of Pathology, St. Jude Children's Research Hospital – sequence: 4 givenname: Michael G surname: Loudin fullname: Loudin, Michael G organization: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine – sequence: 5 givenname: Wei surname: Liu fullname: Liu, Wei organization: Department of Biostatistics, St. Jude Children's Research Hospital – sequence: 6 givenname: Jinghui surname: Zhang fullname: Zhang, Jinghui organization: Center for Biomedical Informatics and Information Technology, National Cancer Institute, National Institutes of Health – sequence: 7 givenname: Jing surname: Ma fullname: Ma, Jing organization: The Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital – sequence: 8 givenname: Elaine surname: Coustan-Smith fullname: Coustan-Smith, Elaine organization: Department of Oncology, St. Jude Children's Research Hospital – sequence: 9 givenname: Richard C surname: Harvey fullname: Harvey, Richard C organization: University of New Mexico Cancer Research & Treatment Center, University of New Mexico Cancer Research Facility – sequence: 10 givenname: Cheryl L surname: Willman fullname: Willman, Cheryl L organization: University of New Mexico Cancer Research & Treatment Center, University of New Mexico Cancer Research Facility – sequence: 11 givenname: Fady M surname: Mikhail fullname: Mikhail, Fady M organization: Department of Genetics, University of Alabama at Birmingham – sequence: 12 givenname: Julia surname: Meyer fullname: Meyer, Julia organization: New York University Cancer Institute, New York University Langone Medical Center – sequence: 13 givenname: Andrew J surname: Carroll fullname: Carroll, Andrew J organization: Department of Genetics, University of Alabama at Birmingham – sequence: 14 givenname: Richard T surname: Williams fullname: Williams, Richard T organization: Department of Oncology, St. Jude Children's Research Hospital – sequence: 15 givenname: Jinjun surname: Cheng fullname: Cheng, Jinjun organization: Department of Pathology, St. Jude Children's Research Hospital – sequence: 16 givenname: Nyla A surname: Heerema fullname: Heerema, Nyla A organization: Department of Pathology, College of Medicine, The Ohio State University Comprehensive Cancer Center – sequence: 17 givenname: Giuseppe surname: Basso fullname: Basso, Giuseppe organization: Department of Pediatrics, University of Padua – sequence: 18 givenname: Andrea surname: Pession fullname: Pession, Andrea organization: Department of Pediatrics, University of Bologna, Hematology and Oncology Unit 'Lalla Seràgnoli' – sequence: 19 givenname: Ching-Hon surname: Pui fullname: Pui, Ching-Hon organization: Department of Oncology, St. Jude Children's Research Hospital – sequence: 20 givenname: Susana C surname: Raimondi fullname: Raimondi, Susana C organization: Department of Pathology, St. Jude Children's Research Hospital – sequence: 21 givenname: Stephen P surname: Hunger fullname: Hunger, Stephen P organization: Section of Pediatric Hematology, Oncology and Bone Marrow Transplantation and Center for Cancer and Blood Disorders, University of Colorado Denver School of Medicine, The Children's Hospital – sequence: 22 givenname: James R surname: Downing fullname: Downing, James R organization: Department of Pathology, St. Jude Children's Research Hospital – sequence: 23 givenname: William L surname: Carroll fullname: Carroll, William L organization: New York University Cancer Institute, New York University Langone Medical Center – sequence: 24 givenname: Karen R surname: Rabin fullname: Rabin, Karen R organization: Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22103334$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19838194$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkl2L1DAUhousuB_qT5CiqAh2zFfT9kZYR1cXBhbGj9uQSU-7WdtkTNJd587_4D_0l5iy444zikguEpLnvOS85z1M9ow1kCT3MZpgRMsXpp0wXt1KDnDOeIYLXO7FM-I4Y4jy_eTQ-wuEMGOovJPs46qkJa7YQQJzkM5J00IPJqS2Safz2QlJtUlfZUtnWzA6WPfj2_dUmjp9ba9M6lemdraHeCm9t0rLAHUq1RAg7Vb98twuOumDVmkHw2fotbyb3G5k5-Heej9KPp68-TB9l83O3p5Oj2eZ4iUPWU0IhrxBPK9r2RQQf4l4tUA1rxqQFMUTyRecEVaBKvJFnitV4TovcK4aoJweJS-vdZfDoodaxZac7MTS6V66lbBSi-0Xo89Fay8FKUZDUBR4uhZw9ssAPoheewVdJw3YwYuCUs7Lqsgj-eSfJMEEM0pGyYc74IUdnIk2CEIILxHKR7VH11ArOxDaNDZ-T42K4pjgcWyEje1N_kLFVUeTVQxEo-P9VsGzrYLIBPgaWjl4L07fz_-fPfu0zT743ecbg3_lKgKP14D0SnZNTJjS_oaLc0aUUrZxUTnrvYNmI4XEGGxhWhGDHcHnO6DSQQZtxznq7k98PUcf9WK43cb0HfInSg4FGw |
| CODEN | NGENEC |
| CitedBy_id | crossref_primary_10_1016_j_clml_2017_03_299 crossref_primary_10_1182_blood_2018890764 crossref_primary_10_1182_blood_2013_08_460311 crossref_primary_10_1172_JCI45284 crossref_primary_10_1038_leu_2012_84 crossref_primary_10_1097_HS9_0000000000000053 crossref_primary_10_3389_fonc_2019_00871 crossref_primary_10_1182_blood_2013_06_509463 crossref_primary_10_1124_pharmrev_122_000612 crossref_primary_10_1038_s41568_020_00315_z crossref_primary_10_1016_j_anndiagpath_2016_02_002 crossref_primary_10_1038_leu_2015_177 crossref_primary_10_1038_s41375_023_02010_y crossref_primary_10_1007_s00277_023_05245_y crossref_primary_10_1038_leu_2013_206 crossref_primary_10_1016_j_canep_2014_07_006 crossref_primary_10_1515_cmble_2015_0006 crossref_primary_10_1016_j_leukres_2011_05_037 crossref_primary_10_1158_1078_0432_CCR_11_1936 crossref_primary_10_1200_JCO_2011_37_8018 crossref_primary_10_1007_s11899_012_0122_5 crossref_primary_10_1182_blood_2017_03_771162 crossref_primary_10_1172_JCI81158 crossref_primary_10_1371_journal_pone_0075472 crossref_primary_10_1038_bjc_2017_152 crossref_primary_10_1097_MPH_0000000000000691 crossref_primary_10_1002_gcc_20944 crossref_primary_10_1016_j_ejca_2017_06_012 crossref_primary_10_1111_bjh_12130 crossref_primary_10_3390_ijms23063067 crossref_primary_10_1177_2040620711403028 crossref_primary_10_1007_s40265_013_0026_2 crossref_primary_10_1002_gcc_20818 crossref_primary_10_1111_j_1365_2141_2010_08282_x crossref_primary_10_1016_j_exphem_2018_07_007 crossref_primary_10_1038_ncomms13331 crossref_primary_10_1097_MPH_0000000000000347 crossref_primary_10_1038_onc_2012_347 crossref_primary_10_1101_gad_349879_122 crossref_primary_10_1016_j_clml_2021_12_006 crossref_primary_10_3390_ph14050443 crossref_primary_10_1093_ajcp_aqx005 crossref_primary_10_5858_arpa_2019_0194_RA crossref_primary_10_1016_j_pcl_2014_09_009 crossref_primary_10_1016_j_jaci_2010_04_037 crossref_primary_10_12688_f1000research_13167_1 crossref_primary_10_18632_oncotarget_12050 crossref_primary_10_1007_BF03262236 crossref_primary_10_1084_jem_20211004 crossref_primary_10_1172_JCI61203 crossref_primary_10_1016_j_leukres_2013_10_008 crossref_primary_10_1002_gcc_20764 crossref_primary_10_1016_j_blre_2012_12_004 crossref_primary_10_1111_ped_13457 crossref_primary_10_1182_blood_2009_09_235986 crossref_primary_10_1200_JCO_2012_47_6770 crossref_primary_10_1016_j_lrr_2025_100530 crossref_primary_10_1111_bjh_12348 crossref_primary_10_1182_blood_2009_07_235291 crossref_primary_10_1182_blood_2012_07_443218 crossref_primary_10_1007_s00277_024_05667_2 crossref_primary_10_1200_EDBK_156628 crossref_primary_10_1038_leu_2016_164 crossref_primary_10_1056_NEJMcpc1011318 crossref_primary_10_1182_blood_2021012004 crossref_primary_10_1073_pnas_1702489114 crossref_primary_10_1016_j_cancergen_2011_04_005 crossref_primary_10_1016_j_bbamem_2024_184359 crossref_primary_10_1182_blood_2015_02_580043 crossref_primary_10_1016_j_pcl_2014_09_004 crossref_primary_10_1097_MPH_0b013e31828f8746 crossref_primary_10_1016_j_biopha_2017_11_033 crossref_primary_10_1136_jim_2016_000076 crossref_primary_10_1053_j_semdp_2023_04_003 crossref_primary_10_1182_blood_2011_07_362723 crossref_primary_10_1053_j_seminhematol_2018_05_001 crossref_primary_10_1038_leu_2012_60 crossref_primary_10_3109_10428194_2014_963076 crossref_primary_10_2165_11594740_000000000_00000 crossref_primary_10_1038_clpt_2013_9 crossref_primary_10_1016_j_exphem_2022_03_005 crossref_primary_10_3389_fcell_2018_00120 crossref_primary_10_1002_pbc_26363 crossref_primary_10_1053_j_semdp_2023_10_001 crossref_primary_10_1016_j_semcancer_2020_10_013 crossref_primary_10_1080_17474086_2018_1509702 crossref_primary_10_1097_MOP_0b013e3283426260 crossref_primary_10_1111_bjh_12442 crossref_primary_10_1016_j_beha_2011_09_004 crossref_primary_10_1111_bjh_14981 crossref_primary_10_1053_j_semdp_2011_02_008 crossref_primary_10_1016_j_blre_2023_101154 crossref_primary_10_1182_blood_2014_03_562918 crossref_primary_10_1038_ng_2949 crossref_primary_10_1016_j_heliyon_2023_e22085 crossref_primary_10_1172_JCI134424 crossref_primary_10_1007_s12185_011_0765_3 crossref_primary_10_1016_j_leukres_2015_11_018 crossref_primary_10_1038_nature10725 crossref_primary_10_1002_gcc_22748 crossref_primary_10_1016_j_cellsig_2017_08_002 crossref_primary_10_1200_JCO_2014_59_1636 crossref_primary_10_4049_jimmunol_1302925 crossref_primary_10_1186_s13059_020_02043_x crossref_primary_10_1182_blood_2016_05_707653 crossref_primary_10_1084_jem_20110580 crossref_primary_10_3390_hemato6020008 crossref_primary_10_1186_s13039_023_00652_2 crossref_primary_10_1158_1078_0432_CCR_19_3519 crossref_primary_10_1038_leu_2012_101 crossref_primary_10_3389_fimmu_2015_00434 crossref_primary_10_1016_j_tips_2012_08_005 crossref_primary_10_1038_nature09727 crossref_primary_10_1182_blood_2014_05_574327 crossref_primary_10_1182_blood_2011_01_329961 crossref_primary_10_1007_s11517_020_02245_2 crossref_primary_10_1111_j_1751_553X_2011_01319_x crossref_primary_10_1002_gcc_22723 crossref_primary_10_1016_j_mayocp_2016_09_010 crossref_primary_10_1007_s12288_025_01968_2 crossref_primary_10_1016_j_retram_2023_103434 crossref_primary_10_1016_j_ymgme_2012_07_011 crossref_primary_10_1182_blood_2009_08_239681 crossref_primary_10_1182_blood_2012_02_413252 crossref_primary_10_3390_life12111770 crossref_primary_10_1111_j_1365_2141_2010_08312_x crossref_primary_10_1074_jbc_M109_071191 crossref_primary_10_1182_blood_2018864173 crossref_primary_10_1016_j_cancergen_2014_11_003 crossref_primary_10_1038_nrg_2016_154 crossref_primary_10_1182_blood_2015_02_626127 crossref_primary_10_1038_s41467_024_50537_0 crossref_primary_10_1016_j_beha_2017_07_003 crossref_primary_10_1038_ncomms5654 crossref_primary_10_1182_blood_2012_02_413021 crossref_primary_10_1158_0008_5472_CAN_10_1528 crossref_primary_10_1073_pnas_1006981107 crossref_primary_10_1182_blood_2012_04_422691 crossref_primary_10_1002_pbc_22996 crossref_primary_10_1016_j_bcp_2023_115809 crossref_primary_10_1038_leu_2012_155 crossref_primary_10_1073_pnas_1121343109 crossref_primary_10_1007_s00277_024_05821_w crossref_primary_10_1038_nrclinonc_2015_38 crossref_primary_10_1016_S0031_3939_11_70504_2 crossref_primary_10_1111_ijlh_13698 crossref_primary_10_1002_gcc_22421 crossref_primary_10_1080_10428194_2022_2164193 crossref_primary_10_1200_JCO_2010_30_7405 crossref_primary_10_1182_blood_2010_05_286492 crossref_primary_10_1016_S2171_9748_10_70011_8 crossref_primary_10_1016_S0929_6646_10_60123_4 crossref_primary_10_1016_S2352_4642_18_30066_X crossref_primary_10_1182_hem_V22_4_2025410 crossref_primary_10_1586_ehm_10_14 crossref_primary_10_1038_s41586_019_1003_z crossref_primary_10_1002_gcc_22439 crossref_primary_10_3390_genes12050687 crossref_primary_10_1038_s41588_021_00993_x crossref_primary_10_1038_s41375_021_01133_4 crossref_primary_10_1182_blood_2011_11_394221 crossref_primary_10_1200_JCO_2016_70_7836 crossref_primary_10_1186_2162_3619_3_16 crossref_primary_10_1016_j_beha_2018_09_003 crossref_primary_10_1016_S1674_8301_10_60016_4 crossref_primary_10_1053_j_seminhematol_2013_10_001 crossref_primary_10_1158_1078_0432_CCR_10_1203 crossref_primary_10_1084_jem_20111694 crossref_primary_10_15252_embr_201439583 crossref_primary_10_3390_diagnostics13172748 crossref_primary_10_1038_s41388_021_02126_4 crossref_primary_10_1111_j_1365_2141_2010_08314_x crossref_primary_10_1038_s41598_021_85213_6 crossref_primary_10_1189_jlb_1211622 crossref_primary_10_1016_j_ejcped_2023_100140 crossref_primary_10_1016_j_humpath_2012_02_004 crossref_primary_10_1016_j_critrevonc_2018_04_002 crossref_primary_10_1172_JCI42442 crossref_primary_10_1182_blood_2010_05_285197 crossref_primary_10_1016_j_jpeds_2011_08_006 crossref_primary_10_1016_j_clml_2025_05_013 crossref_primary_10_1111_imr_12235 crossref_primary_10_1080_10428194_2018_1498492 crossref_primary_10_3889_oamjms_2022_9139 crossref_primary_10_1016_j_canlet_2014_02_009 crossref_primary_10_1038_leu_2012_199 crossref_primary_10_1016_j_chembiol_2023_05_007 crossref_primary_10_1177_2040620713498161 crossref_primary_10_1038_s41572_024_00525_x crossref_primary_10_3390_ijms21249724 crossref_primary_10_1200_JCO_2012_46_8470 crossref_primary_10_1016_j_cancergen_2020_03_001 crossref_primary_10_1016_j_canlet_2017_08_034 crossref_primary_10_3390_ijms22126411 crossref_primary_10_1038_leu_2017_93 crossref_primary_10_1016_S0140_6736_12_62187_4 crossref_primary_10_1016_j_exphem_2014_12_005 crossref_primary_10_1017_erm_2021_6 crossref_primary_10_1016_S1470_2045_15_00369_1 crossref_primary_10_1016_j_immuni_2012_03_017 crossref_primary_10_1182_blood_2010_12_321976 crossref_primary_10_1182_blood_2016_12_758979 crossref_primary_10_1101_gad_307504_117 crossref_primary_10_3389_fped_2017_00258 crossref_primary_10_1182_blood_2012_03_415448 crossref_primary_10_1007_s00018_013_1337_x crossref_primary_10_1002_cncr_29871 crossref_primary_10_1038_s41598_019_50864_z crossref_primary_10_1002_gcc_22477 crossref_primary_10_1111_ijlh_13419 crossref_primary_10_1016_j_ccr_2012_06_005 crossref_primary_10_1182_blood_2012_10_462358 crossref_primary_10_1016_j_coi_2012_01_015 crossref_primary_10_1182_bloodadvances_2017012211 crossref_primary_10_1038_nrc3947 crossref_primary_10_1111_j_1365_2141_2012_09221_x crossref_primary_10_1016_j_ccell_2015_12_013 crossref_primary_10_1007_s40124_015_0078_8 crossref_primary_10_1002_gcc_22201 crossref_primary_10_1002_cncr_28531 crossref_primary_10_1038_ng_924 crossref_primary_10_1016_j_currproblcancer_2014_08_005 crossref_primary_10_1002_pbc_24420 crossref_primary_10_3109_10428194_2013_863307 crossref_primary_10_1002_cncr_35051 crossref_primary_10_1002_pbc_26824 crossref_primary_10_1093_jleuko_qiae216 crossref_primary_10_1186_s13059_022_02784_x crossref_primary_10_1182_bloodadvances_2018030635 crossref_primary_10_1172_JCI66203 crossref_primary_10_1002_ajh_25126 crossref_primary_10_1016_j_transci_2011_01_009 crossref_primary_10_1038_leu_2011_128 crossref_primary_10_1080_17474086_2025_2540401 crossref_primary_10_1002_widm_1146 crossref_primary_10_1158_1078_0432_CCR_11_2206 crossref_primary_10_4049_jimmunol_1400864 crossref_primary_10_1089_jayao_2011_0012 crossref_primary_10_1016_j_blre_2016_09_001 crossref_primary_10_1016_j_cyto_2016_10_012 crossref_primary_10_1016_j_ccr_2012_07_012 crossref_primary_10_3389_fonc_2014_00134 crossref_primary_10_1097_HS9_0000000000000892 crossref_primary_10_1002_ajmg_a_62864 crossref_primary_10_1038_s41375_018_0297_4 crossref_primary_10_1182_blood_2018_04_841676 crossref_primary_10_1177_10815589231191811 crossref_primary_10_1159_000519782 crossref_primary_10_1182_blood_2023022919 crossref_primary_10_1038_s41467_023_37438_4 crossref_primary_10_1136_bcr_2024_259811 crossref_primary_10_1016_j_exphem_2015_05_015 crossref_primary_10_1073_pnas_0911726107 crossref_primary_10_1182_blood_2012_05_378943 crossref_primary_10_1182_blood_2013_05_500850 crossref_primary_10_1016_j_mrfmmm_2015_10_005 crossref_primary_10_1007_s12519_015_0019_1 crossref_primary_10_1038_s41375_024_02493_3 crossref_primary_10_1371_journal_pgen_1008280 crossref_primary_10_1111_bjh_15056 crossref_primary_10_1053_j_semdp_2011_07_004 crossref_primary_10_1002_cam4_87 crossref_primary_10_1002_gcc_23217 crossref_primary_10_1182_blood_2013_07_453480 crossref_primary_10_3390_lymphatics1020011 crossref_primary_10_1182_blood_2010_07_297135 crossref_primary_10_1007_s11845_014_1212_2 crossref_primary_10_1158_0008_5472_CAN_16_1106 crossref_primary_10_1007_s00431_011_1424_7 crossref_primary_10_1200_JCO_2014_55_4105 crossref_primary_10_1038_s41375_025_02602_w crossref_primary_10_1016_j_ejcped_2025_100223 crossref_primary_10_1200_JCO_2011_40_3907 crossref_primary_10_1038_nrclinonc_2011_95 crossref_primary_10_1182_blood_2015_06_650812 crossref_primary_10_1182_blood_2016_07_726588 crossref_primary_10_1186_s13072_022_00471_6 crossref_primary_10_1038_ng_3362 crossref_primary_10_1182_blood_2014_11_612903 crossref_primary_10_1182_blood_2011_03_341412 crossref_primary_10_12688_f1000research_16074_1 crossref_primary_10_1016_j_leukres_2015_10_003 crossref_primary_10_3390_cancers12102815 crossref_primary_10_1016_j_bbagen_2023_130465 crossref_primary_10_1002_cncr_31848 crossref_primary_10_1016_j_beha_2021_101331 crossref_primary_10_1111_bjh_13096 crossref_primary_10_1182_blood_2009_11_256131 crossref_primary_10_1016_j_cll_2011_08_016 crossref_primary_10_3390_ijms20122929 crossref_primary_10_3390_ijms242015325 crossref_primary_10_1007_s10555_025_10291_1 crossref_primary_10_1016_j_blre_2012_01_001 crossref_primary_10_5858_arpa_2016_0260_SA crossref_primary_10_3389_fonc_2023_1177871 crossref_primary_10_1182_blood_2015_03_635821 crossref_primary_10_1586_14737159_2014_927311 crossref_primary_10_3390_ijms25126639 crossref_primary_10_1038_bcj_2017_53 crossref_primary_10_1080_10428194_2024_2378817 crossref_primary_10_1038_ng_3301 crossref_primary_10_1182_blood_2011_12_389932 crossref_primary_10_1182_blood_2017_06_743252 crossref_primary_10_1016_j_cancergen_2012_07_016 crossref_primary_10_1038_bcj_2017_55 crossref_primary_10_3389_fgene_2021_803683 crossref_primary_10_1038_leu_2016_365 crossref_primary_10_1111_bjh_15251 crossref_primary_10_1016_j_bbmt_2010_10_026 crossref_primary_10_1002_gcc_22190 crossref_primary_10_1016_j_jaci_2022_07_003 crossref_primary_10_3390_ijms24010474 crossref_primary_10_1007_s00277_021_04574_0 crossref_primary_10_1053_j_seminhematol_2013_06_007 crossref_primary_10_1016_j_ccell_2015_06_005 crossref_primary_10_1038_ng_3691 crossref_primary_10_1038_leu_2012_23 crossref_primary_10_1038_s41375_020_0854_5 crossref_primary_10_1038_leu_2012_26 crossref_primary_10_1182_blood_2011_05_354266 crossref_primary_10_1182_bloodadvances_2019000163 crossref_primary_10_1016_j_cancergen_2019_02_002 crossref_primary_10_3390_jcm10173792 crossref_primary_10_1007_s40272_017_0268_7 crossref_primary_10_1016_j_ccell_2015_06_010 crossref_primary_10_1007_s00428_022_03448_8 crossref_primary_10_3389_fcell_2022_942053 crossref_primary_10_1111_bjh_16207 crossref_primary_10_1016_j_pathol_2023_12_001 crossref_primary_10_1016_j_ejmg_2015_11_010 crossref_primary_10_1074_jbc_R117_799056 crossref_primary_10_1016_j_heliyon_2024_e34033 crossref_primary_10_1111_cpr_12742 crossref_primary_10_1186_1756_8722_7_32 crossref_primary_10_1038_leu_2010_177 crossref_primary_10_1002_cncr_29573 crossref_primary_10_1016_j_clml_2022_03_007 crossref_primary_10_1182_blood_2013_09_523688 crossref_primary_10_1002_pbc_26539 crossref_primary_10_3390_cancers13164068 crossref_primary_10_1111_bjh_18852 crossref_primary_10_1182_blood_2009_09_245944 crossref_primary_10_1093_gigascience_giy079 crossref_primary_10_2217_cpr_12_30 crossref_primary_10_3389_fonc_2020_579673 crossref_primary_10_1111_ejh_13948 crossref_primary_10_1182_blood_2020006846 crossref_primary_10_1073_pnas_1814397115 crossref_primary_10_1002_pbc_25575 crossref_primary_10_1124_pharmrev_120_000011 crossref_primary_10_1111_bjh_17879 crossref_primary_10_3389_fonc_2023_1256054 crossref_primary_10_1002_pbc_23033 crossref_primary_10_1016_j_clml_2024_08_005 crossref_primary_10_1186_s12887_024_04991_w crossref_primary_10_24287_1726_1708_2019_18_1_112_126 crossref_primary_10_1097_CCO_0000000000000017 crossref_primary_10_1182_blood_2016_03_679209 crossref_primary_10_1055_s_0043_1766133 crossref_primary_10_1111_iep_12478 crossref_primary_10_1002_pbc_24354 crossref_primary_10_1002_pbc_26411 crossref_primary_10_1101_gr_159913_113 crossref_primary_10_1182_blood_2023023153 crossref_primary_10_1002_cncr_29383 crossref_primary_10_1056_NEJMoa1403088 crossref_primary_10_1111_bjh_15683 crossref_primary_10_1111_bjh_14474 crossref_primary_10_1111_j_1365_2141_2011_08846_x crossref_primary_10_1182_blood_2010_03_275347 crossref_primary_10_3390_ijms21062193 crossref_primary_10_1080_17474086_2020_1685866 crossref_primary_10_1182_bloodadvances_2019001216 crossref_primary_10_1016_j_canlet_2018_05_045 crossref_primary_10_1002_pbc_26989 crossref_primary_10_3389_fimmu_2020_569117 crossref_primary_10_1172_JCI81468 crossref_primary_10_1159_000362793 crossref_primary_10_1038_s41590_019_0524_9 crossref_primary_10_1007_s00431_011_1624_1 crossref_primary_10_1016_j_smim_2012_02_005 crossref_primary_10_1016_j_jmoldx_2023_09_007 crossref_primary_10_1002_pbc_24571 crossref_primary_10_1002_pbc_24451 crossref_primary_10_1002_ajmg_a_36097 crossref_primary_10_1016_j_mjafi_2023_11_011 |
| Cites_doi | 10.1016/S0140-6736(99)05264-2 10.2202/1544-6115.1027 10.1038/bjc.1977.1 10.1182/blood-2008-08-170928 10.1056/NEJMoa0808253 10.1182/blood-2007-09-114231 10.1080/01621459.1999.10474144 10.1038/ng1425 10.1038/nature06866 10.1073/pnas.0811761106 10.1111/j.1365-2141.2006.06337.x 10.1093/bioinformatics/btn624 10.1038/ni1360 10.1080/10428190701225882 10.1006/mthe.2002.0549 10.1126/science.1164266 10.1182/blood-2008-03-077966 10.1093/bioinformatics/btl646 10.1128/MCB.24.6.2584-2592.2004 10.1214/aos/1176350951 10.1182/blood-2009-03-208397 10.1038/nature05690 10.1038/ni1247 10.1016/j.coph.2008.03.002 10.1038/sj.leu.2404784 10.1016/j.dnarep.2006.05.015 10.1016/S0140-6736(08)60457-2 10.1016/S0140-6736(08)61341-0 10.1111/j.1365-2141.2008.07552.x 10.4049/jimmunol.0800489 10.1182/blood-2008-11-163501 10.4049/jimmunol.163.11.5971 |
| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2009 2009 INIST-CNRS COPYRIGHT 2009 Nature Publishing Group Copyright Nature Publishing Group Nov 2009 |
| Copyright_xml | – notice: Springer Nature America, Inc. 2009 – notice: 2009 INIST-CNRS – notice: COPYRIGHT 2009 Nature Publishing Group – notice: Copyright Nature Publishing Group Nov 2009 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7N M7P MBDVC P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 7T5 7X8 5PM |
| DOI | 10.1038/ng.469 |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale in Context: Science ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Entomology Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Download PDF from ProQuest Public Health Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest Research Library Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts Immunology Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Research Library Prep ProQuest Central Student ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Public Health ProQuest Central Basic ProQuest SciTech Collection ProQuest Medical Library ProQuest Central (Alumni) Immunology Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic Research Library Prep MEDLINE Genetics Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Agriculture Biology |
| EISSN | 1546-1718 |
| EndPage | 1246 |
| ExternalDocumentID | PMC2783810 1896921321 A211440246 19838194 22103334 10_1038_ng_469 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | United States |
| GeographicLocations_xml | – name: United States |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: P30 CA021765 – fundername: NCI NIH HHS grantid: U01 CA157937 – fundername: NCI NIH HHS grantid: U10 CA098413 – fundername: NCI NIH HHS grantid: K12 CA090433 – fundername: NCI NIH HHS grantid: CA90433-06 – fundername: NCI NIH HHS grantid: U10 CA098543 |
| GroupedDBID | --- -DZ -~X .55 .GJ 0R~ 123 29M 2FS 36B 39C 3O- 3V. 4.4 53G 5BI 5M7 5RE 5S5 70F 7X7 85S 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAEEF AAHBH AARCD AAYOK AAYZH AAZLF ABAWZ ABCQX ABDBF ABDPE ABEFU ABJNI ABLJU ABOCM ABTAH ABUWG ACBWK ACGFO ACGFS ACIWK ACMJI ACNCT ACPRK ACUHS ADBBV ADFRT AENEX AEUYN AFBBN AFFNX AFKRA AFRAH AFSHS AGAYW AGCDD AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 DB5 DU5 DWQXO EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAO IH2 IHR INH INR IOV ISR ITC L7B LGEZI LK8 LOTEE M0L M1P M2O M7P MVM N9A NADUK NNMJJ NXXTH ODYON P2P PKN PQQKQ PROAC PSQYO Q2X RIG RNS RNT RNTTT RVV SHXYY SIXXV SJN SNYQT SOJ SV3 TAOOD TBHMF TDRGL TN5 TSG TUS UKHRP VQA X7M XJT XOL Y6R YHZ ZGI ZXP ZY4 ~8M ~KM AAYXX ABFSG ACSTC AETEA AFANA AFFHD AIEIU ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB AEZWR AFHIU AHWEU AIXLP IQODW NFIDA CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SS 7T7 7TK 7TM 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 7T5 PUEGO 7X8 5PM |
| ID | FETCH-LOGICAL-c686t-d221e5f065ddaf7e983069b0d69fea30b0d25b64249ec75b55cc91d5715cfe363 |
| IEDL.DBID | 8C1 |
| ISICitedReferencesCount | 480 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000271247600019&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1061-4036 1546-1718 |
| IngestDate | Tue Nov 04 01:53:14 EST 2025 Sun Nov 09 12:06:35 EST 2025 Thu Oct 02 14:57:22 EDT 2025 Mon Oct 06 17:13:31 EDT 2025 Sat Nov 29 14:01:17 EST 2025 Mon Nov 24 15:47:28 EST 2025 Wed Nov 26 11:08:32 EST 2025 Wed Nov 26 10:59:07 EST 2025 Mon Jul 21 05:59:10 EDT 2025 Mon Jul 21 09:14:51 EDT 2025 Sat Nov 29 03:07:03 EST 2025 Tue Nov 18 21:20:23 EST 2025 Fri Feb 21 02:37:39 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | Chromosomal aberration Trisomy Lymphoproliferative syndrome Acute leukemia Aneuploidy Malignant hemopathy Down syndrome Acute lymphocytic leukemia Cancer |
| Language | English |
| License | http://www.springer.com/tdm CC BY 4.0 |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c686t-d221e5f065ddaf7e983069b0d69fea30b0d25b64249ec75b55cc91d5715cfe363 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/2783810 |
| PMID | 19838194 |
| PQID | 222680055 |
| PQPubID | 33429 |
| PageCount | 4 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_2783810 proquest_miscellaneous_733668975 proquest_miscellaneous_21214320 proquest_journals_222680055 gale_infotracmisc_A211440246 gale_infotracacademiconefile_A211440246 gale_incontextgauss_ISR_A211440246 gale_incontextgauss_IOV_A211440246 pubmed_primary_19838194 pascalfrancis_primary_22103334 crossref_primary_10_1038_ng_469 crossref_citationtrail_10_1038_ng_469 springer_journals_10_1038_ng_469 |
| PublicationCentury | 2000 |
| PublicationDate | 2009-11-01 |
| PublicationDateYYYYMMDD | 2009-11-01 |
| PublicationDate_xml | – month: 11 year: 2009 text: 2009-11-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: New York, NY – name: United States |
| PublicationTitle | Nature genetics |
| PublicationTitleAbbrev | Nat Genet |
| PublicationTitleAlternate | Nat Genet |
| PublicationYear | 2009 |
| Publisher | Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | Peto (CR31) 1977; 35 Pounds (CR26) 2009; 25 Rochman, Leonard (CR7) 2008; 8 Mullighan (CR3) 2008; 453 Mullighan (CR25) 2009; 360 Malinge, Izraeli, Crispino (CR6) 2009; 113 Forestier (CR4) 2008; 111 Mantel (CR30) 1966; 50 Gray (CR32) 1988; 16 Hanawa (CR29) 2002; 5 Mullighan (CR16) 2009; 106 Parrish (CR21) 2009; 182 Isaksen (CR22) 1999; 163 Levine, Gilliland (CR23) 2008; 112 Hasle, Clemmensen, Mikkelsen (CR17) 2000; 355 Zhou (CR19) 2005; 6 Pui, Robison, Look (CR1) 2008; 371 Smyth (CR27) 2004; 3 Whitlock (CR5) 2006; 135 Mullighan (CR24) 2008; 322 Kearney (CR14) 2009; 113 Storlazzi (CR10) 2007; 21 Gaikwad (CR15) 2009; 144 Venkatraman, Olshen (CR28) 2007; 23 Marculescu (CR12) 2006; 5 Fine, Gray (CR33) 1999; 94 Mullighan (CR2) 2007; 446 Russell (CR11) 2009; 114 Graux (CR18) 2004; 36 Ziegler, Liu (CR8) 2006; 7 Fujiwara (CR9) 2007; 48 Carpino (CR20) 2004; 24 Bercovich (CR13) 2008; 372 RJ Gray (BFng469_CR32) 1988; 16 S Malinge (BFng469_CR6) 2009; 113 RL Levine (BFng469_CR23) 2008; 112 S Pounds (BFng469_CR26) 2009; 25 SF Ziegler (BFng469_CR8) 2006; 7 ES Venkatraman (BFng469_CR28) 2007; 23 A Gaikwad (BFng469_CR15) 2009; 144 DE Isaksen (BFng469_CR22) 1999; 163 CG Mullighan (BFng469_CR16) 2009; 106 B Zhou (BFng469_CR19) 2005; 6 CH Pui (BFng469_CR1) 2008; 371 L Kearney (BFng469_CR14) 2009; 113 CG Mullighan (BFng469_CR2) 2007; 446 CG Mullighan (BFng469_CR3) 2008; 453 CG Mullighan (BFng469_CR24) 2008; 322 C Graux (BFng469_CR18) 2004; 36 JA Whitlock (BFng469_CR5) 2006; 135 N Carpino (BFng469_CR20) 2004; 24 R Peto (BFng469_CR31) 1977; 35 CT Storlazzi (BFng469_CR10) 2007; 21 Y Rochman (BFng469_CR7) 2008; 8 S Fujiwara (BFng469_CR9) 2007; 48 R Marculescu (BFng469_CR12) 2006; 5 LJ Russell (BFng469_CR11) 2009; 114 H Hanawa (BFng469_CR29) 2002; 5 D Bercovich (BFng469_CR13) 2008; 372 H Hasle (BFng469_CR17) 2000; 355 E Forestier (BFng469_CR4) 2008; 111 GK Smyth (BFng469_CR27) 2004; 3 N Mantel (BFng469_CR30) 1966; 50 CG Mullighan (BFng469_CR25) 2009; 360 YK Parrish (BFng469_CR21) 2009; 182 JP Fine (BFng469_CR33) 1999; 94 |
| References_xml | – volume: 355 start-page: 165 year: 2000 end-page: 169 ident: CR17 article-title: Risks of leukaemia and solid tumours in individuals with Down's syndrome publication-title: Lancet doi: 10.1016/S0140-6736(99)05264-2 – volume: 3 start-page: Article 3 year: 2004 ident: CR27 article-title: Linear models and empirical bayes methods for assessing differential expression in microarray experiments publication-title: Stat. Appl. Genet. Mol. Biol. doi: 10.2202/1544-6115.1027 – volume: 35 start-page: 1 year: 1977 end-page: 39 ident: CR31 article-title: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples publication-title: Br. J. Cancer doi: 10.1038/bjc.1977.1 – volume: 113 start-page: 646 year: 2009 end-page: 648 ident: CR14 article-title: A specific mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukaemia publication-title: Blood doi: 10.1182/blood-2008-08-170928 – volume: 360 start-page: 470 year: 2009 end-page: 480 ident: CR25 article-title: Deletion of and prognosis in acute lymphoblastic leukemia publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0808253 – volume: 111 start-page: 1575 year: 2008 end-page: 1583 ident: CR4 article-title: Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study publication-title: Blood doi: 10.1182/blood-2007-09-114231 – volume: 50 start-page: 163 year: 1966 end-page: 170 ident: CR30 article-title: Evaluation of survival data and two new rank order statistics arising in its consideration publication-title: Cancer Chemother. Rep. – volume: 94 start-page: 496 year: 1999 end-page: 509 ident: CR33 article-title: A proportional hazards model for the subdistribution of a competing risk publication-title: J. Am. Stat. Assoc. doi: 10.1080/01621459.1999.10474144 – volume: 36 start-page: 1084 year: 2004 end-page: 1089 ident: CR18 article-title: Fusion of to on amplified episomes in T-cell acute lymphoblastic leukemia publication-title: Nat. Genet. doi: 10.1038/ng1425 – volume: 453 start-page: 110 year: 2008 end-page: 114 ident: CR3 article-title: BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros publication-title: Nature doi: 10.1038/nature06866 – volume: 106 start-page: 9414 year: 2009 end-page: 9418 ident: CR16 article-title: JAK mutations in high-risk childhood acute lymphoblastic leukemia publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0811761106 – volume: 135 start-page: 595 year: 2006 end-page: 602 ident: CR5 article-title: Down syndrome and acute lymphoblastic leukaemia publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.2006.06337.x – volume: 25 start-page: 315 year: 2009 end-page: 321 ident: CR26 article-title: Reference alignment of SNP microarray signals for copy number analysis of tumors publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn624 – volume: 7 start-page: 709 year: 2006 end-page: 714 ident: CR8 article-title: Thymic stromal lymphopoietin in normal and pathogenic T cell development and function publication-title: Nat. Immunol. doi: 10.1038/ni1360 – volume: 48 start-page: 978 year: 2007 end-page: 986 ident: CR9 article-title: Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening publication-title: Leuk. Lymphoma doi: 10.1080/10428190701225882 – volume: 5 start-page: 242 year: 2002 end-page: 251 ident: CR29 article-title: Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood publication-title: Mol. Ther. doi: 10.1006/mthe.2002.0549 – volume: 322 start-page: 1377 year: 2008 end-page: 1380 ident: CR24 article-title: Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia publication-title: Science doi: 10.1126/science.1164266 – volume: 112 start-page: 2190 year: 2008 end-page: 2198 ident: CR23 article-title: Myeloproliferative disorders publication-title: Blood doi: 10.1182/blood-2008-03-077966 – volume: 23 start-page: 657 year: 2007 end-page: 663 ident: CR28 article-title: A faster circular binary segmentation algorithm for the analysis of array CGH data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl646 – volume: 24 start-page: 2584 year: 2004 end-page: 2592 ident: CR20 article-title: Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.6.2584-2592.2004 – volume: 16 start-page: 1141 year: 1988 end-page: 1154 ident: CR32 article-title: A class of K-sample tests for comparing the cumulative incidence of a competing risk publication-title: Ann. Stat. doi: 10.1214/aos/1176350951 – volume: 114 start-page: 2688 year: 2009 end-page: 2698 ident: CR11 article-title: Deregulated expression of cytokine receptor gene, , is involved in lymphoid transformation in B cell precursor acute lymphoblastic leukemia publication-title: Blood doi: 10.1182/blood-2009-03-208397 – volume: 446 start-page: 758 year: 2007 end-page: 764 ident: CR2 article-title: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia publication-title: Nature doi: 10.1038/nature05690 – volume: 6 start-page: 1047 year: 2005 end-page: 1053 ident: CR19 article-title: Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice publication-title: Nat. Immunol. doi: 10.1038/ni1247 – volume: 8 start-page: 249 year: 2008 end-page: 254 ident: CR7 article-title: Thymic stromal lymphopoietin: a new cytokine in asthma publication-title: Curr. Opin. Pharmacol. doi: 10.1016/j.coph.2008.03.002 – volume: 21 start-page: 2221 year: 2007 end-page: 2225 ident: CR10 article-title: Upregulation of the gene by promoter swapping with the gene in primary splenic follicular lymphoma publication-title: Leukemia doi: 10.1038/sj.leu.2404784 – volume: 5 start-page: 1246 year: 2006 end-page: 1258 ident: CR12 article-title: Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures publication-title: DNA Repair (Amst.) doi: 10.1016/j.dnarep.2006.05.015 – volume: 371 start-page: 1030 year: 2008 end-page: 1043 ident: CR1 article-title: Acute lymphoblastic leukaemia publication-title: Lancet doi: 10.1016/S0140-6736(08)60457-2 – volume: 372 start-page: 1484 year: 2008 end-page: 1492 ident: CR13 article-title: Mutations of in acute lymphoblastic leukaemias associated with Down's syndrome publication-title: Lancet doi: 10.1016/S0140-6736(08)61341-0 – volume: 144 start-page: 930 year: 2009 end-page: 932 ident: CR15 article-title: Prevalence and clinical correlates of mutations in Down syndrome acute lymphoblastic leukaemia publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.2008.07552.x – volume: 163 start-page: 5971 year: 1999 end-page: 5977 ident: CR22 article-title: Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction publication-title: J. Immunol. – volume: 182 start-page: 4255 year: 2009 end-page: 4266 ident: CR21 article-title: IL-7 Dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow publication-title: J. Immunol. doi: 10.4049/jimmunol.0800489 – volume: 113 start-page: 2619 year: 2009 end-page: 2628 ident: CR6 article-title: Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome publication-title: Blood doi: 10.1182/blood-2008-11-163501 – volume: 50 start-page: 163 year: 1966 ident: BFng469_CR30 publication-title: Cancer Chemother. Rep. – volume: 135 start-page: 595 year: 2006 ident: BFng469_CR5 publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.2006.06337.x – volume: 163 start-page: 5971 year: 1999 ident: BFng469_CR22 publication-title: J. Immunol. doi: 10.4049/jimmunol.163.11.5971 – volume: 322 start-page: 1377 year: 2008 ident: BFng469_CR24 publication-title: Science doi: 10.1126/science.1164266 – volume: 7 start-page: 709 year: 2006 ident: BFng469_CR8 publication-title: Nat. Immunol. doi: 10.1038/ni1360 – volume: 24 start-page: 2584 year: 2004 ident: BFng469_CR20 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.6.2584-2592.2004 – volume: 446 start-page: 758 year: 2007 ident: BFng469_CR2 publication-title: Nature doi: 10.1038/nature05690 – volume: 355 start-page: 165 year: 2000 ident: BFng469_CR17 publication-title: Lancet doi: 10.1016/S0140-6736(99)05264-2 – volume: 360 start-page: 470 year: 2009 ident: BFng469_CR25 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa0808253 – volume: 3 start-page: Article 3 year: 2004 ident: BFng469_CR27 publication-title: Stat. Appl. Genet. Mol. Biol. doi: 10.2202/1544-6115.1027 – volume: 112 start-page: 2190 year: 2008 ident: BFng469_CR23 publication-title: Blood doi: 10.1182/blood-2008-03-077966 – volume: 144 start-page: 930 year: 2009 ident: BFng469_CR15 publication-title: Br. J. Haematol. doi: 10.1111/j.1365-2141.2008.07552.x – volume: 114 start-page: 2688 year: 2009 ident: BFng469_CR11 publication-title: Blood doi: 10.1182/blood-2009-03-208397 – volume: 94 start-page: 496 year: 1999 ident: BFng469_CR33 publication-title: J. Am. Stat. Assoc. doi: 10.1080/01621459.1999.10474144 – volume: 8 start-page: 249 year: 2008 ident: BFng469_CR7 publication-title: Curr. Opin. Pharmacol. doi: 10.1016/j.coph.2008.03.002 – volume: 453 start-page: 110 year: 2008 ident: BFng469_CR3 publication-title: Nature doi: 10.1038/nature06866 – volume: 25 start-page: 315 year: 2009 ident: BFng469_CR26 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn624 – volume: 113 start-page: 646 year: 2009 ident: BFng469_CR14 publication-title: Blood doi: 10.1182/blood-2008-08-170928 – volume: 371 start-page: 1030 year: 2008 ident: BFng469_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(08)60457-2 – volume: 36 start-page: 1084 year: 2004 ident: BFng469_CR18 publication-title: Nat. Genet. doi: 10.1038/ng1425 – volume: 23 start-page: 657 year: 2007 ident: BFng469_CR28 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btl646 – volume: 6 start-page: 1047 year: 2005 ident: BFng469_CR19 publication-title: Nat. Immunol. doi: 10.1038/ni1247 – volume: 113 start-page: 2619 year: 2009 ident: BFng469_CR6 publication-title: Blood doi: 10.1182/blood-2008-11-163501 – volume: 35 start-page: 1 year: 1977 ident: BFng469_CR31 publication-title: Br. J. Cancer doi: 10.1038/bjc.1977.1 – volume: 106 start-page: 9414 year: 2009 ident: BFng469_CR16 publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0811761106 – volume: 16 start-page: 1141 year: 1988 ident: BFng469_CR32 publication-title: Ann. Stat. doi: 10.1214/aos/1176350951 – volume: 111 start-page: 1575 year: 2008 ident: BFng469_CR4 publication-title: Blood doi: 10.1182/blood-2007-09-114231 – volume: 48 start-page: 978 year: 2007 ident: BFng469_CR9 publication-title: Leuk. Lymphoma doi: 10.1080/10428190701225882 – volume: 372 start-page: 1484 year: 2008 ident: BFng469_CR13 publication-title: Lancet doi: 10.1016/S0140-6736(08)61341-0 – volume: 21 start-page: 2221 year: 2007 ident: BFng469_CR10 publication-title: Leukemia doi: 10.1038/sj.leu.2404784 – volume: 5 start-page: 1246 year: 2006 ident: BFng469_CR12 publication-title: DNA Repair (Amst.) doi: 10.1016/j.dnarep.2006.05.015 – volume: 5 start-page: 242 year: 2002 ident: BFng469_CR29 publication-title: Mol. Ther. doi: 10.1006/mthe.2002.0549 – volume: 182 start-page: 4255 year: 2009 ident: BFng469_CR21 publication-title: J. Immunol. doi: 10.4049/jimmunol.0800489 |
| SSID | ssj0014408 |
| Score | 2.5224345 |
| Snippet | Charles Mullighan and colleagues report a recurrent rearrangement of
CRLF2
in B-progenitor and Down syndrome-associated acute lymphoblastic leukemia. Their... Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many individuals with this cancer lack recurring... Aneuploidy and translocations are hallmarks of B-progenitor acute lymphoblastic leukemia (ALL), but many patients lack a recurring chromosomal alteration. Here... |
| SourceID | pubmedcentral proquest gale pubmed pascalfrancis crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1243 |
| SubjectTerms | Acute lymphocytic leukemia Agriculture Amino Acid Sequence Animal Genetics and Genomics Animals Base Sequence Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell cycle Cell Line Chromosome aberrations Chromosome Deletion Chromosomes Down syndrome Down Syndrome - complications Down Syndrome - genetics Fundamental and applied biological sciences. Psychology Gene Function Gene mutations Gene Rearrangement Genetic aspects Genetics Genetics of eukaryotes. Biological and molecular evolution Genomics Health aspects Hematologic and hematopoietic diseases Hospitals Human Genetics Humans Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Kinases letter Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical genetics Medical research Medical sciences Mice Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Receptors, Cytokine - chemistry Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Risk factors Studies |
| Title | Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia |
| URI | https://link.springer.com/article/10.1038/ng.469 https://www.ncbi.nlm.nih.gov/pubmed/19838194 https://www.proquest.com/docview/222680055 https://www.proquest.com/docview/21214320 https://www.proquest.com/docview/733668975 https://pubmed.ncbi.nlm.nih.gov/PMC2783810 |
| Volume | 41 |
| WOSCitedRecordID | wos000271247600019&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1546-1718 dateEnd: 20241206 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: M7P dateStart: 20000101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1546-1718 dateEnd: 20241206 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: 7X7 dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1546-1718 dateEnd: 20241206 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: BENPR dateStart: 20000101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1546-1718 dateEnd: 20241206 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: 8C1 dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1546-1718 dateEnd: 20241206 omitProxy: false ssIdentifier: ssj0014408 issn: 1061-4036 databaseCode: M2O dateStart: 20000101 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3rb9MwELfYBhIS4v0oG8VCID6FJXbiOJ_QVlaBBF1VHuq3yPGjVJSkNC3S_nvukjQjjPGFL1Ern-LHnc93ufPvCHmeKR4wY3wvFA4clEw7LzOZ83xhNGcy4IFWVbGJeDSS02kybnJzyiatcqsTK0VtCo3fyA_hHBMSEaNeL394WDQKg6tNBY0dshcwP8R9KQdthgeGLeubcALdJIxS1qWFuDzMZ69CzHH-7SxqNPKNpSphdVxd1uJvdufF9Mk_YqjV0TS89Z-Tuk1uNjYpPaqF6A65YvO75FpdpfLsHlETzOfFSwj4JZEWjg4m74eMznN67GF-l0W1sPKoyg19A1493cIgeKphvjVU6c3a0sUZSE-RgckOfdGF3Xyz3-fqPvk8PPk0eOs1lRk8LaRYe4axwEYOzBdjlIttIsHzSDLfiMRZxX34xaIMXJswsTqOsijSOglMFAeRdpYL_oDs5kVuHxEaaSsixYUWOgmNQ-wYrjLLMiWZ4c71yIstj1LdwJZj9YxFWoXPuUzzWQq87JGnLd2yBuq4QPEMWZwi6kWOaTUztSnL9N3pl_QI3GCQFhaKy4g-TjpELxsiV8BYtGquMsCMEE2rQ3nQoYS9qzvN_Y64tSOH9fU552GP7G8FJ22US5m2UgNzblvxzZgvl9tiAyQBA0OY-T1CL6FAGEwhkxhe8rAW5_NlA3aCoQidxx1BbwkQkrzbks-_VtDkWLdFBtjtdkucD7vLjcf_nNk-uV6F7apLnwdkd73a2Cfkqv65nperPtmJp3H1lP1qy_fJ3vHJaDyBfx_YKT7j8S85nGKY |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3JbtNAdFQKCCTEvoSWdoSoOJnGM_HYPiBUWqJGDQGFgnIz41lCRLBDnFDlo_hH3vNWTCm3HrhZmqdZ3-q3EfIsltxlWredjrBgoMTKOrGOrdMWWnEWuNxVMm824Q8GwWgUvl8jP6tcGAyrrHhizqh1qvAf-S7IMRFgxahXs-8ONo1C52rVQaPAiiOzOgGLLXvZO4Dn3WGs--Z4_9Apmwo4SgRi4WjGXONZkLxaS-ubMAClOYzbWoTWSN6GL-bFoJV3QqN8L_Y8pUJXe77rKWu44DDvJXIZ2LiPEWT-qLbv0E1aZN4JNMvQK1q0MuLBbjJ-0cGY6t9kXykBbsxkBq9hizYaf9Nzz4Zr_uGzzUVh99Z_dom3yc1S56Z7BZHcIWsmuUuuFl04V_eIHGK8MiZZ4J9Smlq6P-x3GZ0k9LWD8WsG2d7coTLR9CA9SWhV5sGRJXIbTaVaLgydroA60hhMEliLTs3yq_k2kffJxws53wOynqSJeUSop4zwJBdKqLCjLdbG4TI2LJYB09zaFtmpcCJSZVl27A4yjfLwAB5EyTgC3GmR7RpuVhQiOQPxFFEqwqoeCYYNjeUyy6Leu0_RHpj5gJ2sI84D-jBsAD0vgWwKe1GyTNWAE2G1sAbkZgMSeJNqDG810LveOdxvm3PeaZGNClGjknlmUY2lcOZ6FGfGeMDEpEsAcRko-qzdIvQcCCzzKYLQh0keFuRzem3wnKAIw-J-g7BqACy53hxJJl_y0uvYlyZwcdmKBE-33XyNx_882Ta5dnj8th_1e4OjDXI9d1HmCa6bZH0xX5on5Ir6sZhk862cxVDy-aLJ8ReYZ7ro |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1R3ZbtNAcFVaQEiI-wgt7QpR8WRi78Zr-wGhtmlE1CpEgaK-mfUeISLYIQdVPo2_Y8ZHiinlrQ-8WdrRXnN7ZmcIeZlI7jGtXaclLDgoibJOohPruEIrzkKPe0rmzSaCXi88PY36a-Rn9RYG0yormZgLap0p_EfeBD0mQqwY1bRlVkS_3Xk7-e5gAykMtFbdNAoKOTLLM_DeZm-6bUD1LmOdw48H75yywYCjRCjmjmbMM74FLay1tIGJQjCgo8TVIrJGche-mJ-Ahd6KjAr8xPeVijztB56vrOGCw7zXyEYANgYw18b-Ya8_WIUwsJVzHmoV6KRhjLRobMTDZjp83cIM6980YakPbk_kDHBji6Yaf7N6LyZv_hHBzRVj5-5_fKX3yJ3SGqd7BfvcJ2smfUBuFP05lw-JHGAmMz6_wH-oNLP0YHDcYXSU0n0HM9sMCsSpQ2WqaTs7S2lVAMKRJdkbTaVazA0dL4FvsgScFViLjs3iq_k2ko_IyZWc7zFZT7PUPCXUV0b4kgslVNTSFqvmcJkYlsiQaW5tg-xW9BGrsmA79g0Zx3niAA_jdBgDHTXIzgpuUpQouQDxAskrxnofKeJ5KBezWdx9_yneYx5SKmuJy4A-DGpAr0ogm8FelCwfccCJsI5YDXKrBglSS9WGt2ukvto53K_LOW81yGZFtHEpVmfximLhzKtRnBkzBVOTLQDEY-ACMLdB6CUQWABUhFEAkzwpWOn82gCdYCLD4kGNyVYAWIy9PpKOvuRF2bFjTejhshU7nm-7jo1n_zzZDrkJXBgfd3tHm-RWHrvMX75ukfX5dGGek-vqx3w0m26X8oaSz1fNj78AebzFCQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rearrangement+of+CRLF2+in+B-progenitor-+and+Down+syndrome-associated+acute+lymphoblastic+leukemia&rft.jtitle=Nature+genetics&rft.au=Mullighan%2C+Charles+G&rft.au=Collins-Underwood%2C+J+Racquel&rft.au=Phillips%2C+Letha+A+A&rft.au=Loudin%2C+Michael+G&rft.date=2009-11-01&rft.pub=Nature+Publishing+Group&rft.issn=1061-4036&rft.eissn=1546-1718&rft.volume=41&rft.issue=11&rft.spage=1243&rft_id=info:doi/10.1038%2Fng.469&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=1896921321 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon |