Comparison of the lower limit of normal to the fixed ratio method for the diagnosis of airflow obstruction at high altitudes: a large cross-sectional survey of subjects living between 3000–4700 m above sea level

Background There is no general agreement on the preferential use of a fixed ratio (FR) of forced expiratory volume in 1 s (FEV 1 )/forced vital capacity (FVC) < 0.7 vs. the lower limit of normal (LLN) of FEV 1 /FVC to define airflow obstruction. Determining the impact of these different cut-off l...

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Vydané v:European Journal of Medical Research Ročník 28; číslo 1; s. 189 - 9
Hlavní autori: Huang, Yilin, Xing, Zhenzhen, Janssens, Jean-Paul, Chai, Di, Liu, Weiming, Wang, Yuxia, Mayordome, William Yali-Mona, Tong, Yaqi, Guo, Yanfei
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London Springer Science and Business Media LLC 12.06.2023
BioMed Central
BioMed Central Ltd
Springer Nature B.V
BMC
Predmet:
Age
Air pollution
Airway management
Altitude
Biomedicine
Body mass index
Chronic obstructive pulmonary disease
Comparative analysis
COPD
Cross-Sectional Studies
Diagnosis
Dyspnea
Female
Humans
Humidity
Indoor air quality
Infectious Diseases
info:eu-repo/classification/ddc/616
Internal Medicine
LLN
Lung
Lung diseases, Obstructive
Lung function
Male
Males
Medicine
Medicine & Public Health
Methods
Oncology
Pulmonary Disease, Chronic Obstructive
R
Reference Values
Risk factors
Sea level
Spirometry
Surgery
Surveys
Tuberculosis
Tibet
United States > US
Spirometry
Lung function
Diagnosis
LLN
COPD
ISSN:2047-783X, 0949-2321, 2047-783X
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Shrnutí:Background There is no general agreement on the preferential use of a fixed ratio (FR) of forced expiratory volume in 1 s (FEV 1 )/forced vital capacity (FVC) < 0.7 vs. the lower limit of normal (LLN) of FEV 1 /FVC to define airflow obstruction. Determining the impact of these different cut-off levels in people living at high altitudes has not been studied. We assessed the prevalence of airflow obstruction and its clinical characteristics in residents living at high altitude using a fixed ratio and the LLN of FEV 1 /FVC according to Global Lung Initiative 2012 (GLI) reference values. Methods Using a multistage stratified sampling method, 3702 participants (aged ≥ 15 years) living at an altitude of 3000–4700 m in Tibet were included. Results 11.4% and 7.7% of participants had airflow obstruction according to GLI-LLN and a fixed FEV 1 /FVC cut-off value, respectively. The participants in the FR−/LLN+ group were younger, predominantly female, more frequently exposed to household air pollution, and had a higher proportion of chronic obstructive pulmonary disease assessment test scores ≥ 10 than those in the FR−/LLN− group. They also had a significantly lower FEV 1 and a higher frequency of small airway dysfunction. Compared with the participants of the FR+/LLN+ group, those in the FR−/LLN+ group showed no significant difference in the risk factors for airflow obstruction and respiratory symptoms, but had a lower prevalence of small airway dysfunction. Conclusions Defining airflow obstruction according to LLN, instead of using an FR, identified younger individuals with more frequent clinical symptoms of airflow obstruction and small airway dysfunction.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2047-783X
0949-2321
2047-783X
DOI:10.1186/s40001-023-01151-1