Eosinophilic esophagitis: Epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment

Mechanisms underlying esophageal remodeling with subepithelial fibrosis in subjects with eosinophilic esophagitis (EoE) have not been delineated. We sought to explore a role for epithelial mesenchymal transition (EMT) in subjects with EoE and determine whether EMT resolves with treatment. Esophageal...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 129; no. 5; pp. 1387 - 1396.e7
Main Authors:	Kagalwalla, Amir F., Akhtar, Noorain, Woodruff, Samantha A., Rea, Bryan A., Masterson, Joanne C., Mukkada, Vincent, Parashette, Kalyan R., Du, Jian, Fillon, Sophie, Protheroe, Cheryl A., Lee, James J., Amsden, Katie, Melin-Aldana, Hector, Capocelli, Kelley E., Furuta, Glenn T., Ackerman, Steven J.
Format:	Journal Article
Language:	English
Published:	New York, NY Mosby, Inc 01.05.2012 Elsevier Elsevier Limited
Subjects:	Adolescent adrenal cortex hormones Adrenal Cortex Hormones - therapeutic use Allergy and Immunology Biological and medical sciences biomarkers Biopsy Cell culture Child Child, Preschool Children Children & youth Corticoids Cytokeratin diet Diet Therapy Diets Disease Progression Elemental diet Eosinophil Eosinophilic Esophagitis - pathology Eosinophilic Esophagitis - physiopathology Eosinophilic Esophagitis - therapy eosinophils Eosinophils - metabolism Eosinophils - pathology Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial-Mesenchymal Transition - drug effects epithelium Esophagitis Esophagus Esophagus - drug effects Esophagus - pathology Female Fibronectin fibronectins Fibrosis Food Fundamental and applied biological sciences. Psychology Fundamental immunology Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal reflux Gene expression gene expression regulation genes Humans Immunohistochemistry Immunopathology Infant Inflammation Keratins - metabolism Leukocytes (eosinophilic) Male Medical sciences mesenchymal Mesenchyme Microscopy N-Cadherin Other diseases. Semiology Pediatrics Peroxidase Remission Remission Induction remodeling Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Transforming Growth Factor beta - metabolism Transforming growth factor- beta Transforming growth factor- beta 1 Vimentin Vimentin - metabolism remodeling esophagitis PPI vimentin cytokeratin EPX EMT Eosinophil TC GERD SFED mesenchymal RT-Q-PCR epithelium fibrosis EoE ED hpf Eosinophil peroxidase Elemental diet Proton pump inhibitor Topical corticosteroid Six-food elimination diet Reverse-transcriptase quantitative polymerase chain reaction Eosinophilic esophagitis High-power field Gastroesophageal reflux disease Epithelial mesenchymal transition Vimentin Cytokeratin Immunopathology Digestive system Esophageal disease Granulocyte Mesenchyma Esophagitis Mesenchymal cell Epithelium Cell transformation Remodeling Esophagus Immunology Treatment Fibrosis Digestive diseases Reversibility
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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