Peripheral nerve regeneration and intraneural revascularization

Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regen...

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Bibliographic Details
Published in:Neural regeneration research Vol. 14; no. 1; pp. 24 - 33
Main Authors: Caillaud, Martial, Richard, Laurence, Vallat, Jean-Michel, Desmoulière, Alexis, Billet, Fabrice
Format: Journal Article
Language:English
Published: India Wolters Kluwer India Pvt. Ltd 01.01.2019
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
University of Limoges, Myelin Maintenance and Peripheral Neuropathies, Faculties of Medicine and Pharmacy, Limoges, France%University Hospital of Limoges, Department of Neurology, "Reference Center for Rare Peripheral Neuropathies", Department of Neurology, Limoges, France
Publishing House of Neural Regeneration Research
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects:
Classification
compression; crush; transection; Sunderland′s classification; Wallerian degeneration; angiogenesis; traumatic; glycerol
Diagnosis
Electrophysiology
Injuries
Ischemia
Laboratory animals
Life Sciences
Nervous system
Peripheral nerve diseases
Peripheral neuropathy
Review
traumatic
crush
Wallerian degeneration
angiogenesis
Sunderland's classification
compression
glycerol
transection
Angiogenesis
Compression
Traumatic
Transection
Glycerol
Crush
ISSN:1673-5374, 1876-7958
Online Access:Get full text
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Description
Summary:Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regeneration studies. The current knowledge concerning Wallerian degeneration and nerve regrowth is then described. Finally, the involvement of intraneural vascularization in these processes is addressed. As intraneural vascularization has been poorly studied, histological experiments were carried out from rat sciatic nerves damaged by a glycerol injection. The results, taken together with the data from literature, suggest that revascularization plays an important role in peripheral nerve regeneration and must therefore be studied more carefully.
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PMCID: PMC6263011
Author contributions: Review writing and critical revision: MC, JMV, AD and FB; in vivo study operation: LR and JMV; electron microscopy observation: LR; figures 1 and 2 design and preparation; MC; figure 3 preparation: MC, MC and JMV. All authors approved the final submitted version.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.243699