The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents
Background and Objectives: The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite...
Uložené v:
| Vydané v: | International Journal of Obesity Ročník 39; číslo 3; s. 424 - 429 |
|---|---|
| Hlavní autori: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
London
Nature Publishing Group UK
01.03.2015
Nature Publishing Group |
| Predmet: | |
| ISSN: | 0307-0565, 1476-5497, 1476-5497 |
| On-line prístup: | Získať plný text |
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| Abstract | Background and Objectives:
The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite regulation. Here, we characterise the
in vitro
and
in vivo
effects of colonic propionate on PYY and GLP-1 release in rodents, and investigate the role of FFA2 in mediating these effects using FFA2 knockout mice.
Methods:
We used Wistar rats, C57BL6 mice and free fatty acid receptor 2 knockout (FFA
−/−
) mice on a C57BL6 background to explore the impact of the SCFA propionate on PYY and GLP-1 release. Isolated colonic crypt cultures were used to assess the effects of propionate on gut hormone release
in vitro
. We subsequently developed an
in vivo
technique to assess gut hormone release into the portal vein following colonic infusion of propionate.
Results:
Propionate stimulated the secretion of both PYY and GLP-1 from wild-type primary murine colonic crypt cultures. This effect was significantly attenuated in cultures from FFA2
−/−
mice. Intra-colonic infusion of propionate elevated PYY and GLP-1 levels in jugular vein plasma in rats and in portal vein plasma in both rats and mice. However, propionate did not significantly stimulate gut hormone release in FFA2
−/−
mice.
Conclusions:
Intra-colonic administration of propionate stimulates the concurrent release of both GLP-1 and PYY in rats and mice. These data demonstrate that FFA2 deficiency impairs SCFA-induced gut hormone secretion both
in vitro
and
in vivo
. |
|---|---|
| AbstractList | The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite regulation. Here, we characterise the in vitro and in vivo effects of colonic propionate on PYY and GLP-1 release in rodents, and investigate the role of FFA2 in mediating these effects using FFA2 knockout mice.
We used Wistar rats, C57BL6 mice and free fatty acid receptor 2 knockout (FFA(-/-)) mice on a C57BL6 background to explore the impact of the SCFA propionate on PYY and GLP-1 release. Isolated colonic crypt cultures were used to assess the effects of propionate on gut hormone release in vitro. We subsequently developed an in vivo technique to assess gut hormone release into the portal vein following colonic infusion of propionate.
Propionate stimulated the secretion of both PYY and GLP-1 from wild-type primary murine colonic crypt cultures. This effect was significantly attenuated in cultures from FFA2(-/-) mice. Intra-colonic infusion of propionate elevated PYY and GLP-1 levels in jugular vein plasma in rats and in portal vein plasma in both rats and mice. However, propionate did not significantly stimulate gut hormone release in FFA2(-/-) mice.
Intra-colonic administration of propionate stimulates the concurrent release of both GLP-1 and PYY in rats and mice. These data demonstrate that FFA2 deficiency impairs SCFA-induced gut hormone secretion both in vitro and in vivo. BACKGROUND AND OBJECTIVES: The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite regulation. Here, we characterise the in vitro and in vivo effects of colonic propionate on PYY and GLP-1 release in rodents, and investigate the role of FFA2 in mediating these effects using FFA2 knockout mice. METHODS: We used Wistar rats, C57BL6 mice and free fatty acid receptor 2 knockout ([FFA.sup.-/-]) mice on a C57BL6 background to explore the impact of the SCFA propionate on PYY and GLP-1 release. Isolated colonic crypt cultures were used to assess the effects of propionate on gut hormone release in vitro. We subsequently developed an in vivo technique to assess gut hormone release into the portal vein following colonic infusion of propionate. RESULTS: Propionate stimulated the secretion of both PYY and GLP-1 from wild-type primary murine colonic crypt cultures. This effect was significantly attenuated in cultures from [FFA2.sup.-/-] mice. Intra-colonic infusion of propionate elevated PYY and GLP-1 levels in jugular vein plasma in rats and in portal vein plasma in both rats and mice. However, propionate did not significantly stimulate gut hormone release in [FFA2.sup.-/-] mice. CONCLUSIONS: Intra-colonic administration of propionate stimulates the concurrent release of both GLP-1 and PYY in rats and mice. These data demonstrate that FFA2 deficiency impairs SCFA-induced gut hormone secretion both in vitro and in vivo. International Journal of Obesity (2015) 39, 424-429; doi: 10.1038/ijo.2014.153 Background and Objectives:The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite regulation. Here, we characterise the in vitro and in vivo effects of colonic propionate on PYY and GLP-1 release in rodents, and investigate the role of FFA2 in mediating these effects using FFA2 knockout mice.Methods:We used Wistar rats, C57BL6 mice and free fatty acid receptor 2 knockout (FFA-/- ) mice on a C57BL6 background to explore the impact of the SCFA propionate on PYY and GLP-1 release. Isolated colonic crypt cultures were used to assess the effects of propionate on gut hormone release in vitro. We subsequently developed an in vivo technique to assess gut hormone release into the portal vein following colonic infusion of propionate.Results:Propionate stimulated the secretion of both PYY and GLP-1 from wild-type primary murine colonic crypt cultures. This effect was significantly attenuated in cultures from FFA2-/- mice. Intra-colonic infusion of propionate elevated PYY and GLP-1 levels in jugular vein plasma in rats and in portal vein plasma in both rats and mice. However, propionate did not significantly stimulate gut hormone release in FFA2-/- mice.Conclusions:Intra-colonic administration of propionate stimulates the concurrent release of both GLP-1 and PYY in rats and mice. These data demonstrate that FFA2 deficiency impairs SCFA-induced gut hormone secretion both in vitro and in vivo. The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite regulation. Here, we characterise the in vitro and in vivo effects of colonic propionate on PYY and GLP-1 release in rodents, and investigate the role of FFA2 in mediating these effects using FFA2 knockout mice.BACKGROUND AND OBJECTIVESThe gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite regulation. Here, we characterise the in vitro and in vivo effects of colonic propionate on PYY and GLP-1 release in rodents, and investigate the role of FFA2 in mediating these effects using FFA2 knockout mice.We used Wistar rats, C57BL6 mice and free fatty acid receptor 2 knockout (FFA(-/-)) mice on a C57BL6 background to explore the impact of the SCFA propionate on PYY and GLP-1 release. Isolated colonic crypt cultures were used to assess the effects of propionate on gut hormone release in vitro. We subsequently developed an in vivo technique to assess gut hormone release into the portal vein following colonic infusion of propionate.METHODSWe used Wistar rats, C57BL6 mice and free fatty acid receptor 2 knockout (FFA(-/-)) mice on a C57BL6 background to explore the impact of the SCFA propionate on PYY and GLP-1 release. Isolated colonic crypt cultures were used to assess the effects of propionate on gut hormone release in vitro. We subsequently developed an in vivo technique to assess gut hormone release into the portal vein following colonic infusion of propionate.Propionate stimulated the secretion of both PYY and GLP-1 from wild-type primary murine colonic crypt cultures. This effect was significantly attenuated in cultures from FFA2(-/-) mice. Intra-colonic infusion of propionate elevated PYY and GLP-1 levels in jugular vein plasma in rats and in portal vein plasma in both rats and mice. However, propionate did not significantly stimulate gut hormone release in FFA2(-/-) mice.RESULTSPropionate stimulated the secretion of both PYY and GLP-1 from wild-type primary murine colonic crypt cultures. This effect was significantly attenuated in cultures from FFA2(-/-) mice. Intra-colonic infusion of propionate elevated PYY and GLP-1 levels in jugular vein plasma in rats and in portal vein plasma in both rats and mice. However, propionate did not significantly stimulate gut hormone release in FFA2(-/-) mice.Intra-colonic administration of propionate stimulates the concurrent release of both GLP-1 and PYY in rats and mice. These data demonstrate that FFA2 deficiency impairs SCFA-induced gut hormone secretion both in vitro and in vivo.CONCLUSIONSIntra-colonic administration of propionate stimulates the concurrent release of both GLP-1 and PYY in rats and mice. These data demonstrate that FFA2 deficiency impairs SCFA-induced gut hormone secretion both in vitro and in vivo. International Journal of Obesity (2015) 39, 424-429; doi: 10.1038/ijo.2014.153 Background and Objectives: The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite regulation. Here, we characterise the in vitro and in vivo effects of colonic propionate on PYY and GLP-1 release in rodents, and investigate the role of FFA2 in mediating these effects using FFA2 knockout mice. Methods: We used Wistar rats, C57BL6 mice and free fatty acid receptor 2 knockout (FFA −/− ) mice on a C57BL6 background to explore the impact of the SCFA propionate on PYY and GLP-1 release. Isolated colonic crypt cultures were used to assess the effects of propionate on gut hormone release in vitro . We subsequently developed an in vivo technique to assess gut hormone release into the portal vein following colonic infusion of propionate. Results: Propionate stimulated the secretion of both PYY and GLP-1 from wild-type primary murine colonic crypt cultures. This effect was significantly attenuated in cultures from FFA2 −/− mice. Intra-colonic infusion of propionate elevated PYY and GLP-1 levels in jugular vein plasma in rats and in portal vein plasma in both rats and mice. However, propionate did not significantly stimulate gut hormone release in FFA2 −/− mice. Conclusions: Intra-colonic administration of propionate stimulates the concurrent release of both GLP-1 and PYY in rats and mice. These data demonstrate that FFA2 deficiency impairs SCFA-induced gut hormone secretion both in vitro and in vivo . |
| Audience | Academic |
| Author | Brooks, L Murphy, K G Bewick, G A Frost, G Ghatei, M A Sleeth, M L Psichas, A Bloom, S R Hanyaloglu, A C |
| Author_xml | – sequence: 1 givenname: A surname: Psichas fullname: Psichas, A organization: Division of Diabetes, Department of Medicine, Nutrition and Dietetic Research Group, Section of Investigative Medicine, Endocrinology and Metabolism, Imperial College – sequence: 2 givenname: M L surname: Sleeth fullname: Sleeth, M L organization: Division of Diabetes, Department of Medicine, Nutrition and Dietetic Research Group, Section of Investigative Medicine, Endocrinology and Metabolism, Imperial College – sequence: 3 givenname: K G surname: Murphy fullname: Murphy, K G organization: Division of Diabetes, Department of Medicine, Section of Investigative Medicine, Endocrinology and Metabolism, Imperial College – sequence: 4 givenname: L surname: Brooks fullname: Brooks, L organization: Division of Diabetes, Department of Medicine, Section of Investigative Medicine, Endocrinology and Metabolism, Imperial College – sequence: 5 givenname: G A surname: Bewick fullname: Bewick, G A organization: Division of Diabetes, Department of Medicine, Section of Investigative Medicine, Endocrinology and Metabolism, Imperial College, Division of Diabetes & Nutritional Sciences, Kings College London – sequence: 6 givenname: A C surname: Hanyaloglu fullname: Hanyaloglu, A C organization: Department of Surgery and Cancer, Institute of Reproductive and Developmental Biology, Imperial College – sequence: 7 givenname: M A surname: Ghatei fullname: Ghatei, M A organization: Division of Diabetes, Department of Medicine, Section of Investigative Medicine, Endocrinology and Metabolism, Imperial College – sequence: 8 givenname: S R surname: Bloom fullname: Bloom, S R organization: Division of Diabetes, Department of Medicine, Section of Investigative Medicine, Endocrinology and Metabolism, Imperial College – sequence: 9 givenname: G surname: Frost fullname: Frost, G email: g.frost@imperial.ac.uk organization: Division of Diabetes, Department of Medicine, Nutrition and Dietetic Research Group, Section of Investigative Medicine, Endocrinology and Metabolism, Imperial College |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25109781$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Copyright | The Author(s) 2015 COPYRIGHT 2015 Nature Publishing Group Copyright Nature Publishing Group Mar 2015 Copyright © 2015 Macmillan Publishers Limited 2015 Macmillan Publishers Limited |
| Copyright_xml | – notice: The Author(s) 2015 – notice: COPYRIGHT 2015 Nature Publishing Group – notice: Copyright Nature Publishing Group Mar 2015 – notice: Copyright © 2015 Macmillan Publishers Limited 2015 Macmillan Publishers Limited |
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| DOI | 10.1038/ijo.2014.153 |
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| Snippet | Background and Objectives:
The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA)... The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid... BACKGROUND AND OBJECTIVES: The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA)... International Journal of Obesity (2015) 39, 424-429; doi: 10.1038/ijo.2014.153 Background and Objectives:The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA)... |
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| SubjectTerms | 13 13/106 631/443/163 631/443/319 631/45/287/1183 631/45/776/198 631/80/86 64 64/110 Animals Appetite Biological control systems Colon - metabolism Colon - pathology Diabetes Diet Endocrinology Epidemiology Fatty acids Gastrointestinal hormones Gastrointestinal Hormones - metabolism Glucagon Glucagon-Like Peptide 1 - drug effects Glucagon-Like Peptide 1 - metabolism Glucose Health Promotion and Disease Prevention Hormones Internal Medicine Measurement Medical research Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Inbred C57BL Microbiota Nutrients Nutrition research Obesity Original original-article Peptide YY - metabolism Peptides Physiological research Properties Propionates - pharmacology Public Health Rats Rats, Wistar Receptors, G-Protein-Coupled - drug effects Receptors, G-Protein-Coupled - metabolism Rodents Small intestine Weight control |
| Title | The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents |
| URI | https://link.springer.com/article/10.1038/ijo.2014.153 https://www.ncbi.nlm.nih.gov/pubmed/25109781 https://www.proquest.com/docview/1661605682 https://www.proquest.com/docview/1662431580 https://pubmed.ncbi.nlm.nih.gov/PMC4356745 |
| Volume | 39 |
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