LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor

Cellular cholesterol levels reflect a balance between uptake, efflux, and endogenous synthesis. Here we show that the sterol-responsive nuclear liver X receptor (LXR) helps maintain cholesterol homeostasis, not only through promotion of cholesterol efflux but also through suppression of low-density...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 325; H. 5936; S. 100
Hauptverfasser:	Zelcer, Noam, Hong, Cynthia, Boyadjian, Rima, Tontonoz, Peter
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 03.07.2009
Schlagworte:	Animals Cell Line, Tumor Cholesterol - metabolism DNA-Binding Proteins - agonists DNA-Binding Proteins - metabolism Homeostasis Humans Ligands Lipoproteins, LDL - blood Lipoproteins, LDL - metabolism Liver - metabolism Liver X Receptors Mice Mice, Inbred C57BL Orphan Nuclear Receptors Promoter Regions, Genetic Receptors, Cytoplasmic and Nuclear - agonists Receptors, Cytoplasmic and Nuclear - metabolism Receptors, LDL - genetics Receptors, LDL - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic Ubiquitin-Protein Ligases Ubiquitination
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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