Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms

Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be ‘BRCA1-like’ or ‘non-BRCA1-like’, which refers to resembling a BRCA1-mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approxim...

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Veröffentlicht in:	Molecular oncology Jg. 9; H. 7; S. 1274 - 1286
Hauptverfasser:	Schouten, Philip C., Grigoriadis, Anita, Kuilman, Thomas, Mirza, Hasan, Watkins, Johnathan A., Cooke, Saskia A., van Dyk, Ewald, Severson, Tesa M., Rueda, Oscar M., Hoogstraat, Marlous, Verhagen, Caroline V.M., Natrajan, Rachael, Chin, Suet-Feung, Lips, Esther H., Kruizinga, Janneke, Velds, Arno, Nieuwland, Marja, Kerkhoven, Ron M., Krijgsman, Oscar, Vens, Conchita, Peeper, Daniel, Nederlof, Petra M., Caldas, Carlos, Tutt, Andrew N., Wessels, Lodewyk F., Linn, Sabine C.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier B.V 01.08.2015 John Wiley & Sons, Inc John Wiley and Sons Inc Wiley
Schlagworte:	Artificial chromosomes Bacterial artificial chromosomes BRCA1 BRCA1 protein Breast cancer Breast Neoplasms - genetics Chemotherapy Classification Cohort Studies Comparative Genomic Hybridization Copy number Copy number aberration profiles Datasets Datasets as Topic Deoxyribonucleic acid DNA DNA damage DNA Methylation DNA repair Female Gene Dosage Genes, BRCA1 Genomes Humans Hybridization Medical research Mutation Next-generation sequencing Oligonucleotides Platinum Randomized Controlled Trials as Topic Research Paper Research Papers Tumors United Kingdom > UK Germany hg 18 BAC SNP6 Breast cancer Copy number aberration profiles BRCA1 CN aCGH NG720 FFPE MIP DNA NG135 SNR Classification hg19 VN BAC32K NGS BAC3K dsDNA
ISSN:	1574-7891, 1878-0261, 1878-0261
Online-Zugang:	Volltext
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