Gut Microbiota-brain Axis

Objective: To systematically review the updated information about the gut microbiota-brain axis. Data Sources: All articles about gut microbiota-brain axis published up to July 18, 2016, were identified through a literature search on PubMed, ScienceDirect, and Web of Science, with the keywords of &q...

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Podrobná bibliografie
Vydáno v:	Chinese medical journal Ročník 129; číslo 19; s. 2373 - 2380
Hlavní autoři:	Wang, Hong-Xing, Wang, Yu-Ping
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	China Wolters Kluwer - Medknow Publications 05.10.2016 Medknow Publications and Media Pvt. Ltd Lippincott Williams & Wilkins Ovid Technologies Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China%Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China Center of Epilepsy, Beijing Institute for Brain Disorders, Laboratory of Brain Disorders, Capital Medical University, Beijing 100069, China Medknow Publications & Media Pvt Ltd Wolters Kluwer
Témata:	Analysis Animal cognition Animals Anxiety Bacteria Behavior Blood-brain barrier Brain Brain - metabolism Brain - physiology Brain research Central Nervous System - metabolism Central Nervous System - physiology Cognition Disease Gastrointestinal Microbiome - physiology Gastrointestinal Tract - microbiology Genomes Gut Microbiota; Gut Microbiota-brain Axis; Metagenomics; Microbiome Humans Hypothalamo-Hypophyseal System - metabolism Hypothalamo-Hypophyseal System - physiology Immune system Irritable bowel syndrome Metabolism Metabolites Microbiota (Symbiotic organisms) Neural networks Neurosciences Physiological aspects Physiology Pituitary-Adrenal System - metabolism Pituitary-Adrenal System - physiology Review Studies Metagenomics Gut Microbiota-brain Axis Gut Microbiota Microbiome
ISSN:	0366-6999, 2542-5641, 2542-5641
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Popis
Shrnutí:	Objective: To systematically review the updated information about the gut microbiota-brain axis. Data Sources: All articles about gut microbiota-brain axis published up to July 18, 2016, were identified through a literature search on PubMed, ScienceDirect, and Web of Science, with the keywords of "gut microbiota", "gut-brain axis", and "neuroscience". Study Selection: All relevant articles on gut microbiota and gut-brain axis were included and carefully reviewed, with no limitation of study design. Results: It is well-recognized that gut microbiota affects the brain's physiological, behavioral, and cognitive functions although its precise mechanism has not yet been fully understood. Gut microbiota-brain axis may include gut microbiota and their metabolic products, enteric nervous system, sympathetic and parasympathetic branches within the autonomic nervous system, neural-immune system, neuroendocrine system, and central nervous system. Moreover, there may be five communication routes between gut microbiota and brain, including the gut-brain's neural network, neuroendocrine-hypothalamic-pituitary-adrenal axis, gut immune system, some neurotransmitters and neural regulators synthesized by gut bacteria, and barrier paths including intestinal mucosal barrier and blood-brain barrier. The microbiome is used to define the composition and functional characteristics of gut microbiota, and metagenomics is an appropriate technique to characterize gut microbiota. Conclusions: Gut microbiota-brain axis refers to a bidirectional information network between the gut microbiota and the brain, which may provide a new way to protect the brain in the near future.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0366-6999 2542-5641 2542-5641
DOI:	10.4103/0366-6999.190667